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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AUGGCAC

Z-value: 0.92

Motif logo

logo of

miRNA associated with seed AUGGCAC

NamemiRBASE accession
hsa-miR-183-5p.1
MIMAT0000261

Activity profile of AUGGCAC motif

Sorted Z-values of AUGGCAC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_111195973 19.66 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr3_+_152017181 18.44 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr5_+_65222299 18.34 ENST00000284037.5
ERBB2IP
erbb2 interacting protein
chr5_-_133561752 17.56 ENST00000519718.1
ENST00000481195.1
CTD-2410N18.5
PPP2CA
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme
chr12_-_76953284 16.74 ENST00000547544.1
ENST00000393249.2
OSBPL8
oxysterol binding protein-like 8
chr15_+_57210818 15.78 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr15_+_77223960 15.46 ENST00000394885.3
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr8_+_6565854 15.46 ENST00000285518.6
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chrX_-_20284958 15.19 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr1_-_94374946 14.70 ENST00000370238.3
GCLM
glutamate-cysteine ligase, modifier subunit
chr8_+_26149007 14.57 ENST00000380737.3
ENST00000524169.1
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr2_-_161350305 14.56 ENST00000348849.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr2_+_201676256 14.08 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
BZW1
basic leucine zipper and W2 domains 1
chr8_+_48920960 13.35 ENST00000523111.2
ENST00000523432.1
ENST00000521346.1
ENST00000517630.1
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr8_+_98656336 13.06 ENST00000336273.3
MTDH
metadherin
chr13_-_23949671 12.82 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr13_+_76123883 12.77 ENST00000377595.3
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr6_-_159239257 12.00 ENST00000337147.7
ENST00000392177.4
EZR
ezrin
chr12_+_64798095 11.92 ENST00000332707.5
XPOT
exportin, tRNA
chr3_+_130569429 11.89 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr18_+_29671812 11.60 ENST00000261593.3
ENST00000578914.1
RNF138
ring finger protein 138, E3 ubiquitin protein ligase
chr7_+_39663061 11.57 ENST00000005257.2
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr19_+_7459998 11.35 ENST00000319670.9
ENST00000599752.1
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr1_-_225840747 10.90 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr15_-_52861394 10.49 ENST00000563277.1
ENST00000566423.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr1_-_68299130 10.46 ENST00000370982.3
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr7_-_16685422 10.23 ENST00000306999.2
ANKMY2
ankyrin repeat and MYND domain containing 2
chr15_-_64673630 10.16 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr8_-_103876965 10.15 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr5_+_61602055 10.03 ENST00000381103.2
KIF2A
kinesin heavy chain member 2A
chr3_+_169940153 9.40 ENST00000295797.4
PRKCI
protein kinase C, iota
chr12_-_92539614 9.09 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr1_-_1822495 8.87 ENST00000378609.4
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr12_+_72148614 8.39 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr10_+_22610124 8.29 ENST00000376663.3
BMI1
BMI1 polycomb ring finger oncogene
chr10_-_33246722 7.78 ENST00000437302.1
ENST00000396033.2
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr15_-_90645679 7.77 ENST00000539790.1
ENST00000559482.1
ENST00000330062.3
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr5_+_151151471 7.36 ENST00000394123.3
ENST00000543466.1
G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr20_-_524455 7.33 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr5_+_68462837 7.19 ENST00000256442.5
CCNB1
cyclin B1
chr8_+_41348072 7.19 ENST00000405786.2
GOLGA7
golgin A7
chr4_+_88928777 7.14 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr2_+_120517174 7.03 ENST00000263708.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr2_+_159313452 7.01 ENST00000389757.3
ENST00000389759.3
PKP4
plakophilin 4
chr7_+_69064300 6.90 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr13_-_31736027 6.76 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr6_+_161412759 6.49 ENST00000366919.2
ENST00000392142.4
ENST00000366920.2
ENST00000348824.7
MAP3K4
mitogen-activated protein kinase kinase kinase 4
chr8_+_110346546 6.38 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr1_-_84972248 6.37 ENST00000370645.4
ENST00000370641.3
GNG5
guanine nucleotide binding protein (G protein), gamma 5
chr9_-_127952032 6.13 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
PPP6C
protein phosphatase 6, catalytic subunit
chr3_+_171758344 6.08 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr5_+_133861790 5.83 ENST00000395003.1
PHF15
jade family PHD finger 2
chr3_-_33481835 5.77 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr5_-_142783175 5.69 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chrX_+_41192595 5.36 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr2_-_100106419 5.30 ENST00000393445.3
ENST00000258428.3
REV1
REV1, polymerase (DNA directed)
chr8_+_64081118 5.19 ENST00000539294.1
YTHDF3
YTH domain family, member 3
chr11_+_125439298 4.99 ENST00000278903.6
ENST00000343678.4
ENST00000524723.1
ENST00000527842.2
EI24
etoposide induced 2.4
chr9_+_33025209 4.87 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr14_+_105886150 4.86 ENST00000331320.7
ENST00000406191.1
MTA1
metastasis associated 1
chr10_-_114206649 4.73 ENST00000369404.3
ENST00000369405.3
ZDHHC6
zinc finger, DHHC-type containing 6
chr5_-_137911049 4.59 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr4_-_187644930 4.48 ENST00000441802.2
FAT1
FAT atypical cadherin 1
chr5_-_64064508 4.35 ENST00000513458.4
SREK1IP1
SREK1-interacting protein 1
chr10_+_11206925 4.20 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr3_-_149688896 4.13 ENST00000239940.7
PFN2
profilin 2
chr7_+_35840542 4.10 ENST00000435235.1
ENST00000399034.2
ENST00000350320.6
ENST00000469679.2
SEPT7
septin 7
chr9_-_114246635 4.09 ENST00000338205.5
KIAA0368
KIAA0368
chr1_+_70671363 4.09 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr17_-_60142609 4.07 ENST00000397786.2
MED13
mediator complex subunit 13
chr3_-_72496035 4.01 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr3_-_160283348 3.98 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr3_-_100120223 3.95 ENST00000284320.5
TOMM70A
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr15_-_65809581 3.90 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr10_+_114709999 3.87 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr12_+_19282643 3.85 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr1_-_235491462 3.84 ENST00000418304.1
ENST00000264183.3
ENST00000349213.3
ARID4B
AT rich interactive domain 4B (RBP1-like)
chr2_-_227664474 3.53 ENST00000305123.5
IRS1
insulin receptor substrate 1
chr5_+_102201430 3.49 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr10_+_74033672 3.39 ENST00000307365.3
DDIT4
DNA-damage-inducible transcript 4
chr15_+_64388166 3.29 ENST00000353874.4
ENST00000261889.5
ENST00000559844.1
ENST00000561026.1
ENST00000558040.1
SNX1
sorting nexin 1
chr1_+_203595903 3.29 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_+_37903432 3.20 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr10_+_31608054 3.19 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
ZEB1
zinc finger E-box binding homeobox 1
chr16_+_85646763 3.18 ENST00000411612.1
ENST00000253458.7
GSE1
Gse1 coiled-coil protein
chr1_+_174769006 3.16 ENST00000489615.1
RABGAP1L
RAB GTPase activating protein 1-like
chr9_+_470288 3.10 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr14_-_50999307 3.10 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_+_231577532 3.09 ENST00000258418.5
CAB39
calcium binding protein 39
chr14_+_105331596 3.02 ENST00000556508.1
ENST00000414716.3
ENST00000453495.1
ENST00000418279.1
CEP170B
centrosomal protein 170B
chr12_+_67663056 2.96 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr6_+_88182643 2.86 ENST00000369556.3
ENST00000544441.1
ENST00000369552.4
ENST00000369557.5
SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr5_-_77844974 2.86 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr6_-_132834184 2.69 ENST00000367941.2
ENST00000367937.4
STX7
syntaxin 7
chr2_+_106361333 2.61 ENST00000233154.4
ENST00000451463.2
NCK2
NCK adaptor protein 2
chr17_-_74733404 2.60 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr17_-_1359443 2.58 ENST00000574295.1
ENST00000398970.5
ENST00000300574.2
CRK
v-crk avian sarcoma virus CT10 oncogene homolog
chr14_+_102228123 2.54 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr1_-_115259337 2.40 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chrX_-_110655391 2.33 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr7_-_72936531 2.30 ENST00000339594.4
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr1_+_193091080 2.27 ENST00000367435.3
CDC73
cell division cycle 73
chr2_+_30369807 2.20 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5
yippee-like 5 (Drosophila)
chrX_-_131352152 2.13 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr10_+_22605304 2.03 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr4_-_39640700 2.01 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr5_+_118407053 1.99 ENST00000311085.8
ENST00000539542.1
DMXL1
Dmx-like 1
chr8_+_26240414 1.72 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_+_181452678 1.69 ENST00000367570.1
ENST00000526775.1
ENST00000357570.5
ENST00000358338.5
ENST00000367567.4
CACNA1E
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr8_-_23712312 1.67 ENST00000290271.2
STC1
stanniocalcin 1
chr10_+_112631547 1.57 ENST00000280154.7
ENST00000393104.2
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr14_+_55518349 1.57 ENST00000395468.4
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr5_-_32174369 1.51 ENST00000265070.6
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr3_+_140660634 1.51 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr9_-_80646374 1.51 ENST00000286548.4
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr15_+_63334831 1.49 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
TPM1
tropomyosin 1 (alpha)
chr4_+_170541660 1.48 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr6_+_163835669 1.40 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI
QKI, KH domain containing, RNA binding
chr2_+_169312350 1.38 ENST00000305747.6
CERS6
ceramide synthase 6
chr3_+_186501336 1.37 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chrX_+_12993202 1.36 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr5_-_114961858 1.36 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr1_-_236767779 1.27 ENST00000366579.1
ENST00000366582.3
ENST00000366581.2
HEATR1
HEAT repeat containing 1
chr6_+_7107999 1.25 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1
ras responsive element binding protein 1
chr7_+_155089486 1.18 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr1_-_160254913 0.96 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
PEX19
DCAF8
DCAF8
peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr19_+_11466062 0.95 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr4_+_148538517 0.89 ENST00000296582.3
ENST00000508208.1
TMEM184C
transmembrane protein 184C
chr1_-_93257951 0.89 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr10_-_62704005 0.82 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr12_+_49761224 0.82 ENST00000553127.1
ENST00000321898.6
SPATS2
spermatogenesis associated, serine-rich 2
chr10_-_104262426 0.77 ENST00000487599.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chrX_-_15353629 0.70 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_-_164913777 0.62 ENST00000475390.1
SLITRK3
SLIT and NTRK-like family, member 3
chr10_-_52383644 0.61 ENST00000361781.2
SGMS1
sphingomyelin synthase 1
chr11_+_111945011 0.60 ENST00000532163.1
ENST00000280352.9
ENST00000530104.1
ENST00000526879.1
ENST00000393047.3
ENST00000525785.1
C11orf57
chromosome 11 open reading frame 57
chr20_-_14318248 0.58 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr2_-_183903133 0.51 ENST00000361354.4
NCKAP1
NCK-associated protein 1
chr8_-_30670384 0.48 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr3_-_150264272 0.46 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chr22_+_40573921 0.44 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr1_+_25071848 0.42 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr5_-_168006591 0.42 ENST00000239231.6
PANK3
pantothenate kinase 3
chr10_-_33623564 0.41 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr2_+_42396472 0.41 ENST00000318522.5
ENST00000402711.2
EML4
echinoderm microtubule associated protein like 4
chr7_+_138145076 0.40 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr1_+_78470530 0.39 ENST00000370763.5
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_-_139726181 0.38 ENST00000507104.1
ENST00000230990.6
HBEGF
heparin-binding EGF-like growth factor
chr6_-_52926539 0.38 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr1_-_24306798 0.35 ENST00000374452.5
ENST00000492112.2
ENST00000343255.5
ENST00000344989.6
SRSF10
serine/arginine-rich splicing factor 10
chr11_+_18344106 0.32 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr11_-_62572901 0.30 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
NXF1
nuclear RNA export factor 1
chr11_-_47198380 0.27 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr17_-_37607497 0.26 ENST00000394287.3
ENST00000300651.6
MED1
mediator complex subunit 1
chr13_+_22245522 0.26 ENST00000382353.5
FGF9
fibroblast growth factor 9
chr9_-_107690420 0.21 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_87865262 0.19 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
ZNF292
zinc finger protein 292
chr4_+_154125565 0.18 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr12_-_7079805 0.17 ENST00000536316.2
ENST00000542912.1
ENST00000440277.1
ENST00000545167.1
ENST00000546111.1
ENST00000399433.2
ENST00000535923.1
PHB2
prohibitin 2
chr9_+_35161998 0.10 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
UNC13B
unc-13 homolog B (C. elegans)
chr14_-_68283291 0.08 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr20_-_39928705 0.06 ENST00000436099.2
ENST00000309060.3
ENST00000373261.1
ENST00000436440.2
ENST00000540170.1
ENST00000557816.1
ENST00000560361.1
ZHX3
zinc fingers and homeoboxes 3
chr1_-_240775447 0.00 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist

Network of associatons between targets according to the STRING database.

First level regulatory network of AUGGCAC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.7 GO:0006597 spermine biosynthetic process(GO:0006597)
3.7 14.7 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
2.6 7.8 GO:0006097 glyoxylate cycle(GO:0006097)
2.5 10.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
2.4 12.0 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
2.4 7.2 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
2.4 16.7 GO:0090204 protein localization to nuclear pore(GO:0090204)
2.4 7.1 GO:0031587 detection of endogenous stimulus(GO:0009726) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
2.0 11.9 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
1.7 6.9 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.7 32.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
1.7 11.6 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
1.6 6.5 GO:0007538 primary sex determination(GO:0007538)
1.6 4.9 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
1.6 7.8 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710)
1.5 11.6 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
1.4 7.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.1 6.7 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
1.1 3.3 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
1.0 8.4 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
1.0 3.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.0 15.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
1.0 3.1 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
1.0 11.6 GO:0051665 membrane raft localization(GO:0051665)
1.0 3.8 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.9 10.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.9 3.5 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.8 4.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.8 12.8 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.7 13.3 GO:0000729 DNA double-strand break processing(GO:0000729)
0.7 5.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.7 6.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.7 9.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.7 8.3 GO:0007379 segment specification(GO:0007379)
0.6 3.9 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.6 6.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.6 17.8 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.6 4.6 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.5 3.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.5 1.6 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.5 1.5 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.5 5.8 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.5 8.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.5 4.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.4 2.7 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.4 4.7 GO:0018345 protein palmitoylation(GO:0018345)
0.4 1.3 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.4 1.2 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.4 3.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.3 1.2 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.3 3.0 GO:0010265 SCF complex assembly(GO:0010265)
0.3 1.5 GO:0048388 endosomal lumen acidification(GO:0048388)
0.3 2.6 GO:0001878 response to yeast(GO:0001878)
0.3 1.7 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.3 2.9 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.3 11.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 6.6 GO:0061157 mRNA destabilization(GO:0061157)
0.3 3.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 1.4 GO:2001171 positive regulation of ATP biosynthetic process(GO:2001171)
0.2 3.4 GO:0045820 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.2 10.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.2 0.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.2 2.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.2 0.4 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 2.3 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.2 1.5 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2 7.3 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.2 1.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065) negative regulation of vascular associated smooth muscle cell migration(GO:1904753)
0.2 13.1 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.2 2.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 5.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 2.0 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 2.6 GO:0033197 response to vitamin E(GO:0033197)
0.1 7.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 4.0 GO:0019054 modulation by virus of host process(GO:0019054)
0.1 15.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 3.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 10.0 GO:0090307 mitotic spindle assembly(GO:0090307)
0.1 14.6 GO:0045445 myoblast differentiation(GO:0045445)
0.1 0.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0051541 elastin metabolic process(GO:0051541)
0.1 4.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 4.1 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 7.2 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.1 0.2 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.1 7.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.9 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 4.4 GO:0008380 RNA splicing(GO:0008380)
0.1 1.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 0.2 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 0.4 GO:0061441 renal artery morphogenesis(GO:0061441)
0.1 2.4 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.1 0.5 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 0.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 6.1 GO:0006901 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 11.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.6 GO:0060973 cell migration involved in heart development(GO:0060973)
0.0 4.4 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.4 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 4.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 5.8 GO:0019079 viral genome replication(GO:0019079)
0.0 0.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:2000302 positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0 3.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 6.3 GO:0016579 protein deubiquitination(GO:0016579)
0.0 7.6 GO:0006260 DNA replication(GO:0006260)
0.0 0.2 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 2.9 GO:0002576 platelet degranulation(GO:0002576)
0.0 2.9 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.0 1.4 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.4 GO:0000278 mitotic cell cycle(GO:0000278)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.3 GO:0031372 UBC13-MMS2 complex(GO:0031372)
4.0 12.0 GO:0044393 microspike(GO:0044393)
2.6 7.8 GO:0034680 integrin alpha1-beta1 complex(GO:0034665) integrin alpha3-beta1 complex(GO:0034667) integrin alpha8-beta1 complex(GO:0034678) integrin alpha10-beta1 complex(GO:0034680)
1.9 13.1 GO:0046581 intercellular canaliculus(GO:0046581)
1.8 12.8 GO:0070852 cell body fiber(GO:0070852)
1.7 12.0 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.4 7.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.0 8.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
1.0 7.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
1.0 35.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.0 7.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.7 3.5 GO:0005899 insulin receptor complex(GO:0005899)
0.7 2.0 GO:0043291 RAVE complex(GO:0043291)
0.6 3.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.6 8.3 GO:0035102 PRC1 complex(GO:0035102)
0.6 8.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.5 3.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.5 2.6 GO:0035061 interchromatin granule(GO:0035061)
0.5 13.3 GO:0097228 sperm principal piece(GO:0097228)
0.5 9.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.5 31.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 6.4 GO:0000124 SAGA complex(GO:0000124)
0.4 1.3 GO:0034455 t-UTP complex(GO:0034455)
0.4 10.6 GO:0035861 site of double-strand break(GO:0035861)
0.4 18.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 4.1 GO:0097227 sperm annulus(GO:0097227)
0.3 1.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 6.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.2 2.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 7.0 GO:0051233 spindle midzone(GO:0051233)
0.1 1.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 16.2 GO:0005643 nuclear pore(GO:0005643)
0.1 0.8 GO:0002177 manchette(GO:0002177)
0.1 4.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 2.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 2.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.5 GO:0032059 bleb(GO:0032059)
0.1 5.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.5 GO:0031209 SCAR complex(GO:0031209)
0.1 4.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 15.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 13.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 8.7 GO:0030175 filopodium(GO:0030175)
0.1 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 8.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 8.8 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0097443 sorting endosome(GO:0097443)
0.0 6.6 GO:0005819 spindle(GO:0005819)
0.0 9.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.7 GO:0055037 recycling endosome(GO:0055037)
0.0 11.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.8 GO:0043195 terminal bouton(GO:0043195)
0.0 9.8 GO:0005929 cilium(GO:0005929)
0.0 9.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.4 GO:0005902 microvillus(GO:0005902)
0.0 10.1 GO:0005874 microtubule(GO:0005874)
0.0 1.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 6.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.4 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.6 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.4 GO:0001069 regulatory region RNA binding(GO:0001069)
2.8 8.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
2.6 7.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.2 8.9 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.8 7.1 GO:0048763 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
1.6 7.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
1.5 10.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
1.3 12.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.1 5.7 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
1.1 22.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
1.1 3.3 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
1.0 7.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.9 3.5 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.9 10.5 GO:0042301 phosphate ion binding(GO:0042301)
0.8 17.6 GO:0050811 GABA receptor binding(GO:0050811)
0.8 11.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.8 14.6 GO:0048156 tau protein binding(GO:0048156)
0.7 14.8 GO:0035497 cAMP response element binding(GO:0035497)
0.7 15.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.7 3.3 GO:1990460 leptin receptor binding(GO:1990460)
0.6 14.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.6 12.8 GO:0070628 proteasome binding(GO:0070628)
0.6 12.0 GO:0044548 S100 protein binding(GO:0044548)
0.6 6.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.5 1.5 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.5 7.0 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 11.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 5.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 4.9 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.4 5.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 15.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 19.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 2.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.4 13.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 13.3 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.3 22.1 GO:0019003 GDP binding(GO:0019003)
0.3 7.2 GO:0004697 protein kinase C activity(GO:0004697)
0.3 9.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 4.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.3 3.9 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.3 1.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 11.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 1.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 2.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 10.9 GO:0050699 WW domain binding(GO:0050699)
0.2 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 10.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 0.6 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 3.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 6.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 4.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 3.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 7.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 6.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 6.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 3.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 6.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 11.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 9.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 13.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.3 GO:0035173 histone kinase activity(GO:0035173)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 5.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.1 3.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 2.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.7 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.2 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 1.7 GO:0005521 lamin binding(GO:0005521)
0.1 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 4.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 6.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 0.4 GO:0050733 RS domain binding(GO:0050733)
0.0 2.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 5.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 4.1 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.4 GO:0008026 ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 4.8 GO:0003924 GTPase activity(GO:0003924)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)
0.0 2.2 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.5 34.8 PID PLK1 PATHWAY PLK1 signaling events
0.4 9.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.3 19.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.3 14.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3 12.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.3 11.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 11.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 3.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 6.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 15.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 25.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 10.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 5.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.1 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 4.0 PID E2F PATHWAY E2F transcription factor network
0.0 4.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 2.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 18.0 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
1.1 25.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.8 19.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.7 15.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.6 9.4 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.6 14.0 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.6 11.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 15.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.5 14.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 7.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.5 7.8 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 12.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.4 10.0 REACTOME KINESINS Genes involved in Kinesins
0.4 17.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 14.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 6.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.3 7.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 0.3 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.3 7.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.2 13.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 11.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 2.5 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 1.5 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 6.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 8.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 10.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 3.1 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 22.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 3.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 5.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 5.6 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.4 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport