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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB13

Z-value: 0.39

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 homeobox B13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.195.4e-03Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_118401706 7.57 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
TMEM25
transmembrane protein 25
chr3_-_195310802 5.72 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr18_-_52989217 5.32 ENST00000570287.2
TCF4
transcription factor 4
chr3_-_114790179 4.31 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_84630645 4.18 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_51259292 3.80 ENST00000401669.2
NRXN1
neurexin 1
chr18_-_52989525 3.69 ENST00000457482.3
TCF4
transcription factor 4
chr2_-_51259229 3.60 ENST00000405472.3
NRXN1
neurexin 1
chr19_+_35634146 3.60 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chrM_+_12331 3.57 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr8_+_86376081 3.38 ENST00000285379.5
CA2
carbonic anhydrase II
chr1_+_84630053 3.30 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_136288113 3.30 ENST00000401392.1
ZRANB3
zinc finger, RAN-binding domain containing 3
chr9_-_130829588 2.55 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr1_-_45956822 2.49 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr1_+_66458072 2.11 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr17_-_73663168 2.09 ENST00000578201.1
ENST00000423245.2
RECQL5
RecQ protein-like 5
chr19_+_1440838 2.02 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr19_-_5903714 1.92 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr16_+_30669720 1.77 ENST00000356166.6
FBRS
fibrosin
chr17_-_73663245 1.69 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr2_+_67624430 1.69 ENST00000272342.5
ETAA1
Ewing tumor-associated antigen 1
chr9_+_103947311 1.62 ENST00000395056.2
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr9_+_125132803 1.60 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_14180778 1.53 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr12_-_81992111 1.37 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr12_-_52715179 1.27 ENST00000293670.3
KRT83
keratin 83
chr4_+_95972822 1.26 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr16_-_71610985 1.18 ENST00000355962.4
TAT
tyrosine aminotransferase
chr8_+_119294456 1.09 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr9_-_104198042 1.00 ENST00000374855.4
ALDOB
aldolase B, fructose-bisphosphate
chr1_-_45956800 0.92 ENST00000538496.1
TESK2
testis-specific kinase 2
chr7_-_50860565 0.87 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr8_+_77593474 0.84 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr8_+_97597148 0.82 ENST00000521590.1
SDC2
syndecan 2
chr8_+_77593448 0.79 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr1_+_78769549 0.66 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr2_-_175629135 0.62 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr3_+_89156674 0.58 ENST00000336596.2
EPHA3
EPH receptor A3
chr2_-_175629164 0.54 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr14_-_50583271 0.48 ENST00000395860.2
ENST00000395859.2
VCPKMT
valosin containing protein lysine (K) methyltransferase
chr11_+_63606373 0.45 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
MARK2
MAP/microtubule affinity-regulating kinase 2
chr6_+_27782788 0.44 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr6_-_27782548 0.39 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr3_+_89156799 0.25 ENST00000452448.2
ENST00000494014.1
EPHA3
EPH receptor A3
chr17_-_10560619 0.21 ENST00000583535.1
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr11_-_102826434 0.17 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr1_+_52682052 0.14 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr1_+_210501589 0.13 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr9_+_125133315 0.07 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_123710199 0.03 ENST00000184183.4
ROPN1
rhophilin associated tail protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
1.5 7.5 GO:0097338 response to clozapine(GO:0097338)
1.3 3.8 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
1.1 3.4 GO:0042938 dipeptide transport(GO:0042938)
0.9 7.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.7 3.3 GO:0048478 replication fork protection(GO:0048478)
0.3 1.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.3 0.8 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.3 1.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 1.5 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 2.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 1.9 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.8 GO:0008218 bioluminescence(GO:0008218)
0.1 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.7 GO:0031297 replication fork processing(GO:0031297)
0.1 0.7 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 4.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.9 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 3.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.6 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 9.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.5 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 3.4 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 1.4 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.2 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 1.3 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 5.0 GO:0043596 nuclear replication fork(GO:0043596)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 5.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.4 GO:0048786 presynaptic active zone(GO:0048786)
0.1 7.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 8.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.0 GO:0034451 centriolar satellite(GO:0034451)
0.0 3.1 GO:0005902 microvillus(GO:0005902)
0.0 3.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 5.7 GO:0022626 cytosolic ribosome(GO:0022626)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.6 3.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.5 3.3 GO:0036310 annealing helicase activity(GO:0036310)
0.5 7.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 7.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 3.4 GO:0004064 arylesterase activity(GO:0004064)
0.4 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 1.2 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.4 1.9 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.2 0.7 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 5.7 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 2.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 3.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0005158 insulin receptor binding(GO:0005158)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.5 PID IL3 PATHWAY IL3-mediated signaling events
0.1 9.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID IGF1 PATHWAY IGF1 pathway
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.8 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 3.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 9.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.8 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends