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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for BBX

Z-value: 0.44

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.14 BBX high mobility group box domain containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.261.1e-04Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_28527152 14.36 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr16_-_58768177 5.98 ENST00000434819.2
ENST00000245206.5
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial
chr15_+_65823092 5.47 ENST00000566074.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr4_+_155484103 5.25 ENST00000302068.4
FGB
fibrinogen beta chain
chr6_-_150067696 4.75 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr1_+_95616933 4.68 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr5_+_74011328 4.03 ENST00000513336.1
HEXB
hexosaminidase B (beta polypeptide)
chr4_+_155484155 3.86 ENST00000509493.1
FGB
fibrinogen beta chain
chr11_-_14541872 3.76 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr7_-_16872932 3.20 ENST00000419572.2
ENST00000412973.1
AGR2
anterior gradient 2
chr3_-_133380731 3.19 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr5_-_148929848 3.14 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chrX_+_54834004 3.07 ENST00000375068.1
MAGED2
melanoma antigen family D, 2
chr1_-_206785789 3.01 ENST00000437518.1
ENST00000367114.3
EIF2D
eukaryotic translation initiation factor 2D
chr9_-_116837249 2.99 ENST00000466610.2
AMBP
alpha-1-microglobulin/bikunin precursor
chr20_-_30310336 2.81 ENST00000434194.1
ENST00000376062.2
BCL2L1
BCL2-like 1
chr1_+_52082751 2.76 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9
oxysterol binding protein-like 9
chr3_-_168865522 2.74 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr2_+_63816295 2.73 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr4_-_70080449 2.57 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr5_+_179921344 2.54 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr3_+_130569429 2.32 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr10_+_115674530 2.31 ENST00000451472.1
AL162407.1
CDNA FLJ20147 fis, clone COL07954; HCG1781466; Uncharacterized protein
chr4_-_186733363 2.30 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2
sorbin and SH3 domain containing 2
chr14_+_23235886 2.24 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like
chr9_-_5833027 2.14 ENST00000339450.5
ERMP1
endoplasmic reticulum metallopeptidase 1
chr22_+_32871224 2.10 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr4_-_104021009 2.06 ENST00000509245.1
ENST00000296424.4
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr20_-_30310693 2.02 ENST00000307677.4
ENST00000420653.1
BCL2L1
BCL2-like 1
chr16_+_56672571 2.02 ENST00000290705.8
MT1A
metallothionein 1A
chr20_-_30310656 2.00 ENST00000376055.4
BCL2L1
BCL2-like 1
chr7_+_5085452 1.96 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB-associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr17_-_17184605 1.94 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr19_+_9361606 1.84 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr4_-_186696425 1.75 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr2_-_55237484 1.73 ENST00000394609.2
RTN4
reticulon 4
chrX_+_100663243 1.73 ENST00000316594.5
HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr14_+_75230011 1.70 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr12_-_10978957 1.68 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr4_-_159644507 1.40 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr4_+_108910870 1.39 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
HADH
hydroxyacyl-CoA dehydrogenase
chr5_+_147774275 1.39 ENST00000513826.1
FBXO38
F-box protein 38
chr5_-_78809950 1.39 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr20_-_7921090 1.38 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_59043166 1.24 ENST00000371225.2
TACSTD2
tumor-associated calcium signal transducer 2
chr11_+_118443098 1.21 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
ARCN1
archain 1
chr2_+_102928009 1.08 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr13_+_50570019 0.97 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr4_-_159080806 0.92 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr9_+_35161998 0.91 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
UNC13B
unc-13 homolog B (C. elegans)
chrX_+_54834159 0.90 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
MAGED2
melanoma antigen family D, 2
chr5_+_140514782 0.81 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr3_-_47950745 0.68 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr5_+_125758813 0.61 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr5_+_140480083 0.53 ENST00000231130.2
PCDHB3
protocadherin beta 3
chr11_+_22689648 0.52 ENST00000278187.3
GAS2
growth arrest-specific 2
chr4_-_186697044 0.52 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr5_+_150040403 0.47 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chr6_-_161085291 0.34 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr6_+_31895254 0.34 ENST00000299367.5
ENST00000442278.2
C2
complement component 2
chr18_-_13915530 0.31 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr4_-_987217 0.29 ENST00000361661.2
ENST00000398516.2
SLC26A1
solute carrier family 26 (anion exchanger), member 1
chr12_-_4754339 0.26 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr15_+_49715293 0.25 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr9_-_13175823 0.23 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr6_-_25874440 0.23 ENST00000361703.6
ENST00000397060.4
SLC17A3
solute carrier family 17 (organic anion transporter), member 3
chr7_+_117120017 0.17 ENST00000003084.6
ENST00000454343.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr13_+_33160553 0.16 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr12_-_100378006 0.10 ENST00000547776.2
ENST00000329257.7
ENST00000547010.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_101437487 0.07 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr6_-_49712123 0.06 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr12_-_8765446 0.06 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr14_+_94492674 0.02 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr2_+_232135245 0.02 ENST00000446447.1
ARMC9
armadillo repeat containing 9

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) L-kynurenine metabolic process(GO:0097052)
1.0 6.8 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.9 9.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.8 4.0 GO:0007619 courtship behavior(GO:0007619)
0.7 2.2 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.6 3.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 4.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.5 3.2 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.5 1.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.4 3.1 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.4 3.0 GO:0032790 ribosome disassembly(GO:0032790)
0.4 2.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.4 2.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 1.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 1.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.2 2.7 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.9 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.2 3.0 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 1.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.2 1.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 2.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.2 1.2 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.2 4.6 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 2.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.1 1.9 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 4.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.3 GO:0060437 lung growth(GO:0060437)
0.1 0.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 2.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 2.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 2.0 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 2.6 GO:0008210 estrogen metabolic process(GO:0008210)
0.1 1.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.3 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.1 1.0 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.4 GO:0010976 positive regulation of neuron projection development(GO:0010976)
0.0 3.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.3 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.1 GO:0005577 fibrinogen complex(GO:0005577)
0.5 6.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 2.1 GO:1990037 Lewy body core(GO:1990037)
0.3 3.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 0.9 GO:0044305 calyx of Held(GO:0044305)
0.3 4.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 3.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 3.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 4.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 6.0 GO:0043204 perikaryon(GO:0043204)
0.0 2.2 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 4.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 6.4 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 3.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.7 3.0 GO:0019862 IgA binding(GO:0019862)
0.7 2.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.6 6.8 GO:0051434 BH3 domain binding(GO:0051434)
0.5 2.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.5 4.0 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.5 1.4 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 4.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 1.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 2.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.5 GO:0051373 FATZ binding(GO:0051373)
0.1 1.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.0 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 9.1 GO:0051087 chaperone binding(GO:0051087)
0.1 2.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.8 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.4 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 2.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.6 GO:0002162 dystroglycan binding(GO:0002162)
0.1 2.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 3.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 3.4 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 9.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 3.2 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 9.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 6.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.2 6.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 4.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 3.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 4.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 1.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 2.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 3.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 2.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 1.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing