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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB3

Z-value: 0.83

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Transcription factors associated with HOXB3

Gene Symbol Gene ID Gene Info
HOXB3
ENSG00000120093.7 homeobox B3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB3hg19_v2_chr17_-_46667594_46667619-0.392.1e-09Click!

Activity profile of HOXB3 motif

Sorted Z-values of HOXB3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_187371440 33.22 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr6_+_34204642 12.29 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr15_-_55563072 12.20 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_55562479 11.18 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr4_+_113568207 10.46 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr2_+_172778952 9.91 ENST00000392584.1
ENST00000264108.4
HAT1
histone acetyltransferase 1
chr3_+_158519654 9.58 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr17_-_8113542 9.52 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
AURKB
aurora kinase B
chr2_-_10587897 9.11 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr16_+_103816 9.06 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr3_-_185538849 8.50 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr9_-_116172946 8.44 ENST00000374171.4
POLE3
polymerase (DNA directed), epsilon 3, accessory subunit
chr11_-_107729887 8.32 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr1_-_197115818 7.78 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr11_-_104817919 7.67 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_77225135 7.50 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr17_-_27418537 7.44 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr15_-_55562582 7.41 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr1_+_79115503 6.92 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr12_-_123187890 6.80 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr16_-_66864806 6.77 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr12_-_123201337 6.68 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr12_+_28410128 6.63 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr11_-_104827425 6.63 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr1_-_146040968 6.44 ENST00000401010.3
NBPF11
neuroblastoma breakpoint family, member 11
chr15_-_101835110 6.18 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr4_-_25865159 6.09 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr1_+_220267429 5.97 ENST00000366922.1
ENST00000302637.5
IARS2
isoleucyl-tRNA synthetase 2, mitochondrial
chr1_+_158978768 5.95 ENST00000447473.2
IFI16
interferon, gamma-inducible protein 16
chr11_-_104905840 5.94 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr16_-_28621353 5.84 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_+_121447469 5.76 ENST00000532694.1
ENST00000534286.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr5_+_115177178 5.68 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr1_-_68698197 5.66 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr8_-_49834299 5.57 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr1_+_174843548 5.51 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr17_-_47785504 5.29 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1
solute carrier family 35, member B1
chr3_-_39321512 5.25 ENST00000399220.2
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr17_+_73257945 5.12 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr2_+_143635067 5.12 ENST00000264170.4
KYNU
kynureninase
chr3_-_151047327 5.11 ENST00000325602.5
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr1_+_144173162 5.04 ENST00000356801.6
NBPF8
neuroblastoma breakpoint family, member 8
chr14_-_69864993 4.89 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr2_-_220264703 4.89 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
DNPEP
aspartyl aminopeptidase
chr12_-_118797475 4.63 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr15_+_64680003 4.56 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr19_+_10362577 4.54 ENST00000592514.1
ENST00000307422.5
ENST00000253099.6
ENST00000590150.1
ENST00000590669.1
MRPL4
mitochondrial ribosomal protein L4
chr8_-_121457608 4.47 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr1_+_24019099 4.40 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr6_+_36562132 4.40 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr14_-_54908043 4.31 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr15_+_41057818 4.26 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr19_+_1077393 4.25 ENST00000590577.1
HMHA1
histocompatibility (minor) HA-1
chr8_-_49833978 4.17 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr21_-_15918618 4.14 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_149721495 4.09 ENST00000326669.4
SUMO4
small ubiquitin-like modifier 4
chr7_+_26331541 4.06 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr11_+_73498898 4.05 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr5_+_148737562 3.78 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr11_-_59950486 3.70 ENST00000426738.2
ENST00000533023.1
ENST00000420732.2
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr22_-_29107919 3.68 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr12_+_64798095 3.66 ENST00000332707.5
XPOT
exportin, tRNA
chr12_+_56521840 3.62 ENST00000394048.5
ESYT1
extended synaptotagmin-like protein 1
chr14_+_102276132 3.59 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr19_+_18669809 3.50 ENST00000602094.1
KXD1
KxDL motif containing 1
chr6_-_82957433 3.45 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr15_+_59279851 3.37 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr22_+_21996549 3.30 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chr5_+_140019004 3.29 ENST00000394671.3
ENST00000511410.1
ENST00000537378.1
TMCO6
transmembrane and coiled-coil domains 6
chr11_+_95523621 3.23 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
CEP57
centrosomal protein 57kDa
chr18_+_55888767 3.22 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr22_-_32651326 3.12 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr4_-_102268484 3.07 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_152486950 2.96 ENST00000368790.3
CRCT1
cysteine-rich C-terminal 1
chr15_-_101835414 2.90 ENST00000254193.6
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr19_+_10362882 2.88 ENST00000393733.2
ENST00000588502.1
MRPL4
mitochondrial ribosomal protein L4
chr4_-_164534657 2.83 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr2_+_143635222 2.83 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU
kynureninase
chr2_-_3606206 2.82 ENST00000315212.3
RNASEH1
ribonuclease H1
chr11_-_3818932 2.75 ENST00000324932.7
ENST00000359171.4
NUP98
nucleoporin 98kDa
chr2_+_86669118 2.75 ENST00000427678.1
ENST00000542128.1
KDM3A
lysine (K)-specific demethylase 3A
chr12_-_8088871 2.71 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr12_-_10022735 2.71 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_-_59950519 2.70 ENST00000528851.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr12_+_22778009 2.67 ENST00000266517.4
ENST00000335148.3
ETNK1
ethanolamine kinase 1
chr15_-_37393406 2.62 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr19_+_11071546 2.46 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_+_234637754 2.46 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr11_+_5710919 2.37 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr16_-_28621298 2.36 ENST00000566189.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_59950622 2.34 ENST00000323961.3
ENST00000412309.2
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr16_+_50730910 2.33 ENST00000300589.2
NOD2
nucleotide-binding oligomerization domain containing 2
chr17_+_46970134 2.33 ENST00000503641.1
ENST00000514808.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr18_+_268148 2.31 ENST00000581677.1
RP11-705O1.8
RP11-705O1.8
chr6_-_111804905 2.30 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_+_208423840 2.30 ENST00000539789.1
CREB1
cAMP responsive element binding protein 1
chr19_-_54824344 2.27 ENST00000346508.3
ENST00000446712.3
ENST00000432233.3
ENST00000301219.3
LILRA5
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr14_-_23058063 2.23 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr22_+_22730353 2.23 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr12_-_10978957 2.22 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr2_+_11682790 2.17 ENST00000389825.3
ENST00000381483.2
GREB1
growth regulation by estrogen in breast cancer 1
chr8_-_122653630 2.13 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr12_-_122985067 2.11 ENST00000540586.1
ENST00000543897.1
ZCCHC8
zinc finger, CCHC domain containing 8
chr2_+_138722028 2.10 ENST00000280096.5
HNMT
histamine N-methyltransferase
chr7_+_120628731 2.09 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr17_+_46970178 2.09 ENST00000393366.2
ENST00000506855.1
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr4_+_144354644 2.00 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr17_+_46970127 1.95 ENST00000355938.5
ATP5G1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr12_-_6484376 1.95 ENST00000360168.3
ENST00000358945.3
SCNN1A
sodium channel, non-voltage-gated 1 alpha subunit
chr19_+_12848299 1.95 ENST00000357332.3
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr1_-_1710229 1.94 ENST00000341991.3
NADK
NAD kinase
chrX_-_102757802 1.93 ENST00000372633.1
RAB40A
RAB40A, member RAS oncogene family
chr16_+_12059091 1.89 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_+_140019079 1.89 ENST00000252100.6
TMCO6
transmembrane and coiled-coil domains 6
chr3_+_121774202 1.88 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr12_+_22778116 1.87 ENST00000538218.1
ETNK1
ethanolamine kinase 1
chr22_-_50219548 1.84 ENST00000404034.1
BRD1
bromodomain containing 1
chr4_-_66536057 1.81 ENST00000273854.3
EPHA5
EPH receptor A5
chr1_+_192605252 1.77 ENST00000391995.2
ENST00000543215.1
RGS13
regulator of G-protein signaling 13
chr4_+_40198527 1.77 ENST00000381799.5
RHOH
ras homolog family member H
chr7_-_100239132 1.75 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chrX_-_24690771 1.75 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr1_-_1709845 1.69 ENST00000341426.5
ENST00000344463.4
NADK
NAD kinase
chr6_-_133035185 1.63 ENST00000367928.4
VNN1
vanin 1
chr4_+_110736659 1.61 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr16_+_31366536 1.55 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_-_151034734 1.50 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr16_-_21868739 1.49 ENST00000415645.2
NPIPB4
nuclear pore complex interacting protein family, member B4
chr16_-_21868978 1.48 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
NPIPB4
nuclear pore complex interacting protein family, member B4
chr14_-_90085458 1.45 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr4_-_66536196 1.35 ENST00000511294.1
EPHA5
EPH receptor A5
chr16_-_28621312 1.34 ENST00000314752.7
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr7_-_134896234 1.29 ENST00000354475.4
ENST00000344400.5
WDR91
WD repeat domain 91
chr22_-_30234218 1.25 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr11_-_102709441 1.19 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr16_-_11036300 1.17 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr16_+_12059050 1.16 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_67266939 1.15 ENST00000304526.2
INSL5
insulin-like 5
chr1_+_156030937 1.14 ENST00000361084.5
RAB25
RAB25, member RAS oncogene family
chr7_-_134855517 1.11 ENST00000430372.1
C7orf49
chromosome 7 open reading frame 49
chr2_-_89160770 1.06 ENST00000390240.2
IGKJ3
immunoglobulin kappa joining 3
chr19_+_48949030 1.04 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr14_-_25479811 1.02 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr3_-_105588231 1.00 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr16_-_29415350 0.97 ENST00000524087.1
NPIPB11
nuclear pore complex interacting protein family, member B11
chr1_-_93257951 0.97 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr9_+_125133315 0.96 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_125590818 0.93 ENST00000259467.4
PDCL
phosducin-like
chr1_-_68698222 0.86 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr1_-_109935819 0.85 ENST00000538502.1
SORT1
sortilin 1
chr12_-_51422017 0.85 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr2_-_70780572 0.84 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr1_+_186265399 0.83 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr3_-_164796269 0.82 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chrX_-_48824793 0.80 ENST00000376477.1
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr9_+_130911723 0.79 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
LCN2
lipocalin 2
chr20_+_1099233 0.79 ENST00000246015.4
ENST00000335877.6
ENST00000438768.2
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr7_-_99764853 0.78 ENST00000411994.1
ENST00000426974.2
GAL3ST4
galactose-3-O-sulfotransferase 4
chr12_-_10605929 0.74 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chrX_+_135730297 0.72 ENST00000370629.2
CD40LG
CD40 ligand
chr16_-_21431078 0.72 ENST00000458643.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr14_+_22320634 0.72 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr7_+_100860949 0.71 ENST00000305105.2
ZNHIT1
zinc finger, HIT-type containing 1
chr9_+_125132803 0.70 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_-_21891460 0.68 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr6_-_82462425 0.67 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr16_-_30257122 0.67 ENST00000520915.1
RP11-347C12.1
Putative NPIP-like protein LOC613037
chrX_+_106045891 0.67 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
TBC1D8B
TBC1 domain family, member 8B (with GRAM domain)
chr12_-_53171128 0.66 ENST00000332411.2
KRT76
keratin 76
chr11_+_3819049 0.65 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
PGAP2
post-GPI attachment to proteins 2
chr1_+_144989309 0.63 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr3_+_43732362 0.63 ENST00000458276.2
ABHD5
abhydrolase domain containing 5
chr9_+_130911770 0.62 ENST00000372998.1
LCN2
lipocalin 2
chr2_+_8822113 0.60 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr11_-_118134997 0.59 ENST00000278937.2
MPZL2
myelin protein zero-like 2
chr19_-_46088068 0.58 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr5_+_150639360 0.57 ENST00000523004.1
GM2A
GM2 ganglioside activator
chr22_-_30960876 0.54 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr16_+_31885079 0.53 ENST00000300870.10
ENST00000394846.3
ZNF267
zinc finger protein 267
chr8_-_141810634 0.51 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr5_-_35089722 0.50 ENST00000511486.1
ENST00000310101.5
ENST00000231423.3
ENST00000513753.1
ENST00000348262.3
ENST00000397391.3
ENST00000542609.1
PRLR
prolactin receptor
chr16_-_21436459 0.49 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr13_+_102142296 0.47 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr7_+_129015484 0.44 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr7_+_142458507 0.43 ENST00000492062.1
PRSS1
protease, serine, 1 (trypsin 1)
chr11_-_119991589 0.42 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr2_+_234580499 0.41 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr8_-_57123815 0.38 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr1_+_16090914 0.36 ENST00000441801.2
FBLIM1
filamin binding LIM protein 1
chr12_+_112563335 0.36 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAFD1
TRAF-type zinc finger domain containing 1
chr12_-_10959892 0.34 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr11_-_102651343 0.33 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr2_+_234580525 0.31 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chrX_+_135730373 0.29 ENST00000370628.2
CD40LG
CD40 ligand
chr4_+_5526883 0.27 ENST00000195455.2
C4orf6
chromosome 4 open reading frame 6
chr7_-_99716952 0.25 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_111563076 0.23 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2
chr2_+_234545148 0.21 ENST00000373445.1
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chrX_-_13835147 0.18 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr2_+_234545092 0.18 ENST00000344644.5
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 30.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
3.2 9.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
3.2 9.5 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
3.1 12.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
2.6 7.9 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
2.3 9.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
2.2 6.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
2.0 6.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.9 5.8 GO:1902771 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.9 7.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.8 20.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
1.8 5.3 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
1.7 5.2 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
1.4 4.3 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
1.4 6.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
1.4 6.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 3.8 GO:0030327 prenylated protein catabolic process(GO:0030327)
1.2 9.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
1.2 3.7 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.1 4.4 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
1.0 3.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.0 7.8 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.9 2.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.9 2.8 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.9 2.7 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.8 2.3 GO:0060584 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.7 0.7 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of coagulation(GO:0050818) regulation of hemostasis(GO:1900046)
0.6 3.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6 1.9 GO:0032641 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.6 3.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.6 2.8 GO:0070980 biphenyl catabolic process(GO:0070980)
0.6 6.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.6 2.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.5 2.5 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.4 2.1 GO:0070295 renal water absorption(GO:0070295)
0.4 3.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.4 10.3 GO:0009812 flavonoid metabolic process(GO:0009812)
0.4 2.3 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.4 5.7 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.3 6.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 3.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 21.0 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.3 1.4 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.3 8.4 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.2 1.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 0.9 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.2 1.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.2 1.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 4.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 6.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.2 1.6 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.2 1.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 0.8 GO:0015692 lead ion transport(GO:0015692)
0.2 0.8 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.2 4.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.2 3.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 3.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 3.2 GO:0034453 microtubule anchoring(GO:0034453)
0.1 1.1 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 3.1 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.8 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 4.9 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 6.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 7.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 2.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.8 GO:0045576 mast cell activation(GO:0045576)
0.1 1.1 GO:0031268 pseudopodium organization(GO:0031268)
0.1 0.9 GO:0051005 plasma membrane to endosome transport(GO:0048227) negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 3.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 7.3 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 0.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 2.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.1 13.1 GO:0051028 mRNA transport(GO:0051028)
0.1 4.6 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.1 0.6 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.6 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.1 0.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.8 GO:1903319 positive regulation of protein maturation(GO:1903319)
0.1 1.8 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.1 0.4 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 5.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 1.9 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.5 GO:0035902 response to immobilization stress(GO:0035902)
0.0 1.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 4.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 3.1 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.7 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 3.5 GO:0032418 lysosome localization(GO:0032418)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 2.2 GO:0018279 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.7 GO:0070206 protein trimerization(GO:0070206)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 7.4 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 6.8 GO:0009615 response to virus(GO:0009615)
0.0 1.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 2.6 GO:0031016 pancreas development(GO:0031016)
0.0 3.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.7 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.6 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
0.0 21.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.9 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 5.0 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.9 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.8 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 5.0 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.2 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.5 GO:0006487 protein N-linked glycosylation(GO:0006487)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
2.6 30.8 GO:0033093 Weibel-Palade body(GO:0033093)
1.7 8.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.2 9.5 GO:0032133 chromosome passenger complex(GO:0032133)
1.1 12.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.1 7.8 GO:0036449 microtubule minus-end(GO:0036449)
0.7 4.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.6 9.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.5 4.9 GO:0034709 methylosome(GO:0034709)
0.5 5.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.5 2.8 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.4 15.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 9.1 GO:0005686 U2 snRNP(GO:0005686)
0.4 6.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 3.1 GO:0005955 calcineurin complex(GO:0005955)
0.3 2.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.3 6.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 7.5 GO:0097228 sperm principal piece(GO:0097228)
0.3 1.6 GO:0072589 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.3 2.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 1.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 3.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 6.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 5.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 5.1 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 3.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 5.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 2.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.8 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 5.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.5 GO:0071564 npBAF complex(GO:0071564)
0.1 10.5 GO:0016363 nuclear matrix(GO:0016363)
0.1 5.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 3.2 GO:0005771 multivesicular body(GO:0005771)
0.1 7.0 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.1 GO:0031143 pseudopodium(GO:0031143)
0.0 4.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.4 GO:0015030 Cajal body(GO:0015030)
0.0 3.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.8 GO:0001772 immunological synapse(GO:0001772)
0.0 1.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 28.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.7 GO:0012505 endomembrane system(GO:0012505)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 6.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.5 GO:0031904 endosome lumen(GO:0031904)
0.0 1.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 4.8 GO:0016607 nuclear speck(GO:0016607)
0.0 1.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.7 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.9 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
2.0 7.9 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.9 7.5 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.8 5.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
1.7 5.2 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
1.6 22.6 GO:0050700 CARD domain binding(GO:0050700)
1.4 4.3 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
1.4 9.5 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
1.2 31.9 GO:0031489 myosin V binding(GO:0031489)
1.1 3.4 GO:0032184 SUMO polymer binding(GO:0032184)
1.1 9.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.9 9.1 GO:0030620 U2 snRNA binding(GO:0030620)
0.9 2.7 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.9 12.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.9 3.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.8 3.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.7 2.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.6 2.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 3.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.5 3.8 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.5 6.8 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.5 4.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.5 6.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.4 4.4 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.4 1.8 GO:0004998 transferrin receptor activity(GO:0004998)
0.4 9.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.4 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 3.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.4 10.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 1.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 4.1 GO:0031386 protein tag(GO:0031386)
0.3 1.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.3 6.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 5.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.3 1.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.3 3.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 4.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 3.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 8.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 2.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.3 0.8 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.3 1.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 6.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 2.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 2.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 4.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 4.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 0.9 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.2 4.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 2.5 GO:0030957 Tat protein binding(GO:0030957)
0.2 0.9 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.2 0.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 3.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 4.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 9.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.7 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 1.9 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 3.6 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 3.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.5 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 2.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 3.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 11.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 14.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 33.1 GO:0045296 cadherin binding(GO:0045296)
0.1 2.8 GO:0042287 MHC protein binding(GO:0042287)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.8 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 7.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 2.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 7.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 3.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 7.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 5.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 6.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 14.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 26.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 11.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 5.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 9.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 3.4 PID BCR 5PATHWAY BCR signaling pathway
0.1 4.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 2.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.2 30.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 7.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.5 22.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 9.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 7.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.3 6.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 6.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.3 5.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 3.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 11.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 7.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 5.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 9.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 3.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 8.7 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 10.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 3.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.2 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.3 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 1.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication