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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXD4

Z-value: 0.77

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Transcription factors associated with HOXD4

Gene Symbol Gene ID Gene Info
HOXD4
ENSG00000170166.5 homeobox D4

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_158787041 18.43 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chrX_-_13835147 15.70 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chrX_-_92928557 14.49 ENST00000373079.3
ENST00000475430.2
NAP1L3
nucleosome assembly protein 1-like 3
chrX_+_56590002 12.95 ENST00000338222.5
UBQLN2
ubiquilin 2
chr18_-_21891460 12.61 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr7_-_137028498 10.55 ENST00000393083.2
PTN
pleiotrophin
chr14_+_90863327 9.87 ENST00000356978.4
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr5_+_67586465 9.54 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_84630645 9.48 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_73844722 9.46 ENST00000586257.1
WBP2
WW domain binding protein 2
chr7_-_137028534 9.39 ENST00000348225.2
PTN
pleiotrophin
chr9_-_93405352 8.97 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr15_+_84115868 8.61 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr17_-_29624343 8.28 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr8_-_18871159 7.89 ENST00000327040.8
ENST00000440756.2
PSD3
pleckstrin and Sec7 domain containing 3
chr13_-_24007815 6.76 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr2_+_187371440 6.71 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr16_-_29910853 6.56 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr3_+_111718173 6.53 ENST00000494932.1
TAGLN3
transgelin 3
chr8_-_102803163 6.25 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr2_-_225434538 6.01 ENST00000409096.1
CUL3
cullin 3
chr5_+_140762268 5.91 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr7_+_16793160 5.76 ENST00000262067.4
TSPAN13
tetraspanin 13
chr7_-_104909435 5.39 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr5_-_179499108 5.03 ENST00000521389.1
RNF130
ring finger protein 130
chr16_+_103816 4.84 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr12_-_118628350 4.82 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr17_+_66521936 4.74 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr9_+_470288 4.63 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr3_-_18480260 4.59 ENST00000454909.2
SATB1
SATB homeobox 1
chr2_+_27886330 4.50 ENST00000326019.6
SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr9_-_131790550 4.33 ENST00000372554.4
ENST00000372564.3
SH3GLB2
SH3-domain GRB2-like endophilin B2
chr11_-_77790865 4.17 ENST00000534029.1
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000528251.1
ENST00000530054.1
NDUFC2
NDUFC2-KCTD14
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NDUFC2-KCTD14 readthrough
chr7_-_22233442 4.10 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr5_+_140743859 4.09 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr17_-_78450398 4.09 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr1_-_101360331 4.06 ENST00000416479.1
ENST00000370113.3
EXTL2
exostosin-like glycosyltransferase 2
chr5_-_179499086 4.01 ENST00000261947.4
RNF130
ring finger protein 130
chr11_-_36310958 3.99 ENST00000532705.1
ENST00000263401.5
ENST00000452374.2
COMMD9
COMM domain containing 9
chr13_+_20207782 3.59 ENST00000414242.2
ENST00000361479.5
MPHOSPH8
M-phase phosphoprotein 8
chr2_-_166060552 3.51 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr7_+_101460882 3.35 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr1_+_67632083 3.31 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr2_-_160473114 3.26 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr14_-_101036119 3.24 ENST00000355173.2
BEGAIN
brain-enriched guanylate kinase-associated
chr14_+_78174414 3.20 ENST00000557342.1
ENST00000238688.5
ENST00000557623.1
ENST00000557431.1
ENST00000556831.1
ENST00000556375.1
ENST00000553981.1
SLIRP
SRA stem-loop interacting RNA binding protein
chr16_-_15736953 3.07 ENST00000548025.1
ENST00000551742.1
ENST00000602337.1
ENST00000344181.3
ENST00000396368.3
KIAA0430
KIAA0430
chr14_+_29236269 3.00 ENST00000313071.4
FOXG1
forkhead box G1
chr2_-_176046391 2.97 ENST00000392541.3
ENST00000409194.1
ATP5G3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr2_-_207024233 2.96 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr15_-_65809991 2.94 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
DPP8
dipeptidyl-peptidase 8
chr3_+_173116225 2.75 ENST00000457714.1
NLGN1
neuroligin 1
chr3_+_142342228 2.62 ENST00000337777.3
PLS1
plastin 1
chr17_-_7218631 2.61 ENST00000577040.2
ENST00000389167.5
ENST00000391950.3
GPS2
G protein pathway suppressor 2
chr2_-_166060571 2.54 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr15_+_80364901 2.32 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr5_-_78809950 2.31 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr17_+_47448102 2.28 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr1_-_87380002 2.25 ENST00000331835.5
SEP15
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr1_-_87379785 2.22 ENST00000401030.3
ENST00000370554.1
SEP15
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr12_+_16109519 2.19 ENST00000526530.1
DERA
deoxyribose-phosphate aldolase (putative)
chr11_+_101983176 2.15 ENST00000524575.1
YAP1
Yes-associated protein 1
chr1_-_36948879 2.08 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr5_+_95066823 2.03 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chrX_-_10645773 2.01 ENST00000453318.2
MID1
midline 1 (Opitz/BBB syndrome)
chr21_-_27423339 1.97 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr11_-_104972158 1.97 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr17_-_50235423 1.94 ENST00000340813.6
CA10
carbonic anhydrase X
chr5_+_141346385 1.94 ENST00000513019.1
ENST00000356143.1
RNF14
ring finger protein 14
chr3_-_149095652 1.92 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr10_-_50970322 1.84 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr18_+_32556892 1.82 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr3_-_11623804 1.82 ENST00000451674.2
VGLL4
vestigial like 4 (Drosophila)
chr12_+_12938541 1.78 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr16_+_84801852 1.77 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr2_-_160472952 1.72 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr5_+_69321074 1.63 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr10_+_18629628 1.62 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr19_+_48828788 1.61 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
EMP3
epithelial membrane protein 3
chr7_+_112063192 1.61 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr10_+_13652047 1.57 ENST00000601460.1
RP11-295P9.3
Uncharacterized protein
chr13_+_37581115 1.55 ENST00000481013.1
EXOSC8
exosome component 8
chr3_-_149293990 1.46 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr10_+_48189612 1.38 ENST00000453919.1
AGAP9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr19_+_48828582 1.31 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr14_-_24911868 1.31 ENST00000554698.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr17_-_60142609 1.29 ENST00000397786.2
MED13
mediator complex subunit 13
chr15_-_55700457 1.18 ENST00000442196.3
ENST00000563171.1
ENST00000425574.3
CCPG1
cell cycle progression 1
chr4_-_143227088 1.18 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_144146808 1.16 ENST00000369190.5
ENST00000412624.2
ENST00000369365.3
NBPF8
neuroblastoma breakpoint family, member 8
chr1_-_120935894 1.09 ENST00000369383.4
ENST00000369384.4
FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr3_+_197518100 1.08 ENST00000438796.2
ENST00000414675.2
ENST00000441090.2
ENST00000334859.4
ENST00000425562.2
LRCH3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr14_-_24911971 1.04 ENST00000555365.1
ENST00000399395.3
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr2_+_204571375 0.99 ENST00000374478.4
CD28
CD28 molecule
chr6_-_87804815 0.97 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr5_-_55412774 0.96 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr16_+_24549014 0.94 ENST00000564314.1
ENST00000567686.1
RBBP6
retinoblastoma binding protein 6
chr5_+_179921344 0.91 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr5_+_52083730 0.86 ENST00000282588.6
ENST00000274311.2
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chr15_+_64386261 0.83 ENST00000560829.1
SNX1
sorting nexin 1
chr1_-_190446759 0.83 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr12_+_112279782 0.82 ENST00000550735.2
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
chr4_-_143226979 0.81 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr7_+_55433131 0.81 ENST00000254770.2
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr15_-_55700522 0.81 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr12_+_21168630 0.80 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr16_-_21663919 0.78 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr2_+_109237717 0.75 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_-_49245936 0.74 ENST00000308025.3
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr15_-_56209306 0.67 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr12_+_9980113 0.66 ENST00000537723.1
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr18_-_61311485 0.65 ENST00000436264.1
ENST00000356424.6
ENST00000341074.5
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr5_-_10761206 0.54 ENST00000432074.2
ENST00000230895.6
DAP
death-associated protein
chrX_+_70752917 0.51 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr2_-_99279928 0.49 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr2_+_170440844 0.49 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr1_+_87380299 0.47 ENST00000370551.4
ENST00000370550.5
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr6_+_46761118 0.44 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr4_-_46996424 0.43 ENST00000264318.3
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr3_+_69812877 0.43 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr18_-_19283649 0.41 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr7_+_77428149 0.38 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr17_-_41132410 0.37 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr1_+_197237352 0.35 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr1_+_115572415 0.26 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr2_+_234590556 0.24 ENST00000373426.3
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr14_-_99947168 0.24 ENST00000331768.5
SETD3
SET domain containing 3
chr2_+_234826016 0.22 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr3_+_51575596 0.22 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr18_-_19994830 0.20 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr13_+_33160553 0.19 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr1_-_231560790 0.19 ENST00000366641.3
EGLN1
egl-9 family hypoxia-inducible factor 1
chr2_+_196313239 0.17 ENST00000413290.1
AC064834.1
AC064834.1
chr5_-_137475071 0.17 ENST00000265191.2
NME5
NME/NM23 family member 5
chr2_+_166095898 0.15 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr6_-_44281043 0.14 ENST00000244571.4
AARS2
alanyl-tRNA synthetase 2, mitochondrial
chr6_+_53659746 0.10 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr7_+_77428066 0.09 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr12_-_112279694 0.07 ENST00000443596.1
ENST00000442119.1
MAPKAPK5-AS1
MAPKAPK5 antisense RNA 1
chr20_+_32150140 0.02 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.9 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
3.2 13.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
1.9 9.5 GO:0097338 response to clozapine(GO:0097338)
1.6 15.7 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.5 4.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.5 6.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
1.4 2.7 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
1.4 9.5 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
1.1 5.4 GO:0035063 nuclear speck organization(GO:0035063)
1.0 4.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.8 3.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.8 3.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.8 2.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.6 9.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.5 1.6 GO:0007518 myoblast fate determination(GO:0007518)
0.5 2.6 GO:1902896 terminal web assembly(GO:1902896)
0.5 2.0 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 6.8 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.4 4.1 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.4 2.0 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.4 7.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.4 2.0 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.4 1.5 GO:0071042 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.4 2.2 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.3 4.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 1.8 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.3 4.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 1.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 3.6 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 0.7 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.2 10.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.2 0.7 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.2 4.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.7 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.2 2.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 2.9 GO:0032060 bleb assembly(GO:0032060)
0.1 8.3 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 14.5 GO:0006334 nucleosome assembly(GO:0006334)
0.1 5.7 GO:0019228 neuronal action potential(GO:0019228)
0.1 0.8 GO:1901419 regulation of response to alcohol(GO:1901419)
0.1 3.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 2.1 GO:0097186 amelogenesis(GO:0097186)
0.1 3.0 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 2.3 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.4 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.8 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 1.0 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.1 4.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 2.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.5 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 5.3 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.9 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 1.8 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.2 GO:0030820 regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.2 GO:0009698 phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0 1.8 GO:0019985 translesion synthesis(GO:0019985)
0.0 2.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 2.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 3.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 1.0 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 1.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.8 GO:0051301 cell division(GO:0051301)
0.0 0.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.8 GO:1903393 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of adherens junction organization(GO:1903393)
0.0 0.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 3.5 GO:0055114 oxidation-reduction process(GO:0055114)
0.0 0.2 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.4 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0061053 somite development(GO:0061053)
0.0 0.5 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.0 4.8 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 10.4 GO:0007417 central nervous system development(GO:0007417)
0.0 9.0 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.0 6.8 GO:0070852 cell body fiber(GO:0070852)
0.8 3.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.7 14.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.7 6.0 GO:0005827 polar microtubule(GO:0005827)
0.6 3.0 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.4 2.6 GO:1990357 terminal web(GO:1990357)
0.4 2.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 6.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.4 2.0 GO:0097179 protease inhibitor complex(GO:0097179)
0.4 6.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 0.9 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.3 1.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.3 3.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 21.9 GO:0031594 neuromuscular junction(GO:0031594)
0.2 4.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 2.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 3.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.8 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 13.0 GO:0005776 autophagosome(GO:0005776)
0.1 4.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 12.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 9.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 9.9 GO:0000922 spindle pole(GO:0000922)
0.1 8.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.9 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 10.6 GO:0005770 late endosome(GO:0005770)
0.1 2.3 GO:0043034 costamere(GO:0043034)
0.1 2.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 15.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.4 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 6.2 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 6.5 GO:0043209 myelin sheath(GO:0043209)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 7.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.0 3.7 GO:0030133 transport vesicle(GO:0030133)
0.0 6.6 GO:0042175 endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 19.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.5 6.0 GO:0031208 POZ domain binding(GO:0031208)
1.2 9.5 GO:0043559 insulin binding(GO:0043559)
0.8 3.3 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.8 4.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.7 2.2 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.6 9.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 2.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.4 2.0 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.4 1.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.4 12.6 GO:0015248 sterol transporter activity(GO:0015248)
0.3 6.8 GO:0070628 proteasome binding(GO:0070628)
0.3 4.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 7.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 6.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 4.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 2.0 GO:0051425 PTB domain binding(GO:0051425)
0.2 2.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 6.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 0.8 GO:1990460 leptin receptor binding(GO:1990460)
0.2 2.0 GO:0089720 caspase binding(GO:0089720)
0.2 5.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 9.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 2.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 3.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 2.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 3.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 5.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 10.3 GO:0044325 ion channel binding(GO:0044325)
0.1 2.5 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 2.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.7 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.4 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 4.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 9.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 13.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.5 GO:0070513 death domain binding(GO:0070513)
0.0 0.5 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 10.6 GO:0045296 cadherin binding(GO:0045296)
0.0 8.6 GO:0003924 GTPase activity(GO:0003924)
0.0 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 1.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 3.5 GO:0016491 oxidoreductase activity(GO:0016491)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 19.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 9.5 PID IL5 PATHWAY IL5-mediated signaling events
0.3 9.5 PID IL3 PATHWAY IL3-mediated signaling events
0.2 6.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 4.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 9.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 2.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 4.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 3.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 16.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 9.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 14.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 3.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 1.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.0 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 3.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 3.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 12.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 8.3 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 4.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 7.7 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway