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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AR_NR3C2

Z-value: 1.31

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_667644650.384.7e-09Click!
NR3C2hg19_v2_chr4_-_149365827_1493658700.363.7e-08Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56659687 62.81 ENST00000568293.1
ENST00000330439.6
MT1E
metallothionein 1E
chr16_+_56716336 46.85 ENST00000394485.4
ENST00000562939.1
MT1X
metallothionein 1X
chr3_-_58563094 37.44 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr16_+_56642041 35.97 ENST00000245185.5
MT2A
metallothionein 2A
chr16_+_56642489 34.57 ENST00000561491.1
MT2A
metallothionein 2A
chr1_+_22979474 34.26 ENST00000509305.1
C1QB
complement component 1, q subcomponent, B chain
chr1_+_22979676 33.39 ENST00000432749.2
ENST00000314933.6
C1QB
complement component 1, q subcomponent, B chain
chr12_+_53443680 32.88 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_53443963 30.26 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_+_35630926 29.65 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr19_+_35630628 27.87 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr14_-_21493884 25.04 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr14_-_21493649 21.98 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr16_+_56666563 19.89 ENST00000570233.1
MT1M
metallothionein 1M
chr2_+_238395879 18.73 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr7_-_94285402 16.76 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr2_+_238395803 16.20 ENST00000264605.3
MLPH
melanophilin
chr16_+_56672571 14.97 ENST00000290705.8
MT1A
metallothionein 1A
chr17_-_19290117 14.20 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr7_-_94285511 13.92 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr17_-_19290483 12.37 ENST00000395592.2
ENST00000299610.4
MFAP4
microfibrillar-associated protein 4
chr5_+_140186647 10.64 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr19_+_35630344 10.07 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr18_+_56530136 9.18 ENST00000591083.1
ZNF532
zinc finger protein 532
chr7_+_94285637 8.52 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chrX_-_6453159 8.27 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr7_-_94285472 7.74 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr5_-_149792295 7.29 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chrY_-_16098393 7.00 ENST00000250825.4
VCY
variable charge, Y-linked
chr11_+_18287801 6.58 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr12_+_51318513 6.33 ENST00000332160.4
METTL7A
methyltransferase like 7A
chrX_-_8139308 6.29 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr2_-_242576864 6.21 ENST00000407315.1
THAP4
THAP domain containing 4
chr18_+_7754957 6.13 ENST00000400053.4
PTPRM
protein tyrosine phosphatase, receptor type, M
chr11_+_18287721 6.08 ENST00000356524.4
SAA1
serum amyloid A1
chrY_+_16168097 5.51 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr19_-_8408139 5.43 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr17_-_61996136 5.33 ENST00000342364.4
GH1
growth hormone 1
chr11_-_236326 4.90 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr2_+_102953608 4.85 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr12_+_66582919 4.74 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr8_-_49834299 4.73 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr8_-_49833978 4.69 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr15_+_42694573 4.67 ENST00000397200.4
ENST00000569827.1
CAPN3
calpain 3, (p94)
chr17_-_61996160 4.35 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1
growth hormone 1
chr12_-_11002063 4.15 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr3_-_15382875 4.12 ENST00000408919.3
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr14_+_24616588 4.01 ENST00000324103.6
ENST00000559260.1
RNF31
ring finger protein 31
chr5_-_179499086 3.62 ENST00000261947.4
RNF130
ring finger protein 130
chr16_-_4852915 3.55 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr16_+_67207838 3.52 ENST00000566871.1
ENST00000268605.7
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr5_-_179499108 3.50 ENST00000521389.1
RNF130
ring finger protein 130
chr17_-_61996192 3.32 ENST00000392824.4
CSHL1
chorionic somatomammotropin hormone-like 1
chr12_-_10251603 3.16 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr17_-_61959202 2.91 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
GH2
growth hormone 2
chr16_-_66584059 2.89 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr16_+_67207872 2.76 ENST00000563258.1
ENST00000568146.1
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr6_-_52774464 2.69 ENST00000370968.1
ENST00000211122.3
GSTA3
glutathione S-transferase alpha 3
chr19_-_14117074 2.67 ENST00000588885.1
ENST00000254325.4
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr4_-_8442438 2.63 ENST00000356406.5
ENST00000413009.2
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr12_+_125549925 2.41 ENST00000316519.6
AACS
acetoacetyl-CoA synthetase
chrX_+_17755563 2.21 ENST00000380045.3
ENST00000380041.3
ENST00000380043.3
ENST00000398080.1
SCML1
sex comb on midleg-like 1 (Drosophila)
chr5_-_179498703 2.21 ENST00000522208.2
RNF130
ring finger protein 130
chrX_+_153029633 2.18 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr17_-_16472483 2.04 ENST00000395824.1
ENST00000448349.2
ENST00000395825.3
ZNF287
zinc finger protein 287
chr6_-_111927062 1.96 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr11_-_506739 1.78 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr7_+_94139105 1.77 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr1_+_76262552 1.71 ENST00000263187.3
MSH4
mutS homolog 4
chr15_-_28344439 1.71 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II
chrX_+_2609356 1.54 ENST00000381180.3
ENST00000449611.1
CD99
CD99 molecule
chr8_-_21669826 1.44 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr3_+_169491171 1.38 ENST00000356716.4
MYNN
myoneurin
chrX_+_2609207 1.37 ENST00000381192.3
CD99
CD99 molecule
chrX_+_8433376 1.31 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr17_+_41323204 1.22 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1
neighbor of BRCA1 gene 1
chr12_+_125549973 1.21 ENST00000536752.1
ENST00000261686.6
AACS
acetoacetyl-CoA synthetase
chr13_+_113777105 1.19 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
F10
coagulation factor X
chr1_-_27693349 1.19 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr22_+_18632666 1.04 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr19_+_8117881 1.00 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr22_+_19939026 0.97 ENST00000406520.3
COMT
catechol-O-methyltransferase
chr4_+_87928140 0.94 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr2_+_27435179 0.89 ENST00000606999.1
ENST00000405489.3
ATRAID
all-trans retinoic acid-induced differentiation factor
chr3_+_169490606 0.86 ENST00000349841.5
MYNN
myoneurin
chr14_-_106692191 0.66 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr16_-_67978016 0.60 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr1_-_241799232 0.60 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chrX_+_2609317 0.57 ENST00000381187.3
ENST00000381184.1
CD99
CD99 molecule
chr1_-_24469602 0.55 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr3_-_188665428 0.54 ENST00000444488.1
TPRG1-AS1
TPRG1 antisense RNA 1
chr3_+_13521665 0.54 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
HDAC11
histone deacetylase 11
chr19_+_54704610 0.50 ENST00000302907.4
RPS9
ribosomal protein S9
chr8_-_62602327 0.28 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr13_-_26452679 0.14 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr12_-_56615693 0.08 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
RNF41
ring finger protein 41

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
14.7 117.4 GO:0036018 cellular response to erythropoietin(GO:0036018)
11.3 67.6 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
3.9 97.7 GO:0071294 cellular response to zinc ion(GO:0071294)
3.1 9.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.9 47.0 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.3 34.9 GO:0030050 vesicle transport along actin filament(GO:0030050)
2.2 26.6 GO:0048251 elastic fiber assembly(GO:0048251)
2.1 6.3 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
1.5 7.3 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.2 9.7 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.9 4.7 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.8 4.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.8 4.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.7 2.9 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.6 3.6 GO:0034201 response to oleic acid(GO:0034201)
0.5 4.0 GO:0023035 CD40 signaling pathway(GO:0023035) protein linear polyubiquitination(GO:0097039)
0.5 4.9 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.5 66.8 GO:0030449 regulation of complement activation(GO:0030449)
0.4 1.7 GO:0043474 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.3 12.7 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.3 2.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.2 6.1 GO:0010842 retina layer formation(GO:0010842)
0.2 1.0 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.2 1.7 GO:0051026 chiasma assembly(GO:0051026)
0.2 2.6 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 0.6 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 1.2 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 4.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 1.4 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 2.9 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 37.9 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 2.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 8.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 0.3 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.5 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 2.7 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 10.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 4.1 GO:0001895 retina homeostasis(GO:0001895)
0.1 31.9 GO:0001558 regulation of cell growth(GO:0001558)
0.0 3.3 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.5 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 1.2 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 1.0 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 1.2 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 13.4 GO:0007420 brain development(GO:0007420)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 1.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.5 67.7 GO:0005602 complement component C1 complex(GO:0005602)
4.8 38.4 GO:0016012 sarcoglycan complex(GO:0016012)
3.4 67.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
3.2 9.7 GO:0070195 growth hormone receptor complex(GO:0070195)
2.7 26.6 GO:0071953 elastic fiber(GO:0071953)
1.0 7.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.8 4.0 GO:0071797 LUBAC complex(GO:0071797)
0.5 12.7 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.4 1.7 GO:0005713 recombination nodule(GO:0005713)
0.3 295.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 1.3 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.7 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 6.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 4.7 GO:0030315 T-tubule(GO:0030315)
0.1 6.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.9 GO:0031904 endosome lumen(GO:0031904)
0.1 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 21.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0031430 M band(GO:0031430)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 70.5 GO:0046870 cadmium ion binding(GO:0046870)
3.2 9.7 GO:0005148 prolactin receptor binding(GO:0005148)
1.6 4.8 GO:0002113 interleukin-33 binding(GO:0002113)
1.5 7.3 GO:0042289 MHC class II protein binding(GO:0042289)
1.3 67.6 GO:0017080 sodium channel regulator activity(GO:0017080)
1.0 2.9 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.7 6.3 GO:0035877 death effector domain binding(GO:0035877)
0.5 2.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.5 2.6 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.4 34.9 GO:0017022 myosin binding(GO:0017022)
0.4 4.7 GO:0031432 titin binding(GO:0031432)
0.3 3.6 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.3 12.7 GO:0042056 chemoattractant activity(GO:0042056)
0.3 5.4 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136)
0.2 68.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 6.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 1.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 155.0 GO:0008270 zinc ion binding(GO:0008270)
0.2 1.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 0.6 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 1.0 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 1.3 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 1.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 10.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.5 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 2.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 6.2 GO:0005179 hormone activity(GO:0005179)
0.0 4.0 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 4.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 9.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 4.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 9.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.2 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 70.5 PID AP1 PATHWAY AP-1 transcription factor network
0.4 73.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 12.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 47.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 4.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 26.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 6.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 8.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 4.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 15.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 67.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 70.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.6 9.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 12.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 4.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 7.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.0 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation