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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ETS1
Z-value: 2.18
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Transcription factors associated with ETS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETS1 | hg19_v2_chr11_-_128392085_128392232 | 0.35 | 9.0e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_10450287 Show fit | 62.29 |
ENST00000589261.1
ENST00000590569.1 ENST00000589580.1 ENST00000589249.1 |
intercellular adhesion molecule 3 |
|
| chr19_+_1077393 Show fit | 60.36 |
ENST00000590577.1
|
histocompatibility (minor) HA-1 |
|
| chr21_-_46340770 Show fit | 59.26 |
ENST00000397854.3
|
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr13_-_46756351 Show fit | 56.05 |
ENST00000323076.2
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr7_-_5569588 Show fit | 55.66 |
ENST00000417101.1
|
actin, beta |
|
| chr20_+_43514320 Show fit | 49.17 |
ENST00000372839.3
ENST00000428262.1 ENST00000445830.1 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
|
| chr19_-_10450328 Show fit | 49.04 |
ENST00000160262.5
|
intercellular adhesion molecule 3 |
|
| chr12_-_110888103 Show fit | 47.57 |
ENST00000426440.1
ENST00000228825.7 |
actin related protein 2/3 complex, subunit 3, 21kDa |
|
| chr20_+_43514315 Show fit | 47.39 |
ENST00000353703.4
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
|
| chr2_-_230786619 Show fit | 45.29 |
ENST00000389045.3
ENST00000409677.1 |
thyroid hormone receptor interactor 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETS1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 201.3 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 1.5 | 200.6 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 3.1 | 153.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 9.0 | 143.6 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 3.1 | 141.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.3 | 131.7 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.3 | 116.2 | GO:0006903 | vesicle targeting(GO:0006903) |
| 2.6 | 116.0 | GO:0036260 | 7-methylguanosine mRNA capping(GO:0006370) 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
| 2.1 | 114.3 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 2.4 | 106.9 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 323.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.4 | 267.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.9 | 220.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.6 | 155.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 23.4 | 140.6 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.1 | 137.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.3 | 129.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 3.4 | 128.1 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 6.2 | 124.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.8 | 124.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 268.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 178.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 20.1 | 140.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 6.2 | 135.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 3.0 | 129.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.8 | 116.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.7 | 110.5 | GO:0005178 | integrin binding(GO:0005178) |
| 3.4 | 108.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 15.4 | 107.7 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 5.3 | 105.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 437.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 3.3 | 290.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 5.1 | 267.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 4.9 | 162.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 3.1 | 119.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.9 | 114.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.9 | 107.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 1.5 | 88.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 2.7 | 70.8 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 1.4 | 54.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 355.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 3.5 | 306.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 3.4 | 252.1 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 8.6 | 233.2 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 2.6 | 201.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.6 | 192.3 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 3.4 | 174.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 2.9 | 128.5 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 125.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 119.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |