ISMARA results: HOXB6

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB6_PRRX2

Z-value: 2.13

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol	Gene ID	Gene Info
HOXB6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108511.8	homeobox B6
PRRX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000167157.9	paired related homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRRX2	hg19_v2_chr9_+_132427883_132427951	0.49	2.0e-14	Click!
HOXB6	hg19_v2_chr17_-_46682321_46682362	-0.06	3.6e-01	Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_16761007 Show fit	140.21	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr4_-_176733897 Show fit	133.83	ENST00000393658.2	GPM6A Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6A
chr2_-_175711133 Show fit	74.69	ENST00000409597.1 ENST00000413882.1	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr12_-_16759711 Show fit	64.75	ENST00000447609.1	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr16_+_7382745 Show fit	62.91	ENST00000436368.2 ENST00000311745.5 ENST00000355637.4 ENST00000340209.4	RBFOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_-_50201327 Show fit	58.09	ENST00000412315.1	NRXN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurexin 1
chr18_-_53089723 Show fit	56.11	ENST00000561992.1 ENST00000562512.2	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr1_+_50569575 Show fit	52.82	ENST00000371827.1	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr5_-_88179302 Show fit	52.26	ENST00000504921.2	MEF2C Ensembl NCBI GeneCards UniProt NextProt Show fit	myocyte enhancer factor 2C
chr13_-_67802549 Show fit	47.29	ENST00000328454.5 ENST00000377865.2	PCDH9 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin 9
chr1_+_50574585 Show fit	46.23	ENST00000371824.1 ENST00000371823.4	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr18_-_52989217 Show fit	46.01	ENST00000570287.2	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr3_+_111717600 Show fit	42.93	ENST00000273368.4	TAGLN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin 3
chr8_-_18744528 Show fit	41.55	ENST00000523619.1	PSD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin and Sec7 domain containing 3
chr8_+_80523321 Show fit	40.64	ENST00000518111.1	STMN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin-like 2
chr13_-_36429763 Show fit	40.48	ENST00000379893.1	DCLK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	doublecortin-like kinase 1
chr4_+_41258786 Show fit	39.77	ENST00000503431.1 ENST00000284440.4 ENST00000508768.1 ENST00000512788.1	UCHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr2_-_224467093 Show fit	38.80	ENST00000305409.2	SCG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	secretogranin II
chr3_+_111717511 Show fit	37.27	ENST00000478951.1 ENST00000393917.2	TAGLN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin 3
chr7_-_31380502 Show fit	37.04	ENST00000297142.3	NEUROD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal differentiation 6
chr12_-_16758304 Show fit	36.21	ENST00000320122.6	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr12_-_91576561 Show fit	35.81	ENST00000547568.2 ENST00000552962.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chrX_-_13835147 Show fit	35.69	ENST00000493677.1 ENST00000355135.2	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr3_+_111718036 Show fit	35.35	ENST00000455401.2	TAGLN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin 3
chr3_+_158787041 Show fit	35.18	ENST00000471575.1 ENST00000476809.1 ENST00000485419.1	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQCJ-SCHIP1 readthrough
chr5_-_24645078 Show fit	33.67	ENST00000264463.4	CDH10 Ensembl NCBI GeneCards UniProt NextProt Show fit	cadherin 10, type 2 (T2-cadherin)
chr12_-_16758059 Show fit	32.75	ENST00000261169.6	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr12_+_79258444 Show fit	32.61	ENST00000261205.4	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr3_+_111718173 Show fit	32.11	ENST00000494932.1	TAGLN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin 3
chr8_+_85618155 Show fit	31.34	ENST00000523850.1 ENST00000521376.1	RALYL Ensembl NCBI GeneCards UniProt NextProt Show fit	RALY RNA binding protein-like
chr3_+_159557637 Show fit	30.85	ENST00000445224.2	SCHIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	schwannomin interacting protein 1
chr12_-_91576429 Show fit	30.80	ENST00000552145.1 ENST00000546745.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_+_79258547 Show fit	30.51	ENST00000457153.2	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr12_-_91576750 Show fit	30.20	ENST00000228329.5 ENST00000303320.3 ENST00000052754.5	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr18_-_52989525 Show fit	29.70	ENST00000457482.3	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr6_-_46293378 Show fit	29.58	ENST00000330430.6	RCAN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulator of calcineurin 2
chr3_+_115342349 Show fit	28.54	ENST00000393780.3	GAP43 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth associated protein 43
chr5_+_66300446 Show fit	26.94	ENST00000261569.7	MAST4 Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule associated serine/threonine kinase family member 4
chr3_-_114477787 Show fit	26.70	ENST00000464560.1	ZBTB20 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 20
chr3_+_35721106 Show fit	26.58	ENST00000474696.1 ENST00000412048.1 ENST00000396482.2 ENST00000432682.1	ARPP21 Ensembl NCBI GeneCards UniProt NextProt Show fit	cAMP-regulated phosphoprotein, 21kDa
chr10_-_21786179 Show fit	25.93	ENST00000377113.5	CASC10 Ensembl NCBI GeneCards UniProt NextProt Show fit	cancer susceptibility candidate 10
chrX_-_13835461 Show fit	25.92	ENST00000316715.4 ENST00000356942.5	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr13_-_45010939 Show fit	25.41	ENST00000261489.2	TSC22D1 Ensembl NCBI GeneCards UniProt NextProt Show fit	TSC22 domain family, member 1
chr3_-_114477962 Show fit	25.04	ENST00000471418.1	ZBTB20 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 20
chr11_+_131240373 Show fit	24.56	ENST00000374791.3 ENST00000436745.1	NTM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurotrimin
chr14_+_22977587 Show fit	22.37	ENST00000390504.1	TRAJ33 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor alpha joining 33
chr4_-_41884620 Show fit	21.95	ENST00000504870.1	LINC00682 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 682
chr2_-_2334888 Show fit	21.32	ENST00000428368.2 ENST00000399161.2	MYT1L Ensembl NCBI GeneCards UniProt NextProt Show fit	myelin transcription factor 1-like
chr16_-_29910853 Show fit	21.27	ENST00000308713.5	SEZ6L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	seizure related 6 homolog (mouse)-like 2
chr8_-_102803163 Show fit	21.10	ENST00000523645.1 ENST00000520346.1 ENST00000220931.6 ENST00000522448.1 ENST00000522951.1 ENST00000522252.1 ENST00000519098.1	NCALD Ensembl NCBI GeneCards UniProt NextProt Show fit	neurocalcin delta
chr12_-_91539918 Show fit	20.99	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_-_129062093 Show fit	20.90	ENST00000310343.9	ARHGAP32 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 32
chr1_-_156399184 Show fit	20.42	ENST00000368243.1 ENST00000357975.4 ENST00000310027.5 ENST00000400991.2	C1orf61 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 61
chr1_+_65730385 Show fit	20.39	ENST00000263441.7 ENST00000395325.3	DNAJC6 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_+_87284622 Show fit	20.32	ENST00000395882.1	NTRK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurotrophic tyrosine kinase, receptor, type 2
chr11_-_111794446 Show fit	20.24	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr12_-_91574142 Show fit	20.24	ENST00000547937.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_+_183943464 Show fit	20.14	ENST00000354221.4	DUSP19 Ensembl NCBI GeneCards UniProt NextProt Show fit	dual specificity phosphatase 19
chrX_+_135278908 Show fit	19.70	ENST00000539015.1 ENST00000370683.1	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr8_-_120651020 Show fit	19.58	ENST00000522826.1 ENST00000520066.1 ENST00000259486.6 ENST00000075322.6	ENPP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_-_57045228 Show fit	19.44	ENST00000371250.3	PPAP2B Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidic acid phosphatase type 2B
chr12_+_79439405 Show fit	19.37	ENST00000552744.1	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr17_-_78450398 Show fit	19.26	ENST00000306773.4	NPTX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal pentraxin I
chrX_+_135251783 Show fit	19.13	ENST00000394153.2	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr11_-_111782696 Show fit	19.11	ENST00000227251.3 ENST00000526180.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr3_-_58613323 Show fit	19.05	ENST00000474531.1 ENST00000465970.1	FAM107A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 107, member A
chrX_+_135279179 Show fit	18.82	ENST00000370676.3	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr3_+_35722487 Show fit	18.80	ENST00000441454.1	ARPP21 Ensembl NCBI GeneCards UniProt NextProt Show fit	cAMP-regulated phosphoprotein, 21kDa
chr4_-_186877806 Show fit	18.60	ENST00000355634.5	SORBS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorbin and SH3 domain containing 2
chr4_-_87028478 Show fit	18.55	ENST00000515400.1 ENST00000395157.3	MAPK10 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitogen-activated protein kinase 10
chr1_+_84630053 Show fit	18.53	ENST00000394838.2 ENST00000370682.3 ENST00000432111.1	PRKACB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr5_+_170736243 Show fit	18.37	ENST00000296921.5	TLX3 Ensembl NCBI GeneCards UniProt NextProt Show fit	T-cell leukemia homeobox 3
chr6_+_45296048 Show fit	18.24	ENST00000465038.2 ENST00000352853.5 ENST00000541979.1 ENST00000371438.1	RUNX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	runt-related transcription factor 2
chr15_+_93443419 Show fit	18.22	ENST00000557381.1 ENST00000420239.2	CHD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromodomain helicase DNA binding protein 2
chr16_+_8806800 Show fit	18.01	ENST00000561870.1 ENST00000396600.2	ABAT Ensembl NCBI GeneCards UniProt NextProt Show fit	4-aminobutyrate aminotransferase
chr8_+_104831472 Show fit	17.95	ENST00000262231.10 ENST00000507740.1	RIMS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulating synaptic membrane exocytosis 2
chr18_-_21891460 Show fit	17.59	ENST00000357041.4	OSBPL1A Ensembl NCBI GeneCards UniProt NextProt Show fit	oxysterol binding protein-like 1A
chr18_-_53070913 Show fit	17.39	ENST00000568186.1 ENST00000564228.1	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr4_-_153274078 Show fit	17.37	ENST00000263981.5	FBXW7 Ensembl NCBI GeneCards UniProt NextProt Show fit	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_158141843 Show fit	17.35	ENST00000509417.1 ENST00000296526.7	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr11_-_125366089 Show fit	17.17	ENST00000366139.3 ENST00000278919.3	FEZ1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fasciculation and elongation protein zeta 1 (zygin I)
chr4_+_158141899 Show fit	16.53	ENST00000264426.9 ENST00000506284.1	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr2_+_166428839 Show fit	16.52	ENST00000342316.4	CSRNP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine-serine-rich nuclear protein 3
chr18_-_53177984 Show fit	16.40	ENST00000543082.1	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr4_+_72204755 Show fit	16.36	ENST00000512686.1 ENST00000340595.3	SLC4A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr7_-_27183263 Show fit	16.27	ENST00000222726.3	HOXA5 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox A5
chrX_+_135252050 Show fit	16.11	ENST00000449474.1 ENST00000345434.3	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr2_+_54785485 Show fit	15.83	ENST00000333896.5	SPTBN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin, beta, non-erythrocytic 1
chr4_+_113970772 Show fit	15.60	ENST00000504454.1 ENST00000394537.3 ENST00000357077.4 ENST00000264366.6	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chr14_-_98444386 Show fit	15.13	ENST00000556462.1 ENST00000556138.1	C14orf64 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 14 open reading frame 64
chr11_-_111782484 Show fit	15.06	ENST00000533971.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr8_-_18541603 Show fit	15.01	ENST00000428502.2	PSD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	pleckstrin and Sec7 domain containing 3
chr16_+_6533380 Show fit	14.95	ENST00000552089.1	RBFOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 1
chr5_+_156712372 Show fit	14.87	ENST00000541131.1	CYFIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytoplasmic FMR1 interacting protein 2
chr18_-_53069419 Show fit	14.81	ENST00000570177.2	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr2_-_60780536 Show fit	14.77	ENST00000538214.1	BCL11A Ensembl NCBI GeneCards UniProt NextProt Show fit	B-cell CLL/lymphoma 11A (zinc finger protein)
chrX_-_72434628 Show fit	14.66	ENST00000536638.1 ENST00000373517.3	NAP1L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	nucleosome assembly protein 1-like 2
chr15_+_34261089 Show fit	14.56	ENST00000383263.5	CHRM5 Ensembl NCBI GeneCards UniProt NextProt Show fit	cholinergic receptor, muscarinic 5
chr18_-_53257027 Show fit	14.49	ENST00000568740.1 ENST00000564403.2 ENST00000537578.1	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr1_+_50571949 Show fit	14.39	ENST00000357083.4	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr2_+_102508955 Show fit	14.34	ENST00000414004.2	FLJ20373 Ensembl NCBI GeneCards UniProt NextProt Show fit	FLJ20373
chr11_+_123396528 Show fit	14.32	ENST00000322282.7 ENST00000529750.1	GRAMD1B Ensembl NCBI GeneCards UniProt NextProt Show fit	GRAM domain containing 1B
chr6_+_45296391 Show fit	14.28	ENST00000371436.6 ENST00000576263.1	RUNX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	runt-related transcription factor 2
chr8_+_104892639 Show fit	14.20	ENST00000436393.2	RIMS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulating synaptic membrane exocytosis 2
chr4_+_158141806 Show fit	14.16	ENST00000393815.2	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr5_+_161494521 Show fit	14.08	ENST00000356592.3	GABRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_+_103204553 Show fit	13.94	ENST00000502978.1 ENST00000334943.6	MSANTD3-TMEFF1 Ensembl NCBI GeneCards UniProt NextProt Show fit TMEFF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	MSANTD3-TMEFF1 readthrough transmembrane protein with EGF-like and two follistatin-like domains 1
chr5_+_140810132 Show fit	13.91	ENST00000252085.3	PCDHGA12 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin gamma subfamily A, 12
chr14_-_101036119 Show fit	13.81	ENST00000355173.2	BEGAIN Ensembl NCBI GeneCards UniProt NextProt Show fit	brain-enriched guanylate kinase-associated
chr4_+_113739244 Show fit	13.77	ENST00000503271.1 ENST00000503423.1 ENST00000506722.1	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chr4_+_88754069 Show fit	13.62	ENST00000395102.4 ENST00000497649.2	MEPE Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix extracellular phosphoglycoprotein
chr22_-_36236623 Show fit	13.61	ENST00000405409.2	RBFOX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_114343039 Show fit	13.52	ENST00000481632.1	ZBTB20 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger and BTB domain containing 20
chr7_-_37026108 Show fit	13.36	ENST00000396045.3	ELMO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	engulfment and cell motility 1
chr1_+_162602244 Show fit	13.30	ENST00000367922.3 ENST00000367921.3	DDR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	discoidin domain receptor tyrosine kinase 2
chr11_+_92085707 Show fit	13.19	ENST00000525166.1	FAT3 Ensembl NCBI GeneCards UniProt NextProt Show fit	FAT atypical cadherin 3
chr17_+_76311791 Show fit	13.17	ENST00000586321.1	AC061992.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC061992.2
chr18_+_32290218 Show fit	13.12	ENST00000348997.5 ENST00000588949.1 ENST00000597599.1	DTNA Ensembl NCBI GeneCards UniProt NextProt Show fit	dystrobrevin, alpha
chr17_+_41363854 Show fit	13.11	ENST00000588693.1 ENST00000588659.1 ENST00000541594.1 ENST00000536052.1 ENST00000331615.3	TMEM106A Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 106A
chr12_-_50290839 Show fit	13.10	ENST00000552863.1	FAIM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Fas apoptotic inhibitory molecule 2
chr2_+_166152283 Show fit	13.08	ENST00000375427.2	SCN2A Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type II, alpha subunit
chr5_+_67586465 Show fit	12.95	ENST00000336483.5	PIK3R1 Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_88896819 Show fit	12.94	ENST00000237623.7 ENST00000395080.3 ENST00000508233.1 ENST00000360804.4	SPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	secreted phosphoprotein 1
chr11_-_84634217 Show fit	12.83	ENST00000524982.1	DLG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	discs, large homolog 2 (Drosophila)
chr2_+_166150541 Show fit	12.69	ENST00000283256.6	SCN2A Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type II, alpha subunit
chr2_+_66662690 Show fit	12.67	ENST00000488550.1	MEIS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Meis homeobox 1
chr12_+_54447637 Show fit	12.45	ENST00000609810.1 ENST00000430889.2	HOXC4 Ensembl NCBI GeneCards UniProt NextProt Show fit HOXC4 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox C4 Homeobox protein Hox-C4
chr1_+_155829286 Show fit	12.31	ENST00000368324.4	SYT11 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin XI
chr4_+_158142750 Show fit	12.28	ENST00000505888.1 ENST00000449365.1	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr4_+_41614909 Show fit	12.24	ENST00000509454.1 ENST00000396595.3 ENST00000381753.4	LIMCH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM and calponin homology domains 1
chr12_+_81110684 Show fit	11.99	ENST00000228644.3	MYF5 Ensembl NCBI GeneCards UniProt NextProt Show fit	myogenic factor 5
chr2_+_210444748 Show fit	11.94	ENST00000392194.1	MAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 2
chr6_-_6007200 Show fit	11.91	ENST00000244766.2	NRN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuritin 1
chr1_+_92632542 Show fit	11.85	ENST00000409154.4 ENST00000370378.4	KIAA1107 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA1107
chr2_+_210444142 Show fit	11.85	ENST00000360351.4 ENST00000361559.4	MAP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 2
chr2_+_162272605 Show fit	11.84	ENST00000389554.3	TBR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T-box, brain, 1
chr9_-_124989804 Show fit	11.78	ENST00000373755.2 ENST00000373754.2	LHX6 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM homeobox 6
chr5_+_59783941 Show fit	11.77	ENST00000506884.1 ENST00000504876.2	PART1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prostate androgen-regulated transcript 1 (non-protein coding)
chr5_+_161274940 Show fit	11.53	ENST00000393943.4	GABRA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_88754113 Show fit	11.49	ENST00000560249.1 ENST00000540395.1 ENST00000511670.1 ENST00000361056.3	MEPE Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix extracellular phosphoglycoprotein
chr5_+_66254698 Show fit	11.44	ENST00000405643.1 ENST00000407621.1 ENST00000432426.1	MAST4 Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule associated serine/threonine kinase family member 4
chr12_-_9268707 Show fit	11.26	ENST00000318602.7	A2M Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-2-macroglobulin
chr3_-_127541194 Show fit	11.24	ENST00000453507.2	MGLL Ensembl NCBI GeneCards UniProt NextProt Show fit	monoglyceride lipase
chr16_+_89334512 Show fit	11.23	ENST00000602042.1	AC137932.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC137932.1
chr8_-_27115931 Show fit	11.18	ENST00000523048.1	STMN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin-like 4
chr10_-_62149433 Show fit	11.17	ENST00000280772.2	ANK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_186877502 Show fit	11.07	ENST00000431902.1 ENST00000284776.7 ENST00000415274.1	SORBS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	sorbin and SH3 domain containing 2
chr3_+_129247479 Show fit	11.04	ENST00000296271.3	RHO Ensembl NCBI GeneCards UniProt NextProt Show fit	rhodopsin
chr16_-_21289627 Show fit	10.99	ENST00000396023.2 ENST00000415987.2	CRYM Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, mu
chr2_-_177502659 Show fit	10.96	ENST00000295549.4	AC017048.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 1116
chr5_+_161274685 Show fit	10.94	ENST00000428797.2	GABRA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr6_-_169654139 Show fit	10.87	ENST00000366787.3	THBS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	thrombospondin 2
chr5_+_156696362 Show fit	10.78	ENST00000377576.3	CYFIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytoplasmic FMR1 interacting protein 2
chr5_+_161494770 Show fit	10.62	ENST00000414552.2 ENST00000361925.4	GABRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_-_124990680 Show fit	10.61	ENST00000541397.2 ENST00000560485.1	LHX6 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM homeobox 6
chr2_-_183291741 Show fit	10.56	ENST00000351439.5 ENST00000409365.1	PDE1A Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 1A, calmodulin-dependent
chr5_-_11588907 Show fit	10.44	ENST00000513598.1 ENST00000503622.1	CTNND2 Ensembl NCBI GeneCards UniProt NextProt Show fit	catenin (cadherin-associated protein), delta 2
chr10_-_49813090 Show fit	10.39	ENST00000249601.4	ARHGAP22 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 22
chr9_+_2158443 Show fit	10.23	ENST00000302401.3 ENST00000324954.5 ENST00000423555.1 ENST00000382186.1	SMARCA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_171034646 Show fit	10.21	ENST00000409044.3 ENST00000408978.4	MYO3B Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin IIIB
chr18_-_53303123 Show fit	10.19	ENST00000569357.1 ENST00000565124.1 ENST00000398339.1	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr5_-_1882858 Show fit	10.14	ENST00000511126.1 ENST00000231357.2	IRX4 Ensembl NCBI GeneCards UniProt NextProt Show fit	iroquois homeobox 4
chr8_-_87755878 Show fit	10.12	ENST00000320005.5	CNGB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclic nucleotide gated channel beta 3
chr2_+_66662510 Show fit	10.09	ENST00000272369.9 ENST00000407092.2	MEIS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Meis homeobox 1
chr6_+_69942298 Show fit	10.06	ENST00000238918.8	BAI3 Ensembl NCBI GeneCards UniProt NextProt Show fit	brain-specific angiogenesis inhibitor 3
chr17_-_26220366 Show fit	10.02	ENST00000460380.2 ENST00000508862.1 ENST00000379102.3 ENST00000582441.1	LYRM9 Ensembl NCBI GeneCards UniProt NextProt Show fit RP1-66C13.4 Ensembl NCBI GeneCards UniProt NextProt Show fit	LYR motif containing 9 Uncharacterized protein
chr13_+_96085847 Show fit	10.01	ENST00000376873.3	CLDN10 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 10
chr2_-_213403565 Show fit	10.00	ENST00000342788.4 ENST00000436443.1	ERBB4 Ensembl NCBI GeneCards UniProt NextProt Show fit	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr5_+_140762268 Show fit	9.98	ENST00000518325.1	PCDHGA7 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin gamma subfamily A, 7
chr5_+_161112563 Show fit	9.96	ENST00000274545.5	GABRA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr8_-_120685608 Show fit	9.96	ENST00000427067.2	ENPP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr11_-_123525289 Show fit	9.86	ENST00000392770.2 ENST00000299333.3 ENST00000530277.1	SCN3B Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type III, beta subunit
chr3_+_69985792 Show fit	9.80	ENST00000531774.1	MITF Ensembl NCBI GeneCards UniProt NextProt Show fit	microphthalmia-associated transcription factor
chr15_+_62853562 Show fit	9.80	ENST00000561311.1	TLN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	talin 2
chr15_+_74422585 Show fit	9.79	ENST00000561740.1 ENST00000435464.1 ENST00000453268.2	ISLR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin superfamily containing leucine-rich repeat 2
chr5_+_161275320 Show fit	9.75	ENST00000437025.2	GABRA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_-_69261310 Show fit	9.67	ENST00000336440.3	ZFP36L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ZFP36 ring finger protein-like 1
chr5_-_11589131 Show fit	9.64	ENST00000511377.1	CTNND2 Ensembl NCBI GeneCards UniProt NextProt Show fit	catenin (cadherin-associated protein), delta 2
chr10_+_95517660 Show fit	9.60	ENST00000371413.3	LGI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine-rich, glioma inactivated 1
chr5_-_115910091 Show fit	9.60	ENST00000257414.8	SEMA6A Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_99578776 Show fit	9.58	ENST00000515287.1	TSPAN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 5
chr5_-_138210977 Show fit	9.57	ENST00000274711.6 ENST00000521094.2	LRRTM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine rich repeat transmembrane neuronal 2
chr9_+_2158485 Show fit	9.56	ENST00000417599.1 ENST00000382185.1 ENST00000382183.1	SMARCA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_-_27115903 Show fit	9.48	ENST00000350889.4 ENST00000519997.1 ENST00000519614.1 ENST00000522908.1 ENST00000265770.7	STMN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	stathmin-like 4
chr18_-_53253112 Show fit	9.42	ENST00000568673.1 ENST00000562847.1 ENST00000568147.1	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr17_-_29624343 Show fit	9.32	ENST00000247271.4	OMG Ensembl NCBI GeneCards UniProt NextProt Show fit	oligodendrocyte myelin glycoprotein
chr5_+_174151536 Show fit	9.25	ENST00000239243.6 ENST00000507785.1	MSX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	msh homeobox 2
chr2_-_60780702 Show fit	9.19	ENST00000359629.5	BCL11A Ensembl NCBI GeneCards UniProt NextProt Show fit	B-cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_166060552 Show fit	9.16	ENST00000283254.7 ENST00000453007.1	SCN3A Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type III, alpha subunit
chr15_+_43985084 Show fit	9.04	ENST00000434505.1 ENST00000411750.1	CKMT1A Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, mitochondrial 1A
chrX_+_135251835 Show fit	8.85	ENST00000456445.1	FHL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	four and a half LIM domains 1
chr9_-_14308004 Show fit	8.80	ENST00000493697.1	NFIB Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear factor I/B
chr4_-_99578789 Show fit	8.69	ENST00000511651.1 ENST00000505184.1	TSPAN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 5
chr1_+_84630645 Show fit	8.62	ENST00000394839.2	PRKACB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr9_-_13165457 Show fit	8.62	ENST00000542239.1 ENST00000538841.1 ENST00000433359.2	MPDZ Ensembl NCBI GeneCards UniProt NextProt Show fit	multiple PDZ domain protein
chr4_+_114214125 Show fit	8.62	ENST00000509550.1	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chr1_+_50575292 Show fit	8.53	ENST00000371821.1 ENST00000371819.1	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr5_+_161112754 Show fit	8.51	ENST00000523217.1	GABRA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr11_-_111175739 Show fit	8.48	ENST00000532918.1	COLCA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	colorectal cancer associated 1
chr2_-_152589670 Show fit	8.48	ENST00000604864.1 ENST00000603639.1	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
45.7	273.9	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
27.5	82.5	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
16.2	64.7	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
13.0	38.9	GO:0007412	axon target recognition(GO:0007412)
12.7	38.0	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
12.2	146.6	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
10.2	40.6	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
9.6	28.7	GO:1904800	negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
8.2	65.3	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
7.6	7.6	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
6.2	61.7	GO:0051610	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
5.4	27.1	GO:0097338	response to clozapine(GO:0097338)
5.4	16.3	GO:0060535	trachea cartilage morphogenesis(GO:0060535)
5.3	21.3	GO:0072658	positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
4.9	9.8	GO:0045773	positive regulation of axon extension(GO:0045773)
4.7	23.4	GO:2000638	regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
4.7	23.3	GO:0099538	synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
4.6	23.1	GO:0003322	pancreatic A cell development(GO:0003322)
4.5	18.0	GO:1904450	negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
4.3	12.9	GO:0035938	estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
4.3	86.1	GO:0071420	cellular response to histamine(GO:0071420)
4.3	34.2	GO:0002051	osteoblast fate commitment(GO:0002051)
4.1	12.3	GO:1905154	negative regulation of membrane invagination(GO:1905154)
3.8	15.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
3.7	7.5	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
3.7	37.0	GO:0016198	axon choice point recognition(GO:0016198)
3.6	3.6	GO:0021781	glial cell fate commitment(GO:0021781)
3.4	20.1	GO:0021764	amygdala development(GO:0021764)
3.3	10.0	GO:2000366	regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
3.3	13.2	GO:0045872	positive regulation of rhodopsin gene expression(GO:0045872)
3.2	9.7	GO:0048382	mesendoderm development(GO:0048382)
3.2	25.7	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
3.1	12.4	GO:0018032	peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
3.1	9.3	GO:0051795	positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
3.1	39.9	GO:0048245	eosinophil chemotaxis(GO:0048245)
3.0	121.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
3.0	54.4	GO:0007021	tubulin complex assembly(GO:0007021)
3.0	3.0	GO:1902285	sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285)
2.9	14.7	GO:2000035	regulation of stem cell division(GO:2000035)
2.9	29.1	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
2.9	40.4	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
2.9	17.2	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
2.8	56.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
2.8	2.8	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
2.7	13.6	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
2.6	7.8	GO:0072276	metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
2.5	15.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
2.4	31.6	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
2.4	24.2	GO:0060385	axonogenesis involved in innervation(GO:0060385)
2.4	16.8	GO:0021740	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.3	4.7	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
2.3	18.5	GO:0007258	JUN phosphorylation(GO:0007258)
2.3	25.4	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
2.3	20.4	GO:0016191	synaptic vesicle uncoating(GO:0016191)
2.2	6.7	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
2.2	59.4	GO:0008045	motor neuron axon guidance(GO:0008045)
2.1	4.3	GO:0021779	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
2.1	8.5	GO:0007525	somatic muscle development(GO:0007525)
2.1	6.2	GO:0060018	astrocyte fate commitment(GO:0060018)
2.0	30.5	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
2.0	4.0	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
2.0	23.7	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
1.9	7.7	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.9	7.5	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
1.9	5.6	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.8	40.3	GO:0021542	dentate gyrus development(GO:0021542)
1.8	5.4	GO:0009214	cAMP catabolic process(GO:0006198) cyclic nucleotide catabolic process(GO:0009214)
1.8	3.6	GO:0051866	general adaptation syndrome(GO:0051866)
1.8	5.4	GO:0048867	stem cell fate determination(GO:0048867)
1.8	101.0	GO:0003254	regulation of membrane depolarization(GO:0003254)
1.8	5.3	GO:0014043	negative regulation of neuron maturation(GO:0014043)
1.7	7.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
1.7	7.0	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
1.7	12.0	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
1.7	8.5	GO:0019805	quinolinate biosynthetic process(GO:0019805)
1.7	18.2	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.6	8.2	GO:0006543	glutamine catabolic process(GO:0006543)
1.6	11.2	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
1.6	12.6	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
1.6	11.0	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
1.5	25.7	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
1.5	25.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
1.5	13.1	GO:0021681	cerebellar granular layer development(GO:0021681)
1.4	4.3	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.4	11.4	GO:0008090	retrograde axonal transport(GO:0008090)
1.4	5.5	GO:0036343	psychomotor behavior(GO:0036343) motor behavior(GO:0061744)
1.4	4.1	GO:2000320	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
1.4	53.2	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
1.4	2.7	GO:2000382	positive regulation of mesoderm development(GO:2000382)
1.4	39.4	GO:0008038	neuron recognition(GO:0008038)
1.3	2.7	GO:0034505	tooth mineralization(GO:0034505)
1.3	13.3	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
1.3	14.4	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
1.3	2.6	GO:0061113	pancreas morphogenesis(GO:0061113)
1.3	11.6	GO:0002091	negative regulation of receptor internalization(GO:0002091)
1.3	3.9	GO:0030035	microspike assembly(GO:0030035)
1.3	7.7	GO:0018095	protein polyglutamylation(GO:0018095)
1.3	6.4	GO:0048690	regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.3	68.7	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
1.3	7.6	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
1.2	186.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2	66.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.2	21.3	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
1.2	4.7	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.2	2.3	GO:1990637	response to prolactin(GO:1990637)
1.2	13.9	GO:0060044	negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.1	3.4	GO:0060325	face morphogenesis(GO:0060325)
1.1	6.7	GO:0015811	L-cystine transport(GO:0015811)
1.1	11.2	GO:0048262	determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
1.1	12.2	GO:0006554	lysine catabolic process(GO:0006554)
1.1	4.4	GO:0036269	swimming behavior(GO:0036269)
1.1	4.4	GO:0060023	soft palate development(GO:0060023)
1.1	14.2	GO:0007638	mechanosensory behavior(GO:0007638)
1.1	5.5	GO:0001550	ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.1	4.3	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.1	3.3	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
1.1	1.1	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
1.1	3.2	GO:0003099	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
1.1	7.4	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
1.1	4.2	GO:1902159	regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
1.0	32.2	GO:0097120	receptor localization to synapse(GO:0097120)
1.0	32.7	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
1.0	29.5	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
1.0	3.0	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
1.0	4.9	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.0	6.8	GO:0070166	enamel mineralization(GO:0070166)
1.0	9.7	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.0	1.0	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.9	1.9	GO:0021612	facial nerve structural organization(GO:0021612)
0.9	4.6	GO:0015824	proline transport(GO:0015824)
0.9	2.7	GO:0010025	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.9	5.4	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.9	4.5	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.9	15.2	GO:0051531	NFAT protein import into nucleus(GO:0051531)
0.9	11.3	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.9	1.7	GO:0050955	thermoception(GO:0050955)
0.8	15.8	GO:0035640	exploration behavior(GO:0035640)
0.8	3.3	GO:0048807	ectoderm and mesoderm interaction(GO:0007499) female genitalia morphogenesis(GO:0048807) positive regulation of somatic stem cell population maintenance(GO:1904674)
0.8	0.8	GO:0050787	detoxification of mercury ion(GO:0050787)
0.8	3.3	GO:0061743	motor learning(GO:0061743)
0.8	4.8	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8	6.9	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.8	5.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.8	3.0	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8	3.0	GO:0051454	pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.8	3.0	GO:0051136	regulation of NK T cell differentiation(GO:0051136)
0.7	6.0	GO:0070995	NADPH oxidation(GO:0070995)
0.7	5.2	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.7	5.9	GO:0016926	protein desumoylation(GO:0016926)
0.7	24.3	GO:0007019	microtubule depolymerization(GO:0007019)
0.7	5.1	GO:0061325	cell proliferation involved in outflow tract morphogenesis(GO:0061325)
0.7	7.3	GO:0060539	diaphragm development(GO:0060539)
0.7	3.6	GO:1901660	calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.7	4.4	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.7	3.6	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.7	2.1	GO:0043163	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.7	11.0	GO:0018298	protein-chromophore linkage(GO:0018298)
0.7	188.7	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.7	11.4	GO:0046069	cGMP catabolic process(GO:0046069)
0.7	3.3	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.7	4.7	GO:0036438	maintenance of lens transparency(GO:0036438)
0.7	2.0	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.6	20.7	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6	3.2	GO:0003025	regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025)
0.6	3.2	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.6	9.8	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.6	2.4	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.6	17.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.6	1.8	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.6	0.6	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.6	5.9	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.6	4.1	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.6	3.5	GO:0071105	response to interleukin-11(GO:0071105)
0.6	1.7	GO:0010710	regulation of collagen catabolic process(GO:0010710) negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.6	5.7	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.6	1.7	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
0.6	4.0	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.6	3.4	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.6	1.7	GO:0048664	neuron fate determination(GO:0048664)
0.5	18.5	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.5	10.3	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.5	3.8	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.5	2.2	GO:0002331	pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.5	3.2	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5	6.4	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.5	1.1	GO:0042320	regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.5	0.5	GO:0035711	T-helper 1 cell activation(GO:0035711)
0.5	5.8	GO:0006527	arginine catabolic process(GO:0006527)
0.5	28.3	GO:0051899	membrane depolarization(GO:0051899)
0.5	1.0	GO:0021798	neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798)
0.5	25.4	GO:0015701	bicarbonate transport(GO:0015701)
0.5	4.1	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.5	15.8	GO:0016601	Rac protein signal transduction(GO:0016601)
0.5	3.0	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.5	5.4	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5	5.4	GO:0071670	smooth muscle cell chemotaxis(GO:0071670)
0.5	2.0	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.5	4.4	GO:0018344	protein geranylgeranylation(GO:0018344)
0.5	1.5	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.5	2.9	GO:1990418	response to insulin-like growth factor stimulus(GO:1990418)
0.5	1.0	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.5	10.6	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.5	1.9	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.5	2.8	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.5	3.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.5	27.0	GO:0001578	microtubule bundle formation(GO:0001578)
0.5	3.2	GO:0046485	ether lipid metabolic process(GO:0046485)
0.5	3.6	GO:0098719	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4	1.3	GO:0001865	NK T cell differentiation(GO:0001865)
0.4	2.7	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.4	4.4	GO:0015865	purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.4	3.0	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.4	8.3	GO:0048665	neuron fate specification(GO:0048665)
0.4	0.4	GO:0035990	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.4	1.7	GO:1900425	negative regulation of defense response to bacterium(GO:1900425)
0.4	15.6	GO:0014047	glutamate secretion(GO:0014047)
0.4	4.6	GO:0006600	creatine metabolic process(GO:0006600)
0.4	4.5	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4	7.3	GO:0015874	norepinephrine transport(GO:0015874)
0.4	1.5	GO:0097210	response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.4	1.5	GO:0060133	somatotropin secreting cell development(GO:0060133)
0.4	0.8	GO:0044245	polysaccharide digestion(GO:0044245)
0.4	3.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of heart rate by epinephrine(GO:0003065)
0.4	3.0	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.4	2.2	GO:0035865	cellular response to potassium ion(GO:0035865)
0.4	12.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.4	0.7	GO:0061386	closure of optic fissure(GO:0061386)
0.4	9.0	GO:0006144	purine nucleobase metabolic process(GO:0006144)
0.4	5.0	GO:0045793	positive regulation of cell size(GO:0045793)
0.4	6.0	GO:0035728	response to hepatocyte growth factor(GO:0035728)
0.4	4.2	GO:0035878	nail development(GO:0035878)
0.3	2.8	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.3	20.3	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.3	1.7	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.3	2.0	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.3	1.0	GO:0070781	arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.3	2.3	GO:0006591	ornithine metabolic process(GO:0006591)
0.3	24.8	GO:0050806	positive regulation of synaptic transmission(GO:0050806)
0.3	4.5	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.3	6.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.3	3.8	GO:1903671	negative regulation of sprouting angiogenesis(GO:1903671)
0.3	13.5	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.3	1.5	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.3	3.3	GO:0048251	elastic fiber assembly(GO:0048251)
0.3	13.7	GO:0060997	dendritic spine morphogenesis(GO:0060997)
0.3	5.0	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.3	2.3	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.3	4.0	GO:0006020	inositol metabolic process(GO:0006020)
0.3	2.8	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3	14.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3	2.8	GO:0015889	cobalamin transport(GO:0015889)
0.3	7.6	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3	2.0	GO:0072501	cellular divalent inorganic anion homeostasis(GO:0072501)
0.3	1.4	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3	5.3	GO:0050954	sensory perception of sound(GO:0007605) sensory perception of mechanical stimulus(GO:0050954)
0.3	3.1	GO:0071285	cellular response to lithium ion(GO:0071285)
0.3	0.8	GO:0043416	positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.2	2.2	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.2	2.0	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.2	6.1	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2	0.7	GO:0044537	regulation of circulating fibrinogen levels(GO:0044537)
0.2	1.7	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2	1.3	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.2	1.7	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.2	26.9	GO:0019722	calcium-mediated signaling(GO:0019722)
0.2	4.4	GO:0010107	potassium ion import(GO:0010107)
0.2	0.8	GO:0021997	response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.2	9.4	GO:0007585	respiratory gaseous exchange(GO:0007585)
0.2	2.9	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2	1.9	GO:0034379	very-low-density lipoprotein particle assembly(GO:0034379)
0.2	0.8	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.2	0.7	GO:0042730	fibrinolysis(GO:0042730)
0.2	3.7	GO:0003334	keratinocyte development(GO:0003334)
0.2	1.3	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.2	2.0	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2	2.2	GO:1903861	positive regulation of dendrite extension(GO:1903861)
0.2	0.5	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.2	1.1	GO:0048840	otolith development(GO:0048840)
0.2	0.3	GO:0042441	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.2	0.3	GO:0086053	SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2	4.2	GO:0015695	organic cation transport(GO:0015695)
0.2	0.5	GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.2	2.3	GO:0005513	detection of calcium ion(GO:0005513)
0.2	4.4	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.2	1.6	GO:2001054	negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2	9.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	2.5	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.2	0.8	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.2	0.9	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.2	0.9	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.2	1.5	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2	4.4	GO:0001919	regulation of receptor recycling(GO:0001919)
0.1	1.6	GO:0021670	lateral ventricle development(GO:0021670)
0.1	0.9	GO:0060612	adipose tissue development(GO:0060612)
0.1	1.6	GO:0016048	detection of temperature stimulus(GO:0016048)
0.1	0.4	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1	1.4	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1	0.4	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1	5.1	GO:0042475	odontogenesis of dentin-containing tooth(GO:0042475)
0.1	3.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.1	6.3	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.1	0.3	GO:1901876	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1	0.8	GO:0019375	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1	3.5	GO:0048536	spleen development(GO:0048536)
0.1	0.6	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.1	11.7	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1	15.0	GO:0006813	potassium ion transport(GO:0006813)
0.1	2.3	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	0.4	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.1	1.8	GO:0061053	somite development(GO:0061053)
0.1	6.9	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	2.9	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1	1.4	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.1	0.9	GO:0009642	response to light intensity(GO:0009642)
0.1	1.6	GO:2000353	positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1	1.3	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.1	13.2	GO:0034605	cellular response to heat(GO:0034605)
0.1	1.0	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.1	1.7	GO:2000249	regulation of actin cytoskeleton reorganization(GO:2000249)
0.1	0.7	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.1	4.4	GO:0007368	determination of left/right symmetry(GO:0007368)
0.1	2.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	1.4	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.1	2.9	GO:1901998	toxin transport(GO:1901998)
0.1	2.6	GO:0009408	response to heat(GO:0009408)
0.1	0.5	GO:0008218	bioluminescence(GO:0008218)
0.1	1.8	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.1	0.3	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.1	0.4	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.1	0.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	1.8	GO:0006783	heme biosynthetic process(GO:0006783)
0.1	2.1	GO:0006986	response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.1	2.6	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.1	0.7	GO:0032232	negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.1	0.6	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1	7.4	GO:0008360	regulation of cell shape(GO:0008360)
0.1	1.4	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	1.4	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.1	1.0	GO:0007520	myoblast fusion(GO:0007520)
0.1	0.3	GO:0030070	insulin processing(GO:0030070)
0.0	1.9	GO:0061512	protein localization to cilium(GO:0061512)
0.0	1.5	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.6	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	1.6	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	1.8	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.0	3.1	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.0	1.1	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.0	0.7	GO:0048469	cell maturation(GO:0048469)
0.0	0.6	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	1.5	GO:0042073	intraciliary transport(GO:0042073)
0.0	1.3	GO:0003009	skeletal muscle contraction(GO:0003009)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.2	GO:0045605	negative regulation of epidermal cell differentiation(GO:0045605)
0.0	2.6	GO:1990830	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0	2.3	GO:0007286	spermatid development(GO:0007286)
0.0	0.8	GO:0051693	actin filament capping(GO:0051693)
0.0	0.3	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	2.0	GO:0015698	inorganic anion transport(GO:0015698)
0.0	0.9	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.5	GO:0050906	detection of stimulus involved in sensory perception(GO:0050906)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.6	GO:0009060	aerobic respiration(GO:0009060)
0.0	0.3	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
16.5	82.5	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
12.1	60.3	GO:0098843	postsynaptic endocytic zone(GO:0098843)
10.3	144.8	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
6.1	133.7	GO:0044295	axonal growth cone(GO:0044295)
5.7	28.5	GO:0032584	growth cone membrane(GO:0032584)
4.6	27.6	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
4.5	18.0	GO:0032144	4-aminobutyrate transaminase complex(GO:0032144)
3.9	11.8	GO:0000308	cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
3.9	11.7	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
3.8	15.2	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
3.7	62.3	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
3.4	54.4	GO:0097512	cardiac myofibril(GO:0097512)
3.3	23.4	GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
3.3	115.6	GO:1902711	GABA-A receptor complex(GO:1902711)
2.9	11.4	GO:0031673	H zone(GO:0031673)
2.5	12.3	GO:0048787	presynaptic active zone membrane(GO:0048787)
2.4	38.8	GO:0031045	dense core granule(GO:0031045)
2.2	15.1	GO:0032437	cuticular plate(GO:0032437)
2.1	6.4	GO:0072534	perineuronal net(GO:0072534)
2.0	17.6	GO:0016013	syntrophin complex(GO:0016013)
1.9	26.2	GO:0043194	axon initial segment(GO:0043194)
1.9	16.8	GO:0044300	cerebellar mossy fiber(GO:0044300)
1.7	51.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
1.5	21.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.4	27.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
1.2	12.1	GO:0045180	basal cortex(GO:0045180)
1.2	49.1	GO:0048786	presynaptic active zone(GO:0048786)
1.1	13.4	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
1.1	4.4	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.1	5.4	GO:0044308	axonal spine(GO:0044308)
1.0	10.5	GO:0071953	elastic fiber(GO:0071953)
1.0	88.5	GO:0044291	cell-cell contact zone(GO:0044291)
1.0	68.6	GO:0042734	presynaptic membrane(GO:0042734)
0.9	0.9	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.8	218.9	GO:0060076	excitatory synapse(GO:0060076)
0.8	186.9	GO:0043209	myelin sheath(GO:0043209)
0.8	8.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.7	4.5	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7	11.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.7	157.0	GO:0032993	protein-DNA complex(GO:0032993)
0.7	5.5	GO:0030478	actin cap(GO:0030478)
0.7	6.1	GO:0005579	membrane attack complex(GO:0005579)
0.7	3.4	GO:0070852	cell body fiber(GO:0070852)
0.7	4.0	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6	3.2	GO:0060198	clathrin-sculpted vesicle(GO:0060198) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.6	9.9	GO:0031012	extracellular matrix(GO:0031012)
0.6	19.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.6	1.7	GO:0030314	junctional membrane complex(GO:0030314)
0.6	5.7	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.6	6.2	GO:0002116	semaphorin receptor complex(GO:0002116)
0.5	4.3	GO:0014802	terminal cisterna(GO:0014802)
0.5	2.5	GO:0000836	Hrd1p ubiquitin ligase complex(GO:0000836)
0.5	4.4	GO:0030137	COPI-coated vesicle(GO:0030137)
0.5	2.8	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.5	5.9	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.5	5.0	GO:0005922	connexon complex(GO:0005922)
0.5	3.6	GO:0032591	dendritic spine membrane(GO:0032591)
0.5	5.5	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.4	54.2	GO:0030426	growth cone(GO:0030426)
0.4	43.8	GO:0043204	perikaryon(GO:0043204)
0.4	0.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.4	50.9	GO:0030018	Z disc(GO:0030018)
0.4	58.8	GO:0031225	anchored component of membrane(GO:0031225)
0.3	1.7	GO:0071438	invadopodium membrane(GO:0071438)
0.3	2.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3	4.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.3	4.9	GO:0031430	M band(GO:0031430)
0.3	56.0	GO:0098794	postsynapse(GO:0098794)
0.3	1.7	GO:0097209	epidermal lamellar body(GO:0097209)
0.3	6.2	GO:0035371	microtubule plus-end(GO:0035371)
0.3	1.8	GO:0036019	endolysosome(GO:0036019)
0.3	7.1	GO:0005581	collagen trimer(GO:0005581)
0.2	8.6	GO:0034707	chloride channel complex(GO:0034707)
0.2	3.6	GO:0030128	clathrin coat of endocytic vesicle(GO:0030128)
0.2	1.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2	12.5	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2	5.7	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	44.7	GO:0005802	trans-Golgi network(GO:0005802)
0.2	4.4	GO:0031594	neuromuscular junction(GO:0031594)
0.2	3.0	GO:0032059	bleb(GO:0032059)
0.2	12.7	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2	1.1	GO:0030056	hemidesmosome(GO:0030056)
0.2	5.4	GO:0009925	basal plasma membrane(GO:0009925)
0.2	2.8	GO:0000124	SAGA complex(GO:0000124)
0.2	10.2	GO:0008023	transcription elongation factor complex(GO:0008023)
0.2	13.3	GO:0042383	sarcolemma(GO:0042383)
0.2	9.4	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	1.5	GO:0005921	gap junction(GO:0005921)
0.2	3.0	GO:0097225	sperm midpiece(GO:0097225)
0.2	7.8	GO:0045171	intercellular bridge(GO:0045171)
0.2	0.8	GO:0046581	intercellular canaliculus(GO:0046581)
0.2	4.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.2	0.5	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	3.3	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	0.4	GO:0042584	chromaffin granule membrane(GO:0042584)
0.1	6.6	GO:0001750	photoreceptor outer segment(GO:0001750)
0.1	2.5	GO:0034451	centriolar satellite(GO:0034451)
0.1	1.7	GO:0005720	nuclear heterochromatin(GO:0005720)
0.1	5.7	GO:0005902	microvillus(GO:0005902)
0.1	39.6	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	17.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	1.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	7.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	20.4	GO:0030424	axon(GO:0030424)
0.1	8.9	GO:0070821	tertiary granule membrane(GO:0070821)
0.1	1.1	GO:0031674	I band(GO:0031674)
0.1	7.0	GO:0030133	transport vesicle(GO:0030133)
0.1	1.0	GO:0032994	protein-lipid complex(GO:0032994) plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1	3.0	GO:0005657	replication fork(GO:0005657)
0.1	2.1	GO:0071564	npBAF complex(GO:0071564)
0.1	1.6	GO:0071141	SMAD protein complex(GO:0071141)
0.1	0.3	GO:0097060	synaptic membrane(GO:0097060)
0.1	18.2	GO:0045202	synapse(GO:0045202)
0.1	1.9	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	11.6	GO:0005770	late endosome(GO:0005770)
0.1	3.1	GO:0005811	lipid particle(GO:0005811)
0.1	3.2	GO:0031904	endosome lumen(GO:0031904)
0.1	4.7	GO:0036064	ciliary basal body(GO:0036064)
0.1	9.3	GO:0030027	lamellipodium(GO:0030027)
0.1	11.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	1.5	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	189.5	GO:0016021	integral component of membrane(GO:0016021)
0.1	0.6	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	1.5	GO:0016235	aggresome(GO:0016235)
0.0	8.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	0.5	GO:0098798	mitochondrial protein complex(GO:0098798)
0.0	0.6	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	1.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	1.4	GO:0016324	apical plasma membrane(GO:0016324)
0.0	2.2	GO:0030496	midbody(GO:0030496)
0.0	0.4	GO:0098791	Golgi subcompartment(GO:0098791)
0.0	0.4	GO:0030139	endocytic vesicle(GO:0030139)
0.0	1.9	GO:0005929	cilium(GO:0005929)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
17.0	220.6	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
16.5	82.5	GO:0030348	syntaxin-3 binding(GO:0030348)
9.9	39.8	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
7.4	29.5	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
6.4	32.2	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
6.0	71.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
5.4	32.7	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
5.0	25.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
4.7	23.3	GO:0060175	brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
4.5	18.0	GO:0047298	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
4.4	57.4	GO:0008503	benzodiazepine receptor activity(GO:0008503)
4.1	65.3	GO:0097109	neuroligin family protein binding(GO:0097109)
3.8	11.3	GO:0019959	interleukin-8 binding(GO:0019959)
3.2	107.8	GO:0017091	AU-rich element binding(GO:0017091)
3.1	68.3	GO:0035198	miRNA binding(GO:0035198)
3.1	12.4	GO:0004504	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
3.1	18.5	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.9	22.8	GO:0050816	phosphothreonine binding(GO:0050816)
2.7	8.2	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
2.7	11.0	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.7	13.6	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
2.7	27.1	GO:0035727	lysophosphatidic acid binding(GO:0035727)
2.7	13.3	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
2.6	62.3	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
2.6	7.8	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
2.6	7.7	GO:0001596	angiotensin type I receptor activity(GO:0001596)
2.4	7.3	GO:0005330	dopamine:sodium symporter activity(GO:0005330)
2.4	49.8	GO:0002162	dystroglycan binding(GO:0002162)
2.2	6.6	GO:0005148	prolactin receptor binding(GO:0005148)
2.2	159.2	GO:0050840	extracellular matrix binding(GO:0050840)
2.2	56.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.0	13.7	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
1.9	15.2	GO:0043559	insulin binding(GO:0043559)
1.8	3.6	GO:0004945	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
1.8	7.1	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
1.7	5.2	GO:0005549	odorant binding(GO:0005549)
1.7	27.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
1.7	51.7	GO:0005212	structural constituent of eye lens(GO:0005212)
1.6	8.2	GO:0004359	glutaminase activity(GO:0004359)
1.6	11.4	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.5	10.5	GO:0030021	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
1.5	7.4	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
1.5	34.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
1.4	10.1	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
1.4	5.5	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.3	4.0	GO:0017129	triglyceride binding(GO:0017129)
1.2	155.0	GO:0005262	calcium channel activity(GO:0005262)
1.2	2.4	GO:0005137	interleukin-5 receptor binding(GO:0005137)
1.2	52.4	GO:0030507	spectrin binding(GO:0030507)
1.2	5.8	GO:0016403	dimethylargininase activity(GO:0016403)
1.1	9.0	GO:0004111	creatine kinase activity(GO:0004111)
1.1	6.7	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
1.1	4.5	GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
1.1	53.1	GO:0046875	ephrin receptor binding(GO:0046875)
1.1	33.9	GO:0004385	guanylate kinase activity(GO:0004385)
1.1	15.3	GO:0042043	neurexin family protein binding(GO:0042043)
1.1	7.6	GO:0005237	inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.1	5.4	GO:0008046	axon guidance receptor activity(GO:0008046)
1.1	3.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
1.1	3.2	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
1.0	18.5	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
1.0	11.0	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
1.0	7.0	GO:0003680	AT DNA binding(GO:0003680)
1.0	20.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
1.0	4.8	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.9	3.8	GO:0008422	beta-glucosidase activity(GO:0008422)
0.9	20.4	GO:0030506	ankyrin binding(GO:0030506)
0.9	2.7	GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.9	7.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.9	6.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.9	11.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.9	136.7	GO:0044325	ion channel binding(GO:0044325)
0.8	3.4	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.8	7.5	GO:0045294	alpha-catenin binding(GO:0045294)
0.8	3.3	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.8	1.6	GO:0005174	CD40 receptor binding(GO:0005174)
0.8	14.5	GO:0043522	leucine zipper domain binding(GO:0043522)
0.8	2.3	GO:0047275	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8	3.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.7	5.9	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.7	10.0	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.7	5.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.7	19.6	GO:0043014	alpha-tubulin binding(GO:0043014)
0.7	4.2	GO:0016015	morphogen activity(GO:0016015)
0.7	2.1	GO:0050429	calcium-dependent phospholipase C activity(GO:0050429)
0.7	27.6	GO:0042056	chemoattractant activity(GO:0042056)
0.7	11.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.7	17.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.7	2.6	GO:0030305	heparanase activity(GO:0030305)
0.7	10.5	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.6	4.5	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.6	5.2	GO:0004000	adenosine deaminase activity(GO:0004000)
0.6	9.0	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.6	4.4	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.6	7.0	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6	4.4	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.6	6.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.6	4.9	GO:0070324	thyroid hormone binding(GO:0070324)
0.6	3.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.6	5.5	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.6	123.9	GO:0051015	actin filament binding(GO:0051015)
0.6	17.4	GO:0015248	sterol transporter activity(GO:0015248)
0.6	10.4	GO:0051400	BH domain binding(GO:0051400)
0.6	11.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.6	8.5	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.5	43.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.5	21.9	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.5	3.6	GO:0001515	opioid peptide activity(GO:0001515)
0.5	2.6	GO:0044736	acid-sensing ion channel activity(GO:0044736)
0.5	3.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5	5.4	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.5	6.8	GO:0030215	semaphorin receptor binding(GO:0030215)
0.5	3.9	GO:0038132	neuregulin binding(GO:0038132)
0.5	1.4	GO:0032093	SAM domain binding(GO:0032093)
0.5	9.7	GO:0005523	tropomyosin binding(GO:0005523)
0.5	3.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.5	3.6	GO:0022821	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.5	1.4	GO:0061752	telomeric repeat-containing RNA binding(GO:0061752)
0.4	7.4	GO:0005003	ephrin receptor activity(GO:0005003)
0.4	2.2	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4	5.9	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.4	4.9	GO:0043176	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.4	14.5	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.4	3.2	GO:0005534	galactose binding(GO:0005534)
0.4	8.6	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.4	2.7	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.4	1.6	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.4	64.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4	5.4	GO:0005243	gap junction channel activity(GO:0005243)
0.4	5.6	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.4	1.4	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.4	5.0	GO:0004890	GABA-A receptor activity(GO:0004890)
0.3	48.1	GO:0005057	receptor signaling protein activity(GO:0005057)
0.3	1.0	GO:0005260	channel-conductance-controlling ATPase activity(GO:0005260)
0.3	4.0	GO:0008199	ferric iron binding(GO:0008199)
0.3	7.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.3	5.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3	3.1	GO:0019534	toxin transporter activity(GO:0019534)
0.3	2.8	GO:0031432	titin binding(GO:0031432)
0.3	1.2	GO:0016882	cyclo-ligase activity(GO:0016882)
0.3	50.9	GO:0005516	calmodulin binding(GO:0005516)
0.3	34.0	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3	2.6	GO:0070410	co-SMAD binding(GO:0070410)
0.3	3.3	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.3	2.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3	2.8	GO:0031419	cobalamin binding(GO:0031419)
0.3	0.8	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.2	8.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	2.0	GO:0034185	apolipoprotein binding(GO:0034185)
0.2	3.2	GO:0005522	profilin binding(GO:0005522)
0.2	3.7	GO:0001223	transcription coactivator binding(GO:0001223)
0.2	4.5	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.2	1.6	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2	10.1	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.2	12.9	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2	18.5	GO:0001618	virus receptor activity(GO:0001618)
0.2	137.3	GO:0005509	calcium ion binding(GO:0005509)
0.2	1.9	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2	26.7	GO:0017124	SH3 domain binding(GO:0017124)
0.2	1.3	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.2	2.4	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2	2.0	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.2	5.4	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2	3.3	GO:0070330	aromatase activity(GO:0070330)
0.2	0.4	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2	4.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.2	8.9	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	9.4	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2	6.2	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2	1.8	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2	2.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2	1.0	GO:0042301	phosphate ion binding(GO:0042301)
0.2	0.8	GO:0097108	patched binding(GO:0005113) hedgehog family protein binding(GO:0097108)
0.2	4.6	GO:0004033	aldo-keto reductase (NADP) activity(GO:0004033)
0.2	3.6	GO:0070412	R-SMAD binding(GO:0070412)
0.2	3.9	GO:0003785	actin monomer binding(GO:0003785)
0.2	1.5	GO:0047035	alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1	36.2	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	4.4	GO:0005109	frizzled binding(GO:0005109)
0.1	1.9	GO:0005548	phospholipid transporter activity(GO:0005548)
0.1	0.8	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.1	5.9	GO:0008009	chemokine activity(GO:0008009)
0.1	1.5	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	1.8	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1	2.2	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.1	5.1	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	0.9	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	7.2	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.1	2.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.1	0.8	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1	0.7	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.1	4.7	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
0.1	1.5	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.1	3.3	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1	2.8	GO:0008188	neuropeptide receptor activity(GO:0008188)
0.1	1.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	8.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.7	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.1	2.4	GO:0008144	drug binding(GO:0008144)
0.1	2.0	GO:0032813	tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1	15.4	GO:0015631	tubulin binding(GO:0015631)
0.1	0.6	GO:0031433	telethonin binding(GO:0031433)
0.1	6.9	GO:0003774	motor activity(GO:0003774)
0.1	6.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	2.9	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1	0.8	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.4	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	1.6	GO:0015026	coreceptor activity(GO:0015026)
0.1	6.1	GO:0002020	protease binding(GO:0002020)
0.1	3.2	GO:0005254	chloride channel activity(GO:0005254)
0.1	1.7	GO:0030291	protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0	3.2	GO:0008186	ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0	4.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.6	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	1.2	GO:0001671	ATPase activator activity(GO:0001671)
0.0	1.2	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.7	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	1.6	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	1.7	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.9	GO:0008375	acetylglucosaminyltransferase activity(GO:0008375)
0.0	0.3	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.8	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	1.5	GO:0002039	p53 binding(GO:0002039)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.8	GO:0022843	voltage-gated cation channel activity(GO:0022843)
0.0	0.5	GO:0008013	beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.4	134.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.0	116.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.9	1.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.8	93.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.4	166.2	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.3	88.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.2	63.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
1.0	71.1	PID FGF PATHWAY	FGF signaling pathway
0.7	27.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.7	41.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.7	20.2	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.6	13.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.6	8.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.6	11.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	3.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	31.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.5	40.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.5	5.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	2.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.5	25.6	PID CDC42 PATHWAY	CDC42 signaling events
0.4	5.4	PID SHP2 PATHWAY	SHP2 signaling
0.4	7.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.4	15.9	SIG CHEMOTAXIS	Genes related to chemotaxis
0.4	21.6	PID LKB1 PATHWAY	LKB1 signaling events
0.3	10.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	2.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.3	13.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.3	0.6	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3	12.7	PID MYC PATHWAY	C-MYC pathway
0.3	15.2	PID BMP PATHWAY	BMP receptor signaling
0.3	10.9	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	15.6	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.2	3.9	PID EPHA FWDPATHWAY	EPHA forward signaling
0.2	5.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	51.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	16.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	9.3	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.2	10.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	3.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	2.8	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	1.3	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	3.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	4.7	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	0.5	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	21.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.4	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	5.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	3.8	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	2.7	PID RHOA PATHWAY	RhoA signaling pathway
0.1	2.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	3.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	3.2	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	1.8	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	3.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	3.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	14.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.2	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.5	98.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
5.5	295.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
5.0	136.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
4.5	13.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
3.6	110.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
2.6	71.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
2.5	83.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
2.4	61.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
1.4	41.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.3	15.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
1.2	18.5	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.2	22.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.1	4.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.1	9.7	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
1.0	11.0	REACTOME OPSINS	Genes involved in Opsins
1.0	24.6	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
1.0	24.3	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane
0.9	18.0	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.9	20.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.8	12.7	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.8	11.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.7	10.3	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.7	26.6	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.6	19.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.6	20.1	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6	12.7	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.6	8.5	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.6	9.7	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.6	20.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.6	11.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	5.3	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.5	16.8	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.5	6.9	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.4	27.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	6.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.4	7.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	3.8	REACTOME LIPOPROTEIN METABOLISM	Genes involved in Lipoprotein metabolism
0.4	4.9	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.3	14.0	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.3	2.7	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.3	5.6	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.3	55.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	6.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	6.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.3	6.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.3	11.4	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.3	5.4	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.3	9.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	8.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	15.6	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.3	14.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	12.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.3	6.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	4.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.3	6.4	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.3	6.0	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	7.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	17.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	13.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	10.7	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.2	7.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.2	3.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	3.3	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.2	1.8	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.2	8.8	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	2.0	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	2.5	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	7.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	14.8	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	23.4	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.1	3.1	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	3.3	REACTOME AXON GUIDANCE	Genes involved in Axon guidance
0.1	1.6	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	7.1	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	8.1	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.1	5.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.1	2.6	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	10.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	1.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	2.0	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	2.7	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	3.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	1.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1	0.9	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	0.7	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	0.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1	2.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	5.0	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	1.1	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	0.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.4	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	1.9	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.0	1.5	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	0.8	REACTOME SPHINGOLIPID METABOLISM	Genes involved in Sphingolipid metabolism
0.0	0.6	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.1	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo

Results for HOXB6_PRRX2

Z-value: 2.13

Motif logo

Transcription factors associated with HOXB6_PRRX2

Activity-expression correlation:

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: