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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GSC_GSC2

Z-value: 0.84

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Transcription factors associated with GSC_GSC2

Gene Symbol Gene ID Gene Info
GSC
ENSG00000133937.3 goosecoid homeobox
GSC2
ENSG00000063515.2 goosecoid homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GSC2hg19_v2_chr22_-_19137796_191377960.503.2e-15Click!

Activity profile of GSC_GSC2 motif

Sorted Z-values of GSC_GSC2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_169079823 26.71 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_175711133 21.32 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr11_-_111794446 16.48 ENST00000527950.1
CRYAB
crystallin, alpha B
chr11_-_111783595 14.66 ENST00000528628.1
CRYAB
crystallin, alpha B
chr6_+_111580508 14.01 ENST00000368847.4
KIAA1919
KIAA1919
chr14_-_101034407 12.03 ENST00000443071.2
ENST00000557378.1
BEGAIN
brain-enriched guanylate kinase-associated
chr11_-_76155618 11.94 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr11_-_76155700 11.85 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr9_+_17134980 9.82 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chrX_-_54384425 9.67 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr19_-_36247910 9.36 ENST00000587965.1
ENST00000004982.3
HSPB6
heat shock protein, alpha-crystallin-related, B6
chrX_+_135279179 8.24 ENST00000370676.3
FHL1
four and a half LIM domains 1
chrX_+_100333709 8.23 ENST00000372930.4
TMEM35
transmembrane protein 35
chr1_+_20396649 8.15 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr20_-_18774614 8.10 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr9_-_13279563 8.07 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr7_-_97881429 7.88 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr9_+_103204553 7.88 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1
TMEFF1
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr3_-_170626418 7.78 ENST00000474096.1
ENST00000295822.2
EIF5A2
eukaryotic translation initiation factor 5A2
chr6_+_121756809 7.71 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr18_-_64271363 7.38 ENST00000262150.2
CDH19
cadherin 19, type 2
chr11_+_61522844 7.29 ENST00000265460.5
MYRF
myelin regulatory factor
chr11_+_76156045 7.21 ENST00000533988.1
ENST00000524490.1
ENST00000334736.3
ENST00000343878.3
ENST00000533972.1
C11orf30
chromosome 11 open reading frame 30
chr2_+_120770645 6.93 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr9_+_17135016 6.41 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr10_+_74451883 6.33 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr9_-_13279589 6.26 ENST00000319217.7
MPDZ
multiple PDZ domain protein
chr17_-_26903900 6.16 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr2_+_120770581 5.82 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr5_+_140868717 5.67 ENST00000252087.1
PCDHGC5
protocadherin gamma subfamily C, 5
chrX_-_6146876 5.21 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr11_-_62783303 5.16 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr3_-_10547192 5.10 ENST00000360273.2
ENST00000343816.4
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr17_-_48207157 5.06 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr11_-_62783276 5.04 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr3_-_98241358 4.97 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chrX_-_10588595 4.91 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_48931648 4.87 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr8_-_133123406 4.72 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr10_+_102222798 4.53 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr13_+_73632897 4.46 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chrX_-_10588459 4.37 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr14_+_96722152 4.25 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr5_+_161274940 4.25 ENST00000393943.4
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_70916119 4.20 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr5_+_161274685 4.11 ENST00000428797.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_40021656 4.00 ENST00000319121.3
KLHL11
kelch-like family member 11
chr17_+_44668035 3.98 ENST00000398238.4
ENST00000225282.8
NSF
N-ethylmaleimide-sensitive factor
chr4_-_16077741 3.96 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr18_+_32290218 3.96 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr4_+_70894130 3.87 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr5_-_149324306 3.82 ENST00000255266.5
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr19_-_48547294 3.74 ENST00000293255.2
CABP5
calcium binding protein 5
chr8_-_87755878 3.72 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr6_+_35310391 3.71 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr10_-_104178857 3.66 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chrX_+_135278908 3.53 ENST00000539015.1
ENST00000370683.1
FHL1
four and a half LIM domains 1
chr7_-_128415844 3.49 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr2_+_189156638 3.39 ENST00000410051.1
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr3_-_49058479 3.20 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr1_-_47655686 3.17 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr15_-_27184664 3.16 ENST00000541819.2
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_+_138482695 3.15 ENST00000422794.2
ENST00000397602.3
ENST00000442682.2
ENST00000458494.1
ENST00000413208.1
TMEM213
transmembrane protein 213
chr12_+_7941989 3.01 ENST00000229307.4
NANOG
Nanog homeobox
chr5_+_161275320 2.91 ENST00000437025.2
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_19651654 2.89 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr1_+_17248418 2.85 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr6_+_35310312 2.77 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr11_-_128712362 2.75 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr5_-_33984741 2.73 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr12_-_77272765 2.72 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
CSRP2
cysteine and glycine-rich protein 2
chr4_+_170541678 2.71 ENST00000360642.3
ENST00000512813.1
CLCN3
chloride channel, voltage-sensitive 3
chr19_-_55866061 2.69 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr17_-_40264692 2.67 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr22_-_19137796 2.67 ENST00000086933.2
GSC2
goosecoid homeobox 2
chr17_-_19651668 2.66 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr19_-_49520338 2.63 ENST00000221421.2
LHB
luteinizing hormone beta polypeptide
chr2_-_30144432 2.63 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr16_-_3074231 2.62 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
HCFC1R1
host cell factor C1 regulator 1 (XPO1 dependent)
chr19_-_49560987 2.59 ENST00000596965.1
CGB7
chorionic gonadotropin, beta polypeptide 7
chr16_-_68269971 2.59 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr17_+_68100989 2.59 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_10121144 2.56 ENST00000264828.3
COL5A3
collagen, type V, alpha 3
chr5_-_33984786 2.48 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr4_+_169552748 2.46 ENST00000504519.1
ENST00000512127.1
PALLD
palladin, cytoskeletal associated protein
chr5_-_146461027 2.38 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr19_-_42931567 2.25 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr17_+_77020325 2.22 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr12_-_13248598 2.14 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr1_+_114447763 2.08 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr11_-_35440579 2.03 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_77020224 1.96 ENST00000339142.2
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr3_+_36421826 1.92 ENST00000273183.3
STAC
SH3 and cysteine rich domain
chrX_+_15767971 1.90 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr1_+_197237352 1.85 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr16_-_58004992 1.83 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr1_+_244816237 1.82 ENST00000302550.11
DESI2
desumoylating isopeptidase 2
chr19_+_2476116 1.80 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr12_+_81101277 1.78 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr12_-_113574028 1.77 ENST00000546530.1
ENST00000261729.5
RASAL1
RAS protein activator like 1 (GAP1 like)
chrX_-_138724994 1.74 ENST00000536274.1
MCF2
MCF.2 cell line derived transforming sequence
chr1_+_18957500 1.73 ENST00000375375.3
PAX7
paired box 7
chr14_+_21785693 1.72 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr18_-_24443151 1.69 ENST00000440832.3
AQP4
aquaporin 4
chr2_+_189156389 1.66 ENST00000409843.1
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr14_-_24551195 1.63 ENST00000560550.1
NRL
neural retina leucine zipper
chr11_-_35440796 1.62 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_86001210 1.62 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr6_+_31588478 1.56 ENST00000376007.4
ENST00000376033.2
PRRC2A
proline-rich coiled-coil 2A
chrX_-_138724677 1.49 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr1_-_21606013 1.47 ENST00000357071.4
ECE1
endothelin converting enzyme 1
chr14_-_24551137 1.47 ENST00000396995.1
NRL
neural retina leucine zipper
chr8_+_70378852 1.42 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr1_+_11751748 1.41 ENST00000294485.5
DRAXIN
dorsal inhibitory axon guidance protein
chr17_-_9808887 1.37 ENST00000226193.5
RCVRN
recoverin
chr15_-_31453359 1.29 ENST00000542188.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr6_-_35480640 1.29 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr10_-_126849588 1.29 ENST00000411419.2
CTBP2
C-terminal binding protein 2
chr1_+_244816371 1.26 ENST00000263831.7
DESI2
desumoylating isopeptidase 2
chr22_-_40929812 1.22 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr11_-_62752455 1.20 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr7_-_138482933 1.14 ENST00000310018.2
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr12_-_13248562 1.11 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr11_-_62752429 1.10 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr16_+_69373323 1.08 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr4_+_170541660 1.07 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr22_-_29663954 1.00 ENST00000216085.7
RHBDD3
rhomboid domain containing 3
chr10_-_76868931 1.00 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr12_+_53818855 0.98 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chrX_-_24665353 0.98 ENST00000379144.2
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr15_-_43559055 0.97 ENST00000220420.5
ENST00000349114.4
TGM5
transglutaminase 5
chr4_-_76823681 0.96 ENST00000286719.7
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr4_+_170541835 0.95 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr8_-_116681221 0.94 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chrX_-_49089771 0.94 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr6_-_41130841 0.88 ENST00000373122.4
TREM2
triggering receptor expressed on myeloid cells 2
chr11_-_62752162 0.88 ENST00000458333.2
ENST00000421062.2
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr6_-_41130914 0.85 ENST00000373113.3
ENST00000338469.3
TREM2
triggering receptor expressed on myeloid cells 2
chr12_-_13248705 0.83 ENST00000396310.2
GSG1
germ cell associated 1
chr7_-_138482849 0.76 ENST00000353492.4
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chrX_+_107069063 0.76 ENST00000262843.6
MID2
midline 2
chr1_+_114522049 0.75 ENST00000369551.1
ENST00000320334.4
OLFML3
olfactomedin-like 3
chr11_+_44587141 0.73 ENST00000227155.4
ENST00000342935.3
ENST00000532544.1
CD82
CD82 molecule
chr3_-_54962100 0.73 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr1_+_202431859 0.65 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_+_189156586 0.63 ENST00000409830.1
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr2_+_189156721 0.61 ENST00000409927.1
ENST00000409805.1
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr1_-_165414414 0.60 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chrY_+_16634483 0.55 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr19_+_40877583 0.49 ENST00000596470.1
PLD3
phospholipase D family, member 3
chrX_+_99899180 0.48 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr10_+_118350468 0.46 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr2_+_128175997 0.45 ENST00000234071.3
ENST00000429925.1
ENST00000442644.1
ENST00000453608.2
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_-_35480705 0.43 ENST00000229771.6
TULP1
tubby like protein 1
chr15_+_96876340 0.36 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr15_+_48498480 0.33 ENST00000380993.3
ENST00000396577.3
SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr12_-_13248732 0.32 ENST00000396302.3
GSG1
germ cell associated 1
chr10_+_52750930 0.25 ENST00000401604.2
PRKG1
protein kinase, cGMP-dependent, type I
chrX_+_41306575 0.25 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr5_-_16738451 0.20 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr13_-_36050819 0.17 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr11_+_124735282 0.13 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr6_-_42690312 0.09 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr16_+_87636474 0.04 ENST00000284262.2
JPH3
junctophilin 3
chr1_+_159409512 0.01 ENST00000423932.3
OR10J1
olfactory receptor, family 10, subfamily J, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GSC_GSC2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 26.7 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
4.3 12.8 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
2.4 9.7 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
2.0 8.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
1.9 7.7 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
1.7 31.1 GO:0007021 tubulin complex assembly(GO:0007021)
1.1 3.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.1 19.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
1.1 3.2 GO:0097254 renal tubular secretion(GO:0097254)
1.1 6.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.0 4.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
1.0 4.0 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.0 7.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.9 4.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.8 14.4 GO:0071420 cellular response to histamine(GO:0071420)
0.8 3.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.8 10.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 8.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.7 5.2 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.7 7.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.7 2.1 GO:0031627 telomeric loop formation(GO:0031627)
0.7 2.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.7 2.6 GO:0036269 swimming behavior(GO:0036269)
0.6 3.2 GO:0048066 developmental pigmentation(GO:0048066)
0.6 21.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.6 1.7 GO:0032499 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.5 3.0 GO:0001714 endodermal cell fate specification(GO:0001714)
0.5 4.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.5 3.7 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 4.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.4 2.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.4 1.5 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 6.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.6 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.3 4.5 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 9.4 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.3 10.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 1.0 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 1.0 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 11.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 7.9 GO:0097352 autophagosome maturation(GO:0097352)
0.2 3.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 4.9 GO:0015813 L-glutamate transport(GO:0015813)
0.2 1.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 8.1 GO:0050832 defense response to fungus(GO:0050832)
0.2 3.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.9 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 4.0 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.2 1.8 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 5.3 GO:0010107 potassium ion import(GO:0010107)
0.2 1.4 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 1.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 0.5 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 3.8 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 4.3 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.1 3.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 2.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 2.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 1.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 1.8 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.4 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 13.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.6 GO:0030199 collagen fibril organization(GO:0030199)
0.1 6.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 1.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 2.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 3.6 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 1.9 GO:0006730 one-carbon metabolic process(GO:0006730) bicarbonate transport(GO:0015701)
0.0 1.7 GO:0003091 renal water homeostasis(GO:0003091)
0.0 5.5 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.4 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.6 GO:0007292 female gamete generation(GO:0007292)
0.0 3.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.0 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.1 GO:0042255 ribosome assembly(GO:0042255)
0.0 4.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 3.7 GO:0042391 regulation of membrane potential(GO:0042391)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 31.1 GO:0097512 cardiac myofibril(GO:0097512)
1.6 6.3 GO:1990246 uniplex complex(GO:1990246)
1.3 26.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)
0.7 14.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.6 7.7 GO:0005916 fascia adherens(GO:0005916)
0.4 14.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 2.7 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.5 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.3 4.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 6.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.2 2.9 GO:0035253 ciliary rootlet(GO:0035253)
0.2 1.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 7.9 GO:0000421 autophagosome membrane(GO:0000421)
0.2 0.7 GO:0035838 growing cell tip(GO:0035838)
0.1 16.2 GO:0005814 centriole(GO:0005814)
0.1 9.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.7 GO:0030673 axolemma(GO:0030673)
0.1 6.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 14.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 6.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 7.8 GO:0005643 nuclear pore(GO:0005643)
0.1 5.4 GO:0005901 caveola(GO:0005901)
0.1 2.5 GO:0002102 podosome(GO:0002102)
0.0 5.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.2 GO:0005581 collagen trimer(GO:0005581)
0.0 4.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.9 GO:0042383 sarcolemma(GO:0042383)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 3.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 14.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.7 GO:0031672 A band(GO:0031672)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 24.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.0 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.7 GO:0005912 adherens junction(GO:0005912)
0.0 1.4 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 26.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.4 4.3 GO:0004947 bradykinin receptor activity(GO:0004947)
1.4 11.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.3 40.5 GO:0005212 structural constituent of eye lens(GO:0005212)
1.3 7.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
1.1 5.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.1 3.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.9 9.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.8 8.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.8 5.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.8 4.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 2.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.6 6.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 3.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 21.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 13.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.4 5.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 2.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.4 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 5.2 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.3 3.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.3 3.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 7.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 7.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 2.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 1.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 1.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 6.5 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.2 5.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 3.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 2.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 4.5 GO:0005109 frizzled binding(GO:0005109)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 10.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 12.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 16.2 GO:0030674 protein binding, bridging(GO:0030674)
0.1 11.8 GO:0044325 ion channel binding(GO:0044325)
0.1 2.6 GO:0043394 proteoglycan binding(GO:0043394)
0.1 1.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 8.0 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.9 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 4.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 4.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 2.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.3 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 5.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 14.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 7.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 6.3 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 2.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.4 PID ATR PATHWAY ATR signaling pathway
0.0 2.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.6 26.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.5 8.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.5 14.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 7.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 3.5 REACTOME OPSINS Genes involved in Opsins
0.2 8.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 5.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 5.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 2.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 1.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.2 4.0 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 24.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 6.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 5.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 4.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors