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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GGAAUGU
Z-value: 1.73
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miRNA associated with seed GGAAUGU
Network of associatons between targets according to the STRING database.
First level regulatory network of GGAAUGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.9 | 53.6 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 6.0 | 47.6 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 5.9 | 41.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 2.7 | 40.9 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 1.9 | 34.9 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 8.6 | 34.5 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 6.8 | 33.9 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 10.9 | 32.7 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 15.3 | 30.5 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.9 | 30.4 | GO:0090383 | phagosome acidification(GO:0090383) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 78.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 74.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.8 | 51.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.9 | 49.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 2.3 | 44.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 4.1 | 41.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 40.1 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.5 | 38.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.5 | 37.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.5 | 36.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 131.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 63.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 49.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.6 | 49.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.9 | 40.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 2.8 | 38.8 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.6 | 37.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.9 | 34.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 4.9 | 34.5 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.3 | 32.9 | GO:0008565 | protein transporter activity(GO:0008565) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 51.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 48.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 1.2 | 39.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.9 | 39.0 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 37.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.5 | 32.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 30.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 30.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.4 | 28.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.4 | 26.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 44.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.4 | 42.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.2 | 35.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 34.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 34.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 34.2 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.7 | 30.2 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.3 | 30.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.1 | 29.7 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.4 | 29.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |