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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F6
Z-value: 1.29
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11606275_11606289 | 0.21 | 2.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 43.7 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.4 | 37.6 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 2.4 | 33.5 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 1.9 | 29.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 1.4 | 28.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 5.5 | 27.3 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.2 | 26.1 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.2 | 26.0 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 1.5 | 25.8 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 3.5 | 24.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 55.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.4 | 42.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.4 | 40.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.3 | 37.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.4 | 35.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.4 | 33.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 2.2 | 32.7 | GO:0005916 | fascia adherens(GO:0005916) |
| 3.5 | 28.0 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 6.7 | 26.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.5 | 24.9 | GO:1990391 | DNA repair complex(GO:1990391) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 66.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.6 | 55.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.5 | 50.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.7 | 46.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.4 | 43.2 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 1.0 | 41.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 41.2 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 40.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 1.1 | 36.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.5 | 33.2 | GO:0046332 | SMAD binding(GO:0046332) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 89.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.0 | 66.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.6 | 58.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 55.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.0 | 45.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 1.7 | 43.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 37.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 33.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.3 | 29.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 26.3 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 87.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.0 | 62.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.9 | 60.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.6 | 54.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.8 | 53.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.9 | 43.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 1.5 | 43.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 34.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.2 | 32.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 1.0 | 29.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |