ISMARA results: CDC5L

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CDC5L

Z-value: 0.82

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Transcription factors associated with CDC5L

Gene Symbol	Gene ID	Gene Info
CDC5L Ensembl NCBI GeneCards UniProt NextProt	ENSG00000096401.7	cell division cycle 5 like

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDC5L	hg19_v2_chr6_+_44355257_44355315	-0.34	4.0e-07	Click!

Activity profile of CDC5L motif

Sorted Z-values of CDC5L motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_69597810 Show fit	18.70	ENST00000483798.2	DNAJC12 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 12
chr6_-_32557610 Show fit	10.71	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 1
chr16_-_71610985 Show fit	10.48	ENST00000355962.4	TAT Ensembl NCBI GeneCards UniProt NextProt Show fit	tyrosine aminotransferase
chr12_-_10542617 Show fit	10.06	ENST00000240618.6	KLRK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	killer cell lectin-like receptor subfamily K, member 1
chr4_+_155484155 Show fit	9.23	ENST00000509493.1	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr12_-_53601055 Show fit	7.99	ENST00000552972.1 ENST00000422257.3 ENST00000267082.5	ITGB7 Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, beta 7
chr10_-_69597915 Show fit	7.96	ENST00000225171.2	DNAJC12 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 12
chr11_-_118213331 Show fit	7.55	ENST00000392884.2	CD3D Ensembl NCBI GeneCards UniProt NextProt Show fit	CD3d molecule, delta (CD3-TCR complex)
chr19_-_17185848 Show fit	7.04	ENST00000593360.1	HAUS8 Ensembl NCBI GeneCards UniProt NextProt Show fit	HAUS augmin-like complex, subunit 8
chr12_-_91546926 Show fit	7.04	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CDC5L

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	22.4	GO:0045059	positive thymic T cell selection(GO:0045059)
1.5	18.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	17.8	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.1	16.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	16.0	GO:0006910	phagocytosis, recognition(GO:0006910)
1.5	15.2	GO:0043152	induction of bacterial agglutination(GO:0043152)
3.6	14.5	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.2	11.1	GO:0010107	potassium ion import(GO:0010107)
2.1	10.7	GO:0002399	MHC class II protein complex assembly(GO:0002399)
1.5	10.5	GO:0006572	tyrosine catabolic process(GO:0006572)

Showing 1 to 10 of 205 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	27.8	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	27.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	26.7	GO:0005887	integral component of plasma membrane(GO:0005887)
1.7	18.6	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
1.3	18.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3	17.2	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
1.2	15.2	GO:0005577	fibrinogen complex(GO:0005577)
3.6	14.5	GO:0034669	integrin alpha4-beta7 complex(GO:0034669)
0.0	10.8	GO:0043209	myelin sheath(GO:0043209)
0.2	10.0	GO:0001533	cornified envelope(GO:0001533)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	26.6	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	22.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	19.3	GO:0042605	peptide antigen binding(GO:0042605)
0.3	17.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	13.6	GO:0051087	chaperone binding(GO:0051087)
0.0	12.1	GO:0004888	transmembrane signaling receptor activity(GO:0004888)
3.5	10.5	GO:0080130	L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3	10.5	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.7	10.4	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	10.3	GO:0001618	virus receptor activity(GO:0001618)

Showing 1 to 10 of 168 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	28.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.4	22.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	18.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	15.5	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	15.1	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.5	14.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	12.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	10.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	8.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	8.2	NABA COLLAGENS	Genes encoding collagen proteins

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	46.4	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3	22.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7	18.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.9	15.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	9.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	9.0	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.3	8.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3	6.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	6.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	6.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation

Showing 1 to 10 of 75 entries

Results for CDC5L

Z-value: 0.82

Motif logo

Transcription factors associated with CDC5L

Activity-expression correlation:

Activity profile of CDC5L motif

Sorted Z-values of CDC5L motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CDC5L

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: