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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GCUACAU

Z-value: 0.39

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miRNA associated with seed GCUACAU

NamemiRBASE accession
hsa-miR-221-3p
MIMAT0000278
hsa-miR-222-3p
MIMAT0000279

Activity profile of GCUACAU motif

Sorted Z-values of GCUACAU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_176923483 5.01 ENST00000280187.7
ENST00000512509.1
GPM6A
glycoprotein M6A
chr12_+_12870055 4.22 ENST00000228872.4
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr1_-_41131326 4.11 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr5_+_140254884 3.42 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr4_-_69215699 3.40 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr5_+_140306478 3.28 ENST00000253807.2
PCDHAC1
protocadherin alpha subfamily C, 1
chr5_+_140220769 3.15 ENST00000531613.1
ENST00000378123.3
PCDHA8
protocadherin alpha 8
chr5_+_140213815 3.11 ENST00000525929.1
ENST00000378125.3
PCDHA7
protocadherin alpha 7
chr5_+_140248518 3.04 ENST00000398640.2
PCDHA11
protocadherin alpha 11
chr9_-_111929560 2.80 ENST00000561981.2
FRRS1L
ferric-chelate reductase 1-like
chr5_+_140345820 2.63 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr5_+_140227048 2.55 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr4_+_55524085 2.50 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr5_+_141488070 2.38 ENST00000253814.4
NDFIP1
Nedd4 family interacting protein 1
chr1_-_204380919 2.14 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr5_+_67511524 1.94 ENST00000521381.1
ENST00000521657.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr9_-_123476719 1.90 ENST00000373930.3
MEGF9
multiple EGF-like-domains 9
chr5_+_161274685 1.82 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_-_36278412 1.81 ENST00000389698.3
ENST00000258840.6
RALGAPA1
Ral GTPase activating protein, alpha subunit 1 (catalytic)
chr5_-_175964366 1.79 ENST00000274811.4
RNF44
ring finger protein 44
chr5_+_140165876 1.68 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1
protocadherin alpha 1
chr18_-_53255766 1.58 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr2_-_43453734 1.56 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr2_-_160472952 1.55 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chrX_-_54384425 1.40 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr2_-_2334888 1.37 ENST00000428368.2
ENST00000399161.2
MYT1L
myelin transcription factor 1-like
chr5_+_140261703 1.36 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr13_+_32605437 1.20 ENST00000380250.3
FRY
furry homolog (Drosophila)
chr16_-_69419871 1.18 ENST00000603068.1
ENST00000254942.3
ENST00000567296.2
TERF2
telomeric repeat binding factor 2
chr12_+_70636765 1.18 ENST00000552231.1
ENST00000229195.3
ENST00000547780.1
ENST00000418359.3
CNOT2
CCR4-NOT transcription complex, subunit 2
chr14_+_75745477 1.17 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr14_+_74111578 1.17 ENST00000554113.1
ENST00000555631.2
ENST00000553645.2
ENST00000311089.3
ENST00000555919.3
ENST00000554339.1
ENST00000554871.1
DNAL1
dynein, axonemal, light chain 1
chr5_+_140186647 1.13 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr1_+_114472222 1.09 ENST00000369558.1
ENST00000369561.4
HIPK1
homeodomain interacting protein kinase 1
chr2_-_213403565 0.99 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr5_-_137090028 0.96 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr1_+_24286287 0.95 ENST00000334351.7
ENST00000374468.1
PNRC2
proline-rich nuclear receptor coactivator 2
chr5_+_79703823 0.93 ENST00000338008.5
ENST00000510158.1
ENST00000505560.1
ZFYVE16
zinc finger, FYVE domain containing 16
chr21_+_40177143 0.91 ENST00000360214.3
ETS2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr13_+_88324870 0.91 ENST00000325089.6
SLITRK5
SLIT and NTRK-like family, member 5
chr5_-_176057365 0.89 ENST00000310112.3
SNCB
synuclein, beta
chr1_-_224033596 0.85 ENST00000391878.2
ENST00000343537.7
TP53BP2
tumor protein p53 binding protein, 2
chr6_-_90062543 0.82 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chrX_+_146993449 0.81 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr1_+_97187318 0.77 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
PTBP2
polypyrimidine tract binding protein 2
chr22_-_39151463 0.73 ENST00000405510.1
ENST00000433561.1
SUN2
Sad1 and UNC84 domain containing 2
chr3_+_169684553 0.68 ENST00000337002.4
ENST00000480708.1
SEC62
SEC62 homolog (S. cerevisiae)
chr2_-_24149977 0.59 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr22_+_21271714 0.56 ENST00000354336.3
CRKL
v-crk avian sarcoma virus CT10 oncogene homolog-like
chr9_-_74980113 0.55 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr17_-_58603568 0.55 ENST00000083182.3
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr14_+_77228532 0.55 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr12_+_111471828 0.54 ENST00000261726.6
CUX2
cut-like homeobox 2
chr12_-_123011536 0.53 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr10_+_73975742 0.52 ENST00000299381.4
ANAPC16
anaphase promoting complex subunit 16
chr12_+_6898638 0.50 ENST00000011653.4
CD4
CD4 molecule
chr8_-_93115445 0.49 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_5832799 0.49 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chrX_-_72434628 0.48 ENST00000536638.1
ENST00000373517.3
NAP1L2
nucleosome assembly protein 1-like 2
chr4_+_72204755 0.48 ENST00000512686.1
ENST00000340595.3
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr12_+_113229737 0.43 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr5_+_140235469 0.43 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chrX_-_110655391 0.43 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr2_-_69870835 0.42 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr12_-_121342170 0.42 ENST00000353487.2
SPPL3
signal peptide peptidase like 3
chr1_+_220701456 0.41 ENST00000366918.4
ENST00000402574.1
MARK1
MAP/microtubule affinity-regulating kinase 1
chr16_-_66785699 0.41 ENST00000258198.2
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr1_+_63833261 0.40 ENST00000371108.4
ALG6
ALG6, alpha-1,3-glucosyltransferase
chr10_-_118764862 0.37 ENST00000260777.10
KIAA1598
KIAA1598
chr3_+_47324424 0.37 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
KLHL18
kelch-like family member 18
chr9_-_115095883 0.37 ENST00000450374.1
ENST00000374255.2
ENST00000334318.6
ENST00000374257.1
PTBP3
polypyrimidine tract binding protein 3
chr4_+_144257915 0.36 ENST00000262995.4
GAB1
GRB2-associated binding protein 1
chr6_+_146348782 0.36 ENST00000361719.2
ENST00000392299.2
GRM1
glutamate receptor, metabotropic 1
chr13_-_103053946 0.35 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr8_+_61591337 0.35 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr18_+_46065393 0.35 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr7_+_138916231 0.35 ENST00000473989.3
ENST00000288561.8
UBN2
ubinuclein 2
chr16_+_67596310 0.35 ENST00000264010.4
ENST00000401394.1
CTCF
CCCTC-binding factor (zinc finger protein)
chr4_+_699537 0.35 ENST00000419774.1
ENST00000362003.5
ENST00000400151.2
ENST00000427463.1
ENST00000470161.2
PCGF3
polycomb group ring finger 3
chr12_-_118498958 0.32 ENST00000315436.3
WSB2
WD repeat and SOCS box containing 2
chr10_+_1095416 0.32 ENST00000358220.1
WDR37
WD repeat domain 37
chr4_+_144434584 0.31 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr8_-_116681221 0.30 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr12_+_62860581 0.30 ENST00000393632.2
ENST00000393630.3
ENST00000280379.6
ENST00000546600.1
ENST00000552738.1
ENST00000393629.2
ENST00000552115.1
MON2
MON2 homolog (S. cerevisiae)
chr11_+_119076745 0.30 ENST00000264033.4
CBL
Cbl proto-oncogene, E3 ubiquitin protein ligase
chr9_+_103790991 0.29 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr17_+_61627814 0.29 ENST00000310827.4
ENST00000431926.1
ENST00000415273.2
DCAF7
DDB1 and CUL4 associated factor 7
chr17_-_27278304 0.29 ENST00000577226.1
PHF12
PHD finger protein 12
chr15_+_90808919 0.29 ENST00000379095.3
NGRN
neugrin, neurite outgrowth associated
chr16_+_12070567 0.27 ENST00000566228.1
SNX29
sorting nexin 29
chr2_+_70142189 0.26 ENST00000264444.2
MXD1
MAX dimerization protein 1
chr5_+_140201183 0.26 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr1_+_150980889 0.26 ENST00000450884.1
ENST00000271620.3
ENST00000271619.8
ENST00000368937.1
ENST00000431193.1
ENST00000368936.1
PRUNE
prune exopolyphosphatase
chr1_-_207224307 0.26 ENST00000315927.4
YOD1
YOD1 deubiquitinase
chr4_-_185395672 0.26 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr5_+_140207536 0.26 ENST00000529310.1
ENST00000527624.1
PCDHA6
protocadherin alpha 6
chrX_+_23352133 0.25 ENST00000379361.4
PTCHD1
patched domain containing 1
chr8_+_28747884 0.24 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr12_+_94542459 0.23 ENST00000258526.4
PLXNC1
plexin C1
chr9_-_23821273 0.22 ENST00000380110.4
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr10_-_99094458 0.22 ENST00000371019.2
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr6_+_16129308 0.22 ENST00000356840.3
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr1_-_117210290 0.22 ENST00000369483.1
ENST00000369486.3
IGSF3
immunoglobulin superfamily, member 3
chr11_+_9406169 0.21 ENST00000379719.3
ENST00000527431.1
IPO7
importin 7
chr14_+_105781048 0.20 ENST00000458164.2
ENST00000447393.1
PACS2
phosphofurin acidic cluster sorting protein 2
chr5_-_133512683 0.20 ENST00000353411.6
SKP1
S-phase kinase-associated protein 1
chr22_-_38380543 0.20 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr13_+_20532807 0.20 ENST00000382869.3
ENST00000382881.3
ZMYM2
zinc finger, MYM-type 2
chr4_-_87281224 0.19 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr14_-_27066636 0.19 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chr3_+_183353356 0.19 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr2_-_68479614 0.18 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr3_+_16926441 0.18 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr8_+_58907104 0.18 ENST00000361488.3
FAM110B
family with sequence similarity 110, member B
chr12_+_56401268 0.18 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr8_-_133493200 0.18 ENST00000388996.4
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr20_-_48532019 0.17 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr5_-_168006591 0.16 ENST00000239231.6
PANK3
pantothenate kinase 3
chr17_-_74733404 0.15 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr10_-_94003003 0.15 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr18_+_43753974 0.14 ENST00000282059.6
ENST00000321319.6
C18orf25
chromosome 18 open reading frame 25
chr2_-_152955537 0.14 ENST00000201943.5
ENST00000539935.1
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr5_-_150948414 0.14 ENST00000261800.5
FAT2
FAT atypical cadherin 2
chrX_-_106959631 0.14 ENST00000486554.1
ENST00000372390.4
TSC22D3
TSC22 domain family, member 3
chr12_-_76478686 0.14 ENST00000261182.8
NAP1L1
nucleosome assembly protein 1-like 1
chr13_+_53226963 0.14 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
SUGT1
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr1_+_222791417 0.14 ENST00000344922.5
ENST00000344441.6
ENST00000344507.1
MIA3
melanoma inhibitory activity family, member 3
chr12_+_56473628 0.14 ENST00000549282.1
ENST00000549061.1
ENST00000267101.3
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr12_-_104532062 0.13 ENST00000240055.3
NFYB
nuclear transcription factor Y, beta
chr3_-_135914615 0.13 ENST00000309993.2
MSL2
male-specific lethal 2 homolog (Drosophila)
chr2_+_60983361 0.13 ENST00000238714.3
PAPOLG
poly(A) polymerase gamma
chr6_-_62996066 0.13 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr11_-_70507901 0.13 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr6_+_37225540 0.13 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr16_+_54964740 0.13 ENST00000394636.4
IRX5
iroquois homeobox 5
chr4_-_55991752 0.12 ENST00000263923.4
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr3_+_182511266 0.12 ENST00000323116.5
ENST00000493826.1
ATP11B
ATPase, class VI, type 11B
chr3_-_28390581 0.12 ENST00000479665.1
AZI2
5-azacytidine induced 2
chr10_-_11653753 0.12 ENST00000609104.1
USP6NL
USP6 N-terminal like
chr6_+_45389893 0.11 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr12_+_20522179 0.10 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr2_+_111878483 0.09 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11
BCL2-like 11 (apoptosis facilitator)
chr8_+_23386305 0.09 ENST00000519973.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr15_+_44829255 0.09 ENST00000261868.5
ENST00000424492.3
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr5_+_140180635 0.08 ENST00000522353.2
ENST00000532566.2
PCDHA3
protocadherin alpha 3
chr1_-_154155595 0.08 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
TPM3
tropomyosin 3
chr17_+_42836329 0.08 ENST00000200557.6
ADAM11
ADAM metallopeptidase domain 11
chr8_+_106330920 0.08 ENST00000407775.2
ZFPM2
zinc finger protein, FOG family member 2
chr6_+_163835669 0.07 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI
QKI, KH domain containing, RNA binding
chr2_+_113033164 0.07 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr11_+_118754475 0.07 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr14_-_91720224 0.07 ENST00000238699.3
ENST00000531499.2
GPR68
G protein-coupled receptor 68
chr14_-_99737565 0.06 ENST00000357195.3
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr16_+_68119440 0.06 ENST00000346183.3
ENST00000329524.4
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr2_+_178077477 0.06 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr6_+_44355257 0.06 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr16_-_11350036 0.06 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr5_+_140174429 0.05 ENST00000520672.2
ENST00000378132.1
ENST00000526136.1
PCDHA2
protocadherin alpha 2
chr6_+_152011628 0.05 ENST00000404742.1
ENST00000440973.1
ESR1
estrogen receptor 1
chr17_+_41177220 0.05 ENST00000587250.2
ENST00000544533.1
RND2
Rho family GTPase 2
chr7_+_77325738 0.05 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr14_+_72399833 0.05 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr6_-_111804393 0.05 ENST00000368802.3
ENST00000368805.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr6_-_16761678 0.04 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr1_-_24306798 0.04 ENST00000374452.5
ENST00000492112.2
ENST00000343255.5
ENST00000344989.6
SRSF10
serine/arginine-rich splicing factor 10
chr11_+_33278811 0.04 ENST00000303296.4
ENST00000379016.3
HIPK3
homeodomain interacting protein kinase 3
chr1_+_36273743 0.04 ENST00000373210.3
AGO4
argonaute RISC catalytic component 4
chr9_+_96338860 0.03 ENST00000375376.4
PHF2
PHD finger protein 2
chr9_-_73736511 0.02 ENST00000377110.3
ENST00000377111.2
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr10_+_22610124 0.01 ENST00000376663.3
BMI1
BMI1 polycomb ring finger oncogene
chr7_-_105029329 0.01 ENST00000393651.3
ENST00000460391.1
SRPK2
SRSF protein kinase 2
chr14_-_64010046 0.00 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr5_+_139493665 0.00 ENST00000331327.3
PURA
purine-rich element binding protein A
chr7_+_107110488 0.00 ENST00000304402.4
GPR22
G protein-coupled receptor 22

Network of associatons between targets according to the STRING database.

First level regulatory network of GCUACAU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0048170 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.8 2.4 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.6 4.2 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.4 1.2 GO:0031627 telomeric loop formation(GO:0031627) negative regulation of t-circle formation(GO:1904430)
0.4 1.4 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.3 1.0 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.2 2.1 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.2 1.6 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.2 0.6 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 0.8 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 26.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 0.9 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 1.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 0.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 5.0 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.7 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.5 GO:0060023 soft palate development(GO:0060023)
0.1 1.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.9 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.3 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1 0.6 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.8 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 4.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 4.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.5 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.1 1.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.5 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442) regulation of stem cell division(GO:2000035)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.6 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.9 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.1 0.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.1 3.0 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.0 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.1 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 1.0 GO:0021756 striatum development(GO:0021756)
0.0 0.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.2 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0 0.4 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.3 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 1.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.4 GO:0001764 neuron migration(GO:0001764)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.0 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.5 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.6 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.9 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 1.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.3 GO:0051642 centrosome localization(GO:0051642)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.3 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.0 0.1 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.4 4.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.3 0.8 GO:0019034 viral replication complex(GO:0019034)
0.2 5.0 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.2 GO:0035976 AP1 complex(GO:0035976)
0.1 1.2 GO:0036157 outer dynein arm(GO:0036157)
0.1 2.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0031213 RSF complex(GO:0031213)
0.1 0.4 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.1 4.0 GO:0048786 presynaptic active zone(GO:0048786)
0.1 2.8 GO:0042629 mast cell granule(GO:0042629)
0.1 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.7 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.1 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.5 GO:0043235 receptor complex(GO:0043235)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 27.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 1.9 GO:0043559 insulin binding(GO:0043559)
0.2 4.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 1.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 3.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 0.9 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.4 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 1.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.1 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 1.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.4 GO:0099583 postsynaptic neurotransmitter receptor activity(GO:0098960) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.9 GO:1903136 cuprous ion binding(GO:1903136)
0.1 2.4 GO:0050699 WW domain binding(GO:0050699)
0.0 1.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 4.3 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 3.8 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 21.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.4 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 3.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID ATM PATHWAY ATM pathway
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 2.9 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism