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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA10_HOXB9
Z-value: 0.75
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Transcription factors associated with HOXA10_HOXB9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA10 | hg19_v2_chr7_-_27213893_27213954 | -0.21 | 1.6e-03 | Click! |
| HOXB9 | hg19_v2_chr17_-_46703826_46703845 | -0.13 | 6.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_84630645 Show fit | 8.47 |
ENST00000394839.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr15_-_55541227 Show fit | 8.33 |
ENST00000566877.1
|
RAB27A, member RAS oncogene family |
|
| chr10_-_73848086 Show fit | 7.61 |
ENST00000536168.1
|
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
|
| chr10_-_73848531 Show fit | 7.11 |
ENST00000373109.2
|
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 |
|
| chr3_-_18480260 Show fit | 6.61 |
ENST00000454909.2
|
SATB homeobox 1 |
|
| chr8_-_81083890 Show fit | 6.15 |
ENST00000518937.1
|
tumor protein D52 |
|
| chr4_-_71532339 Show fit | 5.87 |
ENST00000254801.4
|
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr2_-_51259292 Show fit | 5.80 |
ENST00000401669.2
|
neurexin 1 |
|
| chr4_+_71248795 Show fit | 5.74 |
ENST00000304915.3
|
submaxillary gland androgen regulated protein 3B |
|
| chr2_-_51259229 Show fit | 5.74 |
ENST00000405472.3
|
neurexin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA10_HOXB9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 12.5 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 1.4 | 11.5 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.1 | 9.9 | GO:0007338 | single fertilization(GO:0007338) |
| 1.7 | 8.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.4 | 8.3 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.9 | 7.6 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.5 | 7.3 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.2 | 6.9 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.6 | 6.6 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 11.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 9.7 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 8.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 8.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.7 | 8.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 1.5 | 7.6 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.2 | 7.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.3 | 7.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 7.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.8 | 12.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.5 | 8.5 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 8.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 8.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.6 | 8.2 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 7.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 7.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 5.3 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 4.8 | GO:0030295 | protein kinase activator activity(GO:0030295) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 12.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 12.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.3 | 7.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 6.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 4.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 8.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 7.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.4 | 7.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 7.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 6.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 6.0 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 3.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 3.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 3.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |