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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for EGR3_EGR2

Z-value: 1.04

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Transcription factors associated with EGR3_EGR2

Gene Symbol Gene ID Gene Info
EGR3
ENSG00000179388.8 early growth response 3
EGR2
ENSG00000122877.9 early growth response 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
EGR3hg19_v2_chr8_-_22550815_225508440.291.2e-05Click!
EGR2hg19_v2_chr10_-_64576105_64576133-0.194.7e-03Click!

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_124609823 36.04 ENST00000412681.2
NRGN
neurogranin (protein kinase C substrate, RC3)
chr11_+_124609742 35.85 ENST00000284292.6
NRGN
neurogranin (protein kinase C substrate, RC3)
chrX_-_47479246 21.49 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr3_-_149688655 20.12 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr20_+_44035200 19.61 ENST00000372717.1
ENST00000360981.4
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr16_+_23847267 19.29 ENST00000321728.7
PRKCB
protein kinase C, beta
chr15_+_84115868 18.40 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr15_+_84116106 17.80 ENST00000535412.1
ENST00000324537.5
SH3GL3
SH3-domain GRB2-like 3
chr12_+_79258444 16.56 ENST00000261205.4
SYT1
synaptotagmin I
chr3_-_149688896 16.07 ENST00000239940.7
PFN2
profilin 2
chr16_+_23847339 15.15 ENST00000303531.7
PRKCB
protein kinase C, beta
chr12_+_79258547 14.95 ENST00000457153.2
SYT1
synaptotagmin I
chr6_-_110500905 14.88 ENST00000392587.2
WASF1
WAS protein family, member 1
chr20_+_44034676 13.66 ENST00000372723.3
ENST00000372722.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr3_-_149688502 13.63 ENST00000481767.1
ENST00000475518.1
PFN2
profilin 2
chr19_+_35634146 13.54 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr17_+_57697216 13.36 ENST00000393043.1
ENST00000269122.3
CLTC
clathrin, heavy chain (Hc)
chr14_+_100150622 12.94 ENST00000261835.3
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr4_+_83351715 12.24 ENST00000273920.3
ENOPH1
enolase-phosphatase 1
chr4_+_158142750 11.91 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_83351791 11.79 ENST00000509635.1
ENOPH1
enolase-phosphatase 1
chr17_-_42992856 11.77 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr4_-_90758118 11.73 ENST00000420646.2
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr15_-_71146480 11.60 ENST00000299213.8
LARP6
La ribonucleoprotein domain family, member 6
chr11_-_125366089 11.42 ENST00000366139.3
ENST00000278919.3
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr5_+_67584174 11.13 ENST00000320694.8
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_-_110501200 10.95 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WASF1
WAS protein family, member 1
chr17_+_44668035 10.48 ENST00000398238.4
ENST00000225282.8
NSF
N-ethylmaleimide-sensitive factor
chr14_-_23822080 10.35 ENST00000397267.1
ENST00000354772.3
SLC22A17
solute carrier family 22, member 17
chr19_-_36523709 10.28 ENST00000592017.1
ENST00000360535.4
CLIP3
CAP-GLY domain containing linker protein 3
chr15_+_52311398 10.26 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr4_-_90758227 10.04 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr3_+_123813509 9.79 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr19_+_49617581 9.02 ENST00000391864.3
LIN7B
lin-7 homolog B (C. elegans)
chr10_+_105036909 8.63 ENST00000369849.4
INA
internexin neuronal intermediate filament protein, alpha
chr4_-_153274078 8.31 ENST00000263981.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr6_+_30689401 8.26 ENST00000396389.1
ENST00000396384.1
TUBB
tubulin, beta class I
chr1_+_6845384 8.26 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr14_+_100531615 8.22 ENST00000392920.3
EVL
Enah/Vasp-like
chrX_-_140271249 8.06 ENST00000370526.2
LDOC1
leucine zipper, down-regulated in cancer 1
chr14_-_69445968 7.92 ENST00000438964.2
ACTN1
actinin, alpha 1
chr12_-_96794330 7.86 ENST00000261211.3
CDK17
cyclin-dependent kinase 17
chr12_-_49393092 7.61 ENST00000421952.2
DDN
dendrin
chr6_+_30689350 7.40 ENST00000330914.3
TUBB
tubulin, beta class I
chr7_+_95401851 7.37 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr19_-_13617037 7.36 ENST00000360228.5
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr8_-_101963677 7.23 ENST00000395956.3
ENST00000395953.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr19_+_49617609 7.07 ENST00000221459.2
ENST00000486217.2
LIN7B
lin-7 homolog B (C. elegans)
chr7_+_95401877 7.01 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr8_-_101963482 6.97 ENST00000419477.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr10_-_101190202 6.97 ENST00000543866.1
ENST00000370508.5
GOT1
glutamic-oxaloacetic transaminase 1, soluble
chr14_-_102605983 6.95 ENST00000334701.7
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr10_-_75255724 6.95 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr14_-_69445793 6.80 ENST00000538545.2
ENST00000394419.4
ACTN1
actinin, alpha 1
chrX_+_47092314 6.77 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr4_-_83351294 6.72 ENST00000502762.1
HNRNPDL
heterogeneous nuclear ribonucleoprotein D-like
chr14_-_69446034 6.56 ENST00000193403.6
ACTN1
actinin, alpha 1
chr20_+_44034804 6.51 ENST00000357275.2
ENST00000372720.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_-_44365020 6.47 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr17_-_1083078 6.43 ENST00000574266.1
ENST00000302538.5
ABR
active BCR-related
chr17_-_4890919 6.26 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr3_+_35681081 6.24 ENST00000428373.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_187350883 6.20 ENST00000337859.6
ZC3H15
zinc finger CCCH-type containing 15
chr2_+_187350973 6.20 ENST00000544130.1
ZC3H15
zinc finger CCCH-type containing 15
chr3_+_238273 6.18 ENST00000256509.2
CHL1
cell adhesion molecule L1-like
chr4_-_36246060 6.17 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr14_-_23770683 5.94 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E
protein phosphatase 1, regulatory subunit 3E
chr14_-_93651186 5.90 ENST00000556883.1
ENST00000298894.4
MOAP1
modulator of apoptosis 1
chr15_+_91446157 5.83 ENST00000559717.1
MAN2A2
mannosidase, alpha, class 2A, member 2
chr9_+_131451480 5.81 ENST00000322030.8
SET
SET nuclear oncogene
chr6_-_84419101 5.71 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
SNAP91
synaptosomal-associated protein, 91kDa
chr19_+_10400615 5.61 ENST00000221980.4
ICAM5
intercellular adhesion molecule 5, telencephalin
chr11_+_63448955 5.59 ENST00000377819.5
ENST00000339997.4
ENST00000540798.1
ENST00000545432.1
ENST00000543552.1
ENST00000537981.1
RTN3
reticulon 3
chr10_-_135150367 5.55 ENST00000368555.3
ENST00000252939.4
ENST00000368558.1
ENST00000368556.2
CALY
calcyon neuron-specific vesicular protein
chr11_+_63448918 5.53 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
RTN3
reticulon 3
chr8_-_110703819 5.42 ENST00000532779.1
ENST00000534578.1
SYBU
syntabulin (syntaxin-interacting)
chr17_-_4890649 5.29 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr12_+_110718921 5.28 ENST00000308664.6
ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr13_+_42846272 5.23 ENST00000025301.2
AKAP11
A kinase (PRKA) anchor protein 11
chr17_-_8066250 5.18 ENST00000488857.1
ENST00000481878.1
ENST00000316509.6
ENST00000498285.1
VAMP2
RP11-599B13.6
vesicle-associated membrane protein 2 (synaptobrevin 2)
Uncharacterized protein
chr7_-_752577 5.16 ENST00000544935.1
ENST00000430040.1
ENST00000456696.2
ENST00000406797.1
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr2_+_191745535 5.16 ENST00000320717.3
GLS
glutaminase
chr8_-_110704014 5.14 ENST00000529190.1
ENST00000422135.1
ENST00000419099.1
SYBU
syntabulin (syntaxin-interacting)
chr8_-_101964265 4.96 ENST00000395958.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr9_+_33264861 4.95 ENST00000223500.8
CHMP5
charged multivesicular body protein 5
chr1_-_32403903 4.95 ENST00000344035.6
ENST00000356536.3
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr15_+_80696666 4.95 ENST00000303329.4
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr5_-_132112907 4.94 ENST00000458488.2
SEPT8
septin 8
chr5_-_132112921 4.91 ENST00000378721.4
ENST00000378701.1
SEPT8
septin 8
chr16_+_5008290 4.90 ENST00000251170.7
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr11_-_122931881 4.83 ENST00000526110.1
ENST00000227378.3
HSPA8
heat shock 70kDa protein 8
chr9_+_130922537 4.74 ENST00000372994.1
C9orf16
chromosome 9 open reading frame 16
chr3_-_171177852 4.67 ENST00000284483.8
ENST00000475336.1
ENST00000357327.5
ENST00000460047.1
ENST00000488470.1
ENST00000470834.1
TNIK
TRAF2 and NCK interacting kinase
chr19_-_51472031 4.60 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr2_+_191208196 4.50 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1
inositol polyphosphate-1-phosphatase
chr9_+_19049372 4.48 ENST00000380527.1
RRAGA
Ras-related GTP binding A
chr5_-_88179302 4.45 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr9_-_15510989 4.38 ENST00000380715.1
ENST00000380716.4
ENST00000380738.4
ENST00000380733.4
PSIP1
PC4 and SFRS1 interacting protein 1
chr11_-_46867780 4.37 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
CKAP5
cytoskeleton associated protein 5
chr12_+_6875519 4.31 ENST00000389462.4
ENST00000540874.1
ENST00000309083.6
PTMS
parathymosin
chr2_-_27718052 4.26 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr5_+_137774706 4.26 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr14_+_29234870 4.21 ENST00000382535.3
FOXG1
forkhead box G1
chr14_-_23822061 4.20 ENST00000397260.3
SLC22A17
solute carrier family 22, member 17
chr4_-_102267953 4.19 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_+_86274145 4.17 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3
glutamate receptor, metabotropic 3
chr10_+_95517660 4.10 ENST00000371413.3
LGI1
leucine-rich, glioma inactivated 1
chrX_-_49056635 4.09 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr3_-_49907323 4.04 ENST00000296471.7
ENST00000488336.1
ENST00000467248.1
ENST00000466940.1
ENST00000463537.1
ENST00000480398.2
CAMKV
CaM kinase-like vesicle-associated
chr15_-_73925651 3.99 ENST00000545878.1
ENST00000287226.8
ENST00000345330.4
NPTN
neuroplastin
chr15_-_83316711 3.99 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr11_-_122932730 3.97 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr9_+_33265011 3.94 ENST00000419016.2
CHMP5
charged multivesicular body protein 5
chr19_-_51472222 3.93 ENST00000376851.3
KLK6
kallikrein-related peptidase 6
chr7_-_108096765 3.87 ENST00000379024.4
ENST00000351718.4
NRCAM
neuronal cell adhesion molecule
chr8_-_144242020 3.87 ENST00000414417.2
LY6H
lymphocyte antigen 6 complex, locus H
chr21_+_38445539 3.83 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr3_-_52002403 3.81 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4
poly(rC) binding protein 4
chr19_+_40854559 3.79 ENST00000598962.1
ENST00000409419.1
ENST00000409587.1
ENST00000602131.1
ENST00000409735.4
ENST00000600948.1
ENST00000356508.5
ENST00000596682.1
ENST00000594908.1
PLD3
phospholipase D family, member 3
chr6_-_112194484 3.79 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr4_+_41362796 3.75 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr5_+_102595119 3.68 ENST00000510890.1
C5orf30
chromosome 5 open reading frame 30
chr12_-_65515334 3.68 ENST00000286574.4
WIF1
WNT inhibitory factor 1
chr19_-_54693401 3.68 ENST00000338624.6
MBOAT7
membrane bound O-acyltransferase domain containing 7
chr4_-_46391931 3.68 ENST00000381620.4
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr17_+_11924129 3.65 ENST00000353533.5
ENST00000415385.3
MAP2K4
mitogen-activated protein kinase kinase 4
chr13_-_45010939 3.59 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr8_+_94929110 3.58 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr14_-_23772032 3.58 ENST00000452015.4
PPP1R3E
protein phosphatase 1, regulatory subunit 3E
chr1_+_178995021 3.58 ENST00000263733.4
FAM20B
family with sequence similarity 20, member B
chr8_+_94929077 3.57 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr12_-_90102594 3.56 ENST00000428670.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr22_-_39268308 3.56 ENST00000407418.3
CBX6
chromobox homolog 6
chr1_-_85156216 3.52 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr17_+_2496971 3.50 ENST00000397195.5
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr9_-_139940608 3.50 ENST00000371601.4
NPDC1
neural proliferation, differentiation and control, 1
chr7_-_108096822 3.49 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM
neuronal cell adhesion molecule
chr22_-_38380543 3.49 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr4_-_46391805 3.49 ENST00000540012.1
GABRA2
gamma-aminobutyric acid (GABA) A receptor, alpha 2
chr7_+_106685079 3.46 ENST00000265717.4
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr7_+_153749732 3.45 ENST00000377770.3
DPP6
dipeptidyl-peptidase 6
chr7_+_24323782 3.42 ENST00000242152.2
ENST00000407573.1
NPY
neuropeptide Y
chr18_-_43684186 3.42 ENST00000590406.1
ENST00000282050.2
ENST00000590324.1
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr7_-_100493482 3.42 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE
acetylcholinesterase (Yt blood group)
chr17_-_8534031 3.41 ENST00000411957.1
ENST00000396239.1
ENST00000379980.4
MYH10
myosin, heavy chain 10, non-muscle
chr17_-_8534067 3.41 ENST00000360416.3
ENST00000269243.4
MYH10
myosin, heavy chain 10, non-muscle
chr11_+_73882144 3.41 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr20_+_17207665 3.40 ENST00000536609.1
PCSK2
proprotein convertase subtilisin/kexin type 2
chr1_-_161087802 3.40 ENST00000368010.3
PFDN2
prefoldin subunit 2
chr1_-_93426998 3.39 ENST00000370310.4
FAM69A
family with sequence similarity 69, member A
chr10_+_95517616 3.38 ENST00000371418.4
LGI1
leucine-rich, glioma inactivated 1
chr9_-_139922726 3.37 ENST00000265662.5
ENST00000371605.3
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr14_+_66975213 3.35 ENST00000543237.1
ENST00000305960.9
GPHN
gephyrin
chr10_+_95517566 3.35 ENST00000542308.1
LGI1
leucine-rich, glioma inactivated 1
chr1_-_9189229 3.33 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr11_+_73882311 3.33 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr17_+_37026284 3.30 ENST00000433206.2
ENST00000435347.3
LASP1
LIM and SH3 protein 1
chr12_+_49212514 3.29 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr17_-_8066843 3.29 ENST00000404970.3
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_153599732 3.24 ENST00000392623.1
S100A13
S100 calcium binding protein A13
chr5_-_142783694 3.23 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_45409011 3.23 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE
apolipoprotein E
chr3_-_32612263 3.23 ENST00000432458.2
ENST00000424991.1
ENST00000273130.4
DYNC1LI1
dynein, cytoplasmic 1, light intermediate chain 1
chr11_-_47447970 3.22 ENST00000298852.3
ENST00000530912.1
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr5_-_115177247 3.22 ENST00000500945.2
ATG12
autophagy related 12
chr22_+_19701985 3.21 ENST00000455784.2
ENST00000406395.1
SEPT5
septin 5
chr8_+_94929168 3.19 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr17_+_48796905 3.19 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr19_-_13617247 3.18 ENST00000573710.2
CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr9_+_33025209 3.17 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_-_153599426 3.17 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr16_+_2564254 3.16 ENST00000565223.1
ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr1_-_154600421 3.15 ENST00000368471.3
ENST00000292205.5
ADAR
adenosine deaminase, RNA-specific
chr10_-_118764862 3.15 ENST00000260777.10
KIAA1598
KIAA1598
chr5_+_161274940 3.13 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_+_220306745 3.12 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG
SPEG complex locus
chr1_-_85156090 3.12 ENST00000605755.1
ENST00000437941.2
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr14_-_27066960 3.11 ENST00000539517.2
NOVA1
neuro-oncological ventral antigen 1
chr12_+_861717 3.05 ENST00000535572.1
WNK1
WNK lysine deficient protein kinase 1
chr11_+_129939779 3.03 ENST00000533195.1
ENST00000533713.1
ENST00000528499.1
ENST00000539648.1
ENST00000263574.5
APLP2
amyloid beta (A4) precursor-like protein 2
chr12_+_118573663 3.01 ENST00000261313.2
PEBP1
phosphatidylethanolamine binding protein 1
chr1_+_110527308 2.98 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr16_+_2198604 2.97 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr1_-_23670817 2.95 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr6_+_44214824 2.93 ENST00000371646.5
ENST00000353801.3
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chrX_-_51812268 2.93 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
MAGED4B
melanoma antigen family D, 4B
chr9_-_132597529 2.89 ENST00000372447.3
C9orf78
chromosome 9 open reading frame 78
chr5_+_161274685 2.88 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr9_-_139922631 2.86 ENST00000341511.6
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr1_+_174846570 2.85 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr18_+_12948000 2.85 ENST00000585730.1
ENST00000399892.2
ENST00000589446.1
ENST00000587761.1
SEH1L
SEH1-like (S. cerevisiae)
chr1_-_23670813 2.85 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr5_+_161275320 2.84 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_43833628 2.79 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr16_-_30134524 2.77 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
MAPK3
mitogen-activated protein kinase 3
chr21_-_27542972 2.75 ENST00000346798.3
ENST00000439274.2
ENST00000354192.3
ENST00000348990.5
ENST00000357903.3
ENST00000358918.3
ENST00000359726.3
APP
amyloid beta (A4) precursor protein
chr8_-_9760839 2.75 ENST00000519461.1
ENST00000517675.1
LINC00599
long intergenic non-protein coding RNA 599
chr15_+_77223960 2.72 ENST00000394885.3
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr19_-_10530784 2.71 ENST00000593124.1
CDC37
cell division cycle 37
chr8_-_27468842 2.70 ENST00000523500.1
CLU
clusterin

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 34.4 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
10.5 31.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
4.8 58.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
4.4 21.8 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
3.2 25.8 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
3.2 3.2 GO:0097114 NMDA glutamate receptor clustering(GO:0097114)
2.9 14.6 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
2.7 80.7 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
2.6 23.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
2.5 22.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
2.3 7.0 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
2.3 6.8 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
2.3 6.8 GO:0021678 fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
2.1 6.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
2.1 8.3 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
2.1 10.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.0 16.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
2.0 2.0 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
1.8 8.8 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
1.7 6.9 GO:0043335 protein unfolding(GO:0043335)
1.7 8.3 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.6 4.9 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
1.6 9.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
1.6 4.8 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
1.5 13.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.4 21.6 GO:0090168 Golgi reassembly(GO:0090168)
1.4 4.3 GO:0050916 sensory perception of sweet taste(GO:0050916)
1.4 4.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.3 4.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
1.3 21.1 GO:0051639 actin filament network formation(GO:0051639)
1.3 14.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.3 11.7 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.2 6.2 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
1.2 2.5 GO:0097212 lysosomal membrane organization(GO:0097212)
1.2 7.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.2 3.6 GO:0072709 cellular response to sorbitol(GO:0072709)
1.2 8.5 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
1.2 3.6 GO:0006597 spermine biosynthetic process(GO:0006597)
1.1 3.3 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
1.1 5.6 GO:0030070 insulin processing(GO:0030070)
1.1 3.2 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
1.0 7.7 GO:0006013 mannose metabolic process(GO:0006013)
0.9 5.6 GO:0061741 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.9 6.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.9 0.9 GO:0046626 regulation of insulin receptor signaling pathway(GO:0046626)
0.9 9.0 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.9 8.1 GO:0060137 maternal process involved in parturition(GO:0060137)
0.9 2.7 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.9 5.3 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.9 3.5 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.9 4.4 GO:0000189 MAPK import into nucleus(GO:0000189)
0.8 11.8 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.8 11.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.8 8.0 GO:1900125 regulation of hyaluronan biosynthetic process(GO:1900125)
0.8 6.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.8 14.2 GO:0050812 regulation of acyl-CoA biosynthetic process(GO:0050812)
0.8 2.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.8 6.8 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.7 2.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.7 0.7 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.7 3.6 GO:1990034 calcium ion export from cell(GO:1990034)
0.7 3.5 GO:0097338 response to clozapine(GO:0097338)
0.7 8.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.7 2.0 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.7 2.0 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.7 6.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 1.9 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.6 1.9 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.6 6.2 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.6 4.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.6 6.4 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.6 10.5 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.6 2.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.6 1.7 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.6 2.9 GO:0006311 meiotic gene conversion(GO:0006311)
0.6 2.3 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.6 6.7 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 8.5 GO:0016540 protein autoprocessing(GO:0016540)
0.5 3.7 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.5 6.3 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.5 4.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.5 5.1 GO:0008343 adult feeding behavior(GO:0008343)
0.5 1.0 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.5 5.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.5 1.9 GO:0021564 vagus nerve development(GO:0021564)
0.5 2.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.5 3.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.4 5.8 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.4 5.7 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.4 11.6 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.4 3.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 10.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 2.9 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 1.2 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 1.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.4 3.2 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.4 9.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.4 3.2 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.4 0.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.4 15.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 1.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.4 3.2 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.3 1.4 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.3 1.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.3 2.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 1.0 GO:1900454 positive regulation of norepinephrine secretion(GO:0010701) positive regulation of long term synaptic depression(GO:1900454)
0.3 4.9 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.3 10.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 4.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.3 1.8 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.3 3.6 GO:0060019 radial glial cell differentiation(GO:0060019)
0.3 1.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.3 3.8 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.3 1.6 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.3 1.0 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.3 1.0 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.3 0.3 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.3 2.3 GO:0021978 telencephalon regionalization(GO:0021978)
0.2 2.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 1.7 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.2 1.2 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.2 0.7 GO:1904796 regulation of core promoter binding(GO:1904796) positive regulation of core promoter binding(GO:1904798)
0.2 2.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 1.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.2 1.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.5 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.2 0.7 GO:0070541 response to platinum ion(GO:0070541) cellular response to lead ion(GO:0071284)
0.2 1.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.2 0.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 0.7 GO:0033341 regulation of collagen binding(GO:0033341)
0.2 0.9 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.2 0.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.2 1.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2 2.5 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.2 0.8 GO:1901895 positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.2 3.5 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.2 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 0.6 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.2 1.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 1.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 6.2 GO:0035640 exploration behavior(GO:0035640)
0.2 2.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 3.7 GO:0043632 modification-dependent macromolecule catabolic process(GO:0043632)
0.2 8.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 0.8 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.2 0.6 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.2 13.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 4.7 GO:0061157 mRNA destabilization(GO:0061157)
0.2 0.6 GO:0060018 astrocyte fate commitment(GO:0060018)
0.2 3.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 1.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.2 2.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 12.7 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 3.7 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.2 0.9 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.2 0.7 GO:0072183 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.2 1.9 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 1.0 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.2 2.8 GO:0000338 protein deneddylation(GO:0000338)
0.2 2.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.2 3.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.2 2.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 0.5 GO:0018201 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.2 0.3 GO:0021535 cell migration in hindbrain(GO:0021535)
0.2 3.5 GO:0044804 nucleophagy(GO:0044804)
0.2 3.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 2.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.2 0.9 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 2.8 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.2 6.1 GO:0042407 cristae formation(GO:0042407)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.3 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.1 0.3 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 3.0 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1 2.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.3 GO:0006196 AMP catabolic process(GO:0006196)
0.1 4.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 1.9 GO:0021756 striatum development(GO:0021756)
0.1 1.0 GO:0070459 prolactin secretion(GO:0070459)
0.1 2.1 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.9 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 0.8 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.1 2.0 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.1 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.1 0.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 1.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 3.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.4 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 1.8 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 3.0 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.4 GO:0031291 Ran protein signal transduction(GO:0031291)
0.1 0.5 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.7 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 1.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 5.9 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 0.6 GO:0021894 cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.1 1.4 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.1 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.2 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 1.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.6 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.1 0.8 GO:0051382 kinetochore assembly(GO:0051382)
0.1 2.7 GO:0046710 GDP metabolic process(GO:0046710)
0.1 0.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 0.2 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 0.2 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.1 4.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 0.2 GO:1902302 regulation of heart rate by hormone(GO:0003064) regulation of potassium ion export(GO:1902302) negative regulation of potassium ion export(GO:1902303)
0.1 0.6 GO:0032264 IMP salvage(GO:0032264)
0.1 0.8 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 0.4 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.1 2.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:1901678 iron coordination entity transport(GO:1901678)
0.1 0.4 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 1.6 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.1 0.1 GO:0060300 regulation of cytokine activity(GO:0060300)
0.1 13.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 2.7 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 1.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 2.6 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 1.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.4 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 6.3 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.8 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 3.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.0 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 0.5 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.9 GO:0043486 histone exchange(GO:0043486)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.5 GO:0015671 oxygen transport(GO:0015671)
0.0 2.5 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.0 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.0 2.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0007512 adult heart development(GO:0007512)
0.0 0.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 2.1 GO:0050776 regulation of immune response(GO:0050776)
0.0 0.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.5 GO:2000398 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.3 GO:0031100 organ regeneration(GO:0031100)
0.0 0.4 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 2.7 GO:0016042 lipid catabolic process(GO:0016042)
0.0 1.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 1.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 31.5 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
5.9 71.4 GO:0044327 dendritic spine head(GO:0044327)
3.3 13.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
3.0 11.9 GO:0098843 postsynaptic endocytic zone(GO:0098843)
2.1 8.5 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.5 13.4 GO:0071439 clathrin complex(GO:0071439)
1.4 19.3 GO:0031209 SCAR complex(GO:0031209)
1.4 6.8 GO:0097513 myosin II filament(GO:0097513)
1.3 16.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
1.3 8.8 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.2 10.9 GO:0005955 calcineurin complex(GO:0005955)
1.2 8.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
1.2 17.8 GO:0005641 nuclear envelope lumen(GO:0005641)
1.2 17.8 GO:0005916 fascia adherens(GO:0005916)
1.1 97.5 GO:0043195 terminal bouton(GO:0043195)
1.1 3.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.0 2.9 GO:0032302 MutSbeta complex(GO:0032302)
0.9 12.1 GO:0097433 dense body(GO:0097433)
0.9 6.8 GO:0097470 ribbon synapse(GO:0097470)
0.8 7.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 4.6 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.7 4.5 GO:1990130 EGO complex(GO:0034448) Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.7 2.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.6 3.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 38.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.6 5.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.6 10.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 8.6 GO:0005883 neurofilament(GO:0005883)
0.6 6.9 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.5 10.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 15.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.5 1.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.5 3.4 GO:0016272 prefoldin complex(GO:0016272)
0.5 3.8 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 2.8 GO:0035859 Seh1-associated complex(GO:0035859) GATOR2 complex(GO:0061700)
0.4 4.0 GO:0060077 inhibitory synapse(GO:0060077)
0.4 3.5 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.4 5.6 GO:0097418 neurofibrillary tangle(GO:0097418)
0.4 2.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 6.6 GO:0043194 axon initial segment(GO:0043194)
0.4 4.0 GO:0043083 synaptic cleft(GO:0043083)
0.4 3.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.4 2.7 GO:0061617 MICOS complex(GO:0061617)
0.4 3.4 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 8.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.4 15.5 GO:0043198 dendritic shaft(GO:0043198)
0.3 1.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 2.8 GO:0008180 COP9 signalosome(GO:0008180)
0.3 1.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.3 8.2 GO:0035371 microtubule plus-end(GO:0035371)
0.3 9.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 42.3 GO:0031901 early endosome membrane(GO:0031901)
0.3 2.6 GO:0061574 ASAP complex(GO:0061574)
0.3 7.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 0.6 GO:0044094 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.3 3.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 3.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.3 0.8 GO:0044294 dendritic growth cone(GO:0044294)
0.3 6.9 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 14.8 GO:0043679 axon terminus(GO:0043679)
0.3 1.3 GO:0005594 collagen type IX trimer(GO:0005594)
0.3 1.5 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.2 2.7 GO:0030904 retromer complex(GO:0030904)
0.2 1.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.2 2.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 0.9 GO:0016600 flotillin complex(GO:0016600)
0.2 1.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 2.7 GO:0032433 filopodium tip(GO:0032433)
0.2 5.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 2.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 0.6 GO:0089701 U2AF(GO:0089701)
0.2 2.5 GO:0005686 U2 snRNP(GO:0005686)
0.2 1.2 GO:0051286 cell tip(GO:0051286)
0.2 10.4 GO:0045202 synapse(GO:0045202)
0.2 4.4 GO:0031143 pseudopodium(GO:0031143)
0.2 1.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 4.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.2 1.1 GO:0016342 catenin complex(GO:0016342)
0.2 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 7.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 2.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 2.5 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.2 4.4 GO:0042629 mast cell granule(GO:0042629)
0.2 3.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.4 GO:0034709 methylosome(GO:0034709)
0.1 0.8 GO:0032009 early phagosome(GO:0032009)
0.1 1.9 GO:0008091 spectrin(GO:0008091)
0.1 1.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 3.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 5.0 GO:0030496 midbody(GO:0030496)
0.1 3.7 GO:0035869 ciliary transition zone(GO:0035869)
0.1 2.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 10.9 GO:0005882 intermediate filament(GO:0005882)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0097255 R2TP complex(GO:0097255)
0.1 3.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 7.3 GO:0005811 lipid particle(GO:0005811)
0.1 1.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 2.1 GO:0030133 transport vesicle(GO:0030133)
0.1 1.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 4.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.3 GO:0032420 stereocilium(GO:0032420)
0.1 2.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 9.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.8 GO:0097440 apical dendrite(GO:0097440)
0.1 4.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.2 GO:0031213 RSF complex(GO:0031213)
0.1 0.4 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 3.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.6 GO:0001739 sex chromatin(GO:0001739)
0.1 1.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 12.1 GO:0060076 excitatory synapse(GO:0060076)
0.1 1.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 3.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.7 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 1.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.3 GO:0000801 central element(GO:0000801)
0.1 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 1.8 GO:0005769 early endosome(GO:0005769)
0.1 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 2.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.9 GO:0005921 gap junction(GO:0005921)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 7.0 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 3.0 GO:0043204 perikaryon(GO:0043204)
0.0 4.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.8 GO:0005856 cytoskeleton(GO:0005856)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 18.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.6 GO:0005776 autophagosome(GO:0005776)
0.0 2.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 2.4 GO:0098794 postsynapse(GO:0098794)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.5 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.6 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 34.4 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
6.3 31.5 GO:0030348 syntaxin-3 binding(GO:0030348)
4.4 21.8 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
3.3 71.6 GO:0070300 phosphatidic acid binding(GO:0070300)
2.6 10.3 GO:0097001 ceramide binding(GO:0097001)
2.3 7.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
2.0 18.1 GO:0032051 clathrin light chain binding(GO:0032051)
1.7 10.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
1.5 16.1 GO:0097016 L27 domain binding(GO:0097016)
1.5 11.7 GO:0043559 insulin binding(GO:0043559)
1.3 16.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
1.2 4.9 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.2 6.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
1.2 4.8 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.2 30.1 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 12.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.1 10.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.0 8.3 GO:0050816 phosphothreonine binding(GO:0050816)
1.0 46.9 GO:0003785 actin monomer binding(GO:0003785)
1.0 4.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.0 11.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.0 9.9 GO:0030911 TPR domain binding(GO:0030911)
1.0 2.9 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.9 2.7 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.9 7.0 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.9 3.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.9 4.3 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.8 3.3 GO:0008940 nitrate reductase activity(GO:0008940)
0.8 4.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.8 15.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.8 16.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.8 3.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.8 2.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.8 4.6 GO:0019776 Atg8 ligase activity(GO:0019776)
0.7 16.4 GO:0017166 vinculin binding(GO:0017166)
0.7 9.8 GO:0005522 profilin binding(GO:0005522)
0.6 1.9 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.6 12.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 3.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.6 7.0 GO:0097100 supercoiled DNA binding(GO:0097100)
0.6 2.9 GO:0004359 glutaminase activity(GO:0004359)
0.6 7.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.6 12.4 GO:0004707 MAP kinase activity(GO:0004707)
0.5 3.3 GO:0035500 MH2 domain binding(GO:0035500)
0.5 3.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 3.2 GO:0043532 angiostatin binding(GO:0043532)
0.5 1.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.5 10.2 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 7.1 GO:0003680 AT DNA binding(GO:0003680)
0.5 3.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.5 6.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.5 3.9 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.5 2.8 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.4 4.5 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.4 4.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.4 9.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 1.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.4 10.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 11.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 5.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 8.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 4.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 4.5 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 1.4 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 11.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.3 1.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 0.3 GO:1904288 BAT3 complex binding(GO:1904288)
0.3 4.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 21.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.3 3.5 GO:0034452 dynactin binding(GO:0034452)
0.3 4.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.3 4.9 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.3 2.8 GO:0051425 PTB domain binding(GO:0051425)
0.3 3.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 3.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.3 5.2 GO:0051787 misfolded protein binding(GO:0051787)
0.3 0.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.3 3.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 1.1 GO:0052827 inositol pentakisphosphate phosphatase activity(GO:0052827)
0.3 2.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.3 1.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 5.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 0.8 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 12.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 11.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 2.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.5 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 1.7 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 15.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.0 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 4.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 6.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 0.6 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.2 5.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.2 4.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.9 GO:0042731 PH domain binding(GO:0042731)
0.2 1.7 GO:1990239 steroid hormone binding(GO:1990239)
0.2 2.2 GO:0031386 protein tag(GO:0031386)
0.2 1.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 1.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 1.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 0.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.2 0.5 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.2 2.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 0.9 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 4.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 1.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.2 0.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 0.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 0.7 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 2.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 0.5 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.2 2.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 3.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 5.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.5 GO:0033149 FFAT motif binding(GO:0033149)
0.2 1.1 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 2.0 GO:0038132 neuregulin binding(GO:0038132)
0.2 21.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 1.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.8 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 2.9 GO:0000339 RNA cap binding(GO:0000339)
0.1 2.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.7 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.6 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 1.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 6.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 3.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.9 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 1.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 21.5 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.5 GO:0044388 small protein activating enzyme binding(GO:0044388) RING-like zinc finger domain binding(GO:0071535)
0.1 1.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 1.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 3.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 2.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.8 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 6.2 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.1 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.0 GO:0043295 glutathione binding(GO:0043295)
0.1 1.4 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.6 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 7.4 GO:0044325 ion channel binding(GO:0044325)
0.1 0.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.7 GO:0004985 opioid receptor activity(GO:0004985)
0.1 1.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 3.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 2.0 GO:0005507 copper ion binding(GO:0005507)
0.0 4.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 8.5 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 2.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 16.5 GO:0008289 lipid binding(GO:0008289)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 6.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.9 GO:0020037 heme binding(GO:0020037)
0.0 5.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 5.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.0 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.0 0.1 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 35.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
1.3 77.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.8 40.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.6 22.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.5 33.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.4 9.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.4 31.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.3 10.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.3 11.4 PID AURORA A PATHWAY Aurora A signaling
0.3 8.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 14.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 7.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 11.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 0.6 PID IFNG PATHWAY IFN-gamma pathway
0.2 9.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 4.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 7.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 6.3 PID MYC PATHWAY C-MYC pathway
0.1 2.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.8 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 4.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 2.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 2.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 0.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 1.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 6.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 0.7 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 2.0 PID AURORA B PATHWAY Aurora B signaling
0.0 1.5 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 3.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 3.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 53.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.0 56.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.4 34.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.3 58.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
1.2 11.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.2 35.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
1.0 13.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.8 14.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.8 7.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.8 8.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.7 17.9 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.5 1.6 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.5 16.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.5 11.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.5 4.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.5 15.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 8.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.4 22.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 8.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 6.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 3.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 4.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 23.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 4.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3 5.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 2.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 4.7 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 2.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 2.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 3.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 21.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 3.8 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 6.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 5.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 1.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.2 9.4 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.2 18.2 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.2 3.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 16.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 6.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 11.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 0.9 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.4 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 3.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 0.9 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.1 2.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.9 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 3.3 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.1 1.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 3.5 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.2 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 1.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 2.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 2.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 6.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds