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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AGCUGCC

Z-value: 0.62

Motif logo

logo of

miRNA associated with seed AGCUGCC

NamemiRBASE accession
hsa-miR-22-3p
MIMAT0000077

Activity profile of AGCUGCC motif

Sorted Z-values of AGCUGCC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_204380919 20.08 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr1_+_24882560 10.73 ENST00000374392.2
NCMAP
noncompact myelin associated protein
chr1_-_35325400 8.94 ENST00000521580.2
SMIM12
small integral membrane protein 12
chr1_+_52870227 8.65 ENST00000257181.9
PRPF38A
pre-mRNA processing factor 38A
chr22_+_31031639 8.48 ENST00000343605.4
ENST00000300385.8
SLC35E4
solute carrier family 35, member E4
chr7_-_35734730 7.77 ENST00000396081.1
ENST00000311350.3
HERPUD2
HERPUD family member 2
chr17_+_47865917 6.57 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
KAT7
K(lysine) acetyltransferase 7
chr17_-_8055747 6.44 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr2_-_71454185 5.89 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr16_+_30710462 5.82 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr1_-_15911510 5.78 ENST00000375826.3
AGMAT
agmatine ureohydrolase (agmatinase)
chr22_+_40390930 5.58 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr7_-_44924939 5.52 ENST00000395699.2
PURB
purine-rich element binding protein B
chr15_-_45670924 5.42 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr4_+_40058411 5.28 ENST00000261435.6
ENST00000515550.1
N4BP2
NEDD4 binding protein 2
chr6_+_41040678 5.18 ENST00000341376.6
ENST00000353205.5
NFYA
nuclear transcription factor Y, alpha
chr16_-_4292071 4.79 ENST00000399609.3
SRL
sarcalumenin
chr4_-_89205879 4.78 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr3_-_57199397 4.76 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chr5_-_159739532 4.66 ENST00000520748.1
ENST00000393977.3
ENST00000257536.7
CCNJL
cyclin J-like
chr11_+_113930291 4.32 ENST00000335953.4
ZBTB16
zinc finger and BTB domain containing 16
chr11_+_119076745 4.27 ENST00000264033.4
CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase
chr10_-_120514720 4.18 ENST00000369151.3
ENST00000340214.4
CACUL1
CDK2-associated, cullin domain 1
chr2_+_70142189 4.16 ENST00000264444.2
MXD1
MAX dimerization protein 1
chr8_-_48651648 4.12 ENST00000408965.3
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_192778161 4.12 ENST00000235382.5
RGS2
regulator of G-protein signaling 2, 24kDa
chr17_+_47653178 3.98 ENST00000328741.5
NXPH3
neurexophilin 3
chr1_-_212873267 3.81 ENST00000243440.1
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr11_-_62494821 3.79 ENST00000301785.5
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr6_-_152958521 3.75 ENST00000367255.5
ENST00000265368.4
ENST00000448038.1
ENST00000341594.5
SYNE1
spectrin repeat containing, nuclear envelope 1
chr5_+_177540444 3.64 ENST00000274605.5
N4BP3
NEDD4 binding protein 3
chr6_-_99873145 3.62 ENST00000369239.5
ENST00000438806.1
PNISR
PNN-interacting serine/arginine-rich protein
chr2_+_226265364 3.61 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr15_+_41851211 3.60 ENST00000263798.3
TYRO3
TYRO3 protein tyrosine kinase
chr1_+_184356188 3.39 ENST00000235307.6
C1orf21
chromosome 1 open reading frame 21
chr22_+_41777927 3.38 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr2_-_240322643 3.37 ENST00000345617.3
HDAC4
histone deacetylase 4
chr21_-_32931290 3.26 ENST00000286827.3
TIAM1
T-cell lymphoma invasion and metastasis 1
chr11_+_76571911 3.24 ENST00000534206.1
ENST00000532485.1
ENST00000526597.1
ENST00000533873.1
ENST00000538157.1
ACER3
alkaline ceramidase 3
chr10_+_76586348 3.15 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B
K(lysine) acetyltransferase 6B
chr4_-_153457197 3.15 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr19_+_42746927 3.11 ENST00000378108.1
AC006486.1
AC006486.1
chr17_-_36956155 3.05 ENST00000269554.3
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr16_+_1756162 3.05 ENST00000250894.4
ENST00000356010.5
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
chr15_-_83316254 3.03 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr17_-_19771216 2.92 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr6_-_62996066 2.91 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr2_-_43453734 2.84 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr12_+_107168342 2.83 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr2_-_99552620 2.83 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211L
KIAA1211-like
chr1_+_226736446 2.81 ENST00000366788.3
ENST00000366789.4
C1orf95
chromosome 1 open reading frame 95
chr1_+_12227035 2.80 ENST00000376259.3
ENST00000536782.1
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr10_+_92980517 2.79 ENST00000336126.5
PCGF5
polycomb group ring finger 5
chr12_+_56401268 2.71 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr16_+_27561449 2.61 ENST00000261588.4
KIAA0556
KIAA0556
chr17_-_74449252 2.51 ENST00000319380.7
UBE2O
ubiquitin-conjugating enzyme E2O
chr21_+_33245548 2.50 ENST00000270112.2
HUNK
hormonally up-regulated Neu-associated kinase
chr7_-_6312206 2.49 ENST00000350796.3
CYTH3
cytohesin 3
chr5_+_149109825 2.46 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr6_+_53659746 2.43 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr5_-_149492904 2.29 ENST00000286301.3
ENST00000511344.1
CSF1R
colony stimulating factor 1 receptor
chr2_-_25475120 2.27 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr10_-_75634260 2.27 ENST00000372765.1
ENST00000351293.3
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr1_-_20812690 2.26 ENST00000375078.3
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_-_101471479 2.25 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr1_-_169863016 2.23 ENST00000367772.4
ENST00000367771.6
SCYL3
SCY1-like 3 (S. cerevisiae)
chr11_-_31839488 2.20 ENST00000419022.1
ENST00000379132.3
ENST00000379129.2
PAX6
paired box 6
chr16_+_30669720 2.20 ENST00000356166.6
FBRS
fibrosin
chr12_+_70760056 2.18 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr17_-_4890919 2.16 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr2_-_213403565 2.15 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr3_-_135914615 2.14 ENST00000309993.2
MSL2
male-specific lethal 2 homolog (Drosophila)
chr1_-_175161890 2.14 ENST00000545251.2
ENST00000423313.1
KIAA0040
KIAA0040
chr17_+_42836329 1.98 ENST00000200557.6
ADAM11
ADAM metallopeptidase domain 11
chr17_+_54911444 1.97 ENST00000284061.3
ENST00000572810.1
DGKE
diacylglycerol kinase, epsilon 64kDa
chr8_+_17354587 1.92 ENST00000494857.1
ENST00000522656.1
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr12_+_8234807 1.92 ENST00000339754.5
NECAP1
NECAP endocytosis associated 1
chr9_-_95166841 1.89 ENST00000262551.4
OGN
osteoglycin
chr1_+_27561007 1.86 ENST00000319394.3
WDTC1
WD and tetratricopeptide repeats 1
chr7_-_11871815 1.86 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr7_-_14029515 1.75 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr19_+_54705025 1.75 ENST00000441429.1
RPS9
ribosomal protein S9
chr14_-_23288930 1.73 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_+_102295616 1.68 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr3_+_11034403 1.67 ENST00000287766.4
ENST00000425938.1
SLC6A1
solute carrier family 6 (neurotransmitter transporter), member 1
chr21_+_40177143 1.65 ENST00000360214.3
ETS2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr7_+_128577972 1.62 ENST00000357234.5
ENST00000477535.1
ENST00000479582.1
ENST00000464557.1
ENST00000402030.2
IRF5
interferon regulatory factor 5
chr10_-_99094458 1.60 ENST00000371019.2
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr1_-_149889382 1.57 ENST00000369145.1
ENST00000369146.3
SV2A
synaptic vesicle glycoprotein 2A
chr1_-_211307315 1.56 ENST00000271751.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr5_-_175964366 1.56 ENST00000274811.4
RNF44
ring finger protein 44
chr3_+_8775466 1.51 ENST00000343849.2
ENST00000397368.2
CAV3
caveolin 3
chrX_-_54070607 1.51 ENST00000338154.6
ENST00000338946.6
PHF8
PHD finger protein 8
chr7_+_20370746 1.47 ENST00000222573.4
ITGB8
integrin, beta 8
chr19_+_709101 1.46 ENST00000338448.5
PALM
paralemmin
chr4_-_53525406 1.45 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr1_-_28415204 1.41 ENST00000373871.3
EYA3
eyes absent homolog 3 (Drosophila)
chr3_+_43328004 1.40 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr1_+_203444887 1.39 ENST00000343110.2
PRELP
proline/arginine-rich end leucine-rich repeat protein
chr15_-_73661605 1.37 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr16_+_31085714 1.37 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
ZNF646
zinc finger protein 646
chr12_+_9067327 1.36 ENST00000433083.2
ENST00000544916.1
ENST00000544539.1
ENST00000539063.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr16_+_24266874 1.36 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr15_-_72410109 1.33 ENST00000564571.1
MYO9A
myosin IXA
chr9_-_19786926 1.30 ENST00000341998.2
ENST00000286344.3
SLC24A2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr11_-_47788847 1.28 ENST00000263773.5
FNBP4
formin binding protein 4
chr2_-_208030647 1.27 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chrX_-_153363188 1.27 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr2_-_47798044 1.23 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr17_-_617949 1.21 ENST00000401468.3
ENST00000574029.1
ENST00000291074.5
ENST00000571805.1
ENST00000437048.2
ENST00000446250.2
VPS53
vacuolar protein sorting 53 homolog (S. cerevisiae)
chr11_+_65479462 1.20 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5
K(lysine) acetyltransferase 5
chr7_-_79082867 1.19 ENST00000419488.1
ENST00000354212.4
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_344786 1.18 ENST00000264819.4
MIER2
mesoderm induction early response 1, family member 2
chr17_-_73775839 1.16 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3F3B
H3 histone, family 3B (H3.3B)
chr2_+_24714729 1.16 ENST00000406961.1
ENST00000405141.1
NCOA1
nuclear receptor coactivator 1
chr14_+_71108460 1.15 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr9_+_87284622 1.14 ENST00000395882.1
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr1_-_213189108 1.14 ENST00000535388.1
ANGEL2
angel homolog 2 (Drosophila)
chr1_+_159141397 1.14 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr1_+_171810606 1.12 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr16_+_66878814 1.10 ENST00000394069.3
CA7
carbonic anhydrase VII
chr22_-_22221900 1.10 ENST00000215832.6
ENST00000398822.3
MAPK1
mitogen-activated protein kinase 1
chr1_-_36022979 1.09 ENST00000469892.1
ENST00000325722.3
KIAA0319L
KIAA0319-like
chr8_-_41909496 1.08 ENST00000265713.2
ENST00000406337.1
ENST00000396930.3
ENST00000485568.1
ENST00000426524.1
KAT6A
K(lysine) acetyltransferase 6A
chr9_-_132404374 1.06 ENST00000277459.4
ENST00000450050.2
ENST00000277458.4
ASB6
ankyrin repeat and SOCS box containing 6
chr14_+_33408449 1.05 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
NPAS3
neuronal PAS domain protein 3
chr16_+_10971037 1.04 ENST00000324288.8
ENST00000381835.5
CIITA
class II, major histocompatibility complex, transactivator
chr12_+_52306113 1.04 ENST00000547400.1
ENST00000550683.1
ENST00000419526.2
ACVRL1
activin A receptor type II-like 1
chrX_+_24483338 1.01 ENST00000379162.4
ENST00000441463.2
PDK3
pyruvate dehydrogenase kinase, isozyme 3
chr2_+_135676381 0.98 ENST00000537343.1
ENST00000295238.6
ENST00000264157.5
CCNT2
cyclin T2
chr10_-_3827417 0.95 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chrX_-_112084043 0.94 ENST00000304758.1
AMOT
angiomotin
chr1_-_17445930 0.94 ENST00000375486.4
ENST00000375481.1
ENST00000444885.2
PADI2
peptidyl arginine deiminase, type II
chr12_+_62860581 0.92 ENST00000393632.2
ENST00000393630.3
ENST00000280379.6
ENST00000546600.1
ENST00000552738.1
ENST00000393629.2
ENST00000552115.1
MON2
MON2 homolog (S. cerevisiae)
chr4_+_94750014 0.92 ENST00000306011.3
ATOH1
atonal homolog 1 (Drosophila)
chr4_-_120550146 0.90 ENST00000354960.3
PDE5A
phosphodiesterase 5A, cGMP-specific
chr11_-_64646086 0.90 ENST00000320631.3
EHD1
EH-domain containing 1
chr9_-_117568365 0.89 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr1_+_28696111 0.89 ENST00000373839.3
PHACTR4
phosphatase and actin regulator 4
chr2_+_26987111 0.83 ENST00000344420.5
ENST00000416475.2
SLC35F6
solute carrier family 35, member F6
chr18_+_46065393 0.82 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr17_+_40118759 0.82 ENST00000393892.3
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr17_-_40897043 0.81 ENST00000428826.2
ENST00000592492.1
ENST00000585893.1
ENST00000593214.1
ENST00000590078.1
ENST00000586382.1
ENST00000415827.2
ENST00000592743.1
ENST00000586089.1
ENST00000435174.1
EZH1
enhancer of zeste homolog 1 (Drosophila)
chr21_-_35831880 0.80 ENST00000399289.3
ENST00000432085.1
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr1_+_183441600 0.79 ENST00000367537.3
SMG7
SMG7 nonsense mediated mRNA decay factor
chr8_+_1449532 0.77 ENST00000421627.2
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr20_+_49126881 0.77 ENST00000371621.3
ENST00000541713.1
PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr16_-_58663720 0.76 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr20_+_33814457 0.75 ENST00000246186.6
MMP24
matrix metallopeptidase 24 (membrane-inserted)
chr2_+_28615669 0.75 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr21_-_36260980 0.75 ENST00000344691.4
ENST00000358356.5
RUNX1
runt-related transcription factor 1
chr17_+_2240775 0.74 ENST00000268989.3
ENST00000426855.2
SGSM2
small G protein signaling modulator 2
chr10_-_105615164 0.74 ENST00000355946.2
ENST00000369774.4
SH3PXD2A
SH3 and PX domains 2A
chr12_-_57400227 0.74 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr11_+_117014983 0.72 ENST00000527958.1
ENST00000419197.2
ENST00000304808.6
ENST00000529887.2
PAFAH1B2
platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
chr10_+_69644404 0.72 ENST00000212015.6
SIRT1
sirtuin 1
chr4_-_42659102 0.72 ENST00000264449.10
ENST00000510289.1
ENST00000381668.5
ATP8A1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr11_+_118307179 0.70 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
KMT2A
lysine (K)-specific methyltransferase 2A
chr10_+_72164135 0.70 ENST00000373218.4
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr2_-_127864577 0.69 ENST00000376113.2
BIN1
bridging integrator 1
chr5_-_141257954 0.69 ENST00000456271.1
ENST00000394536.3
ENST00000503492.1
ENST00000287008.3
PCDH1
protocadherin 1
chr12_+_103351444 0.67 ENST00000266744.3
ASCL1
achaete-scute family bHLH transcription factor 1
chr20_-_30795511 0.67 ENST00000246229.4
PLAGL2
pleiomorphic adenoma gene-like 2
chr12_+_49372251 0.66 ENST00000293549.3
WNT1
wingless-type MMTV integration site family, member 1
chr4_-_41216619 0.65 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr10_+_96162242 0.63 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr3_-_50649192 0.62 ENST00000443053.2
ENST00000348721.3
CISH
cytokine inducible SH2-containing protein
chr1_+_63788730 0.62 ENST00000371116.2
FOXD3
forkhead box D3
chr22_-_30901637 0.62 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
SEC14L4
SEC14-like 4 (S. cerevisiae)
chr6_-_29527702 0.62 ENST00000377050.4
UBD
ubiquitin D
chr17_+_38219063 0.62 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
THRA
thyroid hormone receptor, alpha
chr20_+_48599506 0.61 ENST00000244050.2
SNAI1
snail family zinc finger 1
chr1_+_209757051 0.58 ENST00000009105.1
ENST00000423146.1
ENST00000361322.2
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr1_+_154377669 0.56 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr20_-_48184638 0.54 ENST00000244043.4
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr22_+_41487711 0.54 ENST00000263253.7
EP300
E1A binding protein p300
chr4_-_87281224 0.53 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr21_-_45660723 0.50 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
ICOSLG
inducible T-cell co-stimulator ligand
chr1_-_11863171 0.49 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr9_+_101867359 0.48 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr3_+_38495333 0.47 ENST00000352511.4
ACVR2B
activin A receptor, type IIB
chr1_+_45965725 0.41 ENST00000401061.4
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr11_+_120207787 0.41 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr12_+_93965451 0.40 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr17_+_35766965 0.38 ENST00000394395.2
ENST00000589153.1
ENST00000586023.1
TADA2A
transcriptional adaptor 2A
chr7_-_27170352 0.38 ENST00000428284.2
ENST00000360046.5
HOXA4
homeobox A4
chr15_-_34502278 0.36 ENST00000559515.1
ENST00000256544.3
ENST00000560108.1
ENST00000559462.1
KATNBL1
katanin p80 subunit B-like 1
chr3_-_197476560 0.36 ENST00000273582.5
KIAA0226
KIAA0226
chr1_+_52682052 0.36 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr12_+_52345448 0.35 ENST00000257963.4
ENST00000541224.1
ENST00000426655.2
ENST00000536420.1
ENST00000415850.2
ACVR1B
activin A receptor, type IB
chr12_+_53774423 0.34 ENST00000426431.2
SP1
Sp1 transcription factor
chr1_-_27481401 0.32 ENST00000263980.3
SLC9A1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
chr1_+_145524891 0.31 ENST00000369304.3
ITGA10
integrin, alpha 10
chr5_+_142149955 0.30 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr11_-_72145669 0.30 ENST00000543042.1
ENST00000294053.3
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr10_-_35930219 0.30 ENST00000374694.1
FZD8
frizzled family receptor 8
chr1_-_154155595 0.29 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
TPM3
tropomyosin 3
chr4_-_104640973 0.28 ENST00000304883.2
TACR3
tachykinin receptor 3
chr13_-_28545276 0.28 ENST00000381020.7
CDX2
caudal type homeobox 2
chr9_+_116207007 0.27 ENST00000374140.2
RGS3
regulator of G-protein signaling 3

Network of associatons between targets according to the STRING database.

First level regulatory network of AGCUGCC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
2.3 20.9 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
1.6 6.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
1.4 5.8 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
1.1 6.4 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.9 4.3 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.7 2.2 GO:2000366 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.6 1.9 GO:1903401 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine transmembrane transport(GO:1903401) L-lysine import into cell(GO:1903410)
0.6 3.1 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.6 4.3 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.6 1.8 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.6 4.1 GO:0010519 negative regulation of phospholipase activity(GO:0010519) regulation of adrenergic receptor signaling pathway(GO:0071877)
0.6 1.7 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.6 1.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.5 3.3 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.5 1.5 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188) histone H3-K27 demethylation(GO:0071557)
0.5 5.4 GO:0006600 creatine metabolic process(GO:0006600)
0.4 2.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.4 1.3 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.4 1.7 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.4 2.9 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.4 4.1 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.4 2.8 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.4 1.5 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 2.3 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.4 3.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 3.8 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.4 1.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.4 1.1 GO:0019858 cytosine metabolic process(GO:0019858)
0.3 1.6 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.3 0.9 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.3 0.9 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 1.2 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.3 0.9 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 1.8 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 0.6 GO:0002384 hepatic immune response(GO:0002384)
0.3 1.7 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.3 2.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 3.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.3 3.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.3 2.3 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.2 1.0 GO:0019086 late viral transcription(GO:0019086)
0.2 6.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 2.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 1.4 GO:0071321 cellular response to cGMP(GO:0071321)
0.2 1.1 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.2 0.7 GO:0003358 noradrenergic neuron development(GO:0003358) neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) stem cell fate determination(GO:0048867) regulation of timing of neuron differentiation(GO:0060164) olfactory pit development(GO:0060166)
0.2 1.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.2 0.7 GO:0060061 Spemann organizer formation(GO:0060061)
0.2 0.6 GO:0070842 aggresome assembly(GO:0070842)
0.2 0.7 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 0.9 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.2 1.5 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.2 0.7 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 0.7 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) regulation of cellular response to drug(GO:2001038)
0.2 3.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.2 0.5 GO:0003343 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
0.2 1.4 GO:0008343 adult feeding behavior(GO:0008343) righting reflex(GO:0060013)
0.2 0.3 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.2 3.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 4.8 GO:0009083 branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083)
0.1 1.0 GO:0035912 dorsal aorta morphogenesis(GO:0035912)
0.1 1.6 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 1.0 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1 0.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.5 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 1.0 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 0.9 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 2.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.6 GO:0061314 regulation of cell differentiation involved in embryonic placenta development(GO:0060800) Notch signaling involved in heart development(GO:0061314)
0.1 2.3 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.1 0.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.1 2.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 1.9 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.1 0.5 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 1.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 2.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 1.5 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.4 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 0.9 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.1 1.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.1 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 2.2 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.1 0.7 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 2.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 4.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 1.9 GO:0001525 angiogenesis(GO:0001525)
0.1 0.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 6.0 GO:0016573 histone acetylation(GO:0016573)
0.1 0.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.7 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.7 GO:0032106 positive regulation of macroautophagy(GO:0016239) positive regulation of response to extracellular stimulus(GO:0032106) positive regulation of response to nutrient levels(GO:0032109)
0.1 2.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.3 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.5 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 4.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.5 GO:0007440 foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.1 0.4 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.1 0.8 GO:0071435 potassium ion export(GO:0071435) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.8 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.9 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 1.7 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.1 GO:1900738 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.4 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.6 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.0 0.6 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.8 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298) regulation of forebrain neuron differentiation(GO:2000977)
0.0 4.1 GO:0048839 inner ear development(GO:0048839)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 5.0 GO:0006986 response to unfolded protein(GO:0006986)
0.0 3.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.5 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.4 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 0.8 GO:0021766 hippocampus development(GO:0021766)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 4.7 GO:0048511 rhythmic process(GO:0048511)
0.0 2.6 GO:0007601 visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953)
0.0 2.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 4.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 20.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 2.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.6 10.7 GO:0033270 paranode region of axon(GO:0033270)
0.5 1.5 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.5 5.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 3.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.4 4.8 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.4 4.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4 2.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.4 5.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 2.8 GO:0043196 varicosity(GO:0043196)
0.3 4.3 GO:0016600 flotillin complex(GO:0016600)
0.3 8.7 GO:0071011 precatalytic spliceosome(GO:0071011)
0.3 2.1 GO:0072487 MSL complex(GO:0072487)
0.3 1.2 GO:1990745 EARP complex(GO:1990745)
0.3 1.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 3.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 0.9 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 2.0 GO:0001741 XY body(GO:0001741)
0.1 2.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 2.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.3 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.8 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.1 7.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 1.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 2.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.7 GO:0043194 axon initial segment(GO:0043194)
0.1 5.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 5.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.8 GO:0005883 neurofilament(GO:0005883)
0.0 4.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 4.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.1 GO:0043235 receptor complex(GO:0043235)
0.0 2.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0032590 dendrite membrane(GO:0032590)
0.0 3.9 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 3.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.8 GO:0016604 nuclear body(GO:0016604)
0.0 0.6 GO:0005901 caveola(GO:0005901)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
1.0 3.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.9 10.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 3.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.8 3.2 GO:0017040 ceramidase activity(GO:0017040)
0.8 0.8 GO:0042054 histone-lysine N-methyltransferase activity(GO:0018024) histone methyltransferase activity(GO:0042054)
0.7 2.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.7 4.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.6 1.9 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.5 1.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.5 6.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 8.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.4 4.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.4 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 3.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.4 4.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 6.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 2.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 2.3 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.4 2.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.3 1.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.3 1.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 5.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.3 1.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.3 2.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 0.6 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.3 1.7 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.3 1.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.3 1.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.3 3.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 0.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 1.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.2 7.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.8 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 5.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 1.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 1.5 GO:0071253 connexin binding(GO:0071253)
0.2 21.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 0.7 GO:0043398 HLH domain binding(GO:0043398)
0.2 12.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 2.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 0.9 GO:0043532 angiostatin binding(GO:0043532)
0.2 0.5 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 3.8 GO:0005521 lamin binding(GO:0005521)
0.1 0.7 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.0 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 7.1 GO:0070888 E-box binding(GO:0070888)
0.1 2.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.3 GO:0035197 siRNA binding(GO:0035197)
0.1 2.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 3.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 2.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.7 GO:0016015 morphogen activity(GO:0016015)
0.1 2.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.5 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 2.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.8 GO:0031433 telethonin binding(GO:0031433)
0.1 4.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 1.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 1.5 GO:0050780 dopamine receptor binding(GO:0050780)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 2.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 3.6 GO:0032561 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 5.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0048156 tau protein binding(GO:0048156)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)
0.0 0.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 3.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.9 GO:0030553 cGMP binding(GO:0030553) 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 2.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 6.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.8 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.7 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.8 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 7.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 2.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 3.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 1.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 7.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 4.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 8.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 7.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 2.3 PID IFNG PATHWAY IFN-gamma pathway
0.1 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 1.5 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.8 PID FGF PATHWAY FGF signaling pathway
0.1 3.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.0 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.3 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 2.2 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3 4.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 5.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 3.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 6.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 6.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.9 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 3.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.2 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.7 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.1 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 1.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 6.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.6 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.0 4.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.5 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.4 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 4.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex