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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for E2F8
Z-value: 1.81
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Transcription factors associated with E2F8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F8 | hg19_v2_chr11_-_19263145_19263176 | 0.54 | 8.9e-18 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_10262857 Show fit | 66.70 |
ENST00000304567.5
|
ribonucleotide reductase M2 |
|
| chr4_-_174254823 Show fit | 60.08 |
ENST00000438704.2
|
high mobility group box 2 |
|
| chr2_-_136633940 Show fit | 54.93 |
ENST00000264156.2
|
minichromosome maintenance complex component 6 |
|
| chr6_+_135502466 Show fit | 40.00 |
ENST00000367814.4
|
v-myb avian myeloblastosis viral oncogene homolog |
|
| chr6_+_135502408 Show fit | 39.23 |
ENST00000341911.5
ENST00000442647.2 ENST00000316528.8 |
v-myb avian myeloblastosis viral oncogene homolog |
|
| chr3_+_127317066 Show fit | 38.14 |
ENST00000265056.7
|
minichromosome maintenance complex component 2 |
|
| chr14_-_55658252 Show fit | 37.74 |
ENST00000395425.2
|
discs, large (Drosophila) homolog-associated protein 5 |
|
| chr22_+_35796108 Show fit | 36.13 |
ENST00000382011.5
ENST00000416905.1 |
minichromosome maintenance complex component 5 |
|
| chr10_-_17659234 Show fit | 36.06 |
ENST00000466335.1
|
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A |
|
| chr8_+_128748308 Show fit | 34.77 |
ENST00000377970.2
|
v-myc avian myelocytomatosis viral oncogene homolog |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.7 | 116.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 30.4 | 91.2 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.9 | 71.4 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.9 | 70.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 11.3 | 67.9 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 2.9 | 66.7 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 11.1 | 66.6 | GO:0072131 | kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133) |
| 6.0 | 60.1 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.5 | 59.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 10.8 | 54.2 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.5 | 188.0 | GO:0042555 | MCM complex(GO:0042555) |
| 0.7 | 72.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.5 | 71.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 8.8 | 70.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 4.0 | 67.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 16.7 | 66.7 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.2 | 63.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 61.3 | GO:0001650 | fibrillar center(GO:0001650) |
| 1.9 | 58.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.4 | 55.2 | GO:0000793 | condensed chromosome(GO:0000793) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 132.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 11.2 | 123.5 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.5 | 102.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.1 | 94.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 1.7 | 87.5 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 14.1 | 70.6 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 0.3 | 68.1 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 16.7 | 66.7 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.1 | 65.6 | GO:0070888 | E-box binding(GO:0070888) |
| 15.0 | 60.1 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 157.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 1.1 | 128.9 | PID E2F PATHWAY | E2F transcription factor network |
| 1.4 | 77.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 1.0 | 46.9 | PID ATR PATHWAY | ATR signaling pathway |
| 1.1 | 44.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.6 | 40.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 31.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.5 | 30.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.5 | 28.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.2 | 28.0 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 211.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.7 | 112.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 91.6 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 3.0 | 81.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.6 | 73.2 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 4.4 | 70.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.5 | 66.6 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 3.0 | 60.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 3.0 | 50.8 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 3.3 | 39.1 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |