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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for EPAS1_BCL3
Z-value: 2.94
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Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg19_v2_chr2_+_46524537_46524553 | 0.55 | 9.6e-19 | Click! |
| BCL3 | hg19_v2_chr19_+_45251804_45251840 | -0.22 | 8.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_35629702 Show fit | 124.39 |
ENST00000351325.4
|
FXYD domain containing ion transport regulator 1 |
|
| chr15_-_60690932 Show fit | 71.07 |
ENST00000559818.1
|
annexin A2 |
|
| chr20_+_10199468 Show fit | 57.06 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chr16_-_70719925 Show fit | 54.56 |
ENST00000338779.6
|
metastasis suppressor 1-like |
|
| chr3_-_58572760 Show fit | 51.71 |
ENST00000447756.2
|
family with sequence similarity 107, member A |
|
| chr1_+_6845384 Show fit | 45.50 |
ENST00000303635.7
|
calmodulin binding transcription activator 1 |
|
| chr6_+_31620191 Show fit | 44.56 |
ENST00000375918.2
ENST00000375920.4 |
apolipoprotein M |
|
| chr8_+_21915368 Show fit | 43.97 |
ENST00000265800.5
ENST00000517418.1 |
dematin actin binding protein |
|
| chr19_+_56915668 Show fit | 42.39 |
ENST00000333201.9
ENST00000391778.3 |
zinc finger protein 583 |
|
| chr4_-_5894777 Show fit | 37.87 |
ENST00000324989.7
|
collapsin response mediator protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.4 | 194.7 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 2.9 | 139.2 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 18.8 | 94.1 | GO:0060611 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 15.5 | 92.9 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 14.8 | 74.1 | GO:0034443 | negative regulation of lipoprotein oxidation(GO:0034443) |
| 23.7 | 71.1 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.9 | 69.2 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 1.0 | 58.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 8.3 | 58.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 3.0 | 57.6 | GO:0072540 | T-helper 17 cell lineage commitment(GO:0072540) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 194.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.5 | 136.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.9 | 132.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 119.9 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 5.3 | 112.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 19.2 | 95.8 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 15.7 | 94.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.2 | 91.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 86.7 | GO:0031901 | early endosome membrane(GO:0031901) |
| 8.0 | 80.2 | GO:0071953 | elastic fiber(GO:0071953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 203.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 3.2 | 157.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 156.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.9 | 121.5 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 7.9 | 95.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 15.3 | 91.8 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 3.1 | 79.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.7 | 77.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 11.8 | 71.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.7 | 66.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 163.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 140.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.9 | 110.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 2.9 | 96.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 86.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 76.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.8 | 60.0 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.8 | 53.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.7 | 35.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.5 | 30.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 107.8 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.5 | 97.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 4.7 | 84.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 2.3 | 56.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 1.8 | 49.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 2.5 | 45.9 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.5 | 43.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 43.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.6 | 43.3 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.9 | 40.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |