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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA4

Z-value: 0.51

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27170352_27170418-0.194.8e-03Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_50144381 8.94 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr15_+_75080883 8.64 ENST00000567571.1
CSK
c-src tyrosine kinase
chr5_+_49962495 7.69 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr13_-_46716969 7.05 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_52486841 6.84 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr17_-_56082455 6.37 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr1_+_155658849 5.84 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
DAP3
death associated protein 3
chr19_-_42806919 5.80 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr12_+_56521840 5.67 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr6_+_63921399 5.28 ENST00000356170.3
FKBP1C
FK506 binding protein 1C
chr15_+_80351910 5.12 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr13_-_41593425 4.78 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr18_+_3247779 4.26 ENST00000578611.1
ENST00000583449.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr15_+_80351977 4.18 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr12_+_53848549 4.10 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr14_-_36988882 3.79 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr6_+_63921351 3.73 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr2_-_43453734 3.71 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr1_+_167298281 3.55 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr3_+_107241783 3.47 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX
bobby sox homolog (Drosophila)
chr11_-_62313090 3.17 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr6_-_55739542 3.14 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr15_+_89631647 3.04 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr12_+_53848505 2.97 ENST00000552819.1
ENST00000455667.3
PCBP2
poly(rC) binding protein 2
chr22_+_22930626 2.90 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr14_-_38064198 2.87 ENST00000250448.2
FOXA1
forkhead box A1
chr7_-_140714430 2.84 ENST00000393008.3
MRPS33
mitochondrial ribosomal protein S33
chr11_+_128563652 2.84 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr8_+_22424551 2.81 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr17_-_10452929 2.80 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr17_-_48785216 2.79 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr7_-_29234802 2.72 ENST00000449801.1
ENST00000409850.1
CPVL
carboxypeptidase, vitellogenic-like
chr14_-_36989336 2.68 ENST00000522719.2
NKX2-1
NK2 homeobox 1
chr8_-_95449155 2.57 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr11_-_69633792 2.51 ENST00000334134.2
FGF3
fibroblast growth factor 3
chr1_+_81771806 2.51 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr12_-_57037284 2.47 ENST00000551570.1
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr10_+_11047259 2.35 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr4_-_41884620 2.23 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr11_-_27494279 2.19 ENST00000379214.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr1_+_214161272 2.04 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr10_-_101825151 2.02 ENST00000441382.1
CPN1
carboxypeptidase N, polypeptide 1
chr17_-_77924627 1.95 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr19_-_51220176 1.88 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr10_-_105845674 1.85 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr17_-_10421853 1.76 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr7_+_100273736 1.70 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chrX_-_119445306 1.68 ENST00000371369.4
ENST00000440464.1
ENST00000519908.1
TMEM255A
transmembrane protein 255A
chr12_-_86650077 1.66 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_145278475 1.66 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_+_87135076 1.62 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr11_+_112832133 1.58 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr10_-_92681033 1.56 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_69134080 1.52 ENST00000273258.3
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr5_+_49962772 1.51 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chr11_-_13517565 1.42 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chrX_-_119445263 1.41 ENST00000309720.5
TMEM255A
transmembrane protein 255A
chr17_-_10372875 1.39 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr3_+_88188254 1.38 ENST00000309495.5
ZNF654
zinc finger protein 654
chr12_-_24103954 1.37 ENST00000441133.2
ENST00000545921.1
SOX5
SRY (sex determining region Y)-box 5
chr1_-_42384343 1.37 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr7_+_32996997 1.34 ENST00000242209.4
ENST00000538336.1
ENST00000538443.1
FKBP9
FK506 binding protein 9, 63 kDa
chr4_-_66536057 1.29 ENST00000273854.3
EPHA5
EPH receptor A5
chr12_+_29376592 1.25 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr15_+_89631381 1.24 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr12_-_91398796 1.23 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr11_-_27494309 1.23 ENST00000389858.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr12_+_29376673 1.17 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr6_-_55740352 1.12 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr7_+_129015484 1.09 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr3_-_57233966 1.08 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr20_+_32150140 1.08 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr17_+_37894570 1.06 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr17_-_39538550 1.06 ENST00000394001.1
KRT34
keratin 34
chr3_+_69134124 1.02 ENST00000478935.1
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr14_-_54423529 1.01 ENST00000245451.4
ENST00000559087.1
BMP4
bone morphogenetic protein 4
chr2_+_128403439 0.99 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr2_+_101437487 0.96 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr11_+_128563948 0.94 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr17_-_10325261 0.93 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr4_-_66536196 0.88 ENST00000511294.1
EPHA5
EPH receptor A5
chr2_+_54683419 0.87 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_-_86650045 0.87 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_190927447 0.81 ENST00000260950.4
MSTN
myostatin
chr7_-_14026063 0.73 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr1_-_204329013 0.70 ENST00000272203.3
ENST00000414478.1
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr2_-_163100045 0.69 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr5_+_159343688 0.69 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr3_+_121311966 0.65 ENST00000338040.4
FBXO40
F-box protein 40
chr1_+_151739131 0.65 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr9_-_113342160 0.62 ENST00000401783.2
ENST00000374461.1
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr7_-_14026123 0.56 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ETV1
ets variant 1
chr14_+_39734482 0.55 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE5
CTAGE family, member 5
chr7_+_107110488 0.55 ENST00000304402.4
GPR22
G protein-coupled receptor 22
chr2_-_163099885 0.53 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr6_+_152011628 0.52 ENST00000404742.1
ENST00000440973.1
ESR1
estrogen receptor 1
chr2_+_128403720 0.52 ENST00000272644.3
GPR17
G protein-coupled receptor 17
chr12_-_10959892 0.51 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr14_+_37131058 0.48 ENST00000361487.6
PAX9
paired box 9
chr8_-_99954788 0.41 ENST00000523601.1
STK3
serine/threonine kinase 3
chr1_+_160160346 0.38 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_+_50786414 0.37 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr10_-_101690650 0.36 ENST00000543621.1
DNMBP
dynamin binding protein
chr10_-_33623310 0.33 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
NRP1
neuropilin 1
chr11_+_120971882 0.24 ENST00000392793.1
TECTA
tectorin alpha
chr6_-_116447283 0.24 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr10_-_69455873 0.23 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr7_+_117251671 0.18 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr1_-_12677714 0.14 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_+_53818855 0.13 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chr17_+_73452545 0.07 ENST00000314256.7
KIAA0195
KIAA0195
chr6_-_26235206 0.06 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr5_-_1882858 0.06 ENST00000511126.1
ENST00000231357.2
IRX4
iroquois homeobox 4
chr2_-_69098566 0.05 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr7_+_95115210 0.03 ENST00000428113.1
ENST00000325885.5
ASB4
ankyrin repeat and SOCS box containing 4
chr1_+_160160283 0.02 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr8_-_67090825 0.01 ENST00000276571.3
CRH
corticotropin releasing hormone

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
1.7 6.8 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
1.5 8.9 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.4 4.3 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
1.3 6.5 GO:0021759 globus pallidus development(GO:0021759)
0.9 3.4 GO:0060995 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.8 2.4 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.7 2.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.7 2.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.6 1.9 GO:0050894 determination of affect(GO:0050894)
0.5 3.7 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.5 1.4 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.4 7.1 GO:0051639 actin filament network formation(GO:0051639)
0.4 7.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.4 1.7 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.4 2.0 GO:0030070 insulin processing(GO:0030070)
0.4 9.3 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.3 1.0 GO:0072099 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.3 2.5 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.3 2.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.3 1.2 GO:0097325 melanocyte proliferation(GO:0097325)
0.2 2.8 GO:0001778 plasma membrane repair(GO:0001778)
0.2 1.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.2 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 10.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 0.8 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell proliferation(GO:0014859) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.2 4.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 3.8 GO:0035855 megakaryocyte development(GO:0035855)
0.2 0.7 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.2 4.5 GO:0048240 sperm capacitation(GO:0048240)
0.2 1.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.6 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 8.7 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 1.5 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 2.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 2.5 GO:0055026 negative regulation of cardiac muscle tissue development(GO:0055026)
0.1 0.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.5 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.3 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.1 GO:0034063 stress granule assembly(GO:0034063)
0.1 2.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.0 GO:0051775 response to redox state(GO:0051775)
0.1 3.2 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 5.7 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 1.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 4.3 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.9 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.4 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.0 3.6 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.1 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 1.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 2.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.2 GO:0086073 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.5 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 2.9 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.0 GO:0042321 negative regulation of epinephrine secretion(GO:0032811) negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.6 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 5.8 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 4.6 GO:0006936 muscle contraction(GO:0006936)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.9 2.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.4 5.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.4 7.1 GO:0001891 phagocytic cup(GO:0001891)
0.4 2.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.3 4.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.3 8.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 4.1 GO:0032982 myosin filament(GO:0032982)
0.1 1.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.9 GO:0032437 cuticular plate(GO:0032437)
0.1 1.2 GO:0071438 invadopodium membrane(GO:0071438)
0.1 2.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 4.3 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 7.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.9 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116) sorting endosome(GO:0097443)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 11.6 GO:0030055 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) cell-substrate junction(GO:0030055)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 3.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.5 GO:0031674 I band(GO:0031674)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.9 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.2 7.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
1.2 5.8 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.8 2.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.6 1.9 GO:0031877 somatostatin receptor binding(GO:0031877)
0.6 6.8 GO:0031013 troponin I binding(GO:0031013)
0.5 1.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.4 6.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.4 2.5 GO:0043532 angiostatin binding(GO:0043532)
0.4 5.3 GO:0070700 BMP receptor binding(GO:0070700)
0.4 2.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 10.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 8.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.3 4.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 4.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 9.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 2.0 GO:0050692 DBD domain binding(GO:0050692)
0.2 3.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 0.7 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.2 2.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 9.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 1.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 3.2 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.9 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 4.2 GO:0000146 microfilament motor activity(GO:0000146)
0.1 2.8 GO:0017166 vinculin binding(GO:0017166)
0.1 2.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 2.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 8.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.5 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 1.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 6.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 1.3 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.6 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.7 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 1.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.1 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 9.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 8.6 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 3.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 5.3 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.6 PID FGF PATHWAY FGF signaling pathway
0.0 8.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 2.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 7.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 7.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 2.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 1.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 2.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo