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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HMX1

Z-value: 0.86

Motif logo

Transcription factors associated with HMX1

Gene Symbol Gene ID Gene Info
ENSG00000215612.5 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMX1hg19_v2_chr4_-_8873531_8873543-0.522.1e-16Click!

Activity profile of HMX1 motif

Sorted Z-values of HMX1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_49066811 23.45 ENST00000442157.1
ENST00000326739.4
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr22_-_37640277 13.25 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr3_+_151986709 12.83 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr12_-_7077125 12.61 ENST00000545555.2
prohibitin 2
chrX_+_131157322 10.83 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
Serine/threonine-protein kinase MST4
chrX_+_131157290 10.79 ENST00000394334.2
Serine/threonine-protein kinase MST4
chr16_+_85645007 10.55 ENST00000405402.2
Gse1 coiled-coil protein
chr13_+_37574678 10.37 ENST00000389704.3
exosome component 8
chr19_+_41768401 9.94 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
heterogeneous nuclear ribonucleoprotein U-like 1
chrX_-_153285251 9.91 ENST00000444230.1
ENST00000393682.1
ENST00000393687.2
ENST00000429936.2
ENST00000369974.2
interleukin-1 receptor-associated kinase 1
chr1_-_153949751 9.35 ENST00000428469.1
jumping translocation breakpoint
chr22_-_37640456 9.26 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_88872176 9.24 ENST00000569140.1
chromatin licensing and DNA replication factor 1
chr4_-_71705027 9.10 ENST00000545193.1
G-rich RNA sequence binding factor 1
chr6_-_31550192 9.06 ENST00000429299.2
ENST00000446745.2
lymphotoxin beta (TNF superfamily, member 3)
chr1_+_110163202 8.95 ENST00000531203.1
ENST00000256578.3
adenosine monophosphate deaminase 2
chr22_-_39096661 8.82 ENST00000216039.5
Josephin domain containing 1
chrX_-_153285395 8.42 ENST00000369980.3
interleukin-1 receptor-associated kinase 1
chr5_-_81046841 8.34 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
single-stranded DNA binding protein 2
chr6_-_7911042 8.23 ENST00000379757.4
thioredoxin domain containing 5 (endoplasmic reticulum)
chr5_-_81046922 8.11 ENST00000514493.1
ENST00000320672.4
single-stranded DNA binding protein 2
chr1_+_155278539 8.03 ENST00000447866.1
farnesyl diphosphate synthase
chr13_+_76123883 7.95 ENST00000377595.3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr1_-_25256368 7.77 ENST00000308873.6
runt-related transcription factor 3
chrX_-_153599578 7.67 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chr7_+_50344289 7.65 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr3_-_18466787 7.62 ENST00000338745.6
ENST00000450898.1
SATB homeobox 1
chr3_+_49711777 7.52 ENST00000442186.1
ENST00000438011.1
ENST00000457042.1
acylaminoacyl-peptide hydrolase
chr14_-_55369525 7.49 ENST00000543643.2
ENST00000536224.2
ENST00000395514.1
ENST00000491895.2
GTP cyclohydrolase 1
chr11_+_105948216 7.40 ENST00000278618.4
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr6_-_8102279 7.29 ENST00000488226.2
eukaryotic translation elongation factor 1 epsilon 1
chr1_+_155278625 7.22 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase
chr14_+_23776167 7.22 ENST00000554635.1
ENST00000557008.1
BCL2-like 2
BCL2L2-PABPN1 readthrough
chr1_-_54405773 7.15 ENST00000371376.1
heat shock protein family B (small), member 11
chr14_+_23776024 6.80 ENST00000553781.1
ENST00000556100.1
ENST00000557236.1
ENST00000557579.1
BCL2L2-PABPN1 readthrough
BCL2-like 2
chr12_+_7060432 6.74 ENST00000318974.9
ENST00000456013.1
protein tyrosine phosphatase, non-receptor type 6
chr17_-_62097927 6.73 ENST00000578313.1
ENST00000584084.1
ENST00000579788.1
ENST00000579687.1
ENST00000578379.1
ENST00000578892.1
ENST00000412356.1
ENST00000418105.1
intercellular adhesion molecule 2
chr2_-_130939115 6.70 ENST00000441135.1
ENST00000339679.7
ENST00000426662.2
ENST00000443958.2
ENST00000351288.6
ENST00000453750.1
ENST00000452225.2
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr22_-_29196030 6.68 ENST00000405219.3
X-box binding protein 1
chr5_-_81046904 6.53 ENST00000515395.1
single-stranded DNA binding protein 2
chr6_-_8102714 6.46 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
eukaryotic translation elongation factor 1 epsilon 1
chr8_-_67525473 6.38 ENST00000522677.3
v-myb avian myeloblastosis viral oncogene homolog-like 1
chrX_+_69509927 6.33 ENST00000374403.3
kinesin family member 4A
chr17_+_40440481 6.27 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
signal transducer and activator of transcription 5A
chrX_-_20284958 6.25 ENST00000379565.3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr16_-_1823114 6.23 ENST00000177742.3
ENST00000397375.2
mitochondrial ribosomal protein S34
chr1_-_26232951 5.99 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr16_-_20753114 5.97 ENST00000396083.2
THUMP domain containing 1
chr2_+_30454390 5.97 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
limb bud and heart development
chr11_-_67275542 5.88 ENST00000531506.1
cyclin-dependent kinase 2 associated protein 2
chr12_-_49318715 5.73 ENST00000444214.2
FK506 binding protein 11, 19 kDa
chr20_-_62601218 5.59 ENST00000369888.1
zinc finger protein 512B
chr19_-_13068012 5.52 ENST00000316939.1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr3_-_52312636 5.46 ENST00000296490.3
WD repeat domain 82
chr8_+_145438870 5.36 ENST00000527931.1
family with sequence similarity 203, member B
chr11_-_65308082 5.26 ENST00000532661.1
latent transforming growth factor beta binding protein 3
chr2_+_130939235 5.24 ENST00000425361.1
ENST00000457492.1
mitotic spindle organizing protein 2B
chr1_+_110163709 5.23 ENST00000369840.2
ENST00000527846.1
adenosine monophosphate deaminase 2
chr7_-_150675372 5.23 ENST00000262186.5
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr5_+_10353780 5.16 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr22_-_29196546 5.14 ENST00000403532.3
ENST00000216037.6
X-box binding protein 1
chr17_-_62097904 5.09 ENST00000583366.1
intercellular adhesion molecule 2
chr16_+_28996364 5.06 ENST00000564277.1
linker for activation of T cells
chr1_+_43148625 5.03 ENST00000436427.1
Y box binding protein 1
chr1_-_28241226 5.00 ENST00000373912.3
ENST00000373909.3
replication protein A2, 32kDa
chr1_+_154947148 4.95 ENST00000368436.1
ENST00000308987.5
CDC28 protein kinase regulatory subunit 1B
chr1_-_115259337 4.94 ENST00000369535.4
neuroblastoma RAS viral (v-ras) oncogene homolog
chr10_-_99258135 4.87 ENST00000327238.10
ENST00000327277.7
ENST00000355839.6
ENST00000437002.1
ENST00000422685.1
MMS19 nucleotide excision repair homolog (S. cerevisiae)
chr3_-_13461807 4.86 ENST00000254508.5
nucleoporin 210kDa
chr6_+_33043703 4.84 ENST00000418931.2
ENST00000535465.1
major histocompatibility complex, class II, DP beta 1
chr9_-_127952187 4.81 ENST00000451402.1
ENST00000415905.1
protein phosphatase 6, catalytic subunit
chr9_-_127952032 4.80 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
protein phosphatase 6, catalytic subunit
chr1_-_207095324 4.73 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
Fas apoptotic inhibitory molecule 3
chr3_+_20081515 4.72 ENST00000263754.4
K(lysine) acetyltransferase 2B
chr4_+_83956237 4.63 ENST00000264389.2
COP9 signalosome subunit 4
chr1_+_53480598 4.58 ENST00000430330.2
ENST00000408941.3
ENST00000478274.2
ENST00000484100.1
ENST00000435345.2
ENST00000488965.1
sterol carrier protein 2
chr1_+_154947126 4.53 ENST00000368439.1
CDC28 protein kinase regulatory subunit 1B
chr19_+_1407517 4.52 ENST00000336761.6
ENST00000233078.4
DAZ associated protein 1
chr11_-_62607036 4.48 ENST00000311713.7
ENST00000278856.4
WD repeat domain 74
chr12_+_53689309 4.40 ENST00000351500.3
ENST00000550846.1
ENST00000334478.4
ENST00000549759.1
prefoldin subunit 5
chr17_-_47755436 4.40 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr4_+_83956312 4.29 ENST00000509317.1
ENST00000503682.1
ENST00000511653.1
COP9 signalosome subunit 4
chr14_+_31343747 4.27 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
cochlin
chr16_+_28996572 4.17 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
linker for activation of T cells
chr14_+_31343951 4.16 ENST00000556908.1
ENST00000555881.1
ENST00000460581.2
cochlin
chr20_+_30639991 4.15 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
hemopoietic cell kinase
chr2_-_24583168 4.11 ENST00000361999.3
intersectin 2
chr12_+_4382917 4.10 ENST00000261254.3
cyclin D2
chr17_-_79876010 4.08 ENST00000328666.6
sirtuin 7
chr22_+_38349670 4.07 ENST00000442738.2
ENST00000460648.1
ENST00000407936.1
ENST00000488684.1
ENST00000492213.1
ENST00000606538.1
ENST00000405557.1
polymerase (RNA) II (DNA directed) polypeptide F
chr3_-_67705006 3.98 ENST00000492795.1
ENST00000493112.1
ENST00000307227.5
succinate-CoA ligase, GDP-forming, beta subunit
chr16_+_85646763 3.98 ENST00000411612.1
ENST00000253458.7
Gse1 coiled-coil protein
chr14_-_21905395 3.92 ENST00000430710.3
ENST00000553283.1
chromodomain helicase DNA binding protein 8
chr16_+_28996416 3.82 ENST00000395456.2
ENST00000454369.2
linker for activation of T cells
chr3_+_47021168 3.79 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
neurobeachin-like 2
chr16_+_29472707 3.78 ENST00000565290.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
chr17_-_42298201 3.70 ENST00000527034.1
upstream binding transcription factor, RNA polymerase I
chr9_-_136024721 3.67 ENST00000393160.3
ral guanine nucleotide dissociation stimulator
chr4_-_151936416 3.58 ENST00000510413.1
ENST00000507224.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr16_-_67190152 3.52 ENST00000486556.1
TNFRSF1A-associated via death domain
chr11_-_417308 3.51 ENST00000397632.3
ENST00000382520.2
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr6_+_163835669 3.51 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI, KH domain containing, RNA binding
chr12_+_100867694 3.48 ENST00000392986.3
ENST00000549996.1
nuclear receptor subfamily 1, group H, member 4
chr14_+_72399114 3.45 ENST00000553525.1
ENST00000555571.1
regulator of G-protein signaling 6
chr1_-_51425902 3.44 ENST00000396153.2
Fas (TNFRSF6) associated factor 1
chr6_-_32157947 3.34 ENST00000375050.4
pre-B-cell leukemia homeobox 2
chr16_+_30212378 3.34 ENST00000569485.1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr22_-_39268308 3.33 ENST00000407418.3
chromobox homolog 6
chr12_+_70133152 3.28 ENST00000550536.1
ENST00000362025.5
RAB3A interacting protein
chr1_-_26232522 3.21 ENST00000399728.1
stathmin 1
chr11_-_128392085 3.20 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr16_+_30210552 3.20 ENST00000338971.5
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_-_41132010 3.19 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1 readthrough
chr20_+_30640004 3.16 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
hemopoietic cell kinase
chrX_+_37545012 3.14 ENST00000378616.3
X-linked Kx blood group (McLeod syndrome)
chr1_+_193091080 3.12 ENST00000367435.3
cell division cycle 73
chr3_-_195270162 3.12 ENST00000438848.1
ENST00000328432.3
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr18_-_33709268 3.11 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
solute carrier family 39 (zinc transporter), member 6
chr11_-_417388 3.08 ENST00000332725.3
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr4_-_151936865 3.07 ENST00000535741.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr14_+_58666824 3.04 ENST00000254286.4
actin-related protein 10 homolog (S. cerevisiae)
chr1_-_32110467 2.98 ENST00000440872.2
ENST00000373703.4
penta-EF-hand domain containing 1
chr5_+_95998746 2.94 ENST00000508608.1
calpastatin
chr2_-_27545431 2.94 ENST00000233545.2
MpV17 mitochondrial inner membrane protein
chr2_+_219081817 2.92 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
actin related protein 2/3 complex, subunit 2, 34kDa
chr14_-_25103388 2.91 ENST00000526004.1
ENST00000415355.3
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr22_+_47070490 2.78 ENST00000408031.1
GRAM domain containing 4
chr12_+_16035307 2.78 ENST00000538352.1
ENST00000025399.6
ENST00000419869.2
serine/threonine kinase receptor associated protein
chr1_-_207095212 2.77 ENST00000420007.2
Fas apoptotic inhibitory molecule 3
chr19_+_41313017 2.76 ENST00000595621.1
ENST00000595051.1
egl-9 family hypoxia-inducible factor 2
chr1_+_39456895 2.72 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr22_-_39268192 2.72 ENST00000216083.6
chromobox homolog 6
chr6_+_20403997 2.70 ENST00000535432.1
E2F transcription factor 3
chr4_-_109087872 2.68 ENST00000510624.1
lymphoid enhancer-binding factor 1
chr22_+_38349724 2.61 ENST00000470701.1
polymerase (RNA) II (DNA directed) polypeptide F
chr15_+_89346699 2.56 ENST00000558207.1
aggrecan
chr5_+_156693159 2.56 ENST00000347377.6
cytoplasmic FMR1 interacting protein 2
chrX_-_107019181 2.54 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22 domain family, member 3
chr5_+_148206156 2.52 ENST00000305988.4
adrenoceptor beta 2, surface
chr1_+_110162448 2.52 ENST00000342115.4
ENST00000469039.2
ENST00000474459.1
ENST00000528667.1
adenosine monophosphate deaminase 2
chr17_-_42298331 2.52 ENST00000343638.5
upstream binding transcription factor, RNA polymerase I
chr1_+_110163682 2.51 ENST00000358729.4
adenosine monophosphate deaminase 2
chr5_+_156693091 2.49 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
cytoplasmic FMR1 interacting protein 2
chr20_-_21494654 2.46 ENST00000377142.4
NK2 homeobox 2
chr1_-_167059830 2.45 ENST00000367868.3
glycoprotein A33 (transmembrane)
chr7_+_44240520 2.44 ENST00000496112.1
ENST00000223369.2
YKT6 v-SNARE homolog (S. cerevisiae)
chr7_+_872107 2.40 ENST00000405266.1
ENST00000401592.1
ENST00000403868.1
ENST00000425407.2
Sad1 and UNC84 domain containing 1
chr15_+_81489213 2.36 ENST00000559383.1
ENST00000394660.2
interleukin 16
chr1_-_28241024 2.33 ENST00000313433.7
ENST00000444045.1
replication protein A2, 32kDa
chr5_-_37371278 2.32 ENST00000231498.3
nucleoporin 155kDa
chr5_-_37371163 2.27 ENST00000513532.1
nucleoporin 155kDa
chr2_-_27545921 2.27 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
MpV17 mitochondrial inner membrane protein
chr19_-_4124079 2.20 ENST00000394867.4
ENST00000262948.5
mitogen-activated protein kinase kinase 2
chr1_+_178995021 2.20 ENST00000263733.4
family with sequence similarity 20, member B
chr9_-_74525658 2.19 ENST00000333421.6
abhydrolase domain containing 17B
chr3_-_107941230 2.17 ENST00000264538.3
intraflagellar transport 57 homolog (Chlamydomonas)
chr1_-_51425772 2.16 ENST00000371778.4
Fas (TNFRSF6) associated factor 1
chr14_-_25103472 2.14 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr17_-_8151353 2.13 ENST00000315684.8
CTS telomere maintenance complex component 1
chrX_-_153744507 2.12 ENST00000442929.1
ENST00000426266.1
ENST00000359889.5
ENST00000369641.3
ENST00000447601.2
ENST00000434658.2
family with sequence similarity 3, member A
chr4_-_109087906 2.10 ENST00000515500.1
lymphoid enhancer-binding factor 1
chr11_+_65819802 2.10 ENST00000528302.1
ENST00000322535.6
ENST00000524627.1
ENST00000533595.1
ENST00000530322.1
splicing factor 3b, subunit 2, 145kDa
chr4_-_144940477 2.04 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
glycophorin B (MNS blood group)
chr7_+_31009148 2.00 ENST00000409904.3
ENST00000409316.1
growth hormone releasing hormone receptor
chr17_-_55038375 1.93 ENST00000240316.4
coilin
chr9_+_116263778 1.88 ENST00000394646.3
regulator of G-protein signaling 3
chr9_-_140082983 1.87 ENST00000323927.2
anaphase promoting complex subunit 2
chr1_+_235490659 1.82 ENST00000488594.1
geranylgeranyl diphosphate synthase 1
chr6_-_2245892 1.77 ENST00000380815.4
GDP-mannose 4,6-dehydratase
chr12_+_4430371 1.76 ENST00000179259.4
chromosome 12 open reading frame 5
chr12_+_100867486 1.76 ENST00000548884.1
nuclear receptor subfamily 1, group H, member 4
chr2_+_204801471 1.75 ENST00000316386.6
ENST00000435193.1
inducible T-cell co-stimulator
chr9_+_140083099 1.73 ENST00000322310.5
Sjogren syndrome nuclear autoantigen 1
chr2_+_46769798 1.70 ENST00000238738.4
ras homolog family member Q
chr9_+_116263639 1.66 ENST00000343817.5
regulator of G-protein signaling 3
chr4_-_144826682 1.63 ENST00000358615.4
ENST00000437468.2
glycophorin E (MNS blood group)
chr11_-_78285804 1.60 ENST00000281038.5
ENST00000529571.1
asparaginyl-tRNA synthetase 2, mitochondrial (putative)
chr17_-_41132410 1.60 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chrX_-_153744434 1.59 ENST00000369643.1
ENST00000393572.1
family with sequence similarity 3, member A
chr5_+_176784837 1.57 ENST00000408923.3
regulator of G-protein signaling 14
chr18_+_11981427 1.57 ENST00000269159.3
inositol(myo)-1(or 4)-monophosphatase 2
chr22_+_37447771 1.56 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
potassium channel tetramerization domain containing 17
chr2_-_24583583 1.52 ENST00000355123.4
intersectin 2
chr16_+_3062457 1.49 ENST00000445369.2
claudin 9
chr3_+_5020801 1.37 ENST00000256495.3
basic helix-loop-helix family, member e40
chr17_+_66508537 1.34 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr21_-_36259445 1.26 ENST00000399240.1
runt-related transcription factor 1
chr9_-_26892765 1.24 ENST00000520187.1
ENST00000333916.5
caspase activity and apoptosis inhibitor 1
chr8_+_38854418 1.21 ENST00000481513.1
ENST00000487273.2
ADAM metallopeptidase domain 9
chr2_-_175462934 1.21 ENST00000392546.2
ENST00000436221.1
WAS/WASL interacting protein family, member 1
chr6_-_89927151 1.17 ENST00000454853.2
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr15_+_89402148 1.17 ENST00000560601.1
aggrecan
chr12_+_53399942 1.16 ENST00000262056.9
eukaryotic translation initiation factor 4B
chr17_+_79989500 1.16 ENST00000306897.4
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr14_+_90422239 1.14 ENST00000393452.3
ENST00000554180.1
ENST00000393454.2
ENST00000553617.1
ENST00000335725.4
ENST00000357382.3
ENST00000556867.1
ENST00000553527.1
tyrosyl-DNA phosphodiesterase 1
chr3_+_57994127 1.08 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
filamin B, beta
chr19_-_10697895 1.04 ENST00000591240.1
ENST00000589684.1
ENST00000591676.1
ENST00000250244.6
ENST00000590923.1
adaptor-related protein complex 1, mu 2 subunit
chr19_+_41305406 1.04 ENST00000406058.2
ENST00000593726.1
egl-9 family hypoxia-inducible factor 2
chr9_-_123555655 1.00 ENST00000340778.5
ENST00000453291.1
ENST00000608872.1
F-box and WD repeat domain containing 2
chr14_-_99947168 0.96 ENST00000331768.5
SET domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HMX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0035470 positive regulation of vascular wound healing(GO:0035470) regulation of lactation(GO:1903487)
3.9 23.4 GO:0006177 GMP biosynthetic process(GO:0006177)
3.4 17.1 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
3.1 9.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
2.6 10.4 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
2.5 7.5 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
2.4 7.3 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
2.4 11.9 GO:2000035 regulation of stem cell division(GO:2000035)
1.9 21.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.9 19.2 GO:0032264 IMP salvage(GO:0032264)
1.8 9.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
1.8 12.6 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
1.7 5.2 GO:0001079 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
1.7 5.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
1.7 6.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.6 4.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
1.6 6.3 GO:0000255 allantoin metabolic process(GO:0000255)
1.4 12.5 GO:0021943 formation of radial glial scaffolds(GO:0021943)
1.4 4.1 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
1.3 5.3 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.3 9.0 GO:0060011 Sertoli cell proliferation(GO:0060011)
1.2 3.7 GO:0061760 antifungal innate immune response(GO:0061760)
1.1 4.6 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
1.1 9.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
1.1 5.5 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
1.0 3.1 GO:0031133 regulation of axon diameter(GO:0031133)
1.0 18.3 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
1.0 4.9 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.9 6.6 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.9 6.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.9 4.6 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.9 13.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.8 2.5 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.8 2.5 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.8 4.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.7 7.4 GO:0015939 lysine metabolic process(GO:0006553) pantothenate metabolic process(GO:0015939)
0.7 5.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.7 5.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.7 6.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.7 2.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.6 2.4 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.6 1.8 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350) 'de novo' GDP-L-fucose biosynthetic process(GO:0042351)
0.6 8.9 GO:0000338 protein deneddylation(GO:0000338)
0.5 7.1 GO:0070986 left/right axis specification(GO:0070986)
0.5 2.2 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.5 7.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.5 1.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.5 6.2 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.4 3.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.4 3.9 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.4 1.7 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.4 2.1 GO:0048539 bone marrow development(GO:0048539)
0.4 3.0 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.4 6.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 1.2 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.4 3.2 GO:1904996 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.4 5.5 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.4 2.5 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.4 3.5 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.3 7.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 9.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 5.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 2.0 GO:0006021 inositol biosynthetic process(GO:0006021)
0.3 3.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 3.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.3 4.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.3 3.1 GO:0001711 endodermal cell fate commitment(GO:0001711) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.3 2.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 0.8 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.3 1.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 4.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 0.7 GO:1990523 bone regeneration(GO:1990523)
0.2 1.7 GO:0060972 left/right pattern formation(GO:0060972)
0.2 1.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 6.3 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.2 3.8 GO:0030220 platelet formation(GO:0030220)
0.2 13.0 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.2 2.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.2 4.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 6.0 GO:0000154 rRNA modification(GO:0000154)
0.2 1.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 2.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 2.4 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.2 8.8 GO:0043277 apoptotic cell clearance(GO:0043277)
0.2 7.5 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.2 6.7 GO:0006363 transcription elongation from RNA polymerase I promoter(GO:0006362) termination of RNA polymerase I transcription(GO:0006363)
0.2 5.7 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.2 9.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 3.8 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 1.1 GO:0000012 single strand break repair(GO:0000012)
0.1 5.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 4.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.3 GO:0021894 regulation of neuron maturation(GO:0014041) cerebral cortex GABAergic interneuron development(GO:0021894)
0.1 1.9 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 1.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 2.8 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.1 1.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 0.5 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.1 1.8 GO:0002517 T cell tolerance induction(GO:0002517)
0.1 1.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 0.4 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 1.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 3.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 6.2 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 12.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 11.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.1 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 9.3 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.1 1.6 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.1 0.4 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 4.8 GO:0031295 T cell costimulation(GO:0031295)
0.1 4.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 6.6 GO:0030218 erythrocyte differentiation(GO:0030218)
0.1 1.1 GO:0003334 keratinocyte development(GO:0003334) cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 8.4 GO:0007605 sensory perception of sound(GO:0007605)
0.1 4.7 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 7.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 8.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 8.9 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 5.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.4 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.8 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.0 GO:2000382 positive regulation of mesoderm development(GO:2000382)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 18.3 GO:0045323 interleukin-1 receptor complex(GO:0045323)
2.6 7.7 GO:0031523 Myb complex(GO:0031523)
1.1 4.6 GO:0044611 nuclear pore inner ring(GO:0044611)
1.0 5.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
1.0 2.9 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.9 10.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.9 5.2 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.8 2.4 GO:0097441 basilar dendrite(GO:0097441)
0.8 4.9 GO:0071817 MMXD complex(GO:0071817)
0.7 9.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.7 4.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.7 4.0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 13.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.6 4.4 GO:0016272 prefoldin complex(GO:0016272)
0.6 5.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 6.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 5.2 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.5 7.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 5.5 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 4.7 GO:0000125 PCAF complex(GO:0000125)
0.5 11.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.5 7.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.5 22.0 GO:0008180 COP9 signalosome(GO:0008180)
0.4 4.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 9.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.4 5.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.4 6.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 3.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.3 25.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3 22.5 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 7.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 2.8 GO:0032797 SMN complex(GO:0032797)
0.2 3.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 6.2 GO:0005840 ribosome(GO:0005840)
0.2 4.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 3.0 GO:0005869 dynactin complex(GO:0005869)
0.2 12.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 2.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.7 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 8.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 3.5 GO:0031264 death-inducing signaling complex(GO:0031264)
0.2 5.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 2.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2 3.9 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 7.0 GO:0001772 immunological synapse(GO:0001772)
0.1 4.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 20.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 8.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 2.7 GO:0005686 U2 snRNP(GO:0005686)
0.1 9.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.4 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 3.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 9.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 5.5 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 7.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 1.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 11.3 GO:0044452 nucleolar part(GO:0044452)
0.1 4.9 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.1 2.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 7.8 GO:0005884 actin filament(GO:0005884)
0.1 3.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 7.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 4.7 GO:0005903 brush border(GO:0005903)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.0 1.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 5.5 GO:0030496 midbody(GO:0030496)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.8 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.6 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 23.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
4.3 12.8 GO:0001069 regulatory region RNA binding(GO:0001069)
3.4 17.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
2.6 18.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
2.1 19.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.9 7.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.7 5.2 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
1.7 16.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.5 4.6 GO:0070538 oleic acid binding(GO:0070538)
1.4 4.1 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
1.4 9.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.2 7.5 GO:0019238 cyclohydrolase activity(GO:0019238)
1.1 6.5 GO:0047685 amine sulfotransferase activity(GO:0047685)
1.0 4.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.9 4.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.9 6.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.9 5.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.9 9.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.8 2.5 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.7 6.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.6 3.5 GO:0070513 death domain binding(GO:0070513)
0.6 6.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.6 1.7 GO:0032427 GBD domain binding(GO:0032427)
0.5 2.0 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.5 2.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.4 3.6 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.4 9.0 GO:0051400 BH domain binding(GO:0051400)
0.4 8.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.4 3.9 GO:0043426 MRF binding(GO:0043426)
0.4 5.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 2.0 GO:0052832 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.4 8.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 3.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 6.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.4 6.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 7.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.3 7.5 GO:0008242 omega peptidase activity(GO:0008242)
0.3 17.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.3 10.4 GO:0017091 AU-rich element binding(GO:0017091)
0.3 1.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.3 13.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 4.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 28.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 3.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 6.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 5.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 5.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 3.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 7.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 5.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 4.8 GO:0042605 peptide antigen binding(GO:0042605)
0.1 2.4 GO:0043495 protein anchor(GO:0043495)
0.1 8.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.4 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 9.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 12.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 3.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 11.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 8.3 GO:0005518 collagen binding(GO:0005518)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 4.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 5.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 2.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 2.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 14.4 GO:0003924 GTPase activity(GO:0003924)
0.0 8.9 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.6 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 1.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 6.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.8 GO:0050661 NADP binding(GO:0050661)
0.0 1.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 18.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 30.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 6.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 6.3 PID IL5 PATHWAY IL5-mediated signaling events
0.3 4.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 8.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 4.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 11.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 21.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 7.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 4.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 14.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 5.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 12.6 PID LKB1 PATHWAY LKB1 signaling events
0.2 9.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 5.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 11.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 7.3 PID ATR PATHWAY ATR signaling pathway
0.1 3.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 8.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 5.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 5.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 8.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 7.2 PID P73PATHWAY p73 transcription factor network
0.1 2.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.5 PID ARF6 PATHWAY Arf6 signaling events
0.1 4.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 7.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 11.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 17.8 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
1.4 23.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.2 10.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.8 11.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.8 19.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 11.9 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.6 7.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.6 17.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.5 7.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.5 7.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.4 18.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 13.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 4.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 13.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 11.6 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.4 10.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 8.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 7.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.3 6.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.3 25.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 12.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 9.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 6.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.2 4.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 6.2 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 10.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 3.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 4.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 6.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 11.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 3.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 5.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 17.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.4 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 3.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 6.6 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.1 2.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.9 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 9.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 2.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.7 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells