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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for DUXA

Z-value: 1.01

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Transcription factors associated with DUXA

Gene Symbol Gene ID Gene Info
DUXA
ENSG00000258873.2 double homeobox A

Activity profile of DUXA motif

Sorted Z-values of DUXA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_64708615 47.66 ENST00000338957.4
ENST00000423889.3
ZC3H12B
zinc finger CCCH-type containing 12B
chr1_-_13390765 22.39 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr3_+_153839149 18.16 ENST00000465093.1
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_+_12976450 17.45 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr11_+_49050504 16.37 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr1_-_13452656 15.63 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr2_+_149632783 12.99 ENST00000435030.1
KIF5C
kinesin family member 5C
chr16_+_6533729 12.91 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_55029628 11.99 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr16_+_6533380 11.84 ENST00000552089.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_-_99417562 11.33 ENST00000375234.3
ENST00000446045.1
AAED1
AhpC/TSA antioxidant enzyme domain containing 1
chr2_-_86333244 11.13 ENST00000263857.6
ENST00000409681.1
POLR1A
polymerase (RNA) I polypeptide A, 194kDa
chr11_-_89540388 11.07 ENST00000532501.2
TRIM49
tripartite motif containing 49
chr14_-_90798418 10.73 ENST00000354366.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr1_-_13005246 9.88 ENST00000415464.2
PRAMEF6
PRAME family member 6
chr2_-_224467093 8.93 ENST00000305409.2
SCG2
secretogranin II
chr1_+_92632542 8.90 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr12_-_91546926 8.70 ENST00000550758.1
DCN
decorin
chr1_+_12916941 8.11 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr5_+_173472607 7.95 ENST00000303177.3
ENST00000519867.1
NSG2
Neuron-specific protein family member 2
chr1_-_153113927 7.89 ENST00000368752.4
SPRR2B
small proline-rich protein 2B
chr15_+_80733570 7.70 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr6_+_150920999 7.66 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr2_-_175629164 7.61 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr17_+_74733744 7.17 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
MFSD11
major facilitator superfamily domain containing 11
chr1_-_13673511 7.02 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr2_+_54342574 7.01 ENST00000303536.4
ENST00000394666.3
ACYP2
acylphosphatase 2, muscle type
chr4_-_87028478 6.95 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr19_-_19302931 6.85 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr17_-_4167142 6.78 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr1_-_12946025 6.71 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr1_-_13115578 6.57 ENST00000414205.2
PRAMEF6
PRAME family member 6
chr16_-_21314360 6.53 ENST00000219599.3
ENST00000576703.1
CRYM
crystallin, mu
chr7_+_77325738 6.26 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr14_-_31926701 6.24 ENST00000310850.4
DTD2
D-tyrosyl-tRNA deacylase 2 (putative)
chr11_-_89653576 6.13 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr5_-_115872142 6.11 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_+_50459990 6.02 ENST00000448346.1
AL645730.2
AL645730.2
chr12_+_14572070 5.93 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr11_-_123525289 5.89 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
SCN3B
sodium channel, voltage-gated, type III, beta subunit
chr7_-_137028534 5.86 ENST00000348225.2
PTN
pleiotrophin
chr1_+_12851545 5.53 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr12_-_114211444 5.53 ENST00000510694.2
ENST00000550223.1
RP11-438N16.1
RP11-438N16.1
chr5_+_150404904 5.51 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr18_+_39766626 5.42 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr11_-_5526834 5.41 ENST00000380237.1
ENST00000396895.1
ENST00000380252.1
HBE1
HBG2
hemoglobin, epsilon 1
hemoglobin, gamma G
chr7_-_137028498 5.37 ENST00000393083.2
PTN
pleiotrophin
chr1_+_152975488 5.35 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr11_+_28129795 5.29 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr11_-_133826852 5.22 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr5_+_149877334 5.21 ENST00000523767.1
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr3_-_138725110 5.07 ENST00000383163.2
PRR23A
proline rich 23A
chr8_+_19796381 5.02 ENST00000524029.1
ENST00000522701.1
ENST00000311322.8
LPL
lipoprotein lipase
chr6_-_133055815 5.01 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr1_+_13359819 4.94 ENST00000376168.1
PRAMEF5
PRAME family member 5
chrX_+_77166172 4.93 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr1_+_13516066 4.82 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr16_-_57219966 4.81 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A
family with sequence similarity 192, member A
chr12_-_110434096 4.55 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr19_-_17488143 4.52 ENST00000599426.1
ENST00000252590.4
PLVAP
plasmalemma vesicle associated protein
chr3_-_33759699 4.26 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr2_+_166428839 4.25 ENST00000342316.4
CSRNP3
cysteine-serine-rich nuclear protein 3
chr11_-_47736896 4.22 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
AGBL2
ATP/GTP binding protein-like 2
chr4_-_100212132 4.22 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr9_-_13279563 4.21 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr20_-_44600810 4.11 ENST00000322927.2
ENST00000426788.1
ZNF335
zinc finger protein 335
chr2_+_54342533 4.10 ENST00000406041.1
ACYP2
acylphosphatase 2, muscle type
chr3_-_39321512 4.01 ENST00000399220.2
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr3_-_93781750 3.94 ENST00000314636.2
DHFRL1
dihydrofolate reductase-like 1
chr2_-_175629135 3.88 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr1_-_13007420 3.84 ENST00000376189.1
PRAMEF6
PRAME family member 6
chr20_-_17539456 3.80 ENST00000544874.1
ENST00000377868.2
BFSP1
beaded filament structural protein 1, filensin
chr12_+_120740119 3.79 ENST00000536460.1
ENST00000202967.4
SIRT4
sirtuin 4
chr17_+_56315936 3.70 ENST00000543544.1
LPO
lactoperoxidase
chr1_+_180601139 3.70 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr2_+_196313239 3.70 ENST00000413290.1
AC064834.1
AC064834.1
chr9_-_95298314 3.68 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr7_+_120702819 3.66 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr8_-_18744528 3.65 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_13421176 3.63 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr10_-_61900762 3.63 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr22_+_45725524 3.61 ENST00000405548.3
FAM118A
family with sequence similarity 118, member A
chr11_-_85376121 3.60 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chr15_-_26874230 3.60 ENST00000400188.3
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_-_14942283 3.59 ENST00000402815.1
DGKB
diacylglycerol kinase, beta 90kDa
chr3_-_120461378 3.57 ENST00000273375.3
RABL3
RAB, member of RAS oncogene family-like 3
chr2_-_74570520 3.56 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
SLC4A5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr8_-_6914251 3.54 ENST00000330590.2
DEFA5
defensin, alpha 5, Paneth cell-specific
chr6_-_31125850 3.54 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
CCHCR1
coiled-coil alpha-helical rod protein 1
chr2_+_60983361 3.52 ENST00000238714.3
PAPOLG
poly(A) polymerase gamma
chr5_+_140227048 3.51 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr8_+_133879193 3.50 ENST00000377869.1
ENST00000220616.4
TG
thyroglobulin
chrX_-_72347916 3.45 ENST00000373518.1
NAP1L6
nucleosome assembly protein 1-like 6
chr5_-_95297534 3.44 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr13_-_113242439 3.44 ENST00000375669.3
ENST00000261965.3
TUBGCP3
tubulin, gamma complex associated protein 3
chr12_-_110434021 3.31 ENST00000355312.3
ENST00000551209.1
ENST00000550186.1
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr1_-_12908578 3.30 ENST00000317869.6
HNRNPCL1
heterogeneous nuclear ribonucleoprotein C-like 1
chr5_-_74326724 3.25 ENST00000322348.4
GCNT4
glucosaminyl (N-acetyl) transferase 4, core 2
chr19_-_12833361 3.25 ENST00000592287.1
TNPO2
transportin 2
chr21_+_34398153 3.22 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
OLIG2
oligodendrocyte lineage transcription factor 2
chr12_-_6055398 3.18 ENST00000327087.8
ENST00000356134.5
ENST00000546188.1
ANO2
anoctamin 2
chr11_+_121447469 3.16 ENST00000532694.1
ENST00000534286.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_+_22615942 3.16 ENST00000390457.2
TRAV27
T cell receptor alpha variable 27
chrX_+_37639302 3.13 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr19_-_51472031 3.12 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr1_+_117963209 3.08 ENST00000449370.2
MAN1A2
mannosidase, alpha, class 1A, member 2
chr2_-_198062758 3.04 ENST00000328737.2
ANKRD44
ankyrin repeat domain 44
chr6_+_167525277 3.03 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr15_-_65426174 3.00 ENST00000204549.4
PDCD7
programmed cell death 7
chr10_-_17171817 3.00 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr4_-_110651143 2.99 ENST00000243501.5
PLA2G12A
phospholipase A2, group XIIA
chr17_+_3118915 2.96 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr12_-_110434183 2.95 ENST00000360185.4
ENST00000354574.4
ENST00000338373.5
ENST00000343646.5
ENST00000356259.4
ENST00000553118.1
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr7_-_82792215 2.91 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr6_-_26199471 2.91 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr12_-_112123524 2.91 ENST00000327551.6
BRAP
BRCA1 associated protein
chr15_+_62853562 2.86 ENST00000561311.1
TLN2
talin 2
chr1_+_50569575 2.82 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr12_+_122688090 2.80 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr5_+_54455946 2.77 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
GPX8
glutathione peroxidase 8 (putative)
chr5_+_176853702 2.70 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chr12_+_12878829 2.66 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr8_+_58890917 2.64 ENST00000522992.1
RP11-1112C15.1
RP11-1112C15.1
chr5_-_75919253 2.63 ENST00000296641.4
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr21_+_43619796 2.60 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr15_+_71228826 2.60 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr1_-_13117736 2.60 ENST00000376192.5
ENST00000376182.1
PRAMEF6
PRAME family member 6
chr12_-_118796910 2.60 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr5_+_54320078 2.59 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr3_-_164914640 2.57 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr6_-_133055896 2.57 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr4_-_130692631 2.54 ENST00000500092.2
ENST00000509105.1
RP11-519M16.1
RP11-519M16.1
chr6_-_152639479 2.54 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr18_-_53253112 2.53 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr5_+_172571445 2.52 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr1_+_17575584 2.51 ENST00000375460.3
PADI3
peptidyl arginine deiminase, type III
chr6_+_73076432 2.51 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr22_+_41956767 2.50 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_89654935 2.49 ENST00000530311.2
TRIM49D1
tripartite motif containing 49D1
chr5_-_75919217 2.48 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_-_92371839 2.48 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr17_-_39553844 2.48 ENST00000251645.2
KRT31
keratin 31
chrX_+_11311533 2.48 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr11_+_68671310 2.46 ENST00000255078.3
ENST00000539224.1
IGHMBP2
immunoglobulin mu binding protein 2
chr1_+_13641973 2.45 ENST00000330087.5
PRAMEF15
PRAME family member 15
chr17_-_2996290 2.42 ENST00000331459.1
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr5_-_150948414 2.41 ENST00000261800.5
FAT2
FAT atypical cadherin 2
chr6_-_73935163 2.41 ENST00000370388.3
KHDC1L
KH homology domain containing 1-like
chr1_-_12958101 2.40 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr12_-_49259643 2.40 ENST00000309739.5
RND1
Rho family GTPase 1
chr6_-_10838710 2.40 ENST00000313243.2
MAK
male germ cell-associated kinase
chr5_-_95297678 2.39 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr6_-_31939734 2.39 ENST00000375356.3
DXO
decapping exoribonuclease
chr4_+_76649797 2.37 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr18_+_61554932 2.32 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
SERPINB2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr18_-_53253323 2.30 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr2_-_208994548 2.29 ENST00000282141.3
CRYGC
crystallin, gamma C
chr5_+_140227357 2.28 ENST00000378122.3
PCDHA9
protocadherin alpha 9
chr6_+_31553978 2.26 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr20_+_23471727 2.26 ENST00000449810.1
ENST00000246012.1
CST8
cystatin 8 (cystatin-related epididymal specific)
chr8_+_24151620 2.25 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr9_-_95186739 2.23 ENST00000375550.4
OMD
osteomodulin
chr1_+_66458072 2.21 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr3_+_93781728 2.20 ENST00000314622.4
NSUN3
NOP2/Sun domain family, member 3
chr8_-_86290333 2.19 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
CA1
carbonic anhydrase I
chr16_+_67226019 2.15 ENST00000379378.3
E2F4
E2F transcription factor 4, p107/p130-binding
chr11_+_30253410 2.13 ENST00000533718.1
FSHB
follicle stimulating hormone, beta polypeptide
chr5_+_176853669 2.13 ENST00000355472.5
GRK6
G protein-coupled receptor kinase 6
chr4_-_186732048 2.12 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
SORBS2
sorbin and SH3 domain containing 2
chr2_-_166930131 2.08 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr10_+_90424196 2.08 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
LIPF
lipase, gastric
chr2_+_169923504 2.07 ENST00000357546.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_-_59668550 2.07 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr4_+_646960 2.04 ENST00000488061.1
ENST00000429163.2
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr11_-_2924970 2.03 ENST00000533594.1
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr15_+_81589254 2.01 ENST00000394652.2
IL16
interleukin 16
chr8_-_91095099 2.01 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr6_+_26402517 2.00 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr17_-_73401567 1.98 ENST00000392562.1
GRB2
growth factor receptor-bound protein 2
chrX_+_37639264 1.97 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr1_-_92351769 1.93 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr8_-_125577940 1.90 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr1_-_165414414 1.90 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr2_+_234600253 1.89 ENST00000373424.1
ENST00000441351.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr3_+_190333097 1.89 ENST00000412080.1
IL1RAP
interleukin 1 receptor accessory protein
chr19_-_14785622 1.87 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_+_56187987 1.86 ENST00000411543.2
EPN1
epsin 1
chr11_-_119991589 1.85 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr8_+_24151553 1.84 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr7_-_14942944 1.78 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr6_-_26199499 1.77 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chrX_-_138724677 1.73 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chrX_+_15525426 1.72 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr7_+_134832808 1.71 ENST00000275767.3
TMEM140
transmembrane protein 140
chr1_+_12834984 1.70 ENST00000357726.4
PRAMEF12
PRAME family member 12
chr6_+_55039050 1.66 ENST00000370862.3
HCRTR2
hypocretin (orexin) receptor 2
chr12_-_81763127 1.66 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_23737534 1.65 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr10_-_46620012 1.65 ENST00000508602.1
ENST00000374339.3
ENST00000502254.1
ENST00000437863.1
ENST00000374342.2
ENST00000395722.3
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr5_+_140723601 1.65 ENST00000253812.6
PCDHGA3
protocadherin gamma subfamily A, 3

Network of associatons between targets according to the STRING database.

First level regulatory network of DUXA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.2 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
2.8 11.1 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
1.8 5.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
1.6 4.9 GO:0071284 cellular response to lead ion(GO:0071284)
1.5 18.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.5 4.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
1.4 11.5 GO:0048630 skeletal muscle tissue growth(GO:0048630)
1.4 4.2 GO:0035610 protein side chain deglutamylation(GO:0035610)
1.3 4.0 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
1.1 6.8 GO:0048549 positive regulation of pinocytosis(GO:0048549)
1.1 3.2 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
1.1 3.2 GO:1902997 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.0 5.1 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.0 3.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.9 3.8 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.9 2.8 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.9 3.6 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.9 0.9 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.9 6.9 GO:0007258 JUN phosphorylation(GO:0007258)
0.9 2.6 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.8 5.9 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.8 3.1 GO:0009822 alkaloid catabolic process(GO:0009822)
0.8 7.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.7 2.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.7 8.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.7 5.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890) lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.7 3.6 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.7 5.3 GO:0070475 rRNA base methylation(GO:0070475)
0.6 6.5 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.6 5.2 GO:0006477 protein sulfation(GO:0006477)
0.5 1.6 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.5 4.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 3.7 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 3.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.5 6.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 2.5 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.5 10.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.5 1.5 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.5 3.4 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.4 1.3 GO:0030264 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.4 7.7 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.4 4.2 GO:0006069 ethanol oxidation(GO:0006069)
0.4 2.5 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.4 3.6 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.4 3.5 GO:0015705 iodide transport(GO:0015705)
0.4 13.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.4 1.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.4 3.3 GO:0002118 aggressive behavior(GO:0002118)
0.4 5.4 GO:0015671 oxygen transport(GO:0015671)
0.3 1.0 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.3 2.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.3 1.7 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.3 1.6 GO:0022417 protein maturation by protein folding(GO:0022417)
0.3 1.9 GO:0030035 microspike assembly(GO:0030035)
0.3 1.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.3 3.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.3 1.5 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.3 0.9 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.3 2.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.3 3.0 GO:0015889 cobalamin transport(GO:0015889)
0.3 0.9 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.3 6.4 GO:0016246 RNA interference(GO:0016246)
0.3 2.0 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.3 1.7 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.3 1.1 GO:0051182 coenzyme transport(GO:0051182)
0.3 14.3 GO:0018149 peptide cross-linking(GO:0018149)
0.3 2.4 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.3 5.3 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.3 5.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.3 3.8 GO:0070307 lens fiber cell development(GO:0070307)
0.3 2.5 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.2 5.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 15.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 4.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.2 2.7 GO:0042118 endothelial cell activation(GO:0042118)
0.2 5.9 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.2 1.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 2.6 GO:0032836 glomerular basement membrane development(GO:0032836)
0.2 0.8 GO:0006710 androgen catabolic process(GO:0006710)
0.2 5.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 2.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.3 GO:0050890 cognition(GO:0050890)
0.2 2.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 3.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 5.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 2.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 3.0 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.2 2.1 GO:0006108 malate metabolic process(GO:0006108)
0.2 2.4 GO:0016322 neuron remodeling(GO:0016322)
0.1 2.4 GO:0071027 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 8.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 2.9 GO:0016540 protein autoprocessing(GO:0016540)
0.1 1.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 1.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.4 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 3.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 1.4 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 1.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 18.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 2.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 2.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.5 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 3.5 GO:0050832 defense response to fungus(GO:0050832)
0.1 1.7 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.1 2.1 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.3 GO:0034505 tooth mineralization(GO:0034505)
0.1 1.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 3.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 1.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 70.3 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 27.1 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.1 0.2 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
0.1 2.8 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 2.2 GO:0006884 cell volume homeostasis(GO:0006884) motile cilium assembly(GO:0044458)
0.1 2.3 GO:0042730 fibrinolysis(GO:0042730)
0.1 6.3 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 0.7 GO:0007635 chemosensory behavior(GO:0007635)
0.1 0.9 GO:0051775 response to redox state(GO:0051775)
0.1 4.4 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 9.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.3 GO:0030220 platelet formation(GO:0030220)
0.1 0.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 4.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 3.1 GO:0014047 glutamate secretion(GO:0014047)
0.1 7.3 GO:0032355 response to estradiol(GO:0032355)
0.1 9.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.5 GO:0007416 synapse assembly(GO:0007416)
0.1 3.5 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.9 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.1 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.6 GO:0051647 nucleus localization(GO:0051647)
0.1 1.8 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.1 4.2 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.0 1.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 2.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 2.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:1904180 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 3.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.5 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 1.8 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 1.3 GO:0009798 axis specification(GO:0009798)
0.0 2.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.0 GO:0060348 bone development(GO:0060348)
0.0 2.3 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 1.4 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 2.6 GO:0016358 dendrite development(GO:0016358)
0.0 2.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.7 GO:0007338 single fertilization(GO:0007338)
0.0 1.1 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.8 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
1.1 4.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
1.0 13.0 GO:0035253 ciliary rootlet(GO:0035253)
0.7 2.1 GO:0031251 PAN complex(GO:0031251)
0.7 3.4 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.6 8.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 11.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.5 3.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.5 11.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.5 8.9 GO:0031045 dense core granule(GO:0031045)
0.5 8.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 5.2 GO:0060077 inhibitory synapse(GO:0060077)
0.4 4.3 GO:0045180 basal cortex(GO:0045180)
0.4 1.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.4 5.4 GO:0005833 hemoglobin complex(GO:0005833)
0.4 8.0 GO:0032585 multivesicular body membrane(GO:0032585)
0.3 3.7 GO:0005614 interstitial matrix(GO:0005614)
0.3 2.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.3 5.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 2.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.3 3.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 3.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.3 14.3 GO:0001533 cornified envelope(GO:0001533)
0.3 1.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.3 3.6 GO:0043194 axon initial segment(GO:0043194)
0.3 1.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 4.2 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.2 2.5 GO:0032797 SMN complex(GO:0032797)
0.2 9.8 GO:0048786 presynaptic active zone(GO:0048786)
0.2 5.0 GO:0042627 chylomicron(GO:0042627)
0.2 2.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.1 4.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 6.9 GO:0097542 ciliary tip(GO:0097542)
0.1 1.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.0 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 4.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 11.2 GO:0005604 basement membrane(GO:0005604)
0.1 24.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 1.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 3.2 GO:0034707 chloride channel complex(GO:0034707)
0.1 4.2 GO:0036064 ciliary basal body(GO:0036064)
0.1 1.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 6.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 6.3 GO:0005882 intermediate filament(GO:0005882)
0.1 13.8 GO:0001726 ruffle(GO:0001726)
0.1 2.5 GO:0031201 SNARE complex(GO:0031201)
0.0 2.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 4.5 GO:0005901 caveola(GO:0005901)
0.0 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 19.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.6 GO:0055037 recycling endosome(GO:0055037)
0.0 5.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 7.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0045177 apical part of cell(GO:0045177)
0.0 6.3 GO:0030424 axon(GO:0030424)
0.0 0.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 9.0 GO:0044431 Golgi apparatus part(GO:0044431)
0.0 1.7 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0 0.7 GO:0043204 perikaryon(GO:0043204)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.8 5.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
1.7 5.0 GO:0017129 triglyceride binding(GO:0017129)
1.6 4.9 GO:0032767 copper-dependent protein binding(GO:0032767)
1.6 6.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.6 4.8 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
1.5 7.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.5 9.1 GO:0003998 acylphosphatase activity(GO:0003998)
1.3 4.0 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
1.3 5.2 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
1.2 3.7 GO:0070052 collagen V binding(GO:0070052)
1.2 5.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.2 6.9 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.1 3.3 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.9 3.8 GO:0047708 biotinidase activity(GO:0047708)
0.9 2.8 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.9 3.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.9 5.4 GO:0030492 hemoglobin binding(GO:0030492)
0.9 8.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.9 2.6 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.9 5.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.8 2.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.8 2.4 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.7 2.2 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.7 4.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.7 9.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.6 6.9 GO:0008430 selenium binding(GO:0008430)
0.6 11.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.5 2.5 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 11.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.5 1.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.5 5.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 4.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.4 2.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.4 3.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 1.3 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.4 13.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 1.7 GO:0016499 orexin receptor activity(GO:0016499)
0.4 2.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.4 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 4.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 1.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.3 2.0 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.9 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.3 1.5 GO:0070568 guanylyltransferase activity(GO:0070568)
0.3 43.3 GO:0004519 endonuclease activity(GO:0004519)
0.3 3.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.3 5.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 0.9 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.3 3.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 3.6 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 1.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.3 27.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 2.2 GO:0004064 arylesterase activity(GO:0004064)
0.3 3.0 GO:0031419 cobalamin binding(GO:0031419)
0.3 1.3 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.3 3.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.3 1.0 GO:0004461 lactose synthase activity(GO:0004461)
0.3 5.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 1.5 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 0.7 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 3.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 0.9 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 3.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 3.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 3.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 6.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 4.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 2.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 2.9 GO:0005522 profilin binding(GO:0005522)
0.2 1.4 GO:0004969 histamine receptor activity(GO:0004969)
0.1 2.0 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 4.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 3.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 1.4 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 3.2 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 2.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 10.0 GO:0016209 antioxidant activity(GO:0016209)
0.1 2.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 2.5 GO:0005521 lamin binding(GO:0005521)
0.1 1.1 GO:0051525 NFAT protein binding(GO:0051525)
0.1 1.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.8 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 8.0 GO:0005518 collagen binding(GO:0005518)
0.1 2.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 21.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 0.8 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 3.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 4.2 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 1.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.2 GO:0030507 spectrin binding(GO:0030507)
0.1 0.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 9.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.9 GO:0070330 aromatase activity(GO:0070330)
0.1 1.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 1.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 5.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 1.5 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 2.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 24.2 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 6.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.3 GO:0003924 GTPase activity(GO:0003924)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.0 2.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.5 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 5.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 17.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 14.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 10.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.4 PID ARF 3PATHWAY Arf1 pathway
0.1 2.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 10.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 6.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 5.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 1.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 4.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 1.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 3.6 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 3.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 8.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.5 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.5 4.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 7.3 REACTOME DEFENSINS Genes involved in Defensins
0.4 8.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 9.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 12.9 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.3 9.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 10.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.3 6.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 11.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 3.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 3.0 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.2 2.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 3.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 5.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 2.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 6.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 5.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 5.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 5.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 4.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 5.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 2.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.9 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 3.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell