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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IKZF1
Z-value: 1.85
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg19_v2_chr7_+_50344289_50344378 | -0.62 | 1.9e-24 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 216.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 5.7 | 160.1 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 17.0 | 136.2 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 2.1 | 136.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.2 | 120.6 | GO:0070268 | cornification(GO:0070268) |
| 3.3 | 95.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 8.6 | 94.3 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 2.3 | 70.5 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 1.4 | 66.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 4.8 | 62.8 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 560.6 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.7 | 337.5 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.7 | 199.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 8.8 | 167.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 2.2 | 141.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.5 | 124.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 2.9 | 120.1 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 2.6 | 119.1 | GO:0045095 | keratin filament(GO:0045095) |
| 1.3 | 114.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.3 | 107.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 341.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.6 | 264.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.9 | 190.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 185.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 138.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 2.4 | 128.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.9 | 127.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 102.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 3.6 | 98.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 2.0 | 91.7 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 157.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 131.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.0 | 127.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.6 | 110.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 1.6 | 97.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.9 | 95.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 1.3 | 89.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.9 | 88.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 3.4 | 88.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 1.4 | 79.6 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 261.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.4 | 201.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.3 | 199.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.6 | 142.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 1.8 | 140.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 3.6 | 122.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.8 | 116.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.2 | 107.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 2.5 | 99.4 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 1.8 | 85.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |