ISMARA results: FOSL2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for FOSL2_SMARCC1

Z-value: 1.71

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Transcription factors associated with FOSL2_SMARCC1

Gene Symbol	Gene ID	Gene Info
FOSL2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000075426.7	FOS like 2, AP-1 transcription factor subunit
SMARCC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000173473.6	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL2	hg19_v2_chr2_+_28615669_28615733	0.24	3.4e-04	Click!
SMARCC1	hg19_v2_chr3_-_47823298_47823423	0.23	6.2e-04	Click!

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_223889285 Show fit	74.89	ENST00000433674.2	CAPN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	calpain 2, (m/II) large subunit
chr1_-_113247543 Show fit	71.58	ENST00000414971.1 ENST00000534717.1	RHOC Ensembl NCBI GeneCards UniProt NextProt Show fit	ras homolog family member C
chr6_-_31704282 Show fit	59.93	ENST00000375784.3 ENST00000375779.2	CLIC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chloride intracellular channel 1
chr22_+_23241661 Show fit	45.39	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 2
chr1_+_156096336 Show fit	42.14	ENST00000504687.1 ENST00000473598.2	LMNA Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin A/C
chr1_+_156084461 Show fit	41.84	ENST00000347559.2 ENST00000361308.4 ENST00000368300.4 ENST00000368299.3	LMNA Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin A/C
chr1_-_151965048 Show fit	39.20	ENST00000368809.1	S100A10 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A10
chr2_+_89901292 Show fit	34.61	ENST00000448155.2	IGKV1D-39 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-39
chr1_+_156095951 Show fit	33.25	ENST00000448611.2 ENST00000368297.1	LMNA Ensembl NCBI GeneCards UniProt NextProt Show fit	lamin A/C
chr2_+_90060377 Show fit	33.18	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	314.3	GO:0030449	regulation of complement activation(GO:0030449)
1.2	202.8	GO:0002377	immunoglobulin production(GO:0002377)
23.4	117.2	GO:0035105	sterol regulatory element binding protein import into nucleus(GO:0035105)
0.9	80.7	GO:0070527	platelet aggregation(GO:0070527)
2.5	73.2	GO:0031581	hemidesmosome assembly(GO:0031581)
11.9	71.6	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.7	68.6	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
5.2	68.1	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
8.6	51.3	GO:0007296	vitellogenesis(GO:0007296)
2.5	50.2	GO:0016540	protein autoprocessing(GO:0016540)

Showing 1 to 10 of 231 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	195.9	GO:0072562	blood microparticle(GO:0072562)
0.1	186.9	GO:0070062	extracellular exosome(GO:0070062)
0.1	177.0	GO:0005615	extracellular space(GO:0005615)
13.0	117.2	GO:0005638	lamin filament(GO:0005638)
7.4	88.8	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
2.0	72.2	GO:0032420	stereocilium(GO:0032420)
0.2	71.5	GO:0030055	cell-substrate junction(GO:0030055)
2.0	62.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
6.9	55.3	GO:0005610	laminin-5 complex(GO:0005610)
0.4	43.8	GO:0005913	cell-cell adherens junction(GO:0005913)

Showing 1 to 10 of 110 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	531.6	GO:0003823	antigen binding(GO:0003823)
0.2	184.0	GO:0005198	structural molecule activity(GO:0005198)
2.4	92.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2	87.7	GO:0003924	GTPase activity(GO:0003924)
1.5	81.2	GO:0019212	phosphatase inhibitor activity(GO:0019212)
1.2	59.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.1	53.0	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.5	40.6	GO:0005518	collagen binding(GO:0005518)
5.8	40.3	GO:0048408	epidermal growth factor binding(GO:0048408)
5.8	34.9	GO:1990254	keratin filament binding(GO:1990254)

Showing 1 to 10 of 152 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	150.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.3	140.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.0	82.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
3.2	74.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
2.0	68.8	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
1.2	65.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
2.0	61.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.8	57.3	PID ILK PATHWAY	Integrin-linked kinase signaling
1.0	52.6	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.7	44.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	166.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
1.7	87.1	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
1.1	85.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.9	68.6	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.4	66.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.2	44.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.1	43.9	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
1.5	39.8	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
1.4	39.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
2.0	38.8	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 10 of 73 entries

Results for FOSL2_SMARCC1

Z-value: 1.71

Motif logo

Transcription factors associated with FOSL2_SMARCC1

Activity-expression correlation:

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: