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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GGAGUGU

Z-value: 0.21

Motif logo

miRNA associated with seed GGAGUGU

NamemiRBASE accession
MIMAT0000421

Activity profile of GGAGUGU motif

Sorted Z-values of GGAGUGU motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_162864575 2.39 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
cyclin G1
chr10_-_74856608 2.06 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
prolyl 4-hydroxylase, alpha polypeptide I
chr19_-_2456922 1.78 ENST00000582871.1
ENST00000325327.3
lamin B2
chr8_-_29208183 1.64 ENST00000240100.2
dual specificity phosphatase 4
chr7_+_94285637 1.42 ENST00000482108.1
ENST00000488574.1
paternally expressed 10
chr1_-_245027833 1.37 ENST00000444376.2
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr5_+_179125907 1.33 ENST00000247461.4
ENST00000452673.2
ENST00000502498.1
ENST00000507307.1
ENST00000513246.1
ENST00000502673.1
ENST00000506654.1
ENST00000512607.2
ENST00000510810.1
calnexin
chr15_-_72523454 1.29 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
pyruvate kinase, muscle
chr17_+_45608430 1.25 ENST00000322157.4
aminopeptidase puromycin sensitive
chr12_-_56694142 1.06 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
citrate synthase
chr8_+_102504651 0.89 ENST00000251808.3
ENST00000521085.1
grainyhead-like 2 (Drosophila)
chr14_+_23340822 0.77 ENST00000359591.4
low density lipoprotein receptor-related protein 10
chr20_+_32581452 0.64 ENST00000375114.3
ENST00000448364.1
RALY heterogeneous nuclear ribonucleoprotein
chr4_-_76598296 0.63 ENST00000395719.3
GTPase activating protein (SH3 domain) binding protein 2
chr1_+_25071848 0.56 ENST00000374379.4
chloride intracellular channel 4
chr19_-_47291843 0.53 ENST00000542575.2
solute carrier family 1 (neutral amino acid transporter), member 5
chr1_-_244615425 0.45 ENST00000366535.3
adenylosuccinate synthase
chr8_-_117886955 0.44 ENST00000297338.2
RAD21 homolog (S. pombe)
chr19_-_8373173 0.41 ENST00000537716.2
ENST00000301458.5
CD320 molecule
chr8_-_57123815 0.38 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
pleiomorphic adenoma gene 1
chr16_+_69599861 0.37 ENST00000354436.2
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_86790593 0.36 ENST00000263856.4
ENST00000409225.2
charged multivesicular body protein 3
chr1_+_36348790 0.35 ENST00000373204.4
argonaute RISC catalytic component 1
chr5_-_141392538 0.34 ENST00000503794.1
ENST00000510194.1
ENST00000504424.1
ENST00000513454.1
ENST00000458112.2
ENST00000542860.1
ENST00000503229.1
ENST00000500692.2
ENST00000311337.6
ENST00000504139.1
ENST00000505689.1
glucosamine-6-phosphate deaminase 1
chr14_-_103523745 0.34 ENST00000361246.2
CDC42 binding protein kinase beta (DMPK-like)
chr8_-_68255912 0.34 ENST00000262215.3
ENST00000519436.1
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr10_-_32345305 0.33 ENST00000302418.4
kinesin family member 5B
chr16_+_30077055 0.30 ENST00000564595.2
ENST00000569798.1
aldolase A, fructose-bisphosphate
chr17_-_4269768 0.30 ENST00000396981.2
ubiquitin-conjugating enzyme E2G 1
chr22_+_38201114 0.27 ENST00000340857.2
H1 histone family, member 0
chr1_-_72748417 0.27 ENST00000357731.5
neuronal growth regulator 1
chr6_-_35464727 0.26 ENST00000402886.3
TEA domain family member 3
chr4_-_103266219 0.26 ENST00000394833.2
solute carrier family 39 (zinc transporter), member 8
chr21_-_40685477 0.25 ENST00000342449.3
bromodomain and WD repeat domain containing 1
chr6_-_45983581 0.24 ENST00000339561.6
chloride intracellular channel 5
chr6_+_152011628 0.21 ENST00000404742.1
ENST00000440973.1
estrogen receptor 1
chr7_-_95225768 0.16 ENST00000005178.5
pyruvate dehydrogenase kinase, isozyme 4
chr2_-_219925189 0.13 ENST00000295731.6
indian hedgehog
chr19_-_49314269 0.13 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
branched chain amino-acid transaminase 2, mitochondrial
chr10_-_61666267 0.10 ENST00000263102.6
coiled-coil domain containing 6
chr5_+_96271141 0.09 ENST00000231368.5
leucyl/cystinyl aminopeptidase
chr16_-_30381580 0.08 ENST00000409939.3
TBC1 domain family, member 10B
chr5_+_125758813 0.06 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr16_-_31076332 0.06 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
zinc finger protein 668
chr1_-_149982624 0.06 ENST00000417191.1
ENST00000369135.4
OTU domain containing 7B
chr1_+_161087873 0.02 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
nitrilase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GGAGUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 0.9 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.2 1.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 1.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.4 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.5 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.3 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 1.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 0.4 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.1 0.3 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.6 GO:0061299 endothelial cell morphogenesis(GO:0001886) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.4 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.4 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253) stress granule assembly(GO:0034063)
0.0 0.1 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.0 0.6 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 1.1 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 2.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 1.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 1.8 GO:0005638 lamin filament(GO:0005638)
0.1 1.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.4 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.4 1.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3 1.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 1.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 0.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.5 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 1.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.8 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.4 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.4 GO:0035198 miRNA binding(GO:0035198)
0.0 0.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0005113 patched binding(GO:0005113)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane