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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for CDX2
Z-value: 0.58
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Transcription factors associated with CDX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDX2 | hg19_v2_chr13_-_28545276_28545276 | -0.04 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.6 | 8.0 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 7.5 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.6 | 6.9 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.4 | 6.5 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 2.1 | 6.3 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.2 | 5.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 5.6 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 5.2 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.1 | 4.0 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0016459 | myosin complex(GO:0016459) |
| 1.0 | 6.9 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 6.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 6.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 6.5 | GO:0031514 | motile cilium(GO:0031514) |
| 0.4 | 6.4 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 6.0 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.5 | 5.7 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 4.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.4 | 3.0 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 8.7 | GO:0001047 | core promoter binding(GO:0001047) |
| 1.6 | 8.0 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.2 | 6.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.2 | 6.5 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 6.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 2.1 | 6.3 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.0 | 5.8 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 4.6 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.3 | 4.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 4.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 4.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 1.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.3 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 8.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 8.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 4.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 4.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 3.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 3.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 3.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |