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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXC10_HOXD13
Z-value: 1.55
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Transcription factors associated with HOXC10_HOXD13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD13 | hg19_v2_chr2_+_176957619_176957619 | 0.39 | 1.5e-09 | Click! |
| HOXC10 | hg19_v2_chr12_+_54378923_54378970 | -0.15 | 2.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91539918 Show fit | 54.23 |
ENST00000548218.1
|
decorin |
|
| chr12_-_15038779 Show fit | 44.42 |
ENST00000228938.5
ENST00000539261.1 |
matrix Gla protein |
|
| chr11_+_118401706 Show fit | 44.40 |
ENST00000411589.2
ENST00000442938.2 ENST00000359862.4 |
transmembrane protein 25 |
|
| chr6_+_42847348 Show fit | 37.07 |
ENST00000493763.1
ENST00000304734.5 |
ribosomal protein L7-like 1 |
|
| chr6_+_151042224 Show fit | 36.99 |
ENST00000358517.2
|
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 |
|
| chr5_-_42825983 Show fit | 34.48 |
ENST00000506577.1
|
selenoprotein P, plasma, 1 |
|
| chr1_+_90460661 Show fit | 34.02 |
ENST00000340281.4
ENST00000361911.5 ENST00000370447.3 ENST00000455342.2 |
zinc finger protein 326 |
|
| chr12_-_91576561 Show fit | 33.21 |
ENST00000547568.2
ENST00000552962.1 |
decorin |
|
| chr18_-_52989217 Show fit | 30.03 |
ENST00000570287.2
|
transcription factor 4 |
|
| chr12_-_91576429 Show fit | 29.78 |
ENST00000552145.1
ENST00000546745.1 |
decorin |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC10_HOXD13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.4 | 196.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 61.5 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 2.2 | 56.1 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.2 | 42.7 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.2 | 40.1 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 3.1 | 37.1 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.4 | 34.9 | GO:0070268 | cornification(GO:0070268) |
| 0.6 | 34.0 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 3.9 | 31.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.7 | 30.5 | GO:0010107 | potassium ion import(GO:0010107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.1 | 225.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 124.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 93.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 44.4 | GO:0005615 | extracellular space(GO:0005615) |
| 2.7 | 41.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 38.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.8 | 35.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 34.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 34.2 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 11.3 | 34.0 | GO:0044609 | DBIRD complex(GO:0044609) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 226.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 6.3 | 81.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.8 | 75.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.4 | 42.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.5 | 41.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.4 | 35.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.1 | 34.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 33.0 | GO:0003823 | antigen binding(GO:0003823) |
| 6.2 | 30.9 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.7 | 30.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 262.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.7 | 84.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.3 | 62.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 1.4 | 58.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 58.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 30.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 25.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 20.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 17.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 14.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 196.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.5 | 79.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.1 | 72.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 62.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 48.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 30.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 29.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.1 | 27.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.4 | 24.6 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 1.0 | 24.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |