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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA1

Z-value: 1.07

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Transcription factors associated with HOXA1

Gene Symbol Gene ID Gene Info
ENSG00000105991.7 homeobox A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA1hg19_v2_chr7_-_27135591_27135658-0.045.2e-01Click!

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_104152922 31.82 ENST00000309982.5
ENST00000438105.2
ENST00000297574.6
brain and acute leukemia, cytoplasmic
chr8_-_27468842 28.84 ENST00000523500.1
clusterin
chr5_-_42825983 28.79 ENST00000506577.1
selenoprotein P, plasma, 1
chr8_-_27462822 23.03 ENST00000522098.1
clusterin
chr8_-_27468945 22.94 ENST00000405140.3
clusterin
chr8_-_27115931 19.27 ENST00000523048.1
stathmin-like 4
chr20_-_23618582 18.46 ENST00000398411.1
ENST00000376925.3
cystatin C
chrX_-_13835147 18.39 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr8_-_27469196 18.10 ENST00000546343.1
ENST00000560566.1
clusterin
chr20_+_44036620 17.53 ENST00000372710.3
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr12_-_91539918 17.24 ENST00000548218.1
decorin
chr3_-_149688655 17.15 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
profilin 2
chr8_-_27115903 16.65 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
stathmin-like 4
chr2_+_149632783 16.54 ENST00000435030.1
kinesin family member 5C
chr6_+_121756809 15.98 ENST00000282561.3
gap junction protein, alpha 1, 43kDa
chr11_-_5248294 15.61 ENST00000335295.4
hemoglobin, beta
chr11_-_72353451 15.37 ENST00000376450.3
phosphodiesterase 2A, cGMP-stimulated
chr20_+_44036900 14.43 ENST00000443296.1
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_+_166300084 14.14 ENST00000402744.4
carboxypeptidase E
chr9_-_101471479 13.56 ENST00000259455.2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_+_24272576 13.42 ENST00000380986.4
ENST00000452109.1
FK506 binding protein 1B, 12.6 kDa
chr19_+_5681011 13.25 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
hydroxysteroid (11-beta) dehydrogenase 1-like
chr6_-_52705641 12.76 ENST00000370989.2
glutathione S-transferase alpha 5
chr1_+_2005425 12.31 ENST00000461106.2
protein kinase C, zeta
chr20_+_34742650 12.24 ENST00000373945.1
ENST00000338074.2
erythrocyte membrane protein band 4.1-like 1
chr20_-_3154162 11.69 ENST00000360342.3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr4_+_113970772 11.57 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr16_+_15596123 10.95 ENST00000452191.2
chromosome 16 open reading frame 45
chr11_-_104034827 10.51 ENST00000393158.2
platelet derived growth factor D
chr1_-_241520385 10.30 ENST00000366564.1
regulator of G-protein signaling 7
chr2_+_24272543 10.19 ENST00000380991.4
FK506 binding protein 1B, 12.6 kDa
chr5_-_693500 10.16 ENST00000360578.5
tubulin polymerization promoting protein
chr16_+_66914264 10.02 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr19_-_49944806 9.86 ENST00000221485.3
solute carrier family 17 (vesicular glutamate transporter), member 7
chr14_-_23822061 9.81 ENST00000397260.3
solute carrier family 22, member 17
chr8_+_22132847 9.31 ENST00000521356.1
piwi-like RNA-mediated gene silencing 2
chr11_-_104035088 9.26 ENST00000302251.5
platelet derived growth factor D
chr8_+_22132810 9.01 ENST00000356766.6
piwi-like RNA-mediated gene silencing 2
chr2_-_50574856 8.94 ENST00000342183.5
neurexin 1
chr7_+_100136811 8.90 ENST00000300176.4
ENST00000262935.4
ArfGAP with FG repeats 2
chr4_+_71587669 8.23 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr3_+_159557637 8.15 ENST00000445224.2
schwannomin interacting protein 1
chr19_+_19144384 8.04 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
armadillo repeat containing 6
chr1_+_10271674 7.86 ENST00000377086.1
kinesin family member 1B
chr22_-_29711645 7.79 ENST00000401450.3
RAS-like, family 10, member A
chr2_-_44588694 7.78 ENST00000409957.1
prolyl endopeptidase-like
chr19_+_13875316 7.54 ENST00000319545.8
ENST00000593245.1
ENST00000040663.6
methylthioribose-1-phosphate isomerase 1
chrX_-_57937067 7.41 ENST00000358697.4
zinc finger, X-linked, duplicated A
chr7_-_137028534 7.28 ENST00000348225.2
pleiotrophin
chr2_-_44588679 7.24 ENST00000409411.1
prolyl endopeptidase-like
chr3_+_159570722 6.93 ENST00000482804.1
schwannomin interacting protein 1
chr7_-_137028498 6.89 ENST00000393083.2
pleiotrophin
chr10_+_7745303 6.88 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_38537960 6.70 ENST00000453767.1
endo/exonuclease (5'-3'), endonuclease G-like
chr12_+_12878829 6.15 ENST00000326765.6
apolipoprotein L domain containing 1
chr1_+_65730385 6.11 ENST00000263441.7
ENST00000395325.3
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_-_129612394 6.10 ENST00000505616.1
ENST00000426664.2
transmembrane and coiled-coil domain family 1
chr7_-_994302 6.08 ENST00000265846.5
ArfGAP with dual PH domains 1
chr5_+_175792459 6.01 ENST00000310389.5
ADP-ribosylation factor-like 10
chr9_-_97402413 5.58 ENST00000414122.1
fructose-1,6-bisphosphatase 1
chr1_-_13673511 5.57 ENST00000344998.3
ENST00000334600.6
PRAME family member 14
chr17_-_42277203 5.52 ENST00000587097.1
ataxin 7-like 3
chr6_+_151561085 5.49 ENST00000402676.2
A kinase (PRKA) anchor protein 12
chr16_+_75256507 5.48 ENST00000495583.1
chymotrypsinogen B1
chr10_+_7745232 5.32 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr19_-_39368887 5.28 ENST00000340740.3
ENST00000591812.1
Ras and Rab interactor-like
chr17_-_3499125 5.25 ENST00000399759.3
transient receptor potential cation channel, subfamily V, member 1
chrM_+_4431 5.15 ENST00000361453.3
mitochondrially encoded NADH dehydrogenase 2
chr19_-_40732594 5.10 ENST00000430325.2
ENST00000433940.1
cyclin N-terminal domain containing 2
chr9_+_10613163 5.06 ENST00000429581.2
RP11-87N24.2
chr12_-_101604185 5.03 ENST00000536262.2
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr6_-_154677900 4.97 ENST00000265198.4
ENST00000520261.1
interaction protein for cytohesin exchange factors 1
chr1_-_13452656 4.91 ENST00000376132.3
PRAME family member 13
chr16_-_49890016 4.87 ENST00000563137.2
zinc finger protein 423
chrX_+_57618269 4.85 ENST00000374888.1
zinc finger, X-linked, duplicated B
chr10_-_79397391 4.84 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr16_+_29674540 4.75 ENST00000436527.1
ENST00000360121.3
ENST00000449759.1
sialophorin
quinolinate phosphoribosyltransferase
chr12_+_125478241 4.73 ENST00000341446.8
BRI3 binding protein
chr1_-_40098672 4.65 ENST00000535435.1
hes-related family bHLH transcription factor with YRPW motif-like
chr12_-_121342170 4.58 ENST00000353487.2
signal peptide peptidase like 3
chr12_-_11548496 4.54 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr22_+_29834572 4.51 ENST00000354373.2
ret finger protein-like 1
chr3_+_4535155 4.50 ENST00000544951.1
inositol 1,4,5-trisphosphate receptor, type 1
chr10_+_60272814 4.40 ENST00000373886.3
bicaudal C homolog 1 (Drosophila)
chr1_+_205473720 4.40 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chrX_-_148586804 4.33 ENST00000428056.2
ENST00000340855.6
ENST00000370441.4
ENST00000370443.4
iduronate 2-sulfatase
chr6_+_7108210 4.32 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
ras responsive element binding protein 1
chr8_-_91095099 4.31 ENST00000265431.3
calbindin 1, 28kDa
chr20_+_8112824 4.28 ENST00000378641.3
phospholipase C, beta 1 (phosphoinositide-specific)
chr4_-_90229142 4.25 ENST00000609438.1
GPRIN family member 3
chr17_-_3195876 4.18 ENST00000323404.1
olfactory receptor, family 3, subfamily A, member 1
chr4_+_86396265 4.16 ENST00000395184.1
Rho GTPase activating protein 24
chr6_+_151561506 4.15 ENST00000253332.1
A kinase (PRKA) anchor protein 12
chr7_-_22233442 4.06 ENST00000401957.2
Rap guanine nucleotide exchange factor (GEF) 5
chr11_+_68228186 4.02 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
protein phosphatase 6, regulatory subunit 3
chr1_-_7913089 3.99 ENST00000361696.5
urotensin 2
chr4_+_154178520 3.98 ENST00000433687.1
tripartite motif containing 2
chr1_+_3614591 3.93 ENST00000378290.4
tumor protein p73
chr11_+_61717336 3.76 ENST00000378042.3
bestrophin 1
chr11_+_61717279 3.73 ENST00000378043.4
bestrophin 1
chr1_+_162602244 3.70 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr5_-_177210399 3.68 ENST00000510276.1
family with sequence similarity 153, member A
chrX_-_63005405 3.66 ENST00000374878.1
ENST00000437457.2
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr9_-_97402531 3.65 ENST00000415431.1
fructose-1,6-bisphosphatase 1
chr12_+_57610562 3.61 ENST00000349394.5
neurexophilin 4
chr5_-_20575959 3.60 ENST00000507958.1
cadherin 18, type 2
chr1_+_202976493 3.56 ENST00000367242.3
transmembrane protein 183A
chr1_-_12958101 3.55 ENST00000235347.4
PRAME family member 10
chr1_-_45140074 3.52 ENST00000420706.1
ENST00000372235.3
ENST00000372242.3
ENST00000372243.3
ENST00000372244.3
transmembrane protein 53
chr7_+_94139105 3.49 ENST00000297273.4
CAS1 domain containing 1
chr5_-_125930929 3.48 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr9_+_132962843 3.45 ENST00000458469.1
neuronal calcium sensor 1
chr5_+_36152179 3.38 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr12_-_89919965 3.33 ENST00000548729.1
POC1B-GALNT4 readthrough
chr7_+_79765071 3.33 ENST00000457358.2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chrX_+_82763265 3.33 ENST00000373200.2
POU class 3 homeobox 4
chr9_-_5304432 3.31 ENST00000416837.1
ENST00000308420.3
relaxin 2
chr19_+_54641444 3.29 ENST00000221232.5
ENST00000358389.3
CCR4-NOT transcription complex, subunit 3
chr12_-_71533055 3.29 ENST00000552128.1
tetraspanin 8
chr2_+_162016827 3.26 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TRAF family member-associated NFKB activator
chr5_-_133702761 3.19 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
cyclin-dependent kinase-like 3
chr16_+_23847267 3.19 ENST00000321728.7
protein kinase C, beta
chr12_+_123459127 3.16 ENST00000397389.2
ENST00000538755.1
ENST00000536150.1
ENST00000545056.1
ENST00000545612.1
ENST00000538628.1
ENST00000545317.1
2-oxoglutarate and iron-dependent oxygenase domain containing 2
chr12_-_21927736 3.12 ENST00000240662.2
potassium inwardly-rectifying channel, subfamily J, member 8
chrX_+_15808569 3.04 ENST00000380308.3
ENST00000307771.7
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr10_-_105615164 3.03 ENST00000355946.2
ENST00000369774.4
SH3 and PX domains 2A
chrX_+_9217932 2.99 ENST00000432442.1
GS1-519E5.1
chr1_+_12916941 2.98 ENST00000240189.2
PRAME family member 2
chr11_+_2482661 2.98 ENST00000335475.5
potassium voltage-gated channel, KQT-like subfamily, member 1
chr17_-_44896047 2.95 ENST00000225512.5
wingless-type MMTV integration site family, member 3
chr13_-_20735178 2.95 ENST00000241125.3
gap junction protein, alpha 3, 46kDa
chr19_-_42927251 2.88 ENST00000597001.1
lipase, hormone-sensitive
chr17_-_15502111 2.86 ENST00000354433.3
CMT1A duplicated region transcript 1
chr12_-_96794330 2.80 ENST00000261211.3
cyclin-dependent kinase 17
chr13_+_92050928 2.80 ENST00000377067.3
glypican 5
chr11_+_63870660 2.78 ENST00000246841.3
fibronectin leucine rich transmembrane protein 1
chr11_-_2162162 2.77 ENST00000381389.1
insulin-like growth factor 2 (somatomedin A)
chr15_-_58306295 2.72 ENST00000559517.1
aldehyde dehydrogenase 1 family, member A2
chr5_+_159656437 2.67 ENST00000402432.3
fatty acid binding protein 6, ileal
chr3_+_4535025 2.66 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
inositol 1,4,5-trisphosphate receptor, type 1
chr19_-_51192661 2.47 ENST00000391813.1
SH3 and multiple ankyrin repeat domains 1
chr14_+_65453432 2.45 ENST00000246166.2
farnesyltransferase, CAAX box, beta
chr16_+_71660079 2.38 ENST00000565261.1
ENST00000268485.3
ENST00000299952.4
MARVEL domain containing 3
chr19_-_33360647 2.38 ENST00000590341.1
ENST00000587772.1
ENST00000023064.4
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr9_-_89562104 2.32 ENST00000298743.7
growth arrest-specific 1
chr17_+_26800296 2.32 ENST00000444914.3
ENST00000314669.5
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr12_-_96794143 2.31 ENST00000543119.2
cyclin-dependent kinase 17
chr12_+_54402790 2.31 ENST00000040584.4
homeobox C8
chr7_-_44180884 2.31 ENST00000458240.1
ENST00000223364.3
myosin, light chain 7, regulatory
chr12_+_8276495 2.31 ENST00000546339.1
C-type lectin domain family 4, member A
chr9_+_87285257 2.28 ENST00000323115.4
neurotrophic tyrosine kinase, receptor, type 2
chr1_+_17634689 2.20 ENST00000375453.1
ENST00000375448.4
peptidyl arginine deiminase, type IV
chr6_+_25754927 2.19 ENST00000377905.4
ENST00000439485.2
solute carrier family 17, member 4
chr2_-_79313973 2.18 ENST00000454188.1
regenerating islet-derived 1 beta
chr7_-_126892303 2.12 ENST00000358373.3
glutamate receptor, metabotropic 8
chr5_-_141338627 2.11 ENST00000231484.3
protocadherin 12
chr15_-_63674034 2.10 ENST00000344366.3
ENST00000422263.2
carbonic anhydrase XII
chr9_+_33795533 2.07 ENST00000379405.3
protease, serine, 3
chr1_-_20306909 2.04 ENST00000375111.3
ENST00000400520.3
phospholipase A2, group IIA (platelets, synovial fluid)
chrX_+_37639302 2.04 ENST00000545017.1
ENST00000536160.1
cytochrome b-245, beta polypeptide
chr10_-_134756030 2.03 ENST00000368586.5
ENST00000368582.2
tetratricopeptide repeat domain 40
chr11_+_60739249 1.96 ENST00000542157.1
ENST00000433107.2
ENST00000452451.2
ENST00000352009.5
CD6 molecule
chr8_+_143530791 1.94 ENST00000517894.1
brain-specific angiogenesis inhibitor 1
chr2_+_65215604 1.90 ENST00000531327.1
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr5_+_125758865 1.90 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr17_+_61554413 1.80 ENST00000538928.1
ENST00000290866.4
ENST00000428043.1
angiotensin I converting enzyme
chr3_+_44916098 1.78 ENST00000296125.4
transglutaminase 4
chr1_-_111061797 1.75 ENST00000369771.2
potassium voltage-gated channel, shaker-related subfamily, member 10
chr14_+_24779340 1.72 ENST00000533293.1
ENST00000543919.1
leukotriene B4 receptor 2
chr14_+_22948510 1.71 ENST00000390483.1
T cell receptor alpha joining 56
chr17_-_18950950 1.68 ENST00000284154.5
GRB2-related adaptor protein
chr17_-_39041479 1.65 ENST00000167588.3
keratin 20
chr15_-_43513187 1.64 ENST00000540029.1
ENST00000441366.2
erythrocyte membrane protein band 4.2
chr8_-_40755333 1.63 ENST00000297737.6
ENST00000315769.7
zinc finger, matrin-type 4
chr20_+_52105495 1.61 ENST00000439873.2
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr19_+_54371114 1.61 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
myeloid-associated differentiation marker
chr2_+_8822113 1.60 ENST00000396290.1
ENST00000331129.3
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr6_-_47009996 1.58 ENST00000371243.2
G protein-coupled receptor 110
chr13_+_102104952 1.57 ENST00000376180.3
integrin, beta-like 1 (with EGF-like repeat domains)
chr16_-_55867146 1.56 ENST00000422046.2
carboxylesterase 1
chr17_+_72270429 1.54 ENST00000311014.6
dynein, axonemal, intermediate chain 2
chr6_+_42123141 1.54 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr20_+_36012051 1.52 ENST00000373567.2
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr11_+_122753391 1.52 ENST00000307257.6
ENST00000227349.2
chromosome 11 open reading frame 63
chr10_+_98741041 1.51 ENST00000286067.2
chromosome 10 open reading frame 12
chr16_+_23847339 1.50 ENST00000303531.7
protein kinase C, beta
chr17_-_40264692 1.49 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr17_-_15501932 1.49 ENST00000583965.1
CMT1A duplicated region transcript 1
chr16_+_14805546 1.41 ENST00000552140.1
nuclear pore complex interacting protein family, member A3
chr19_-_42192096 1.40 ENST00000602225.1
carcinoembryonic antigen-related cell adhesion molecule 7
chr16_+_16472912 1.37 ENST00000530217.2
nuclear pore complex interacting protein family, member A7
chr7_-_99332719 1.31 ENST00000336374.2
cytochrome P450, family 3, subfamily A, polypeptide 7
chr17_-_73401567 1.27 ENST00000392562.1
growth factor receptor-bound protein 2
chr12_-_23737534 1.27 ENST00000396007.2
SRY (sex determining region Y)-box 5
chr10_+_18689637 1.25 ENST00000377315.4
calcium channel, voltage-dependent, beta 2 subunit
chr22_+_35695793 1.23 ENST00000456128.1
ENST00000449058.2
ENST00000411850.1
ENST00000425375.1
ENST00000436462.2
ENST00000382034.5
target of myb1 (chicken)
chr19_+_58193337 1.23 ENST00000601064.1
ENST00000282296.5
ENST00000356715.4
zinc finger protein 551
chr19_-_15544099 1.22 ENST00000599910.2
widely interspaced zinc finger motifs
chr7_+_97736197 1.22 ENST00000297293.5
lemur tyrosine kinase 2
chr11_+_3666335 1.20 ENST00000250693.1
ADP-ribosyltransferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 92.9 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
6.6 19.8 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
6.1 18.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
5.1 15.4 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
4.7 14.2 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
4.6 18.5 GO:0051541 elastin metabolic process(GO:0051541) negative regulation of blood vessel remodeling(GO:0060313)
4.3 4.3 GO:2000437 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
4.0 16.0 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
3.9 15.6 GO:0030185 nitric oxide transport(GO:0030185)
3.9 11.6 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.3 9.9 GO:0042137 sequestering of neurotransmitter(GO:0042137)
2.8 14.1 GO:0030070 insulin processing(GO:0030070)
2.6 7.9 GO:1904647 response to rotenone(GO:1904647)
2.4 23.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.3 9.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
2.2 10.9 GO:1903976 negative regulation of glial cell migration(GO:1903976)
2.1 12.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
2.0 9.8 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
1.8 18.4 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.7 5.2 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
1.6 4.7 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
1.6 17.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
1.6 4.7 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
1.4 4.3 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
1.4 17.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.4 7.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.2 4.7 GO:0002884 regulation of type IV hypersensitivity(GO:0001807) negative regulation of hypersensitivity(GO:0002884)
1.1 8.9 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.0 4.0 GO:0042320 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
1.0 2.9 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) Spemann organizer formation(GO:0060061)
0.9 0.9 GO:0086100 endothelin receptor signaling pathway(GO:0086100)
0.8 7.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.8 2.5 GO:0050894 determination of affect(GO:0050894)
0.8 3.0 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.7 3.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 4.3 GO:0015811 L-cystine transport(GO:0015811)
0.7 32.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.7 6.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.6 2.9 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.6 7.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.6 4.6 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.6 10.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.5 2.2 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.5 4.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.5 4.8 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.5 1.6 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.5 3.2 GO:0055064 chloride ion homeostasis(GO:0055064)
0.5 2.0 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.5 1.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.5 3.5 GO:0042426 choline catabolic process(GO:0042426)
0.5 5.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.5 17.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.5 2.3 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.4 11.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 2.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 2.5 GO:0018343 protein farnesylation(GO:0018343)
0.4 1.2 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.4 1.5 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.4 15.0 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.4 1.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.4 3.0 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.4 5.0 GO:0015671 oxygen transport(GO:0015671)
0.4 15.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.4 4.2 GO:0042118 endothelial cell activation(GO:0042118)
0.3 2.7 GO:0035799 ureter maturation(GO:0035799)
0.3 13.8 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.3 0.9 GO:0035524 proline transmembrane transport(GO:0035524)
0.3 3.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.3 7.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 8.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.3 3.3 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.3 1.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.3 2.8 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.3 12.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 1.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.3 0.8 GO:1904861 excitatory synapse assembly(GO:1904861)
0.2 1.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 2.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.2 3.9 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.2 3.1 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.2 2.4 GO:1902414 protein localization to cell junction(GO:1902414)
0.2 1.2 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 12.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 4.3 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.2 11.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 1.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.2 1.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 1.6 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 2.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 1.5 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 3.2 GO:0030517 negative regulation of axon extension(GO:0030517)
0.1 12.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 6.1 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 2.0 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 3.3 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 2.0 GO:0001771 immunological synapse formation(GO:0001771) positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.2 GO:0042940 D-amino acid transport(GO:0042940)
0.1 2.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 4.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.9 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 3.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 28.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 1.1 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.1 0.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 4.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 1.7 GO:0045109 intermediate filament organization(GO:0045109)
0.1 2.8 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939) vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.1 3.4 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 2.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 2.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.5 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 0.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.6 GO:0070831 basement membrane assembly(GO:0070831)
0.1 3.3 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 42.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 3.5 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.9 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 3.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 3.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.2 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 1.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 3.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 3.3 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.4 GO:0048535 lymph node development(GO:0048535)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 2.3 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.8 GO:0018146 keratan sulfate biosynthetic process(GO:0018146) keratan sulfate metabolic process(GO:0042339)
0.0 2.3 GO:0006936 muscle contraction(GO:0006936)
0.0 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 6.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 4.0 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.1 GO:0061086 regulation of mRNA export from nucleus(GO:0010793) negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.3 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.5 GO:0072678 T cell migration(GO:0072678)
0.0 1.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0002507 tolerance induction(GO:0002507)
0.0 0.8 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 92.9 GO:0097418 neurofibrillary tangle(GO:0097418)
4.5 13.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
3.9 15.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
3.7 18.3 GO:0071546 perinucleolar chromocenter(GO:0010370) pi-body(GO:0071546)
1.5 12.3 GO:0045179 apical cortex(GO:0045179)
1.3 16.5 GO:0035253 ciliary rootlet(GO:0035253)
1.2 9.9 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
1.2 17.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.1 16.0 GO:0005916 fascia adherens(GO:0005916)
1.0 3.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
1.0 10.2 GO:0097427 microtubule bundle(GO:0097427)
0.8 7.2 GO:0005955 calcineurin complex(GO:0005955)
0.7 4.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.6 2.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.6 3.0 GO:0089701 U2AF(GO:0089701)
0.5 24.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 32.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 3.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 22.9 GO:0043195 terminal bouton(GO:0043195)
0.3 3.4 GO:0031045 dense core granule(GO:0031045)
0.3 37.9 GO:0005604 basement membrane(GO:0005604)
0.3 26.7 GO:0042734 presynaptic membrane(GO:0042734)
0.3 2.9 GO:1990909 Wnt signalosome(GO:1990909)
0.3 5.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 10.9 GO:0043034 costamere(GO:0043034)
0.3 7.8 GO:0071437 invadopodium(GO:0071437)
0.2 53.5 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 37.4 GO:0030426 growth cone(GO:0030426)
0.2 1.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.2 7.9 GO:1904115 axon cytoplasm(GO:1904115)
0.2 2.9 GO:0000124 SAGA complex(GO:0000124)
0.2 1.5 GO:0036157 outer dynein arm(GO:0036157)
0.1 2.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 6.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.8 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 9.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 7.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 10.7 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 3.0 GO:0002102 podosome(GO:0002102)
0.1 1.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 2.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 9.2 GO:0001650 fibrillar center(GO:0001650)
0.1 4.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 15.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 12.6 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 3.1 GO:0043197 dendritic spine(GO:0043197)
0.0 2.9 GO:0005901 caveola(GO:0005901)
0.0 13.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.0 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 4.9 GO:0001726 ruffle(GO:0001726)
0.0 4.3 GO:0043209 myelin sheath(GO:0043209)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 5.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 1.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:0034584 piRNA binding(GO:0034584)
4.7 23.6 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
4.6 92.9 GO:0051787 misfolded protein binding(GO:0051787)
4.5 13.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
3.5 14.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
2.7 16.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
2.6 15.6 GO:0030492 hemoglobin binding(GO:0030492)
2.6 15.4 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
2.5 9.9 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
2.3 9.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.8 7.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.7 10.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
1.6 4.7 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
1.6 4.7 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
1.3 5.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
1.3 29.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
1.2 4.7 GO:0035939 microsatellite binding(GO:0035939)
1.1 4.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
1.0 3.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
1.0 6.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
1.0 2.9 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.9 10.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.9 19.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.8 2.5 GO:0031877 somatostatin receptor binding(GO:0031877)
0.8 2.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.7 3.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 4.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.7 4.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.7 7.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.6 13.6 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.6 2.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.6 3.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.6 9.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 18.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 8.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 3.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.5 3.0 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.5 7.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.5 2.3 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.5 5.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.4 2.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.4 3.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 1.2 GO:0070984 SET domain binding(GO:0070984)
0.4 7.9 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.4 1.5 GO:0071253 connexin binding(GO:0071253)
0.4 17.1 GO:0003785 actin monomer binding(GO:0003785)
0.4 6.7 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.4 2.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.4 1.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 3.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.6 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.3 4.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 1.5 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 2.7 GO:0005243 gap junction channel activity(GO:0005243)
0.3 3.9 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 0.9 GO:0004962 endothelin receptor activity(GO:0004962)
0.3 2.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.3 3.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 2.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.3 1.1 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.3 6.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 12.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 7.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 1.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 3.3 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.2 18.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 15.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.8 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.2 4.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.2 0.8 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.2 2.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.2 3.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 2.7 GO:0032052 bile acid binding(GO:0032052)
0.2 4.3 GO:0005521 lamin binding(GO:0005521)
0.2 1.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 2.9 GO:0048018 receptor agonist activity(GO:0048018)
0.2 0.9 GO:0004447 iodide peroxidase activity(GO:0004447)
0.1 0.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 2.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.8 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 12.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 3.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 6.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 5.1 GO:0030507 spectrin binding(GO:0030507)
0.1 2.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 5.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 2.8 GO:0030546 receptor activator activity(GO:0030546)
0.1 0.9 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.1 28.2 GO:0015631 tubulin binding(GO:0015631)
0.1 4.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.3 GO:0070330 aromatase activity(GO:0070330)
0.1 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 1.3 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 18.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 8.3 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 2.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.0 GO:0008066 glutamate receptor activity(GO:0008066)
0.0 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 3.3 GO:0005178 integrin binding(GO:0005178)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 1.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 4.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 1.2 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 87.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.5 33.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.5 15.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 18.3 PID RAS PATHWAY Regulation of Ras family activation
0.3 4.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 17.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 13.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 5.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3 16.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 11.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 14.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 4.3 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 6.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 34.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.5 PID CONE PATHWAY Visual signal transduction: Cones
0.1 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 4.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID ENDOTHELIN PATHWAY Endothelins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 16.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.9 15.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.8 21.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.6 10.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.6 90.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.5 14.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 12.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 9.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.4 4.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 15.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.4 17.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 12.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 7.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 10.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 7.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 2.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 3.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 6.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 9.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 4.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 2.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 6.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 1.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 2.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.0 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 6.0 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 3.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 1.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 3.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 6.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.4 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.1 1.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 4.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 8.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation