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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXD10

Z-value: 1.06

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Transcription factors associated with HOXD10

Gene Symbol Gene ID Gene Info
HOXD10
ENSG00000128710.5 homeobox D10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD10hg19_v2_chr2_+_176981307_176981307-0.428.5e-11Click!

Activity profile of HOXD10 motif

Sorted Z-values of HOXD10 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_84035905 24.09 ENST00000311507.4
PLAC8
placenta-specific 8
chr4_-_84035868 22.77 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr1_-_149900122 21.39 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr3_-_185641681 16.88 ENST00000259043.7
TRA2B
transformer 2 beta homolog (Drosophila)
chr5_+_162930114 16.79 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr1_+_158978768 16.74 ENST00000447473.2
IFI16
interferon, gamma-inducible protein 16
chr1_+_198608146 16.37 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_+_40198527 15.30 ENST00000381799.5
RHOH
ras homolog family member H
chr8_-_101719159 15.00 ENST00000520868.1
ENST00000522658.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr5_+_167913450 14.69 ENST00000231572.3
ENST00000538719.1
RARS
arginyl-tRNA synthetase
chr1_+_41204506 14.49 ENST00000525290.1
ENST00000530965.1
ENST00000416859.2
ENST00000308733.5
NFYC
nuclear transcription factor Y, gamma
chr11_-_104827425 14.27 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_-_109590174 12.93 ENST00000372054.1
GNG5P2
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chr9_+_42671887 12.62 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr11_+_60223225 12.43 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr2_+_102456277 12.39 ENST00000421882.1
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_-_99698338 11.94 ENST00000354230.3
ENST00000425308.1
MCM7
minichromosome maintenance complex component 7
chr6_-_32557610 11.93 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_150067632 11.83 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
NUP43
nucleoporin 43kDa
chr15_-_55562479 11.60 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr8_-_101718991 11.28 ENST00000517990.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr1_-_111743285 11.07 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr12_+_20963647 10.97 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chrX_+_119737806 10.61 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr17_+_48823896 10.57 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr12_+_20963632 10.40 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr18_+_3252265 10.17 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_-_150067696 10.06 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr14_+_73563735 9.97 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr6_-_36515177 9.90 ENST00000229812.7
STK38
serine/threonine kinase 38
chr16_-_24942273 9.65 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr1_+_174844645 9.23 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr12_-_9102549 9.21 ENST00000000412.3
M6PR
mannose-6-phosphate receptor (cation dependent)
chr6_-_32498046 9.02 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_24667232 8.84 ENST00000378198.4
TDP2
tyrosyl-DNA phosphodiesterase 2
chr13_-_47012325 8.75 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr2_+_118572226 8.70 ENST00000263239.2
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr8_+_26150628 8.55 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr12_-_118797475 8.55 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr2_+_68961905 8.46 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chrX_-_100872911 8.43 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr6_+_26365443 8.39 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr2_+_68961934 8.37 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr11_-_104905840 8.36 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr12_+_16109519 8.31 ENST00000526530.1
DERA
deoxyribose-phosphate aldolase (putative)
chr11_+_60223312 8.09 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr12_-_49333446 8.01 ENST00000537495.1
AC073610.5
Uncharacterized protein
chr17_+_48823975 7.80 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr15_+_64680003 7.76 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr6_-_24936170 7.74 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr2_-_89521942 7.72 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr2_+_90458201 7.70 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr9_+_70856397 7.69 ENST00000360171.6
CBWD3
COBW domain containing 3
chr11_-_104972158 7.57 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr3_+_136649311 7.55 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr11_-_64647144 7.55 ENST00000359393.2
ENST00000433803.1
ENST00000411683.1
EHD1
EH-domain containing 1
chr6_-_5261141 7.44 ENST00000330636.4
ENST00000500576.2
LYRM4
LYR motif containing 4
chr7_+_77469439 7.27 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr6_-_5260963 7.26 ENST00000464010.1
ENST00000468929.1
ENST00000480566.1
LYRM4
LYR motif containing 4
chr8_+_74903580 7.21 ENST00000284818.2
ENST00000518893.1
LY96
lymphocyte antigen 96
chr6_-_8102714 7.18 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr12_+_21525818 7.08 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
IAPP
islet amyloid polypeptide
chr2_+_122513109 7.06 ENST00000389682.3
ENST00000536142.1
TSN
translin
chr2_+_187371440 7.05 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr1_-_54405773 7.02 ENST00000371376.1
HSPB11
heat shock protein family B (small), member 11
chr10_+_51576285 6.95 ENST00000443446.1
NCOA4
nuclear receptor coactivator 4
chr10_+_11047259 6.87 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr2_+_68592305 6.83 ENST00000234313.7
PLEK
pleckstrin
chr17_-_38978847 6.77 ENST00000269576.5
KRT10
keratin 10
chr12_-_10022735 6.67 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr13_-_50367057 6.58 ENST00000261667.3
KPNA3
karyopherin alpha 3 (importin alpha 4)
chr1_+_236558694 6.49 ENST00000359362.5
EDARADD
EDAR-associated death domain
chr2_-_90538397 6.22 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr2_+_87565634 6.04 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr18_+_32556892 5.84 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_-_40042073 5.67 ENST00000372858.3
PABPC4
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr14_+_72399114 5.64 ENST00000553525.1
ENST00000555571.1
RGS6
regulator of G-protein signaling 6
chr3_+_196466710 5.57 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr5_+_96211643 5.47 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr5_+_156607829 5.46 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr22_+_41258250 5.45 ENST00000544094.1
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr3_+_30647994 5.45 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr10_-_43892279 5.42 ENST00000443950.2
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr6_-_24667180 5.40 ENST00000545995.1
TDP2
tyrosyl-DNA phosphodiesterase 2
chr17_-_55038375 5.28 ENST00000240316.4
COIL
coilin
chr3_+_130569429 5.24 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr2_+_86333301 5.22 ENST00000254630.7
PTCD3
pentatricopeptide repeat domain 3
chr6_+_24667257 5.18 ENST00000537591.1
ENST00000230048.4
ACOT13
acyl-CoA thioesterase 13
chrX_+_37639264 5.10 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr7_-_38305279 5.09 ENST00000443402.2
TRGC1
T cell receptor gamma constant 1
chr5_+_1801503 5.01 ENST00000274137.5
ENST00000469176.1
NDUFS6
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
chr16_+_30751953 4.90 ENST00000483578.1
RP11-2C24.4
RP11-2C24.4
chr2_+_47630255 4.88 ENST00000406134.1
MSH2
mutS homolog 2
chr2_+_90273679 4.79 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr14_-_107049312 4.78 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr8_-_117886955 4.78 ENST00000297338.2
RAD21
RAD21 homolog (S. pombe)
chr1_+_79115503 4.71 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr17_+_73663402 4.56 ENST00000355423.3
SAP30BP
SAP30 binding protein
chr3_+_30648066 4.44 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr2_+_89998789 4.42 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr4_-_72649763 4.40 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chrX_+_37639302 4.32 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr2_+_90198535 4.23 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr1_-_197036364 4.11 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr15_+_57511609 4.08 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr7_-_115608304 4.00 ENST00000457268.1
TFEC
transcription factor EC
chr3_-_185538849 3.98 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr4_-_102268628 3.93 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr8_+_132952112 3.89 ENST00000520362.1
ENST00000519656.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr8_+_21823726 3.81 ENST00000433566.4
XPO7
exportin 7
chr7_-_115670804 3.80 ENST00000320239.7
TFEC
transcription factor EC
chr1_+_145883868 3.76 ENST00000447947.2
GPR89C
G protein-coupled receptor 89C
chr1_+_154229547 3.73 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr5_+_54603566 3.73 ENST00000230640.5
SKIV2L2
superkiller viralicidic activity 2-like 2 (S. cerevisiae)
chr5_-_96518907 3.62 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2
chr18_+_3252206 3.60 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_158801095 3.53 ENST00000368141.4
MNDA
myeloid cell nuclear differentiation antigen
chr15_-_64673665 3.52 ENST00000300035.4
KIAA0101
KIAA0101
chr5_-_43557129 3.52 ENST00000514514.1
ENST00000504075.1
ENST00000306846.3
ENST00000436644.2
PAIP1
poly(A) binding protein interacting protein 1
chr7_-_115670792 3.50 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr14_+_89060739 3.44 ENST00000318308.6
ZC3H14
zinc finger CCCH-type containing 14
chr3_+_138340049 3.42 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr6_+_25963020 3.37 ENST00000357085.3
TRIM38
tripartite motif containing 38
chr1_+_74701062 3.34 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr16_-_15736881 3.33 ENST00000540441.2
KIAA0430
KIAA0430
chr3_+_120461484 3.26 ENST00000484715.1
ENST00000469772.1
ENST00000283875.5
ENST00000492959.1
GTF2E1
general transcription factor IIE, polypeptide 1, alpha 56kDa
chr12_-_7656357 3.24 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr3_+_63953415 3.23 ENST00000484332.1
ATXN7
ataxin 7
chr7_+_101460882 3.16 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr3_+_158288999 3.16 ENST00000482628.1
ENST00000478894.2
ENST00000392822.3
ENST00000466246.1
MLF1
myeloid leukemia factor 1
chr3_+_43328004 3.15 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr16_-_15180257 3.14 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr12_+_75784850 3.14 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr19_+_54619125 3.10 ENST00000445811.1
ENST00000419967.1
ENST00000445124.1
ENST00000447810.1
PRPF31
pre-mRNA processing factor 31
chr5_-_150460914 3.05 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr1_-_231560790 3.02 ENST00000366641.3
EGLN1
egl-9 family hypoxia-inducible factor 1
chr2_-_165424973 2.89 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr19_-_39881669 2.88 ENST00000221266.7
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr14_-_106453155 2.86 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr19_+_49588677 2.79 ENST00000598984.1
ENST00000598441.1
SNRNP70
small nuclear ribonucleoprotein 70kDa (U1)
chr2_+_183580954 2.78 ENST00000264065.7
DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr1_+_244214577 2.78 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr1_-_155942086 2.74 ENST00000368315.4
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr8_-_79717750 2.57 ENST00000263851.4
ENST00000379113.2
IL7
interleukin 7
chr5_-_64064508 2.52 ENST00000513458.4
SREK1IP1
SREK1-interacting protein 1
chr3_+_169629354 2.52 ENST00000428432.2
ENST00000335556.3
SAMD7
sterile alpha motif domain containing 7
chr2_-_190044480 2.52 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr10_-_75226166 2.50 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr3_+_158288960 2.49 ENST00000484955.1
ENST00000359117.5
ENST00000498592.1
ENST00000477042.1
ENST00000471745.1
ENST00000469452.1
MLF1
myeloid leukemia factor 1
chr5_+_141346385 2.45 ENST00000513019.1
ENST00000356143.1
RNF14
ring finger protein 14
chr6_+_158733692 2.42 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chr22_-_29107919 2.41 ENST00000434810.1
ENST00000456369.1
CHEK2
checkpoint kinase 2
chr16_+_4896659 2.41 ENST00000592120.1
UBN1
ubinuclein 1
chr2_+_90211643 2.41 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr22_+_32871224 2.41 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr11_+_120973375 2.30 ENST00000264037.2
TECTA
tectorin alpha
chr6_-_133055896 2.27 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr5_-_180665195 2.22 ENST00000509148.1
GNB2L1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr3_-_27498235 2.21 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr9_-_36401155 2.20 ENST00000377885.2
RNF38
ring finger protein 38
chr14_+_75988851 2.19 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr15_+_41549105 2.18 ENST00000560965.1
CHP1
calcineurin-like EF-hand protein 1
chr1_+_207262881 2.14 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr12_-_13248732 2.13 ENST00000396302.3
GSG1
germ cell associated 1
chrX_+_12924732 2.12 ENST00000218032.6
ENST00000311912.5
TLR8
toll-like receptor 8
chr5_-_39203093 2.12 ENST00000515010.1
FYB
FYN binding protein
chr2_+_185463093 2.07 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr9_+_82187487 2.07 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_158288942 2.02 ENST00000491767.1
ENST00000355893.5
MLF1
myeloid leukemia factor 1
chr8_+_124084899 2.01 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr3_+_108541608 1.96 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr12_-_25055177 1.91 ENST00000538118.1
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr10_+_35456444 1.74 ENST00000361599.4
CREM
cAMP responsive element modulator
chr6_-_25830785 1.73 ENST00000468082.1
SLC17A1
solute carrier family 17 (organic anion transporter), member 1
chr12_-_10588539 1.66 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chrX_+_149887090 1.65 ENST00000538506.1
MTMR1
myotubularin related protein 1
chr12_-_13248705 1.63 ENST00000396310.2
GSG1
germ cell associated 1
chr4_-_76928641 1.53 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr6_-_134639180 1.53 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_37216055 1.52 ENST00000336686.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr6_-_133055815 1.52 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr6_+_5261225 1.48 ENST00000324331.6
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr5_-_58882219 1.48 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_108541545 1.47 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr4_-_102268484 1.43 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr12_-_13248562 1.42 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr5_-_111312622 1.37 ENST00000395634.3
NREP
neuronal regeneration related protein
chr4_-_70080449 1.30 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_+_82187630 1.30 ENST00000265284.6
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr2_+_166326157 1.28 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr6_-_100016527 1.27 ENST00000523985.1
ENST00000518714.1
ENST00000520371.1
CCNC
cyclin C
chr16_+_1728257 1.25 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L
hematological and neurological expressed 1-like
chr18_+_55816546 1.22 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr12_+_60083118 1.20 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr11_-_30608413 1.19 ENST00000528686.1
MPPED2
metallophosphoesterase domain containing 2
chr13_+_78109884 1.17 ENST00000377246.3
ENST00000349847.3
SCEL
sciellin
chr7_-_7782204 1.13 ENST00000418534.2
AC007161.5
AC007161.5
chr14_+_75988768 1.11 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr12_-_131323754 1.09 ENST00000261653.6
STX2
syntaxin 2
chr7_+_107224364 1.06 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
4.2 16.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
4.2 16.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
4.0 15.9 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
3.5 10.6 GO:0002188 translation reinitiation(GO:0002188)
3.3 9.9 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
3.3 16.4 GO:0048539 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
2.9 26.3 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
2.6 46.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
2.5 7.5 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
2.4 11.9 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.9 11.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.9 9.4 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.8 5.4 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.6 14.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
1.4 5.6 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
1.4 8.3 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
1.2 24.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.2 3.6 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
1.2 11.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.1 6.8 GO:0070560 protein secretion by platelet(GO:0070560)
1.1 7.5 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
1.0 7.2 GO:0032497 detection of lipopolysaccharide(GO:0032497)
1.0 3.1 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.0 4.9 GO:0010520 meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520)
1.0 5.8 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.9 9.2 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.8 2.4 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.8 4.8 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.8 7.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.7 5.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.7 2.7 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.7 25.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.6 2.5 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.6 3.7 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 7.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.5 7.0 GO:0070986 left/right axis specification(GO:0070986)
0.5 12.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 2.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.5 3.1 GO:0048254 snoRNA localization(GO:0048254)
0.5 3.0 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.5 21.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 21.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.5 8.6 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.4 3.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.4 7.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.4 5.5 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.4 2.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.4 8.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 2.3 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.4 3.8 GO:0015939 pantothenate metabolic process(GO:0015939)
0.4 3.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.4 1.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 1.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 16.7 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.3 1.0 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.3 1.0 GO:2000360 positive regulation of female gonad development(GO:2000196) negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.3 2.9 GO:0016584 nucleosome positioning(GO:0016584)
0.3 1.9 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3 7.0 GO:0006622 protein targeting to lysosome(GO:0006622)
0.3 15.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.3 3.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 8.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 2.2 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.3 2.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.2 1.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 3.4 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.2 3.4 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.2 14.5 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 1.5 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.2 1.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 20.9 GO:0042100 B cell proliferation(GO:0042100)
0.2 10.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 9.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 4.4 GO:0042359 vitamin D metabolic process(GO:0042359)
0.2 3.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 2.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 1.7 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 5.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 7.8 GO:1901998 toxin transport(GO:1901998)
0.2 2.4 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.2 1.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 21.0 GO:0002377 immunoglobulin production(GO:0002377)
0.1 2.2 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 1.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 3.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 0.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.5 GO:0019249 lactate biosynthetic process(GO:0019249)
0.1 0.9 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 9.1 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 3.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 0.4 GO:1903961 positive regulation of anion channel activity(GO:1901529) positive regulation of anion transmembrane transport(GO:1903961)
0.1 0.3 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 4.7 GO:0009615 response to virus(GO:0009615)
0.1 1.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 9.0 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 3.5 GO:0048255 mRNA stabilization(GO:0048255)
0.1 2.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.1 7.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 8.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 5.4 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 16.4 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 5.2 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 3.2 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 0.7 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 1.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 3.2 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 5.2 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 2.5 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 12.5 GO:0006302 double-strand break repair(GO:0006302)
0.1 6.8 GO:0098773 skin epidermis development(GO:0098773)
0.1 6.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 4.0 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.1 2.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.1 2.4 GO:0061512 protein localization to cilium(GO:0061512)
0.1 1.0 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 1.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.3 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 4.8 GO:0051289 protein homotetramerization(GO:0051289)
0.0 1.0 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.4 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 3.3 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.7 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.9 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.3 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.7 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0034378 chylomicron assembly(GO:0034378)
0.0 2.4 GO:0051028 mRNA transport(GO:0051028)
0.0 6.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.2 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.2 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.8 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
5.0 30.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
1.6 4.9 GO:0032302 MutSbeta complex(GO:0032302)
1.5 7.5 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.4 7.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.4 26.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.4 21.9 GO:0031080 nuclear pore outer ring(GO:0031080)
1.3 14.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.2 4.8 GO:0000798 nuclear cohesin complex(GO:0000798)
1.1 9.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.0 21.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.0 20.9 GO:0042613 MHC class II protein complex(GO:0042613)
1.0 11.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.9 16.7 GO:0071004 U2-type prespliceosome(GO:0071004)
0.9 11.9 GO:0042555 MCM complex(GO:0042555)
0.9 7.9 GO:0005955 calcineurin complex(GO:0005955)
0.8 2.5 GO:0005588 collagen type V trimer(GO:0005588)
0.8 3.1 GO:0005687 U4 snRNP(GO:0005687)
0.8 20.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.6 9.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 7.0 GO:0044754 autolysosome(GO:0044754)
0.5 3.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.4 7.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 2.4 GO:1990037 Lewy body core(GO:1990037)
0.3 1.0 GO:0002081 outer acrosomal membrane(GO:0002081)
0.3 8.0 GO:0030904 retromer complex(GO:0030904)
0.3 7.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 32.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 3.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 2.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.3 14.2 GO:0016235 aggresome(GO:0016235)
0.3 15.3 GO:0001772 immunological synapse(GO:0001772)
0.3 1.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.3 8.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 1.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.2 5.8 GO:0035371 microtubule plus-end(GO:0035371)
0.2 3.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 14.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 3.4 GO:0042101 T cell receptor complex(GO:0042101)
0.1 2.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 10.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.7 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 12.1 GO:0016459 myosin complex(GO:0016459)
0.1 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 2.1 GO:0036020 endolysosome membrane(GO:0036020)
0.1 5.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 10.4 GO:0005643 nuclear pore(GO:0005643)
0.1 5.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.3 GO:0015030 Cajal body(GO:0015030)
0.1 15.4 GO:0005681 spliceosomal complex(GO:0005681)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 2.2 GO:0032420 stereocilium(GO:0032420)
0.1 0.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 20.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 46.9 GO:0016604 nuclear body(GO:0016604)
0.1 2.8 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.7 GO:0002102 podosome(GO:0002102)
0.0 2.3 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 3.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 6.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 5.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 4.9 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 2.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
4.7 14.2 GO:0070260 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
2.8 8.3 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
2.5 9.9 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
2.2 30.2 GO:0050700 CARD domain binding(GO:0050700)
1.9 5.7 GO:0017130 poly(C) RNA binding(GO:0017130)
1.8 29.8 GO:0008494 translation activator activity(GO:0008494)
1.6 4.9 GO:0032181 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
1.5 12.4 GO:0004111 creatine kinase activity(GO:0004111)
1.5 7.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
1.0 3.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
1.0 32.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.0 21.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.8 7.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.8 7.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.8 3.8 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.7 4.4 GO:0005499 vitamin D binding(GO:0005499)
0.7 20.3 GO:0070717 poly-purine tract binding(GO:0070717)
0.7 15.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.5 9.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.5 5.9 GO:0070990 snRNP binding(GO:0070990)
0.5 6.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.5 9.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.5 9.2 GO:0005537 mannose binding(GO:0005537)
0.4 11.6 GO:0031489 myosin V binding(GO:0031489)
0.4 5.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.4 11.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4 1.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 3.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.7 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.3 1.9 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.3 3.3 GO:0031013 troponin I binding(GO:0031013)
0.3 0.9 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.3 1.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.3 4.6 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.3 5.4 GO:0048156 tau protein binding(GO:0048156)
0.3 6.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 9.0 GO:0042605 peptide antigen binding(GO:0042605)
0.3 1.1 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.3 11.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 3.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.3 7.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 5.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 2.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 0.7 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 1.7 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2 6.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 3.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 5.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 12.9 GO:0008026 ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.2 4.1 GO:0035497 cAMP response element binding(GO:0035497)
0.2 5.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 5.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 9.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 28.5 GO:0003823 antigen binding(GO:0003823)
0.2 10.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 39.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 1.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 9.4 GO:0050681 androgen receptor binding(GO:0050681)
0.1 7.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 12.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 6.9 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 7.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 5.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384) acrosin binding(GO:0032190)
0.1 52.3 GO:0003682 chromatin binding(GO:0003682)
0.1 34.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 15.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 1.5 GO:0030275 LRR domain binding(GO:0030275)
0.1 3.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 3.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 1.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.5 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.1 2.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 3.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 4.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 4.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 11.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 4.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.6 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 1.0 GO:0008289 lipid binding(GO:0008289)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 15.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 34.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.4 20.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.3 14.4 PID CD40 PATHWAY CD40/CD40L signaling
0.2 7.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 9.9 PID ALK1 PATHWAY ALK1 signaling events
0.2 14.6 PID TNF PATHWAY TNF receptor signaling pathway
0.2 11.9 PID ATR PATHWAY ATR signaling pathway
0.2 11.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 9.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 9.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 16.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 4.4 PID INSULIN PATHWAY Insulin Pathway
0.1 10.9 PID CMYB PATHWAY C-MYB transcription factor network
0.1 10.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 7.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 5.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 2.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 3.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 4.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 3.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 37.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.3 20.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.9 29.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.7 11.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.7 29.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.6 20.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.6 21.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.6 7.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.6 21.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 16.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 9.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 21.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 2.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 7.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 38.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 9.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 9.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 3.4 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.2 2.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 7.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 6.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 8.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 4.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 5.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 8.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.5 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 1.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 4.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 5.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 5.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.0 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport