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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HSF4

Z-value: 2.05

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Transcription factors associated with HSF4

Gene Symbol Gene ID Gene Info
HSF4
ENSG00000102878.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF4hg19_v2_chr16_+_67197288_67197362-0.681.2e-30Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_56119323 87.99 ENST00000275603.4
ENST00000335503.3
ENST00000540286.1
CCT6A
chaperonin containing TCP1, subunit 6A (zeta 1)
chr9_+_33025209 58.49 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr2_+_201170770 52.61 ENST00000409988.3
ENST00000409385.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_-_122933043 52.09 ENST00000534624.1
ENST00000453788.2
ENST00000527387.1
HSPA8
heat shock 70kDa protein 8
chr13_-_31736027 51.80 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr11_-_122932730 51.52 ENST00000532182.1
ENST00000524590.1
ENST00000528292.1
ENST00000533540.1
ENST00000525463.1
HSPA8
heat shock 70kDa protein 8
chr11_+_63953691 50.69 ENST00000543847.1
STIP1
stress-induced-phosphoprotein 1
chr9_-_88715044 49.77 ENST00000388711.3
ENST00000466178.1
GOLM1
golgi membrane protein 1
chr12_+_2904102 48.10 ENST00000001008.4
FKBP4
FK506 binding protein 4, 59kDa
chr14_-_102553371 47.29 ENST00000553585.1
ENST00000216281.8
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr2_+_201171242 45.86 ENST00000360760.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr6_+_44215603 44.57 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_-_45987526 44.50 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
PRDX1
peroxiredoxin 1
chrX_-_102942961 42.91 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr2_-_62115725 41.94 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr21_-_30445886 41.48 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr11_+_63953587 41.35 ENST00000305218.4
ENST00000538945.1
STIP1
stress-induced-phosphoprotein 1
chrX_-_102943022 41.00 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chr2_-_62115659 40.40 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr1_+_154947148 39.71 ENST00000368436.1
ENST00000308987.5
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr9_-_88714421 38.36 ENST00000388712.3
GOLM1
golgi membrane protein 1
chr7_+_26240776 38.05 ENST00000337620.4
CBX3
chromobox homolog 3
chr2_+_198365122 36.74 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr2_+_201171372 36.54 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr1_-_6453426 35.86 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr7_-_26240357 34.75 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_-_17513702 33.84 ENST00000428702.2
ENST00000508623.1
ENST00000513615.1
QDPR
quinoid dihydropteridine reductase
chr1_+_154947126 33.68 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr11_+_75273101 33.60 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr9_-_86593238 32.99 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr12_+_104324112 32.11 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr12_-_110883346 31.22 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr11_+_65770227 30.80 ENST00000527348.1
BANF1
barrier to autointegration factor 1
chrX_-_152989531 29.93 ENST00000458587.2
ENST00000416815.1
BCAP31
B-cell receptor-associated protein 31
chr2_+_198365095 28.98 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr5_+_10250328 28.87 ENST00000515390.1
CCT5
chaperonin containing TCP1, subunit 5 (epsilon)
chr13_-_31191642 28.80 ENST00000405805.1
HMGB1
high mobility group box 1
chr11_+_75273246 28.45 ENST00000526397.1
ENST00000529643.1
ENST00000525492.1
ENST00000530284.1
ENST00000532356.1
ENST00000524558.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr11_+_65769550 28.16 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr13_-_31736478 27.59 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr7_-_56119238 26.95 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chr11_+_65769946 26.92 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr1_-_6453399 26.91 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr11_-_82997371 26.59 ENST00000525503.1
CCDC90B
coiled-coil domain containing 90B
chrX_-_152989798 26.50 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
BCAP31
B-cell receptor-associated protein 31
chr2_-_69664586 25.94 ENST00000303698.3
ENST00000394305.1
ENST00000410022.2
NFU1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
chr11_-_82997013 25.82 ENST00000529073.1
ENST00000529611.1
CCDC90B
coiled-coil domain containing 90B
chr4_+_41258786 25.49 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_+_75931861 24.97 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr15_+_44092784 24.38 ENST00000458412.1
HYPK
huntingtin interacting protein K
chrX_+_123095155 24.13 ENST00000371160.1
ENST00000435103.1
STAG2
stromal antigen 2
chr1_-_6260896 24.07 ENST00000497965.1
RPL22
ribosomal protein L22
chr1_+_27248203 23.89 ENST00000321265.5
NUDC
nudC nuclear distribution protein
chr1_-_156308018 22.95 ENST00000496684.2
ENST00000368259.2
ENST00000368261.3
ENST00000472765.2
ENST00000533194.1
ENST00000478640.2
CCT3
chaperonin containing TCP1, subunit 3 (gamma)
chr11_-_82997420 22.26 ENST00000455220.2
ENST00000529689.1
CCDC90B
coiled-coil domain containing 90B
chr21_-_40720974 22.15 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr17_-_79805146 21.82 ENST00000415593.1
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr11_+_20385327 21.77 ENST00000451739.2
ENST00000532505.1
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr17_-_61850894 21.47 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr22_-_41252962 21.21 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr11_+_20385231 20.87 ENST00000530266.1
ENST00000421577.2
ENST00000443524.2
ENST00000419348.2
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr16_-_8955570 20.52 ENST00000567554.1
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr21_-_40720995 20.28 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chr3_+_158787041 20.24 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr1_-_53704157 19.97 ENST00000371466.4
ENST00000371470.3
MAGOH
mago-nashi homolog, proliferation-associated (Drosophila)
chrX_-_20236970 19.96 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr20_+_19867150 19.73 ENST00000255006.6
RIN2
Ras and Rab interactor 2
chr10_-_74856608 19.49 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr3_-_185655795 19.14 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr11_-_134123142 18.70 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr4_-_159644507 18.65 ENST00000307720.3
PPID
peptidylprolyl isomerase D
chr15_+_96869165 18.56 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_+_133707252 18.10 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr14_-_23540826 17.48 ENST00000357481.2
ACIN1
apoptotic chromatin condensation inducer 1
chr2_+_201171064 17.48 ENST00000451764.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_+_2269485 16.70 ENST00000582888.4
ENST00000602676.2
ENST00000322297.4
ENST00000583542.4
OAZ1
ornithine decarboxylase antizyme 1
chr14_-_23540747 16.34 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
ACIN1
apoptotic chromatin condensation inducer 1
chr14_-_68141535 16.32 ENST00000554659.1
VTI1B
vesicle transport through interaction with t-SNAREs 1B
chr19_-_14628645 16.23 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr11_-_89956461 15.57 ENST00000320585.6
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr11_+_86013253 15.55 ENST00000533986.1
ENST00000278483.3
C11orf73
chromosome 11 open reading frame 73
chr9_-_6015607 15.19 ENST00000259569.5
RANBP6
RAN binding protein 6
chr16_-_8955601 14.99 ENST00000569398.1
ENST00000568968.1
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr11_-_89956227 14.69 ENST00000457199.2
ENST00000530765.1
CHORDC1
cysteine and histidine-rich domain (CHORD) containing 1
chr7_-_56118981 14.65 ENST00000419984.2
ENST00000413218.1
ENST00000424596.1
PSPH
phosphoserine phosphatase
chr1_+_144811744 14.07 ENST00000338347.4
ENST00000440491.2
ENST00000375552.4
NBPF9
neuroblastoma breakpoint family, member 9
chr20_+_4666882 13.47 ENST00000379440.4
ENST00000430350.2
PRNP
prion protein
chr1_-_26232522 12.57 ENST00000399728.1
STMN1
stathmin 1
chr19_+_50354393 12.57 ENST00000391842.1
PTOV1
prostate tumor overexpressed 1
chr7_+_157129660 12.45 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr18_+_57567180 12.30 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr7_-_56119156 12.00 ENST00000421312.1
ENST00000416592.1
PSPH
phosphoserine phosphatase
chrX_-_106243451 11.97 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr19_+_50354462 11.90 ENST00000601675.1
PTOV1
prostate tumor overexpressed 1
chr20_-_43589109 11.80 ENST00000372813.3
TOMM34
translocase of outer mitochondrial membrane 34
chr12_-_123011536 11.19 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr15_+_79165151 11.05 ENST00000331268.5
MORF4L1
mortality factor 4 like 1
chrX_+_123094369 10.99 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr17_+_1936687 10.94 ENST00000570477.1
DPH1
diphthamide biosynthesis 1
chr5_-_140053152 10.92 ENST00000542735.1
DND1
DND microRNA-mediated repression inhibitor 1
chr15_+_79165112 10.75 ENST00000426013.2
MORF4L1
mortality factor 4 like 1
chr8_+_37594130 10.59 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2
ER lipid raft associated 2
chr2_+_85766280 10.43 ENST00000306434.3
MAT2A
methionine adenosyltransferase II, alpha
chr22_+_29664248 10.33 ENST00000406548.1
ENST00000437155.2
ENST00000415761.1
ENST00000331029.7
EWSR1
EWS RNA-binding protein 1
chr4_-_22517620 10.29 ENST00000502482.1
ENST00000334304.5
GPR125
G protein-coupled receptor 125
chr19_+_50354430 10.07 ENST00000599732.1
PTOV1
prostate tumor overexpressed 1
chr6_+_4890226 9.93 ENST00000343762.5
CDYL
chromodomain protein, Y-like
chr16_-_18468926 9.91 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr18_-_19284724 9.71 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr8_-_81083731 9.26 ENST00000379096.5
TPD52
tumor protein D52
chr12_-_125401885 8.90 ENST00000542416.1
UBC
ubiquitin C
chr14_+_72052983 8.57 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr20_+_57430162 8.56 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS
GNAS complex locus
chr16_+_29911666 8.49 ENST00000563177.1
ENST00000483405.1
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr2_+_228678550 8.41 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr6_-_106773291 8.35 ENST00000343245.3
ATG5
autophagy related 5
chr6_-_41909466 7.81 ENST00000414200.2
CCND3
cyclin D3
chr6_-_41909561 7.16 ENST00000372991.4
CCND3
cyclin D3
chr2_-_238499303 7.08 ENST00000409576.1
RAB17
RAB17, member RAS oncogene family
chr18_+_11751466 6.90 ENST00000535121.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr5_+_140602904 6.75 ENST00000515856.2
ENST00000239449.4
PCDHB14
protocadherin beta 14
chrX_+_123094672 6.54 ENST00000354548.5
ENST00000458700.1
STAG2
stromal antigen 2
chr3_+_130613226 6.54 ENST00000509662.1
ENST00000328560.8
ENST00000428331.2
ENST00000359644.3
ENST00000422190.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr16_+_14844670 6.43 ENST00000553201.1
NPIPA2
nuclear pore complex interacting protein family, member A2
chr5_+_74062806 5.24 ENST00000296802.5
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr17_-_62308087 5.11 ENST00000583097.1
TEX2
testis expressed 2
chr4_-_25865159 5.03 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr3_+_130613001 4.96 ENST00000504948.1
ENST00000513801.1
ENST00000505072.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr5_+_446253 4.91 ENST00000315013.5
EXOC3
exocyst complex component 3
chr13_-_31736132 4.88 ENST00000429785.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr3_+_130612803 4.85 ENST00000510168.1
ENST00000508532.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr14_+_96722539 4.74 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr3_+_186501336 4.67 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr18_+_11751493 3.41 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr19_-_14629224 3.37 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr7_-_139763521 3.25 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr15_+_79165222 3.14 ENST00000559930.1
MORF4L1
mortality factor 4 like 1
chr6_+_31683117 3.13 ENST00000375825.3
ENST00000375824.1
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr11_+_45825896 3.11 ENST00000314134.3
SLC35C1
solute carrier family 35 (GDP-fucose transporter), member C1
chr22_+_32871224 2.44 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
FBXO7
F-box protein 7
chr6_-_41909191 2.14 ENST00000512426.1
ENST00000372987.4
CCND3
cyclin D3
chr5_+_133706865 2.01 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr7_+_130020180 2.01 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr12_-_57505121 1.80 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr1_-_24469602 1.55 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr2_-_238499131 1.49 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr19_+_751122 1.36 ENST00000215582.6
MISP
mitotic spindle positioning
chr6_+_29910301 1.35 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr8_+_140943416 1.30 ENST00000507535.3
C8orf17
chromosome 8 open reading frame 17
chr7_+_130020932 1.07 ENST00000484324.1
CPA1
carboxypeptidase A1 (pancreatic)
chr11_-_47869865 0.72 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr12_-_4754339 0.67 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr11_-_1587166 0.56 ENST00000331588.4
DUSP8
dual specificity phosphatase 8
chrX_+_108780062 0.49 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
20.7 103.6 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
20.3 263.6 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
17.8 142.8 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
15.7 62.8 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
11.8 47.3 GO:0043335 protein unfolding(GO:0043335)
11.3 56.4 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
11.3 33.8 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
11.1 44.6 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
10.1 30.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
8.5 25.5 GO:0007412 axon target recognition(GO:0007412)
8.2 33.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
7.8 62.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
7.2 28.8 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
7.2 85.9 GO:0015074 DNA integration(GO:0015074)
6.9 34.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
6.7 20.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
6.2 25.0 GO:0099640 axo-dendritic protein transport(GO:0099640)
5.2 41.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
4.8 19.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
4.7 18.7 GO:0071492 cellular response to UV-A(GO:0071492)
4.6 18.6 GO:0009956 radial pattern formation(GO:0009956)
4.5 13.5 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
4.1 53.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
4.0 48.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
3.8 41.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
3.8 108.9 GO:0043968 histone H2A acetylation(GO:0043968)
3.5 21.2 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
3.4 33.8 GO:0030263 apoptotic chromosome condensation(GO:0030263)
3.3 16.7 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
2.8 8.4 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
2.8 8.3 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
2.8 60.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
2.7 16.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
2.7 21.5 GO:0006983 ER overload response(GO:0006983)
2.6 10.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
2.3 16.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
2.3 32.1 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
2.1 10.6 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
2.1 12.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
1.8 90.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.8 12.3 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
1.7 8.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.5 42.4 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
1.4 44.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.4 10.9 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.2 8.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
1.2 25.9 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
1.0 3.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
1.0 15.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.7 20.0 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.7 10.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.7 10.9 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.7 31.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.6 1.8 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.5 8.9 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.4 4.9 GO:0051601 exocyst localization(GO:0051601)
0.3 20.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 52.3 GO:0006997 nucleus organization(GO:0006997)
0.2 23.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.2 5.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.2 37.6 GO:0006338 chromatin remodeling(GO:0006338)
0.2 20.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 35.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 8.6 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.2 2.4 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.2 7.4 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 3.1 GO:0098926 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 4.7 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.1 1.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 4.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 23.2 GO:0045765 regulation of angiogenesis(GO:0045765)
0.1 11.8 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.1 9.9 GO:0016573 histone acetylation(GO:0016573)
0.0 5.1 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 1.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.7 GO:0010738 acrosome reaction(GO:0007340) regulation of protein kinase A signaling(GO:0010738)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
14.8 103.6 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
13.9 263.6 GO:0005832 chaperonin-containing T-complex(GO:0005832)
13.8 41.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
11.1 44.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
9.4 56.4 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
8.4 58.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
5.8 163.7 GO:0071682 endocytic vesicle lumen(GO:0071682)
4.0 20.1 GO:0033503 HULC complex(GO:0033503)
3.8 33.8 GO:0061574 ASAP complex(GO:0061574)
3.5 10.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
3.3 108.9 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
2.7 38.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
2.5 35.5 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
2.2 48.1 GO:0044295 axonal growth cone(GO:0044295)
1.6 31.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
1.4 8.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.4 87.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.1 50.5 GO:1904115 axon cytoplasm(GO:1904115)
0.9 20.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.8 13.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.6 90.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 67.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 2.4 GO:1990037 Lewy body core(GO:1990037)
0.4 85.9 GO:0000793 condensed chromosome(GO:0000793)
0.4 29.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 18.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 17.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.3 53.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 4.9 GO:0000145 exocyst(GO:0000145)
0.3 8.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 16.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 21.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 4.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 20.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 5.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 149.2 GO:0005730 nucleolus(GO:0005730)
0.1 41.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 70.9 GO:0005739 mitochondrion(GO:0005739)
0.1 15.2 GO:0034399 nuclear periphery(GO:0034399)
0.1 68.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 30.7 GO:0005635 nuclear envelope(GO:0005635)
0.1 9.1 GO:0030018 Z disc(GO:0030018)
0.1 16.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 28.0 GO:0000785 chromatin(GO:0000785)
0.1 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 30.5 GO:0043005 neuron projection(GO:0043005)
0.1 16.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 9.9 GO:0016607 nuclear speck(GO:0016607)
0.0 11.2 GO:0005874 microtubule(GO:0005874)
0.0 3.1 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
22.0 88.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
16.0 48.1 GO:0032767 copper-dependent protein binding(GO:0032767)
14.9 44.6 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
14.7 162.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
10.7 53.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
10.5 73.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
8.3 25.0 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
8.3 41.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
7.0 84.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
6.8 33.8 GO:0070404 NADH binding(GO:0070404)
6.4 25.5 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
6.3 62.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
5.9 47.3 GO:0030911 TPR domain binding(GO:0030911)
5.6 44.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
5.5 175.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
5.3 21.2 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
4.9 34.6 GO:1990226 histone methyltransferase binding(GO:1990226)
4.8 28.8 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
3.9 34.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
3.3 16.7 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
2.9 32.1 GO:0046790 virion binding(GO:0046790)
2.8 8.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
2.5 130.3 GO:0030544 Hsp70 protein binding(GO:0030544)
2.2 13.5 GO:1903135 cupric ion binding(GO:1903135)
1.9 9.7 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
1.7 56.4 GO:0042288 MHC class I protein binding(GO:0042288)
1.6 4.7 GO:0004947 bradykinin receptor activity(GO:0004947)
1.5 16.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.4 8.3 GO:0019776 Atg8 ligase activity(GO:0019776)
1.0 3.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.9 35.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 135.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.8 8.6 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.8 30.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.6 10.9 GO:0035198 miRNA binding(GO:0035198)
0.6 16.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.6 50.9 GO:0005518 collagen binding(GO:0005518)
0.6 19.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 3.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.5 1.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.5 18.6 GO:0001972 retinoic acid binding(GO:0001972)
0.4 20.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 15.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 10.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.4 35.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 33.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 10.6 GO:0015485 cholesterol binding(GO:0015485)
0.2 8.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 7.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 9.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 247.2 GO:0003723 RNA binding(GO:0003723)
0.1 23.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 8.6 GO:0019003 GDP binding(GO:0019003)
0.1 3.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 3.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 28.8 GO:0045296 cadherin binding(GO:0045296)
0.1 32.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 4.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 6.0 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 47.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
1.1 132.7 PID CMYB PATHWAY C-MYB transcription factor network
1.0 66.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
1.0 12.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.0 65.6 PID PLK1 PATHWAY PLK1 signaling events
0.9 105.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.9 28.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.8 58.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.6 25.0 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.5 10.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.5 44.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.5 16.7 PID AURORA A PATHWAY Aurora A signaling
0.5 31.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.5 32.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.5 13.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 20.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.4 19.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.4 18.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.3 67.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 7.8 PID BARD1 PATHWAY BARD1 signaling events
0.2 4.9 PID INSULIN PATHWAY Insulin Pathway
0.2 12.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 85.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
8.5 263.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
3.0 91.9 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
3.0 103.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
2.3 32.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.9 53.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
1.7 16.7 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
1.4 28.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.3 90.5 REACTOME G1 PHASE Genes involved in G1 Phase
1.3 83.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.9 10.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.8 65.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.8 103.8 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.7 65.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 87.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.4 38.0 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.4 8.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 13.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 8.6 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.3 16.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 25.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3 10.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 33.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 4.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 4.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.2 18.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 8.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 1.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 9.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 20.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 3.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 13.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 4.7 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction