Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for HLF_TEF

Z-value: 0.98

Motif logo

Transcription factors associated with HLF_TEF

Gene Symbol Gene ID Gene Info
ENSG00000108924.9 HLF transcription factor, PAR bZIP family member
ENSG00000167074.10 TEF transcription factor, PAR bZIP family member

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TEFhg19_v2_chr22_+_41777927_41777971,
hg19_v2_chr22_+_41763274_41763337
-0.522.4e-16Click!
HLFhg19_v2_chr17_+_53344945_53344977-0.252.0e-04Click!

Activity profile of HLF_TEF motif

Sorted Z-values of HLF_TEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_102216925 27.59 ENST00000517844.1
zinc finger protein 706
chr1_+_169079823 22.05 ENST00000367813.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr8_-_102217796 21.87 ENST00000519744.1
ENST00000311212.4
ENST00000521272.1
ENST00000519882.1
zinc finger protein 706
chr8_-_102217515 21.79 ENST00000520347.1
ENST00000523922.1
ENST00000520984.1
zinc finger protein 706
chr17_-_61850894 20.53 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
coiled-coil domain containing 47
chr19_+_17413663 20.39 ENST00000594999.1
mitochondrial ribosomal protein L34
chr20_+_4666882 19.52 ENST00000379440.4
ENST00000430350.2
prion protein
chr9_+_71819927 18.68 ENST00000535702.1
tight junction protein 2
chr9_+_71820057 18.55 ENST00000539225.1
tight junction protein 2
chr1_-_156721389 18.24 ENST00000537739.1
hepatoma-derived growth factor
chr8_-_102218292 17.91 ENST00000518336.1
ENST00000520454.1
zinc finger protein 706
chr17_-_685559 16.13 ENST00000301329.6
glyoxalase domain containing 4
chr2_-_225362533 15.97 ENST00000451538.1
cullin 3
chr20_+_33759854 15.41 ENST00000216968.4
protein C receptor, endothelial
chr17_-_685493 15.35 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
glyoxalase domain containing 4
chr21_+_45138941 15.30 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
pyridoxal (pyridoxine, vitamin B6) kinase
chr8_+_110552337 13.51 ENST00000337573.5
estrogen receptor binding site associated, antigen, 9
chr1_-_161087802 13.15 ENST00000368010.3
prefoldin subunit 2
chr3_+_169684553 11.60 ENST00000337002.4
ENST00000480708.1
SEC62 homolog (S. cerevisiae)
chr7_+_23145884 11.01 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr9_+_110045537 10.43 ENST00000358015.3
RAD23 homolog B (S. cerevisiae)
chr17_-_73178599 10.38 ENST00000578238.1
small ubiquitin-like modifier 2
chr8_+_110552831 8.98 ENST00000530629.1
estrogen receptor binding site associated, antigen, 9
chr14_-_67826486 8.88 ENST00000555431.1
ENST00000554236.1
ENST00000555474.1
ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
chr20_-_33732952 8.88 ENST00000541621.1
ER degradation enhancer, mannosidase alpha-like 2
chr5_+_95997918 8.82 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
calpastatin
chr20_-_49547731 8.74 ENST00000396029.3
activity-dependent neuroprotector homeobox
chr1_-_156721502 8.62 ENST00000357325.5
hepatoma-derived growth factor
chr1_+_45212074 8.49 ENST00000372217.1
kinesin family member 2C
chr7_+_23146271 8.32 ENST00000545771.1
kelch-like family member 7
chr5_+_34757309 8.09 ENST00000397449.1
retinoic acid induced 14
chr5_+_95997769 8.00 ENST00000338252.3
ENST00000508830.1
calpastatin
chr20_+_4667094 7.77 ENST00000424424.1
ENST00000457586.1
prion protein
chr12_+_57624085 7.70 ENST00000553474.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr4_-_74088800 7.43 ENST00000509867.2
ankyrin repeat domain 17
chr5_-_179050066 7.40 ENST00000329433.6
ENST00000510411.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_+_45212051 7.30 ENST00000372222.3
kinesin family member 2C
chr11_+_105948216 7.29 ENST00000278618.4
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr16_-_53537105 7.16 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKT interacting protein
chr7_-_44887620 7.01 ENST00000349299.3
ENST00000521529.1
ENST00000308153.4
ENST00000350771.3
ENST00000222690.6
ENST00000381124.5
ENST00000437072.1
ENST00000446531.1
H2A histone family, member V
chr17_-_73179046 6.94 ENST00000314523.7
ENST00000420826.2
small ubiquitin-like modifier 2
chr3_+_62304712 6.91 ENST00000494481.1
chromosome 3 open reading frame 14
chr5_-_43557791 6.83 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
poly(A) binding protein interacting protein 1
chr20_-_49547910 6.78 ENST00000396032.3
activity-dependent neuroprotector homeobox
chr3_+_62304648 6.58 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
chromosome 3 open reading frame 14
chr10_+_94050913 6.45 ENST00000358935.2
membrane-associated ring finger (C3HC4) 5
chr2_+_191208196 6.43 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
inositol polyphosphate-1-phosphatase
chr2_-_203103185 6.14 ENST00000409205.1
small ubiquitin-like modifier 1
chr12_+_57624119 6.13 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_41623075 5.83 ENST00000545089.1
ets variant 4
chr1_-_247094628 5.81 ENST00000366508.1
ENST00000326225.3
ENST00000391829.2
AT hook containing transcription factor 1
chr17_+_685513 5.78 ENST00000304478.4
RNA methyltransferase like 1
chr1_-_244013384 5.76 ENST00000366539.1
v-akt murine thymoma viral oncogene homolog 3
chr5_+_95998070 5.55 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
calpastatin
chr17_-_41623009 5.54 ENST00000393664.2
ets variant 4
chr9_-_128246769 4.82 ENST00000444226.1
mitogen-activated protein kinase associated protein 1
chr17_-_42144949 4.65 ENST00000591247.1
LSM12 homolog (S. cerevisiae)
chr3_+_158787041 4.58 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr17_-_41623259 4.51 ENST00000538265.1
ENST00000591713.1
ets variant 4
chr8_-_103424986 4.43 ENST00000521922.1
ubiquitin protein ligase E3 component n-recognin 5
chr18_+_3262954 4.36 ENST00000584539.1
myosin, light chain 12B, regulatory
chr12_+_57623869 4.30 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr8_-_27469196 4.25 ENST00000546343.1
ENST00000560566.1
clusterin
chr11_-_33795893 4.02 ENST00000526785.1
ENST00000534136.1
ENST00000265651.3
ENST00000530401.1
ENST00000448981.2
F-box protein 3
chr8_-_27468842 3.86 ENST00000523500.1
clusterin
chr17_+_61851504 3.85 ENST00000359353.5
ENST00000389924.2
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr11_+_35201826 3.83 ENST00000531873.1
CD44 molecule (Indian blood group)
chr3_+_101504200 3.78 ENST00000422132.1
neurexophilin and PC-esterase domain family, member 3
chr2_-_113594279 3.76 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr17_-_41623691 3.74 ENST00000545954.1
ets variant 4
chr5_-_111091948 3.65 ENST00000447165.2
neuronal regeneration related protein
chr4_+_41937131 3.45 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr12_+_57623477 3.43 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr17_+_61851157 3.39 ENST00000578681.1
ENST00000583590.1
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr8_-_103424916 3.26 ENST00000220959.4
ubiquitin protein ligase E3 component n-recognin 5
chr12_-_101801505 3.20 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ADP-ribosylation factor-like 1
chr19_+_33865218 3.12 ENST00000585933.2
CCAAT/enhancer binding protein (C/EBP), gamma
chr16_-_70323422 3.02 ENST00000261772.8
alanyl-tRNA synthetase
chr17_+_39975455 2.84 ENST00000455106.1
FK506 binding protein 10, 65 kDa
chr15_+_49913201 2.75 ENST00000329873.5
ENST00000558653.1
ENST00000559164.1
ENST00000560632.1
ENST00000559405.1
ENST00000251250.6
DTW domain containing 1
chr6_+_4706368 2.71 ENST00000328908.5
chromodomain protein, Y-like
chr10_-_65028817 2.69 ENST00000542921.1
jumonji domain containing 1C
chr2_+_102608306 2.69 ENST00000332549.3
interleukin 1 receptor, type II
chr10_-_65028938 2.68 ENST00000402544.1
jumonji domain containing 1C
chr18_+_21032781 2.63 ENST00000339486.3
RIO kinase 3
chr4_+_110354928 2.56 ENST00000504968.2
ENST00000399100.2
ENST00000265175.5
SEC24 family member B
chr14_+_60715928 2.50 ENST00000395076.4
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr17_-_41623716 2.49 ENST00000319349.5
ets variant 4
chr7_+_73868439 2.43 ENST00000424337.2
GTF2I repeat domain containing 1
chr8_+_107738240 2.37 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr2_+_46769798 2.32 ENST00000238738.4
ras homolog family member Q
chr14_+_96722539 2.28 ENST00000553356.1
bradykinin receptor B1
chr14_+_93260642 2.22 ENST00000355976.2
golgin A5
chr9_-_114246635 2.19 ENST00000338205.5
KIAA0368
chr4_+_75230853 2.16 ENST00000244869.2
epiregulin
chr1_-_101491319 2.04 ENST00000342173.7
ENST00000488176.1
ENST00000370109.3
diphthamide biosynthesis 5
chr4_-_153274078 2.03 ENST00000263981.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr8_-_27468945 2.00 ENST00000405140.3
clusterin
chr20_+_39657454 1.91 ENST00000361337.2
topoisomerase (DNA) I
chr10_-_97416400 1.88 ENST00000371224.2
ENST00000371221.3
aldehyde dehydrogenase 18 family, member A1
chr16_+_70332956 1.87 ENST00000288071.6
ENST00000393657.2
ENST00000355992.3
ENST00000567706.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Uncharacterized protein
chr3_-_196910721 1.84 ENST00000443183.1
discs, large homolog 1 (Drosophila)
chr14_+_93260569 1.82 ENST00000163416.2
golgin A5
chr10_-_14372870 1.81 ENST00000357447.2
FERM domain containing 4A
chr1_+_161087873 1.68 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
nitrilase 1
chr13_-_45010939 1.64 ENST00000261489.2
TSC22 domain family, member 1
chr8_-_103425047 1.61 ENST00000520539.1
ubiquitin protein ligase E3 component n-recognin 5
chr1_+_229440129 1.58 ENST00000366688.3
S-phase response (cyclin related)
chr7_+_44646218 1.42 ENST00000444676.1
ENST00000222673.5
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr17_+_73089382 1.37 ENST00000538213.2
ENST00000584118.1
solute carrier family 16 (monocarboxylate transporter), member 5
chr17_-_39538550 1.22 ENST00000394001.1
keratin 34
chr3_-_48130707 1.18 ENST00000360240.6
ENST00000383737.4
microtubule-associated protein 4
chr7_-_22259845 1.12 ENST00000420196.1
Rap guanine nucleotide exchange factor (GEF) 5
chr2_+_198318147 1.11 ENST00000263960.2
coenzyme Q10 homolog B (S. cerevisiae)
chr21_+_19617140 1.04 ENST00000299295.2
ENST00000338326.3
chondrolectin
chr14_+_102276132 1.03 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
protein phosphatase 2, regulatory subunit B', gamma
chr6_-_74231303 1.03 ENST00000309268.6
eukaryotic translation elongation factor 1 alpha 1
chr11_-_62313090 1.00 ENST00000528508.1
ENST00000533365.1
AHNAK nucleoprotein
chr7_-_83824169 1.00 ENST00000265362.4
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_154797877 0.91 ENST00000462745.1
ENST00000493237.1
membrane metallo-endopeptidase
chr17_-_19651668 0.86 ENST00000494157.2
ENST00000225740.6
aldehyde dehydrogenase 3 family, member A1
chr11_-_102576537 0.79 ENST00000260229.4
matrix metallopeptidase 27
chr6_+_97010424 0.71 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
four and a half LIM domains 5
chr1_+_115572415 0.62 ENST00000256592.1
thyroid stimulating hormone, beta
chr17_-_32690239 0.52 ENST00000225842.3
chemokine (C-C motif) ligand 1
chr15_+_58430567 0.51 ENST00000536493.1
aquaporin 9
chr18_+_13824154 0.47 ENST00000589410.1
melanocortin 5 receptor
chr2_-_100106419 0.45 ENST00000393445.3
ENST00000258428.3
REV1, polymerase (DNA directed)
chr7_-_73153178 0.43 ENST00000437775.2
ENST00000222800.3
abhydrolase domain containing 11
chr4_+_187187098 0.37 ENST00000403665.2
ENST00000264692.4
coagulation factor XI
chr2_-_99279928 0.36 ENST00000414521.2
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_34524157 0.35 ENST00000378354.4
ENST00000394484.1
chemokine (C-C motif) ligand 3-like 3
chr22_-_50221160 0.35 ENST00000404760.1
bromodomain containing 1
chr21_-_30365136 0.29 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
listerin E3 ubiquitin protein ligase 1
chr1_+_144989309 0.29 ENST00000596396.1
Uncharacterized protein
chr2_-_31637560 0.24 ENST00000379416.3
xanthine dehydrogenase
chrX_+_9431324 0.22 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr12_-_68619586 0.21 ENST00000229134.4
interleukin 26
chr8_+_24298531 0.15 ENST00000175238.6
ADAM metallopeptidase domain 7
chr2_-_214014959 0.15 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKAROS family zinc finger 2 (Helios)
chr1_+_174933899 0.13 ENST00000367688.3
RAB GTPase activating protein 1-like
chr19_-_41945804 0.12 ENST00000221943.9
ENST00000597457.1
ENST00000589970.1
ENST00000595425.1
ENST00000438807.3
ENST00000589102.1
ENST00000592922.2
ATP5S-like
chr3_-_158390282 0.12 ENST00000264265.3
latexin
chr8_+_24298597 0.09 ENST00000380789.1
ADAM metallopeptidase domain 7
chr11_+_123986069 0.08 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
von Willebrand factor A domain containing 5A
chr1_+_65730385 0.04 ENST00000263441.7
ENST00000395325.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_-_19651654 0.01 ENST00000395555.3
aldehyde dehydrogenase 3 family, member A1
chr15_+_58430368 0.00 ENST00000558772.1
ENST00000219919.4
aquaporin 9

Network of associatons between targets according to the STRING database.

First level regulatory network of HLF_TEF

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 27.3 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
8.9 89.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
5.5 22.0 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
5.1 15.3 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
4.0 16.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.7 37.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
3.1 21.6 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
3.0 8.9 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
2.3 11.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
2.2 15.5 GO:0033484 nitric oxide homeostasis(GO:0033484)
1.9 20.5 GO:0006983 ER overload response(GO:0006983)
1.9 7.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.7 22.4 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.7 10.1 GO:0061517 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.6 15.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.3 9.3 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.3 3.8 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
1.2 6.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
1.1 3.4 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.0 3.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.9 2.8 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.9 2.6 GO:0039534 regulation of MDA-5 signaling pathway(GO:0039533) negative regulation of MDA-5 signaling pathway(GO:0039534)
0.9 2.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.8 4.8 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.7 2.2 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.7 2.7 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.6 27.7 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.5 2.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.5 3.8 GO:0070487 monocyte aggregation(GO:0070487)
0.4 2.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.4 2.0 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.4 6.4 GO:0090344 negative regulation of cell aging(GO:0090344)
0.4 3.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.4 5.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 4.3 GO:0006553 lysine metabolic process(GO:0006553)
0.3 1.9 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3 1.8 GO:1903286 regulation of potassium ion import(GO:1903286)
0.3 5.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 3.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.3 5.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 26.9 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.3 8.9 GO:0090383 phagosome acidification(GO:0090383)
0.3 20.4 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 0.9 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 1.9 GO:0040016 embryonic cleavage(GO:0040016)
0.2 1.0 GO:0048880 sensory system development(GO:0048880)
0.2 7.2 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.2 9.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 1.0 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 2.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 6.8 GO:0048255 mRNA stabilization(GO:0048255)
0.1 2.3 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 4.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722) glycerol transport(GO:0015793) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.4 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 6.3 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 0.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 7.0 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.0 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 6.4 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 1.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.1 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 8.4 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 12.7 GO:0051495 positive regulation of cytoskeleton organization(GO:0051495)
0.0 0.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.6 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 12.7 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 4.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 14.2 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.5 GO:0030817 regulation of cAMP biosynthetic process(GO:0030817) positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0035902 response to immobilization stress(GO:0035902)
0.0 0.9 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 1.0 GO:0010975 regulation of neuron projection development(GO:0010975)
0.0 1.2 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 21.6 GO:0070552 BRISC complex(GO:0070552)
1.9 13.1 GO:0016272 prefoldin complex(GO:0016272)
1.8 7.2 GO:0070695 FHF complex(GO:0070695)
1.8 16.0 GO:0005827 polar microtubule(GO:0005827)
1.5 6.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
1.3 21.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.1 22.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.6 1.9 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.6 10.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.6 10.4 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.5 3.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.5 20.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 5.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 2.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.3 32.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 19.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 2.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.3 8.9 GO:0035371 microtubule plus-end(GO:0035371)
0.3 8.9 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.3 8.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 4.8 GO:0031932 TORC2 complex(GO:0031932)
0.2 24.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 29.2 GO:0005923 bicellular tight junction(GO:0005923)
0.2 0.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 2.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 4.4 GO:0099738 cell cortex region(GO:0099738)
0.1 7.0 GO:0000786 nucleosome(GO:0000786)
0.1 13.0 GO:0016605 PML body(GO:0016605)
0.1 7.2 GO:0015030 Cajal body(GO:0015030)
0.1 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 8.9 GO:0035580 specific granule lumen(GO:0035580)
0.1 9.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 4.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 8.1 GO:0001650 fibrillar center(GO:0001650)
0.1 2.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 3.4 GO:0005643 nuclear pore(GO:0005643)
0.0 3.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 12.3 GO:0030425 dendrite(GO:0030425)
0.0 16.9 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)
0.0 19.5 GO:0005730 nucleolus(GO:0005730)
0.0 7.5 GO:0000785 chromatin(GO:0000785)
0.0 28.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 7.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 5.7 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 27.3 GO:1903135 cupric ion binding(GO:1903135)
4.0 16.0 GO:0031208 POZ domain binding(GO:0031208)
3.7 22.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
3.1 50.3 GO:0001222 transcription corepressor binding(GO:0001222)
3.1 21.6 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.8 37.3 GO:0030955 potassium ion binding(GO:0030955)
1.6 15.8 GO:0019237 centromeric DNA binding(GO:0019237)
1.0 3.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
1.0 38.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.8 22.5 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.8 8.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.8 2.3 GO:0032427 GBD domain binding(GO:0032427)
0.6 6.4 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.6 9.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.6 10.1 GO:0051787 misfolded protein binding(GO:0051787)
0.5 2.7 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.5 6.8 GO:0008494 translation activator activity(GO:0008494)
0.5 1.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 13.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 7.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 7.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.3 15.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 1.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.3 5.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 4.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 10.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 2.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 4.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 2.6 GO:0089720 caspase binding(GO:0089720)
0.2 0.6 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 1.1 GO:0048039 ubiquinone binding(GO:0048039)
0.2 0.9 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 4.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1 9.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 3.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 20.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 32.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 8.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 29.3 GO:0045296 cadherin binding(GO:0045296)
0.1 2.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 2.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 15.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 1.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 16.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 2.0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.5 27.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 6.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.4 10.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.3 45.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.3 22.1 PID LKB1 PATHWAY LKB1 signaling events
0.3 22.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 15.8 PID AURORA B PATHWAY Aurora B signaling
0.2 7.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 8.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 1.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID MYC PATHWAY C-MYC pathway
0.0 1.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 37.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6 5.8 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.6 15.8 REACTOME KINESINS Genes involved in Kinesins
0.5 8.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.5 7.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.4 17.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.4 26.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.4 10.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.3 26.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 13.1 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3 8.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.3 15.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 6.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.2 3.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 6.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 4.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 2.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 5.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 4.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.0 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 15.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 7.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 3.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 3.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation