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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GAUUGUC
Z-value: 0.48
Motif logo
miRNA associated with seed GAUUGUC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-219a-5p
|
MIMAT0000276 |
|
hsa-miR-4782-3p
|
MIMAT0019945 |
|
hsa-miR-6766-3p
|
MIMAT0027433 |
Activity profile of GAUUGUC motif
Sorted Z-values of GAUUGUC motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GAUUGUC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 5.0 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.9 | 2.6 | GO:0045994 | positive regulation of translational initiation by iron(GO:0045994) |
| 0.6 | 1.9 | GO:0007509 | mesoderm migration involved in gastrulation(GO:0007509) |
| 0.6 | 4.8 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.6 | 2.3 | GO:0061304 | extracellular matrix-cell signaling(GO:0035426) retinal blood vessel morphogenesis(GO:0061304) |
| 0.5 | 1.5 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.5 | 1.5 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.5 | 1.4 | GO:2000705 | dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705) |
| 0.5 | 3.7 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.5 | 0.9 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.4 | 1.3 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.4 | 1.3 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.3 | 1.6 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.3 | 4.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 2.1 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
| 0.2 | 3.7 | GO:0021702 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.2 | 1.9 | GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) |
| 0.2 | 0.9 | GO:0070253 | somatostatin secretion(GO:0070253) |
| 0.2 | 0.9 | GO:0097676 | histone H3-K36 dimethylation(GO:0097676) |
| 0.2 | 1.4 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.2 | 1.3 | GO:0014004 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.2 | 1.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.2 | 1.2 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.2 | 0.8 | GO:1904016 | response to Thyroglobulin triiodothyronine(GO:1904016) |
| 0.2 | 1.2 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.2 | 3.5 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.2 | 0.6 | GO:0035621 | ER to Golgi ceramide transport(GO:0035621) |
| 0.2 | 0.8 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.2 | 2.5 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.2 | 1.3 | GO:0006848 | pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475) |
| 0.2 | 0.6 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.1 | 1.9 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 0.7 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 1.3 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.1 | 0.7 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 1.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 0.4 | GO:0032900 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of neurotrophin production(GO:0032900) |
| 0.1 | 0.9 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 4.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 1.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 0.5 | GO:2000639 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.1 | 0.6 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 0.7 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 1.3 | GO:1904903 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.1 | 2.5 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 1.7 | GO:0044803 | multi-organism membrane organization(GO:0044803) |
| 0.1 | 0.5 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 3.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.3 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.1 | 0.3 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 0.1 | 2.1 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.1 | 0.4 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 0.3 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) |
| 0.1 | 0.7 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 1.1 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 4.2 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.1 | 1.0 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.1 | 0.2 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.1 | 0.2 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.1 | 0.5 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.1 | 0.3 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.1 | 0.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 0.4 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 0.6 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.1 | 0.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.1 | 0.2 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.1 | 1.2 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.1 | 1.1 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.1 | 0.2 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.1 | 1.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 2.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 4.1 | GO:0046427 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.0 | 1.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.5 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
| 0.0 | 6.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.4 | GO:0003344 | pericardium morphogenesis(GO:0003344) |
| 0.0 | 0.4 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 0.7 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.6 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.2 | GO:0042670 | amacrine cell differentiation(GO:0035881) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.3 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.1 | GO:0060437 | lung growth(GO:0060437) |
| 0.0 | 0.7 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.0 | 0.9 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.0 | 0.1 | GO:0072179 | vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve formation(GO:0021650) nephric duct formation(GO:0072179) |
| 0.0 | 1.1 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 1.8 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
| 0.0 | 0.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 1.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 2.4 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.4 | GO:0007173 | epidermal growth factor receptor signaling pathway(GO:0007173) |
| 0.0 | 1.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.1 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.0 | 0.4 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.0 | 0.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.1 | GO:1900736 | minus-end-directed organelle transport along microtubule(GO:0072385) regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) |
| 0.0 | 2.4 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.0 | 0.4 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.0 | 1.5 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.6 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.5 | GO:0046785 | microtubule polymerization(GO:0046785) |
| 0.0 | 2.8 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.7 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 0.0 | GO:0061386 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.0 | 0.5 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.8 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.0 | 1.2 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 3.9 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 0.3 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 5.1 | GO:0030099 | myeloid cell differentiation(GO:0030099) |
| 0.0 | 1.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 0.0 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.0 | 0.2 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling(GO:0014066) |
| 0.0 | 0.6 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 0.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 0.3 | GO:0061756 | leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756) |
| 0.0 | 0.1 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0019034 | viral replication complex(GO:0019034) |
| 0.5 | 5.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.4 | 1.1 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 0.2 | 1.4 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.2 | 0.6 | GO:0005953 | CAAX-protein geranylgeranyltransferase complex(GO:0005953) |
| 0.2 | 1.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.2 | 1.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 2.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 3.6 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 1.0 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 4.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 1.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 4.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.4 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 0.7 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 3.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 1.1 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 0.4 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 0.1 | GO:0033647 | host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) |
| 0.0 | 2.4 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 3.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 4.2 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 0.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 3.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.2 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.0 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 4.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.2 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 1.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 4.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 3.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.0 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.0 | 0.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 2.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.5 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 3.2 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.6 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.6 | 2.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.5 | 3.7 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.4 | 1.9 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.3 | 1.3 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.3 | 1.6 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.3 | 5.4 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.3 | 1.7 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.2 | 0.7 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.2 | 4.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 0.6 | GO:0004662 | CAAX-protein geranylgeranyltransferase activity(GO:0004662) |
| 0.2 | 0.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 0.8 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.2 | 0.8 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 0.7 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.2 | 0.7 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.2 | 1.4 | GO:0050072 | m7G(5')pppN diphosphatase activity(GO:0050072) |
| 0.1 | 1.5 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.6 | GO:0017089 | glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001) |
| 0.1 | 1.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 1.1 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
| 0.1 | 0.4 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.1 | 1.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 1.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 1.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 2.0 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.1 | 0.9 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 4.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 0.3 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.1 | 2.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.7 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.1 | 1.4 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.1 | 1.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.4 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.1 | 0.4 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 2.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 3.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.5 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 0.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 1.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 2.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 1.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 0.9 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 1.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0001727 | lipid kinase activity(GO:0001727) |
| 0.0 | 3.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.9 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.9 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 3.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.7 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.3 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) kainate selective glutamate receptor activity(GO:0015277) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 10.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.0 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 1.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.7 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.3 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 6.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.1 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 1.6 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 0.1 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.0 | 0.3 | GO:0005005 | GPI-linked ephrin receptor activity(GO:0005004) transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731) |
| 0.0 | 0.6 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.0 | 0.5 | GO:0015278 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.0 | 0.6 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.2 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 3.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 1.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 3.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 1.3 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 0.3 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 1.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 6.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.3 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.1 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.0 | 0.1 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 8.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 4.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 1.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.3 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 5.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 3.5 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 4.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 2.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 5.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 1.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 1.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.2 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 1.6 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 1.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |