ISMARA results: CUX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for CUX1

Z-value: 1.65

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Transcription factors associated with CUX1

Gene Symbol	Gene ID	Gene Info
CUX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000257923.5	cut like homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CUX1	hg19_v2_chr7_+_101917407_101917445	0.53	3.8e-17	Click!

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_23241661 Show fit	29.22	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 2
chr6_-_32557610 Show fit	28.88	ENST00000360004.5	HLA-DRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 1
chr17_+_1665345 Show fit	26.72	ENST00000576406.1 ENST00000571149.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_106092403 Show fit	25.22	ENST00000390543.2	IGHG4 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant gamma 4 (G4m marker)
chr6_-_32498046 Show fit	24.60	ENST00000374975.3	HLA-DRB5 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR beta 5
chr22_+_23243156 Show fit	21.72	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr2_+_90139056 Show fit	19.29	ENST00000492446.1	IGKV1D-16 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-16
chr14_+_75745477 Show fit	18.55	ENST00000303562.4 ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1	FOS Ensembl NCBI GeneCards UniProt NextProt Show fit	FBJ murine osteosarcoma viral oncogene homolog
chrX_+_129473859 Show fit	18.54	ENST00000424447.1	SLC25A14 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25 (mitochondrial carrier, brain), member 14
chr6_-_33048483 Show fit	18.34	ENST00000419277.1	HLA-DPA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP alpha 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	88.6	GO:0006910	phagocytosis, recognition(GO:0006910)
0.7	71.9	GO:0006958	complement activation, classical pathway(GO:0006958)
0.6	57.5	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.5	41.4	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
8.1	40.4	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.3	37.2	GO:0002377	immunoglobulin production(GO:0002377)
0.4	35.6	GO:0031295	T cell costimulation(GO:0031295)
0.6	34.3	GO:0042417	dopamine metabolic process(GO:0042417)
4.6	32.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.8	29.3	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)

Showing 1 to 10 of 321 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	161.4	GO:0016021	integral component of membrane(GO:0016021)
1.6	81.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
3.4	71.8	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	55.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	53.9	GO:0005615	extracellular space(GO:0005615)
0.2	40.5	GO:0016323	basolateral plasma membrane(GO:0016323)
3.4	40.4	GO:0043203	axon hillock(GO:0043203)
0.2	39.8	GO:0030426	growth cone(GO:0030426)
3.6	39.5	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.4	34.6	GO:0042734	presynaptic membrane(GO:0042734)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	95.7	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.6	89.7	GO:0003823	antigen binding(GO:0003823)
1.6	81.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
1.9	69.7	GO:0042605	peptide antigen binding(GO:0042605)
0.2	53.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	52.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.5	34.3	GO:1903136	cuprous ion binding(GO:1903136)
0.1	33.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
8.0	32.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
1.7	29.3	GO:0038191	neuropilin binding(GO:0038191)

Showing 1 to 10 of 243 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	86.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	51.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	46.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	26.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.6	26.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	23.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	21.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3	19.7	PID FOXO PATHWAY	FoxO family signaling
1.6	17.6	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	16.8	PID EPO PATHWAY	EPO signaling pathway

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	96.5	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.3	34.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.7	32.5	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.3	32.1	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.4	31.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	29.4	REACTOME AMYLOIDS	Genes involved in Amyloids
1.2	29.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.5	25.0	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport
0.5	23.6	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.6	23.0	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport

Showing 1 to 10 of 99 entries

Results for CUX1

Z-value: 1.65

Motif logo

Transcription factors associated with CUX1

Activity-expression correlation:

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: