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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HSF1
Z-value: 1.22
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Transcription factors associated with HSF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF1 | hg19_v2_chr8_+_145515263_145515299 | -0.12 | 7.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_33041378 Show fit | 41.32 |
ENST00000428995.1
|
major histocompatibility complex, class II, DP alpha 1 |
|
| chr19_+_1065922 Show fit | 26.17 |
ENST00000539243.2
|
histocompatibility (minor) HA-1 |
|
| chr1_+_111415757 Show fit | 22.73 |
ENST00000429072.2
ENST00000271324.5 |
CD53 molecule |
|
| chr4_-_84030996 Show fit | 21.37 |
ENST00000411416.2
|
placenta-specific 8 |
|
| chr2_-_89513402 Show fit | 18.91 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr6_-_32557610 Show fit | 18.30 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr1_-_153363452 Show fit | 18.04 |
ENST00000368732.1
ENST00000368733.3 |
S100 calcium binding protein A8 |
|
| chr6_-_32498046 Show fit | 17.51 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr6_+_32605195 Show fit | 17.31 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr14_-_106092403 Show fit | 17.14 |
ENST00000390543.2
|
immunoglobulin heavy constant gamma 4 (G4m marker) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 87.6 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.6 | 40.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 34.6 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.3 | 34.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 29.2 | GO:0044146 | negative regulation of growth of symbiont involved in interaction with host(GO:0044146) |
| 0.6 | 25.6 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 7.8 | 23.3 | GO:1900159 | iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308) |
| 1.0 | 22.7 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 4.3 | 21.4 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 1.2 | 21.4 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 108.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.8 | 41.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 4.7 | 33.1 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 3.9 | 31.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.5 | 30.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 28.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.4 | 26.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 23.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 17.3 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 13.1 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 72.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 1.5 | 45.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.8 | 41.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 31.9 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.0 | 31.0 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 29.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 21.5 | GO:0003823 | antigen binding(GO:0003823) |
| 6.0 | 18.0 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.5 | 16.6 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.2 | 15.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.5 | 23.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 20.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.4 | 15.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.6 | 14.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 14.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 12.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.4 | 11.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.4 | 10.9 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 10.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 111.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 51.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 32.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.7 | 28.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 18.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 17.5 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.2 | 17.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 14.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.3 | 12.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 12.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |