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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HIF1A
Z-value: 1.14
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Transcription factors associated with HIF1A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIF1A | hg19_v2_chr14_+_62162258_62162269 | 0.61 | 7.8e-24 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIF1A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.0 | 77.0 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 2.7 | 51.1 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.4 | 49.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 46.5 | GO:0045087 | innate immune response(GO:0045087) |
| 2.0 | 42.7 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.5 | 39.4 | GO:0031663 | lipopolysaccharide-mediated signaling pathway(GO:0031663) |
| 0.2 | 37.5 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 7.2 | 36.0 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 2.2 | 32.8 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 5.8 | 29.0 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.3 | 92.0 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 75.8 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.9 | 51.1 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.2 | 47.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.8 | 46.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.4 | 44.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 5.8 | 40.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.3 | 29.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 4.8 | 29.0 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 9.4 | 28.1 | GO:0005960 | glycine cleavage complex(GO:0005960) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.3 | 92.0 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 1.6 | 63.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.3 | 60.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 17.0 | 51.1 | GO:0072510 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 1.1 | 50.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 14.2 | 42.7 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 0.6 | 34.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 4.7 | 32.8 | GO:0004459 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 0.9 | 32.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 32.1 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 213.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 58.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 44.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.0 | 36.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.7 | 34.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.5 | 30.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.6 | 24.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.3 | 19.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 11.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 10.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 166.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 2.4 | 77.3 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.3 | 58.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.6 | 55.7 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.2 | 33.7 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.5 | 29.4 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.5 | 26.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.9 | 25.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 1.5 | 25.0 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.9 | 24.1 | REACTOME KINESINS | Genes involved in Kinesins |