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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ACAGUAU
Z-value: 0.82
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miRNA associated with seed ACAGUAU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-144-3p
|
MIMAT0000436 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ACAGUAU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 15.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 3.4 | 13.5 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.2 | 11.8 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 2.8 | 11.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.5 | 11.0 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.2 | 10.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.1 | 10.0 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 1.4 | 9.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.2 | 9.8 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.9 | 8.8 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.5 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.1 | 15.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 14.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.6 | 14.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 14.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.7 | 11.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.5 | 10.0 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 9.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.9 | 9.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.5 | 9.6 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.7 | 16.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.4 | 16.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.9 | 15.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.7 | 15.3 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 2.3 | 13.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.4 | 12.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 11.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.5 | 11.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 10.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 14.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 13.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 12.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 11.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 10.0 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.1 | 10.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 8.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 8.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 15.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 13.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 9.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.3 | 8.7 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.4 | 8.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 8.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 7.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 7.5 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 7.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |