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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GATA5

Z-value: 0.64

Motif logo

Transcription factors associated with GATA5

Gene Symbol Gene ID Gene Info
ENSG00000130700.6 GATA binding protein 5

Activity profile of GATA5 motif

Sorted Z-values of GATA5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_66874502 11.78 ENST00000558797.1
HCG2003567; Uncharacterized protein
chr1_-_160681593 10.42 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chr6_-_32557610 9.53 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr6_+_33043703 7.64 ENST00000418931.2
ENST00000535465.1
major histocompatibility complex, class II, DP beta 1
chr13_-_46756351 7.55 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_155484155 7.05 ENST00000509493.1
fibrinogen beta chain
chr19_+_35820064 6.90 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22 molecule
chr4_+_175204818 6.66 ENST00000503780.1
centrosomal protein 44kDa
chr6_+_32709119 6.52 ENST00000374940.3
major histocompatibility complex, class II, DQ alpha 2
chr15_+_99791567 6.27 ENST00000558879.1
ENST00000301981.3
ENST00000422500.2
ENST00000447360.2
ENST00000442993.2
leucine rich repeat containing 28
chr1_-_213031418 6.23 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1 antisense RNA 1 (head to head)
chr1_+_174844645 5.92 ENST00000486220.1
RAB GTPase activating protein 1-like
chr8_+_9046503 5.41 ENST00000512942.2
RP11-10A14.5
chr10_+_7745232 5.11 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745303 4.90 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_155484103 4.79 ENST00000302068.4
fibrinogen beta chain
chr6_-_32908765 4.53 ENST00000416244.2
major histocompatibility complex, class II, DM beta
chr11_+_128563652 3.96 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_24936170 3.90 ENST00000538035.1
family with sequence similarity 65, member B
chr8_-_6837602 3.79 ENST00000382692.2
defensin, alpha 1
chr12_-_45270077 3.77 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NEL-like 2 (chicken)
chr8_-_6875778 3.75 ENST00000535841.1
ENST00000327857.2
defensin, alpha 1B
defensin, alpha 3, neutrophil-specific
chr12_-_45270151 3.74 ENST00000429094.2
NEL-like 2 (chicken)
chr1_-_158656488 3.74 ENST00000368147.4
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr11_+_121461097 3.73 ENST00000527934.1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_45269430 3.68 ENST00000395487.2
NEL-like 2 (chicken)
chr9_-_35650900 3.55 ENST00000259608.3
signaling threshold regulating transmembrane adaptor 1
chr11_-_33891362 3.36 ENST00000395833.3
LIM domain only 2 (rhombotin-like 1)
chr6_+_31916733 3.16 ENST00000483004.1
complement factor B
chr16_+_31539183 3.11 ENST00000302312.4
alpha hemoglobin stabilizing protein
chr2_+_102615416 3.03 ENST00000393414.2
interleukin 1 receptor, type II
chr4_-_72649763 2.93 ENST00000513476.1
group-specific component (vitamin D binding protein)
chr6_-_133079022 2.87 ENST00000525289.1
ENST00000326499.6
vanin 2
chr12_+_54892550 2.83 ENST00000545638.2
NCK-associated protein 1-like
chr7_+_134331550 2.79 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
2,3-bisphosphoglycerate mutase
chr1_+_115572415 2.75 ENST00000256592.1
thyroid stimulating hormone, beta
chr9_+_91933407 2.73 ENST00000375807.3
ENST00000339901.4
SECIS binding protein 2
chr1_-_17445930 2.67 ENST00000375486.4
ENST00000375481.1
ENST00000444885.2
peptidyl arginine deiminase, type II
chr4_-_110723335 2.63 ENST00000394634.2
complement factor I
chr8_+_28196157 2.50 ENST00000522209.1
prepronociceptin
chr4_-_110723194 2.44 ENST00000394635.3
complement factor I
chr8_+_117778736 2.44 ENST00000309822.2
ENST00000357148.3
ENST00000517814.1
ENST00000517820.1
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_+_156123318 2.43 ENST00000368285.3
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_9296279 2.41 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr12_-_9268707 2.40 ENST00000318602.7
alpha-2-macroglobulin
chr12_+_9102632 2.35 ENST00000539240.1
killer cell lectin-like receptor subfamily G, member 1
chr1_-_203274418 2.33 ENST00000457348.1
long intergenic non-protein coding RNA 1136
chr13_-_107214291 2.32 ENST00000375926.1
arginine and glutamate rich 1
chr19_-_14889349 2.31 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
egf-like module containing, mucin-like, hormone receptor-like 2
chr6_-_133055896 2.30 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
vanin 3
chr5_-_150537279 2.28 ENST00000517486.1
ENST00000377751.5
ENST00000356496.5
ENST00000521512.1
ENST00000517757.1
ENST00000354546.5
annexin A6
chr9_-_6645628 2.27 ENST00000321612.6
glycine dehydrogenase (decarboxylating)
chr17_-_61996192 2.26 ENST00000392824.4
chorionic somatomammotropin hormone-like 1
chr19_-_52133588 2.23 ENST00000570106.2
sialic acid binding Ig-like lectin 5
chr14_+_76618242 2.20 ENST00000557542.1
ENST00000557263.1
ENST00000557207.1
ENST00000312858.5
ENST00000261530.7
G patch domain containing 2-like
chr16_-_33647696 2.19 ENST00000558425.1
ENST00000569103.2
Uncharacterized protein
chr16_+_31366455 2.11 ENST00000268296.4
integrin, alpha X (complement component 3 receptor 4 subunit)
chr17_-_61996160 2.07 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
growth hormone 1
chr19_-_10450328 2.01 ENST00000160262.5
intercellular adhesion molecule 3
chr7_+_26332645 1.94 ENST00000396376.1
sorting nexin 10
chr6_-_135271260 1.92 ENST00000265605.2
aldehyde dehydrogenase 8 family, member A1
chr6_-_135271219 1.89 ENST00000367847.2
ENST00000367845.2
aldehyde dehydrogenase 8 family, member A1
chr16_+_31366536 1.88 ENST00000562522.1
integrin, alpha X (complement component 3 receptor 4 subunit)
chr18_-_5419797 1.86 ENST00000542146.1
ENST00000427684.2
erythrocyte membrane protein band 4.1-like 3
chr4_-_110723134 1.85 ENST00000510800.1
ENST00000512148.1
complement factor I
chr3_+_178276488 1.78 ENST00000432997.1
ENST00000455865.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr6_-_52710893 1.73 ENST00000284562.2
glutathione S-transferase alpha 5
chr13_-_99910673 1.71 ENST00000397473.2
ENST00000397470.2
G protein-coupled receptor 18
chr4_-_47983519 1.68 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
cyclic nucleotide gated channel alpha 1
chr15_-_20193370 1.68 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr10_-_98031265 1.64 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr19_+_42580274 1.57 ENST00000359044.4
zinc finger protein 574
chr14_+_61995722 1.56 ENST00000556347.1
RP11-47I22.4
chr12_+_62860581 1.51 ENST00000393632.2
ENST00000393630.3
ENST00000280379.6
ENST00000546600.1
ENST00000552738.1
ENST00000393629.2
ENST00000552115.1
MON2 homolog (S. cerevisiae)
chr16_+_77224732 1.50 ENST00000569610.1
ENST00000248248.3
ENST00000567291.1
ENST00000320859.6
ENST00000563612.1
ENST00000563279.1
MON1 secretory trafficking family member B
chr10_+_43916052 1.44 ENST00000442526.2
RP11-517P14.2
chr5_+_140261703 1.43 ENST00000409494.1
ENST00000289272.2
protocadherin alpha 13
chrX_-_65253506 1.42 ENST00000427538.1
V-set and immunoglobulin domain containing 4
chr17_-_61996136 1.38 ENST00000342364.4
growth hormone 1
chr16_+_67927147 1.35 ENST00000291041.5
protein serine kinase H1
chr6_+_131571535 1.34 ENST00000474850.2
A kinase (PRKA) anchor protein 7
chr17_+_53344945 1.32 ENST00000575345.1
hepatic leukemia factor
chr18_+_39766626 1.32 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
long intergenic non-protein coding RNA 907
chr2_+_29336855 1.30 ENST00000404424.1
CAP-GLY domain containing linker protein family, member 4
chrX_-_55020511 1.28 ENST00000375006.3
ENST00000374992.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr6_+_31783291 1.27 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
heat shock 70kDa protein 1A
chr6_-_33290580 1.26 ENST00000446511.1
ENST00000446403.1
ENST00000414083.2
ENST00000266000.6
ENST00000374542.5
death-domain associated protein
chr1_+_196857144 1.25 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
complement factor H-related 4
chr10_+_15085936 1.23 ENST00000378217.3
oleoyl-ACP hydrolase
chr5_-_39270725 1.21 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr6_-_154677900 1.20 ENST00000265198.4
ENST00000520261.1
interaction protein for cytohesin exchange factors 1
chr2_+_69201705 1.19 ENST00000377938.2
gastrokine 1
chr2_+_143635067 1.19 ENST00000264170.4
kynureninase
chr1_-_182921119 1.19 ENST00000423786.1
SHC SH2-domain binding protein 1-like
chr19_-_14952689 1.17 ENST00000248058.1
olfactory receptor, family 7, subfamily A, member 10
chr14_+_21785693 1.17 ENST00000382933.4
ENST00000557351.1
retinitis pigmentosa GTPase regulator interacting protein 1
chr14_-_82000140 1.14 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
sel-1 suppressor of lin-12-like (C. elegans)
chr2_-_109605663 1.12 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
ectodysplasin A receptor
chr15_-_63674034 1.11 ENST00000344366.3
ENST00000422263.2
carbonic anhydrase XII
chr15_+_41245160 1.09 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr15_+_100106126 1.07 ENST00000558812.1
ENST00000338042.6
myocyte enhancer factor 2A
chr10_+_53806501 1.06 ENST00000373975.2
protein kinase, cGMP-dependent, type I
chr11_+_30252549 1.06 ENST00000254122.3
ENST00000417547.1
follicle stimulating hormone, beta polypeptide
chr18_+_21032781 1.03 ENST00000339486.3
RIO kinase 3
chr15_+_100106155 0.95 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
myocyte enhancer factor 2A
chr11_+_118754475 0.92 ENST00000292174.4
chemokine (C-X-C motif) receptor 5
chr6_-_90529418 0.91 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1, midasin homolog (yeast)
chr22_+_23412479 0.90 ENST00000248996.4
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr5_-_75919253 0.90 ENST00000296641.4
coagulation factor II (thrombin) receptor-like 2
chr1_+_150229554 0.87 ENST00000369111.4
carbonic anhydrase XIV
chr10_+_15085895 0.85 ENST00000378228.3
oleoyl-ACP hydrolase
chr15_-_34628951 0.83 ENST00000397707.2
ENST00000560611.1
solute carrier family 12 (potassium/chloride transporter), member 6
chr6_-_29395509 0.81 ENST00000377147.2
olfactory receptor, family 11, subfamily A, member 1
chrX_+_11777671 0.81 ENST00000380693.3
ENST00000380692.2
male-specific lethal 3 homolog (Drosophila)
chr4_+_71570430 0.79 ENST00000417478.2
RUN and FYVE domain containing 3
chr14_+_39735411 0.78 ENST00000603904.1
cTAGE family member 5 isoform 4
chr3_+_46283916 0.78 ENST00000395940.2
chemokine (C-C motif) receptor 3
chr3_-_137851220 0.77 ENST00000236709.3
alpha-1,4-N-acetylglucosaminyltransferase
chr12_-_54582655 0.69 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr19_-_14992264 0.68 ENST00000327462.2
olfactory receptor, family 7, subfamily A, member 17
chr5_-_75919217 0.67 ENST00000504899.1
coagulation factor II (thrombin) receptor-like 2
chr1_+_104159999 0.67 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr7_+_136553370 0.66 ENST00000445907.2
cholinergic receptor, muscarinic 2
chr4_-_48782259 0.63 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRY-like
chr4_-_83769996 0.62 ENST00000511338.1
SEC31 homolog A (S. cerevisiae)
chr8_-_18666360 0.60 ENST00000286485.8
pleckstrin and Sec7 domain containing 3
chr3_+_108541545 0.59 ENST00000295756.6
T cell receptor associated transmembrane adaptor 1
chr18_-_3874752 0.54 ENST00000534970.1
discs, large (Drosophila) homolog-associated protein 1
chr3_+_108541608 0.53 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr10_+_103911926 0.53 ENST00000605788.1
ENST00000405356.1
nucleolar and coiled-body phosphoprotein 1
chr14_-_61748550 0.52 ENST00000555868.1
transmembrane protein 30B
chr9_-_95244781 0.52 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
asporin
chr1_+_196743943 0.50 ENST00000471440.2
ENST00000391985.3
complement factor H-related 3
chr15_+_100106244 0.49 ENST00000557942.1
myocyte enhancer factor 2A
chr1_+_57320437 0.49 ENST00000361249.3
complement component 8, alpha polypeptide
chr2_+_191792376 0.48 ENST00000409428.1
ENST00000409215.1
glutaminase
chr7_-_81399411 0.48 ENST00000423064.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_-_183145873 0.47 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF.2 cell line derived transforming sequence-like 2
chr1_+_79115503 0.46 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr17_+_41323204 0.42 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
neighbor of BRCA1 gene 1
chr16_-_87466740 0.40 ENST00000561928.1
zinc finger, CCHC domain containing 14
chr3_-_183145765 0.40 ENST00000473233.1
MCF.2 cell line derived transforming sequence-like 2
chr6_+_153019023 0.39 ENST00000367245.5
ENST00000529453.1
myc target 1
chr17_-_72772462 0.37 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
N-acetyltransferase 9 (GCN5-related, putative)
chrX_+_1733876 0.37 ENST00000381241.3
acetylserotonin O-methyltransferase
chr3_+_46283863 0.35 ENST00000545097.1
ENST00000541018.1
chemokine (C-C motif) receptor 3
chr3_-_178984759 0.34 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_+_201997676 0.31 ENST00000462763.1
ENST00000479953.2
CASP8 and FADD-like apoptosis regulator
chr12_-_68619586 0.31 ENST00000229134.4
interleukin 26
chr2_-_136594740 0.30 ENST00000264162.2
lactase
chrX_+_1734051 0.29 ENST00000381229.4
ENST00000381233.3
acetylserotonin O-methyltransferase
chr3_-_182817297 0.29 ENST00000539926.1
ENST00000476176.1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr16_-_28503357 0.27 ENST00000333496.9
ENST00000561505.1
ENST00000567963.1
ENST00000354630.5
ENST00000355477.5
ENST00000357076.5
ENST00000565688.1
ENST00000359984.7
ceroid-lipofuscinosis, neuronal 3
chr5_-_58652788 0.17 ENST00000405755.2
phosphodiesterase 4D, cAMP-specific
chr11_+_124824000 0.17 ENST00000529051.1
ENST00000344762.5
coiled-coil domain containing 15
chr3_+_118905564 0.14 ENST00000460625.1
uroplakin 1B
chr12_+_75874580 0.13 ENST00000456650.3
GLI pathogenesis-related 1
chr6_-_55739542 0.11 ENST00000446683.2
bone morphogenetic protein 5
chr4_+_110834033 0.10 ENST00000509793.1
ENST00000265171.5
epidermal growth factor
chr15_-_63674218 0.08 ENST00000178638.3
carbonic anhydrase XII
chr3_+_155860751 0.08 ENST00000471742.1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_171454639 0.05 ENST00000392078.3
ENST00000426496.2
proline-rich coiled-coil 2C
chr2_+_166150541 0.02 ENST00000283256.6
sodium channel, voltage-gated, type II, alpha subunit
chr6_+_126102292 0.01 ENST00000368357.3
nuclear receptor coactivator 7

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 14.1 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.3 3.8 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.2 3.7 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.2 11.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.9 2.7 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.8 3.0 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.8 10.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.7 2.8 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.7 2.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.5 5.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.5 7.6 GO:0051639 actin filament network formation(GO:0051639)
0.5 2.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 3.4 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.4 2.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.4 2.4 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.4 1.2 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.4 1.5 GO:0019086 late viral transcription(GO:0019086)
0.3 3.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 1.3 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.3 1.3 GO:1903935 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.3 2.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.9 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 1.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 3.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 0.7 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2 1.3 GO:0033133 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.2 5.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.2 GO:0055064 chloride ion homeostasis(GO:0055064)
0.2 1.7 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.2 2.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 4.0 GO:0035855 megakaryocyte development(GO:0035855)
0.2 0.5 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.8 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 10.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 3.1 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.2 3.4 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 1.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.0 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 14.2 GO:0031295 T cell costimulation(GO:0031295)
0.1 2.9 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 2.7 GO:0033189 response to vitamin A(GO:0033189)
0.1 7.3 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 0.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 2.3 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 1.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.9 GO:0048535 lymph node development(GO:0048535)
0.1 10.2 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.1 1.2 GO:0015671 oxygen transport(GO:0015671)
0.1 1.9 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 2.1 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 1.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 5.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 8.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 1.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 1.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 3.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.7 GO:0045008 depyrimidination(GO:0045008)
0.1 4.0 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.1 0.1 GO:0021502 neural fold elevation formation(GO:0021502) allantois development(GO:1905069)
0.1 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 3.5 GO:0006968 cellular defense response(GO:0006968)
0.0 1.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 1.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0006552 leucine catabolic process(GO:0006552)
0.0 1.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.6 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0099536 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) synaptic signaling(GO:0099536) trans-synaptic signaling(GO:0099537)
0.0 1.3 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.9 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 28.2 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 3.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.9 11.8 GO:0005577 fibrinogen complex(GO:0005577)
0.8 2.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.6 0.6 GO:0030427 site of polarized growth(GO:0030427)
0.5 3.7 GO:0032437 cuticular plate(GO:0032437)
0.5 1.9 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.4 7.6 GO:0001891 phagocytic cup(GO:0001891)
0.2 3.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.2 3.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 2.8 GO:0031209 SCAR complex(GO:0031209)
0.2 0.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.2 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.9 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.8 GO:0072487 MSL complex(GO:0072487)
0.1 1.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 10.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 15.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 18.9 GO:0072562 blood microparticle(GO:0072562)
0.1 4.0 GO:0008305 integrin complex(GO:0008305)
0.1 2.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.3 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0 0.7 GO:0071437 invadopodium(GO:0071437)
0.0 6.1 GO:0000922 spindle pole(GO:0000922)
0.0 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.8 GO:0005769 early endosome(GO:0005769)
0.0 1.9 GO:0043679 axon terminus(GO:0043679)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.3 GO:0070603 SWI/SNF superfamily-type complex(GO:0070603)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0005148 prolactin receptor binding(GO:0005148)
1.0 5.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.8 2.4 GO:0019959 interleukin-8 binding(GO:0019959)
0.7 2.8 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.7 2.1 GO:0016297 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.6 3.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.6 17.2 GO:0042605 peptide antigen binding(GO:0042605)
0.5 2.7 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 3.1 GO:0030492 hemoglobin binding(GO:0030492)
0.5 6.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 2.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.4 2.3 GO:0005499 vitamin D binding(GO:0005499)
0.4 2.5 GO:0001515 opioid peptide activity(GO:0001515)
0.3 3.8 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 2.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 1.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.3 1.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.3 1.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 3.7 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.7 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 4.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 0.7 GO:0016160 amylase activity(GO:0016160)
0.2 2.3 GO:0016594 glycine binding(GO:0016594)
0.1 2.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 2.4 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.7 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 11.8 GO:0051087 chaperone binding(GO:0051087)
0.1 3.7 GO:0001848 complement binding(GO:0001848)
0.1 1.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.5 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.0 GO:0089720 caspase binding(GO:0089720)
0.1 9.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 5.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 1.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 5.2 GO:0005179 hormone activity(GO:0005179)
0.0 2.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 4.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 5.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 7.5 GO:0051020 GTPase binding(GO:0051020)
0.0 2.9 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 5.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 9.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 8.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 2.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 6.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 3.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 23.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.7 11.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 7.5 REACTOME DEFENSINS Genes involved in Defensins
0.4 10.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 3.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 3.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 14.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 2.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 3.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 6.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)