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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for E2F4

Z-value: 1.00

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Transcription factors associated with E2F4

Gene Symbol Gene ID Gene Info
E2F4
ENSG00000205250.4 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_672261270.212.1e-03Click!

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_172778952 25.70 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr2_+_10262857 24.14 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr14_-_55658323 23.60 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_197115818 22.80 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr4_-_185655278 21.31 ENST00000281453.5
MLF1IP
centromere protein U
chr19_+_16187085 19.71 ENST00000300933.4
TPM4
tropomyosin 4
chr3_+_180630444 19.18 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr4_-_1714037 19.16 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
SLBP
stem-loop binding protein
chr17_-_76183111 19.13 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
TK1
thymidine kinase 1, soluble
chr9_-_113018746 15.84 ENST00000374515.5
TXN
thioredoxin
chr6_-_52149475 14.49 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
MCM3
minichromosome maintenance complex component 3
chr7_-_99698338 14.33 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr4_-_1713977 14.28 ENST00000318386.4
SLBP
stem-loop binding protein
chr8_+_128748308 13.85 ENST00000377970.2
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr5_-_79950371 13.54 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr6_-_17706618 13.48 ENST00000262077.2
ENST00000537253.1
NUP153
nucleoporin 153kDa
chr8_+_128748466 13.31 ENST00000524013.1
ENST00000520751.1
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr13_+_34392185 12.39 ENST00000380071.3
RFC3
replication factor C (activator 1) 3, 38kDa
chr2_+_48010312 12.24 ENST00000540021.1
MSH6
mutS homolog 6
chr3_+_180630090 12.07 ENST00000357559.4
ENST00000305586.7
FXR1
fragile X mental retardation, autosomal homolog 1
chr1_-_8939265 11.93 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr2_+_48010221 11.58 ENST00000234420.5
MSH6
mutS homolog 6
chr11_+_58910201 11.48 ENST00000528737.1
FAM111A
family with sequence similarity 111, member A
chr3_+_52719936 11.47 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr15_+_48624300 11.47 ENST00000455976.2
ENST00000559540.1
DUT
deoxyuridine triphosphatase
chr21_-_33651324 11.46 ENST00000290130.3
MIS18A
MIS18 kinetochore protein A
chr12_-_102513843 11.41 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr5_+_892745 11.25 ENST00000166345.3
TRIP13
thyroid hormone receptor interactor 13
chr14_+_105219437 11.21 ENST00000329967.6
ENST00000347067.5
ENST00000553810.1
SIVA1
SIVA1, apoptosis-inducing factor
chr19_-_1095330 11.02 ENST00000586746.1
POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr3_+_179280668 10.99 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr3_+_160117418 10.95 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr5_+_177631523 10.66 ENST00000506339.1
ENST00000355836.5
ENST00000514633.1
ENST00000515193.1
ENST00000506259.1
ENST00000504898.1
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr11_+_58910295 10.61 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr3_+_133502877 10.60 ENST00000466490.2
SRPRB
signal recognition particle receptor, B subunit
chr8_+_48873453 10.43 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr20_+_47662805 10.31 ENST00000262982.2
ENST00000542325.1
CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr8_-_124408652 10.28 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr8_+_48873479 10.23 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr17_-_38804061 10.02 ENST00000474246.1
ENST00000377808.4
ENST00000578044.1
ENST00000580419.1
ENST00000400122.3
ENST00000580654.1
ENST00000577721.1
ENST00000478349.2
ENST00000431889.2
SMARCE1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr6_+_30687978 9.53 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr19_-_8070474 9.38 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr22_+_24951949 9.25 ENST00000402849.1
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr1_-_33283754 9.21 ENST00000373477.4
YARS
tyrosyl-tRNA synthetase
chr10_+_92631709 9.14 ENST00000413330.1
ENST00000277882.3
RPP30
ribonuclease P/MRP 30kDa subunit
chr1_+_28844648 9.10 ENST00000373832.1
ENST00000373831.3
RCC1
regulator of chromosome condensation 1
chr6_+_135502466 8.92 ENST00000367814.4
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr7_-_102985288 8.86 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr22_-_42342692 8.76 ENST00000404067.1
ENST00000402338.1
CENPM
centromere protein M
chr6_+_135502408 8.54 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr2_-_38978492 8.43 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
SRSF7
serine/arginine-rich splicing factor 7
chr2_+_47630255 8.38 ENST00000406134.1
MSH2
mutS homolog 2
chr22_-_42343117 8.37 ENST00000407253.3
ENST00000215980.5
CENPM
centromere protein M
chr1_+_33116743 8.34 ENST00000414241.3
ENST00000373493.5
RBBP4
retinoblastoma binding protein 4
chrX_+_109245863 8.26 ENST00000372072.3
TMEM164
transmembrane protein 164
chr12_+_16064258 8.13 ENST00000524480.1
ENST00000531803.1
ENST00000532964.1
DERA
deoxyribose-phosphate aldolase (putative)
chr19_+_50180317 7.98 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr15_+_91260552 7.79 ENST00000355112.3
ENST00000560509.1
BLM
Bloom syndrome, RecQ helicase-like
chrX_+_109246285 7.72 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164
transmembrane protein 164
chr7_-_102985035 7.69 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr2_+_47630108 7.68 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chr4_-_157892498 7.60 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr7_-_73668692 7.58 ENST00000352131.3
ENST00000055077.3
RFC2
replication factor C (activator 1) 2, 40kDa
chr7_+_138145145 7.55 ENST00000415680.2
TRIM24
tripartite motif containing 24
chr9_-_35080013 7.38 ENST00000378643.3
FANCG
Fanconi anemia, complementation group G
chr12_-_57146095 7.36 ENST00000550770.1
ENST00000338193.6
PRIM1
primase, DNA, polypeptide 1 (49kDa)
chr1_+_91966656 7.33 ENST00000428239.1
ENST00000426137.1
CDC7
cell division cycle 7
chr7_+_116166331 7.27 ENST00000393468.1
ENST00000393467.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr9_-_113018835 7.25 ENST00000374517.5
TXN
thioredoxin
chr7_+_116165754 7.13 ENST00000405348.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr14_-_50154921 7.06 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr22_+_19467261 6.96 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45
cell division cycle 45
chr1_+_91966384 6.93 ENST00000430031.2
ENST00000234626.6
CDC7
cell division cycle 7
chr8_-_67525473 6.88 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr4_+_88928777 6.86 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chrX_+_133594168 6.80 ENST00000298556.7
HPRT1
hypoxanthine phosphoribosyltransferase 1
chr10_-_88281494 6.71 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr10_-_43892279 6.71 ENST00000443950.2
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr15_-_50647347 6.63 ENST00000220429.8
ENST00000429662.2
GABPB1
GA binding protein transcription factor, beta subunit 1
chr11_+_34073269 6.51 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr12_-_56843161 6.41 ENST00000554616.1
ENST00000553532.1
ENST00000229201.4
TIMELESS
timeless circadian clock
chr16_-_67693846 6.41 ENST00000602850.1
ACD
adrenocortical dysplasia homolog (mouse)
chr8_-_95907423 6.20 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr11_-_118972575 6.11 ENST00000432443.2
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr4_+_113558272 6.11 ENST00000509061.1
ENST00000508577.1
ENST00000513553.1
LARP7
La ribonucleoprotein domain family, member 7
chr9_-_21994344 6.09 ENST00000530628.2
ENST00000361570.3
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr3_-_185655795 5.99 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr16_-_8962853 5.98 ENST00000565287.1
ENST00000311052.5
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr3_-_10028366 5.94 ENST00000429759.1
EMC3
ER membrane protein complex subunit 3
chr5_+_36152091 5.92 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr1_-_26185844 5.81 ENST00000538789.1
ENST00000374298.3
AUNIP
aurora kinase A and ninein interacting protein
chr11_+_34073195 5.79 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr11_+_17298297 5.73 ENST00000529010.1
NUCB2
nucleobindin 2
chr20_+_42295745 5.70 ENST00000396863.4
ENST00000217026.4
MYBL2
v-myb avian myeloblastosis viral oncogene homolog-like 2
chr1_+_10490779 5.64 ENST00000477755.1
APITD1
apoptosis-inducing, TAF9-like domain 1
chr8_-_17104356 5.62 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr3_+_133292574 5.61 ENST00000264993.3
CDV3
CDV3 homolog (mouse)
chr19_+_10982189 5.60 ENST00000327064.4
ENST00000588947.1
CARM1
coactivator-associated arginine methyltransferase 1
chr7_-_30544405 5.57 ENST00000409390.1
ENST00000409144.1
ENST00000005374.6
ENST00000409436.1
ENST00000275428.4
GGCT
gamma-glutamylcyclotransferase
chr1_+_28844778 5.53 ENST00000411533.1
RCC1
regulator of chromosome condensation 1
chr19_+_13049413 5.52 ENST00000316448.5
ENST00000588454.1
CALR
calreticulin
chr7_+_138145076 5.51 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr16_+_29817399 5.50 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr3_-_148804275 5.36 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
HLTF
helicase-like transcription factor
chr11_+_17298255 5.34 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr12_+_102513950 5.23 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr6_+_167412835 5.22 ENST00000349556.4
FGFR1OP
FGFR1 oncogene partner
chr2_+_71357434 5.21 ENST00000244230.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr10_-_43892668 5.18 ENST00000544000.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr5_+_36152163 5.04 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr1_+_63833261 5.00 ENST00000371108.4
ALG6
ALG6, alpha-1,3-glucosyltransferase
chr13_-_113862948 4.95 ENST00000375457.2
ENST00000375477.1
ENST00000246505.5
ENST00000337344.4
ENST00000375479.2
PCID2
PCI domain containing 2
chr2_+_27440229 4.95 ENST00000264705.4
ENST00000403525.1
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr8_+_95732095 4.93 ENST00000414645.2
DPY19L4
dpy-19-like 4 (C. elegans)
chr1_-_241683001 4.82 ENST00000366560.3
FH
fumarate hydratase
chr17_+_73008755 4.82 ENST00000584208.1
ENST00000301585.5
ICT1
immature colon carcinoma transcript 1
chr5_+_141348640 4.73 ENST00000540015.1
ENST00000506938.1
ENST00000394514.2
ENST00000512565.1
ENST00000394515.3
RNF14
ring finger protein 14
chr4_-_39367949 4.71 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
RFC1
replication factor C (activator 1) 1, 145kDa
chr2_+_68384976 4.65 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr22_+_20105012 4.57 ENST00000331821.3
ENST00000411892.1
RANBP1
RAN binding protein 1
chr11_+_85955787 4.51 ENST00000528180.1
EED
embryonic ectoderm development
chr14_-_71067360 4.50 ENST00000554963.1
ENST00000430055.2
ENST00000440435.2
ENST00000256379.5
MED6
mediator complex subunit 6
chr19_+_797443 4.41 ENST00000394601.4
ENST00000589575.1
PTBP1
polypyrimidine tract binding protein 1
chr19_+_34919257 4.39 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr12_+_49717019 4.36 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr12_+_16064106 4.29 ENST00000428559.2
DERA
deoxyribose-phosphate aldolase (putative)
chr1_+_27248203 4.29 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr7_+_130794846 4.24 ENST00000421797.2
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr3_+_37903432 4.22 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr10_-_35104185 4.08 ENST00000374789.3
ENST00000374788.3
ENST00000346874.4
ENST00000374794.3
ENST00000350537.4
ENST00000374790.3
ENST00000374776.1
ENST00000374773.1
ENST00000545693.1
ENST00000545260.1
ENST00000340077.5
PARD3
par-3 family cell polarity regulator
chr5_-_134734901 4.05 ENST00000312469.4
ENST00000423969.2
H2AFY
H2A histone family, member Y
chr12_-_57472522 4.04 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr4_+_178230985 4.01 ENST00000264596.3
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr15_-_50647370 3.99 ENST00000558970.1
ENST00000396464.3
ENST00000560825.1
GABPB1
GA binding protein transcription factor, beta subunit 1
chr17_-_17184605 3.98 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr3_-_55521323 3.97 ENST00000264634.4
WNT5A
wingless-type MMTV integration site family, member 5A
chr11_-_78285804 3.92 ENST00000281038.5
ENST00000529571.1
NARS2
asparaginyl-tRNA synthetase 2, mitochondrial (putative)
chr7_-_86849883 3.90 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chrX_+_70752917 3.87 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_+_10490441 3.84 ENST00000470413.2
ENST00000309048.3
APITD1-CORT
APITD1
APITD1-CORT readthrough
apoptosis-inducing, TAF9-like domain 1
chr20_+_23331373 3.83 ENST00000254998.2
NXT1
NTF2-like export factor 1
chr5_-_137548997 3.83 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
CDC23
cell division cycle 23
chr7_+_77428149 3.81 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr5_+_72794233 3.81 ENST00000335895.8
ENST00000380591.3
ENST00000507081.2
BTF3
basic transcription factor 3
chr17_-_41277467 3.74 ENST00000494123.1
ENST00000346315.3
ENST00000309486.4
ENST00000468300.1
ENST00000354071.3
ENST00000352993.3
ENST00000471181.2
BRCA1
breast cancer 1, early onset
chr19_+_797392 3.71 ENST00000350092.4
ENST00000349038.4
ENST00000586481.1
ENST00000585535.1
PTBP1
polypyrimidine tract binding protein 1
chr9_-_21994597 3.66 ENST00000579755.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr8_-_103668114 3.62 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr6_-_27114577 3.58 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr12_-_15942309 3.57 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr5_+_65222299 3.54 ENST00000284037.5
ERBB2IP
erbb2 interacting protein
chr15_-_50647274 3.50 ENST00000543881.1
GABPB1
GA binding protein transcription factor, beta subunit 1
chr9_-_139304979 3.48 ENST00000357365.3
ENST00000371723.4
SDCCAG3
serologically defined colon cancer antigen 3
chr1_-_229761717 3.40 ENST00000366675.3
ENST00000258281.2
ENST00000366674.1
TAF5L
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr19_+_18284477 3.38 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr12_-_15942503 3.35 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr20_-_32274179 3.30 ENST00000343380.5
E2F1
E2F transcription factor 1
chr5_-_43313574 3.25 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr13_-_111358504 3.23 ENST00000257347.4
CARS2
cysteinyl-tRNA synthetase 2, mitochondrial (putative)
chr5_+_138629417 3.22 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3
matrin 3
chrX_-_15511438 3.21 ENST00000380420.5
PIR
pirin (iron-binding nuclear protein)
chr15_+_52121822 3.14 ENST00000558455.1
ENST00000308580.7
TMOD3
tropomodulin 3 (ubiquitous)
chr17_-_41277370 3.02 ENST00000476777.1
ENST00000491747.2
ENST00000478531.1
ENST00000477152.1
ENST00000357654.3
ENST00000493795.1
ENST00000493919.1
BRCA1
breast cancer 1, early onset
chr17_-_41277317 3.01 ENST00000497488.1
ENST00000489037.1
ENST00000470026.1
ENST00000586385.1
ENST00000591534.1
ENST00000591849.1
BRCA1
breast cancer 1, early onset
chr7_+_77166592 2.98 ENST00000248594.6
PTPN12
protein tyrosine phosphatase, non-receptor type 12
chr7_-_42971759 2.93 ENST00000538645.1
ENST00000445517.1
ENST00000223321.4
PSMA2
proteasome (prosome, macropain) subunit, alpha type, 2
chr3_-_124774802 2.89 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr6_-_136610911 2.86 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCLAF1
BCL2-associated transcription factor 1
chr18_-_54318353 2.80 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr6_-_100016678 2.80 ENST00000523799.1
ENST00000520429.1
CCNC
cyclin C
chr8_-_41754231 2.76 ENST00000265709.8
ANK1
ankyrin 1, erythrocytic
chr1_-_28241226 2.76 ENST00000373912.3
ENST00000373909.3
RPA2
replication protein A2, 32kDa
chr7_+_77428066 2.75 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr16_+_2510081 2.73 ENST00000361837.4
ENST00000569496.1
ENST00000567489.1
ENST00000563531.1
ENST00000483320.1
C16orf59
chromosome 16 open reading frame 59
chr2_-_46844242 2.72 ENST00000281382.6
PIGF
phosphatidylinositol glycan anchor biosynthesis, class F
chr17_-_73781567 2.71 ENST00000586607.1
H3F3B
H3 histone, family 3B (H3.3B)
chr2_-_128785688 2.68 ENST00000259234.6
SAP130
Sin3A-associated protein, 130kDa
chr16_-_67694129 2.67 ENST00000602320.1
ACD
adrenocortical dysplasia homolog (mouse)
chr9_-_35732362 2.67 ENST00000314888.9
ENST00000540444.1
TLN1
talin 1
chrX_-_20159934 2.66 ENST00000379593.1
ENST00000379607.5
EIF1AX
eukaryotic translation initiation factor 1A, X-linked
chr11_-_73694346 2.66 ENST00000310473.3
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr1_-_36615051 2.66 ENST00000373163.1
TRAPPC3
trafficking protein particle complex 3
chr19_-_48673580 2.64 ENST00000427526.2
LIG1
ligase I, DNA, ATP-dependent
chrX_-_119763835 2.61 ENST00000371313.2
ENST00000304661.5
C1GALT1C1
C1GALT1-specific chaperone 1
chr2_-_11484710 2.60 ENST00000315872.6
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr2_-_203103185 2.59 ENST00000409205.1
SUMO1
small ubiquitin-like modifier 1
chr5_-_127873659 2.59 ENST00000262464.4
FBN2
fibrillin 2
chr2_-_46844159 2.57 ENST00000474980.1
ENST00000306465.4
PIGF
phosphatidylinositol glycan anchor biosynthesis, class F
chr19_+_50887585 2.56 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr6_-_34855773 2.55 ENST00000420584.2
ENST00000361288.4
TAF11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
chr16_+_30064444 2.52 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
ALDOA
aldolase A, fructose-bisphosphate
chr5_+_141348721 2.50 ENST00000507163.1
ENST00000394519.1
RNF14
ring finger protein 14
chr11_-_95657231 2.45 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr19_-_6424783 2.44 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr17_-_12921270 2.41 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
ELAC2
elaC ribonuclease Z 2
chr6_+_57182400 2.39 ENST00000607273.1
PRIM2
primase, DNA, polypeptide 2 (58kDa)
chr6_+_31633011 2.38 ENST00000375885.4
CSNK2B
casein kinase 2, beta polypeptide
chr16_+_30064411 2.38 ENST00000338110.5
ALDOA
aldolase A, fructose-bisphosphate
chr19_+_41770349 2.36 ENST00000602130.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr20_-_61493115 2.36 ENST00000335351.3
ENST00000217162.5
TCFL5
transcription factor-like 5 (basic helix-loop-helix)

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 6.8 GO:0043103 hypoxanthine salvage(GO:0043103)
6.7 33.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
6.6 19.8 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
5.5 16.6 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
4.8 14.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
4.8 19.1 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
4.5 27.2 GO:0072133 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
4.5 40.7 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
4.0 20.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
3.9 23.6 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
3.8 11.5 GO:0046080 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
3.8 22.8 GO:0051661 maintenance of centrosome location(GO:0051661)
3.7 29.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
3.7 11.0 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) positive regulation of telomeric DNA binding(GO:1904744)
3.4 13.5 GO:0046452 dihydrofolate metabolic process(GO:0046452)
3.3 32.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.3 9.8 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
3.2 9.7 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
2.6 23.1 GO:0030091 protein repair(GO:0030091)
2.5 12.4 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
2.4 14.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
2.3 6.9 GO:0031587 detection of endogenous stimulus(GO:0009726) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
2.3 11.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
2.0 10.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
1.9 13.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
1.7 6.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.7 11.9 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
1.7 5.0 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
1.6 4.9 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
1.6 4.8 GO:0006106 fumarate metabolic process(GO:0006106)
1.6 6.4 GO:0072719 cellular response to cisplatin(GO:0072719)
1.5 6.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.4 4.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.4 11.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.4 13.6 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
1.4 4.1 GO:1901837 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
1.3 4.0 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
1.3 4.0 GO:1904933 cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933)
1.3 38.8 GO:0051290 protein heterotetramerization(GO:0051290)
1.2 37.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.2 2.5 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
1.2 6.1 GO:0019348 dolichol metabolic process(GO:0019348)
1.1 10.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.1 11.3 GO:0007144 female meiosis I(GO:0007144)
1.1 29.9 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
1.1 3.2 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
1.0 13.5 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
1.0 4.0 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
1.0 5.0 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.0 9.8 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
1.0 5.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.9 5.5 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.8 14.7 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.8 27.8 GO:0006270 DNA replication initiation(GO:0006270)
0.8 2.4 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.8 5.6 GO:0060339 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.7 3.3 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.6 3.7 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.6 3.0 GO:0000710 meiotic mismatch repair(GO:0000710)
0.6 9.4 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.6 1.7 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.5 1.6 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.5 7.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.5 8.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.5 3.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.5 2.6 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.5 9.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.5 9.2 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.5 6.9 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.5 1.8 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.4 1.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.4 1.3 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.4 1.2 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.4 21.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.4 12.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.4 2.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.4 6.1 GO:0043248 proteasome assembly(GO:0043248)
0.4 22.4 GO:0060964 regulation of gene silencing by miRNA(GO:0060964)
0.3 2.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 3.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.3 1.9 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 3.7 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.3 5.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.5 GO:0040031 snRNA modification(GO:0040031)
0.3 2.4 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.3 7.6 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.3 2.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.3 7.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.3 22.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.3 2.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 4.1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.3 2.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 3.1 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.3 1.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.3 3.0 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.3 2.7 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 5.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.2 4.0 GO:0000338 protein deneddylation(GO:0000338)
0.2 19.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 1.4 GO:0045144 meiotic sister chromatid segregation(GO:0045144)
0.2 2.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.2 4.6 GO:0044764 multi-organism cellular process(GO:0044764)
0.2 2.9 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 2.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 2.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 1.2 GO:0033504 floor plate development(GO:0033504)
0.2 3.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 5.2 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 0.7 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 9.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 1.2 GO:1904951 positive regulation of establishment of protein localization(GO:1904951)
0.2 2.8 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2 3.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.1 0.6 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 7.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 2.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 3.6 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 1.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 1.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 11.0 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 1.4 GO:0043032 positive regulation of macrophage activation(GO:0043032)
0.1 1.8 GO:0010668 ectodermal cell differentiation(GO:0010668) nail development(GO:0035878)
0.1 3.9 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 8.3 GO:0006611 protein export from nucleus(GO:0006611)
0.1 5.4 GO:0006301 postreplication repair(GO:0006301)
0.1 1.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 2.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 2.6 GO:0036344 platelet morphogenesis(GO:0036344)
0.1 11.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 3.2 GO:0030224 monocyte differentiation(GO:0030224)
0.1 0.3 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 11.4 GO:0051225 spindle assembly(GO:0051225)
0.1 3.2 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 4.0 GO:0006284 base-excision repair(GO:0006284)
0.1 0.3 GO:0048627 myoblast development(GO:0048627)
0.1 2.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.1 2.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 5.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.6 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.4 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.6 GO:0006309 apoptotic DNA fragmentation(GO:0006309) modulation by virus of host process(GO:0019054)
0.1 9.8 GO:0046718 viral entry into host cell(GO:0046718)
0.1 0.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 4.4 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.3 GO:0009233 menaquinone metabolic process(GO:0009233)
0.1 3.5 GO:0001541 ovarian follicle development(GO:0001541)
0.1 1.4 GO:0070646 protein deubiquitination(GO:0016579) protein modification by small protein removal(GO:0070646)
0.1 2.3 GO:0051028 mRNA transport(GO:0051028)
0.1 3.8 GO:0045087 innate immune response(GO:0045087)
0.1 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 1.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 2.9 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.0 2.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.2 GO:0061441 renal artery morphogenesis(GO:0061441)
0.0 1.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.6 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.4 GO:0010952 positive regulation of peptidase activity(GO:0010952)
0.0 3.4 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.0 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 1.4 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 3.1 GO:0006413 translational initiation(GO:0006413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 39.9 GO:0032301 MutSalpha complex(GO:0032301)
6.0 24.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
4.2 33.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
4.0 24.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.5 24.7 GO:0005663 DNA replication factor C complex(GO:0005663)
3.3 23.3 GO:0036449 microtubule minus-end(GO:0036449)
2.9 35.0 GO:0042555 MCM complex(GO:0042555)
2.6 13.1 GO:0005726 perichromatin fibrils(GO:0005726)
2.4 9.8 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
2.3 7.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
2.1 8.3 GO:0033186 CAF-1 complex(GO:0033186)
2.0 11.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.9 5.7 GO:0031523 Myb complex(GO:0031523)
1.8 9.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.7 7.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
1.7 23.6 GO:0031616 spindle pole centrosome(GO:0031616)
1.6 6.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.5 9.2 GO:0005683 U7 snRNP(GO:0005683)
1.4 14.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.4 7.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.4 5.6 GO:0042025 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
1.3 9.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.3 8.8 GO:0005785 signal recognition particle receptor complex(GO:0005785)
1.1 13.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.1 11.1 GO:0001739 sex chromatin(GO:0001739)
1.1 11.0 GO:0070187 telosome(GO:0070187)
1.1 3.3 GO:0035189 Rb-E2F complex(GO:0035189)
1.1 11.0 GO:0000796 condensin complex(GO:0000796)
1.0 19.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.0 6.9 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.0 13.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.9 8.4 GO:0000800 lateral element(GO:0000800)
0.9 9.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.9 21.0 GO:0071564 npBAF complex(GO:0071564)
0.8 7.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.8 0.8 GO:0032302 MutSbeta complex(GO:0032302)
0.8 11.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 8.0 GO:0034709 methylosome(GO:0034709)
0.7 2.8 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.7 5.5 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.6 2.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 9.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 11.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 6.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.6 1.8 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.6 4.1 GO:0033269 internode region of axon(GO:0033269)
0.5 24.4 GO:0043034 costamere(GO:0043034)
0.5 2.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.5 1.4 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.5 6.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 3.0 GO:0070522 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.4 7.0 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 4.5 GO:0030008 TRAPP complex(GO:0030008)
0.4 1.1 GO:0098536 deuterosome(GO:0098536)
0.4 1.1 GO:0031213 RSF complex(GO:0031213)
0.4 49.5 GO:0016363 nuclear matrix(GO:0016363)
0.3 4.8 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 2.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 1.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 3.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 2.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.2 2.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 11.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 5.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 10.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 2.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 20.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 8.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 2.1 GO:0031209 SCAR complex(GO:0031209)
0.1 3.5 GO:0030904 retromer complex(GO:0030904)
0.1 5.1 GO:0016592 mediator complex(GO:0016592)
0.1 19.8 GO:0001650 fibrillar center(GO:0001650)
0.1 3.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 11.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.9 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 2.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.7 GO:0070822 Sin3-type complex(GO:0070822)
0.1 3.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 4.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.0 GO:0035861 site of double-strand break(GO:0035861)
0.1 5.6 GO:0005643 nuclear pore(GO:0005643)
0.1 11.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 3.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 27.8 GO:0005635 nuclear envelope(GO:0005635)
0.1 3.3 GO:0002102 podosome(GO:0002102)
0.1 12.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 7.7 GO:0000922 spindle pole(GO:0000922)
0.1 3.3 GO:0045178 basal part of cell(GO:0045178)
0.1 4.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 4.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.8 GO:0000502 proteasome complex(GO:0000502)
0.0 2.4 GO:0005884 actin filament(GO:0005884)
0.0 3.6 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.6 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 5.4 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 2.4 GO:0043197 dendritic spine(GO:0043197)
0.0 9.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 39.9 GO:0032143 single thymine insertion binding(GO:0032143)
8.5 42.7 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
6.4 19.1 GO:0004797 thymidine kinase activity(GO:0004797)
6.0 24.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
4.8 14.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
4.1 12.4 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
3.8 11.5 GO:0004170 dUTP diphosphatase activity(GO:0004170)
3.7 25.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
3.5 10.6 GO:0005047 signal recognition particle binding(GO:0005047)
3.5 24.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.9 32.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.8 31.3 GO:0002151 G-quadruplex RNA binding(GO:0002151)
2.8 16.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
2.4 2.4 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
2.3 13.5 GO:0051870 methotrexate binding(GO:0051870)
2.1 14.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
2.0 6.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
2.0 11.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.8 7.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
1.7 8.6 GO:0000403 Y-form DNA binding(GO:0000403)
1.7 6.9 GO:0048763 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
1.7 5.0 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.4 4.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
1.4 13.6 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
1.3 5.3 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
1.3 25.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
1.2 13.1 GO:0034056 estrogen response element binding(GO:0034056)
1.2 2.3 GO:0009055 electron carrier activity(GO:0009055)
1.2 7.0 GO:0044388 small protein activating enzyme binding(GO:0044388)
1.2 7.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.1 3.2 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.9 10.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.8 35.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.8 4.0 GO:0000405 bubble DNA binding(GO:0000405)
0.8 33.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.7 5.5 GO:0001849 complement component C1q binding(GO:0001849)
0.7 13.5 GO:0043495 protein anchor(GO:0043495)
0.6 3.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.6 5.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 11.0 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 9.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.6 9.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.6 11.5 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.6 1.7 GO:0098809 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.5 9.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.5 27.2 GO:0070888 E-box binding(GO:0070888)
0.4 0.9 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.4 1.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.4 12.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 5.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 3.0 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.4 4.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 2.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4 2.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.4 8.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 1.8 GO:0016882 cyclo-ligase activity(GO:0016882)
0.4 11.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 11.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 2.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.3 14.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 1.9 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 2.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 18.3 GO:0050681 androgen receptor binding(GO:0050681)
0.3 5.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 4.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 10.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 9.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 5.0 GO:0046527 glucosyltransferase activity(GO:0046527)
0.3 4.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 2.7 GO:0030274 LIM domain binding(GO:0030274)
0.2 7.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 3.0 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 4.0 GO:0048018 receptor agonist activity(GO:0048018)
0.2 9.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 19.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 3.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 4.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 0.9 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 2.6 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 1.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 2.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.4 GO:0036459 cysteine-type peptidase activity(GO:0008234) ubiquitin-like protein-specific protease activity(GO:0019783) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 3.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 7.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 14.2 GO:0004386 helicase activity(GO:0004386)
0.1 24.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 2.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 4.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.6 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 4.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 4.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 1.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 2.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.5 GO:0045545 syndecan binding(GO:0045545)
0.1 2.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 3.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.7 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 4.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.4 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.4 GO:0001047 core promoter binding(GO:0001047)
0.0 1.1 GO:0016887 ATPase activity(GO:0016887)
0.0 4.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.5 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 3.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 2.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0033613 activating transcription factor binding(GO:0033613)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 59.3 PID MYC PATHWAY C-MYC pathway
0.9 102.6 PID E2F PATHWAY E2F transcription factor network
0.6 27.9 PID PLK1 PATHWAY PLK1 signaling events
0.5 17.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 10.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.4 22.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 16.8 PID ALK1 PATHWAY ALK1 signaling events
0.4 23.6 PID AURORA A PATHWAY Aurora A signaling
0.4 13.6 PID ATR PATHWAY ATR signaling pathway
0.4 14.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 37.9 PID CMYB PATHWAY C-MYB transcription factor network
0.3 32.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 2.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 3.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.3 11.0 PID AURORA B PATHWAY Aurora B signaling
0.2 12.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.2 11.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 25.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 5.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 6.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 0.7 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 1.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 4.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 4.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 3.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID FAS PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 56.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
2.7 42.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
2.4 2.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
2.2 32.3 REACTOME POL SWITCHING Genes involved in Polymerase switching
2.0 4.0 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
1.7 41.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.3 9.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.2 23.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.1 35.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
1.1 16.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
1.0 14.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.7 27.8 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.6 28.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.6 10.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.5 50.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 11.0 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.5 18.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.5 8.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 14.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.4 5.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4 22.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 8.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 3.0 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.3 7.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 6.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 21.7 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.3 9.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 20.4 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 7.2 REACTOME MEIOSIS Genes involved in Meiosis
0.2 22.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 5.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 9.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.3 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.2 11.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 3.8 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 3.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 17.3 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.2 5.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 9.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 0.1 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 1.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 4.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 2.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 5.3 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 2.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.6 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 4.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters