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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for INSM1

Z-value: 0.67

Motif logo

Transcription factors associated with INSM1

Gene Symbol Gene ID Gene Info
ENSG00000173404.3 INSM transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
INSM1hg19_v2_chr20_+_20348740_203487650.111.1e-01Click!

Activity profile of INSM1 motif

Sorted Z-values of INSM1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_42992856 18.46 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
glial fibrillary acidic protein
chr17_-_56606664 10.59 ENST00000580844.1
septin 4
chr17_-_56606705 10.57 ENST00000317268.3
septin 4
chr17_-_56606639 10.55 ENST00000579371.1
septin 4
chr8_-_120685608 10.22 ENST00000427067.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr9_+_137979506 10.21 ENST00000539529.1
ENST00000392991.4
ENST00000371793.3
olfactomedin 1
chr20_+_44657845 9.35 ENST00000243964.3
solute carrier family 12 (potassium/chloride transporter), member 5
chr16_-_19896220 8.98 ENST00000562469.1
ENST00000300571.2
G protein-coupled receptor, family C, group 5, member B
chr5_-_11904100 8.64 ENST00000359640.2
catenin (cadherin-associated protein), delta 2
chr5_-_11904152 8.45 ENST00000304623.8
ENST00000458100.2
catenin (cadherin-associated protein), delta 2
chr7_+_86273952 7.22 ENST00000536043.1
glutamate receptor, metabotropic 3
chr7_+_86274145 6.86 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
glutamate receptor, metabotropic 3
chr7_+_86273700 6.46 ENST00000546348.1
glutamate receptor, metabotropic 3
chr13_-_36705425 6.45 ENST00000255448.4
ENST00000360631.3
ENST00000379892.4
doublecortin-like kinase 1
chr8_-_103136481 5.67 ENST00000524209.1
ENST00000517822.1
ENST00000523923.1
ENST00000521599.1
ENST00000521964.1
ENST00000311028.3
ENST00000518166.1
neurocalcin delta
chr19_+_35629702 5.57 ENST00000351325.4
FXYD domain containing ion transport regulator 1
chr19_+_35630022 5.28 ENST00000589209.1
FXYD domain containing ion transport regulator 1
chr15_+_89181974 5.28 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 5.24 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr15_+_89182178 5.23 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr15_+_68924327 5.10 ENST00000543950.1
coronin, actin binding protein, 2B
chr1_+_220863187 4.67 ENST00000294889.5
chromosome 1 open reading frame 115
chr3_+_35681081 4.63 ENST00000428373.1
cAMP-regulated phosphoprotein, 21kDa
chr12_+_70760056 4.59 ENST00000258111.4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_154531095 4.45 ENST00000292211.4
ubiquitin-conjugating enzyme E2Q family member 1
chr8_-_101571933 4.26 ENST00000520311.1
ankyrin repeat domain 46
chr15_+_43803143 3.96 ENST00000382031.1
microtubule-associated protein 1A
chr11_+_46383121 3.53 ENST00000454345.1
diacylglycerol kinase, zeta
chr19_+_10196781 3.49 ENST00000253110.11
chromosome 19 open reading frame 66
chr19_+_10197463 3.25 ENST00000590378.1
ENST00000397881.3
chromosome 19 open reading frame 66
chr17_-_4890919 3.22 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
calmodulin binding transcription activator 2
chr10_-_104001231 3.04 ENST00000370002.3
paired-like homeodomain 3
chr12_-_118810688 3.04 ENST00000542532.1
ENST00000392533.3
TAO kinase 3
chr17_-_27507395 2.97 ENST00000354329.4
ENST00000527372.1
myosin XVIIIA
chr17_-_27507377 2.92 ENST00000531253.1
myosin XVIIIA
chrX_+_51927919 2.90 ENST00000416960.1
melanoma antigen family D, 4
chr19_+_41284121 2.88 ENST00000594800.1
ENST00000357052.2
ENST00000602173.1
RAB4B, member RAS oncogene family
chr18_-_34408902 2.87 ENST00000593035.1
ENST00000383056.3
ENST00000588909.1
ENST00000590337.1
tubulin polyglutamylase complex subunit 2
chrX_-_51812268 2.76 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
melanoma antigen family D, 4B
chr12_+_7342178 2.73 ENST00000266563.5
ENST00000543974.1
peroxisomal biogenesis factor 5
chr7_-_79082867 2.72 ENST00000419488.1
ENST00000354212.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_+_65879668 2.61 ENST00000553924.1
ENST00000358307.2
ENST00000557338.1
ENST00000554610.1
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr17_-_4890649 2.60 ENST00000361571.5
calmodulin binding transcription activator 2
chr18_-_34409116 2.40 ENST00000334295.4
tubulin polyglutamylase complex subunit 2
chr2_-_73511559 2.37 ENST00000521871.1
F-box protein 41
chr2_+_24272543 2.31 ENST00000380991.4
FK506 binding protein 1B, 12.6 kDa
chr11_+_117049445 2.28 ENST00000324225.4
ENST00000532960.1
SID1 transmembrane family, member 2
chr16_-_30134524 2.16 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
mitogen-activated protein kinase 3
chr9_-_140115775 2.15 ENST00000391553.1
ENST00000392827.1
ring finger protein 208
chr2_+_24272576 2.11 ENST00000380986.4
ENST00000452109.1
FK506 binding protein 1B, 12.6 kDa
chr12_-_123756781 2.07 ENST00000544658.1
cyclin-dependent kinase 2 associated protein 1
chrX_-_153059958 2.05 ENST00000370092.3
ENST00000217901.5
isocitrate dehydrogenase 3 (NAD+) gamma
chrX_-_153059811 1.99 ENST00000427365.2
ENST00000444450.1
ENST00000370093.1
isocitrate dehydrogenase 3 (NAD+) gamma
chr6_-_29595779 1.97 ENST00000355973.3
ENST00000377012.4
gamma-aminobutyric acid (GABA) B receptor, 1
chr9_-_123691439 1.90 ENST00000540010.1
TNF receptor-associated factor 1
chr13_-_31736132 1.89 ENST00000429785.2
heat shock 105kDa/110kDa protein 1
chr18_-_34408693 1.74 ENST00000587382.1
ENST00000589049.1
ENST00000587129.1
tubulin polyglutamylase complex subunit 2
chr14_+_85996471 1.69 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr13_-_31736027 1.68 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
heat shock 105kDa/110kDa protein 1
chr20_-_45981138 1.67 ENST00000446994.2
zinc finger, MYND-type containing 8
chr5_-_175964366 1.64 ENST00000274811.4
ring finger protein 44
chr12_-_123756687 1.61 ENST00000261692.2
cyclin-dependent kinase 2 associated protein 1
chr17_-_73389854 1.61 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
growth factor receptor-bound protein 2
chr14_+_73563735 1.60 ENST00000532192.1
RNA binding motif protein 25
chr18_+_46065393 1.58 ENST00000256413.3
CBP80/20-dependent translation initiation factor
chr22_-_20104700 1.58 ENST00000439169.2
ENST00000445045.1
ENST00000404751.3
ENST00000252136.7
ENST00000403707.3
tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr13_+_35516390 1.54 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
neurobeachin
chr9_+_35538616 1.49 ENST00000455600.1
RUN and SH3 domain containing 2
chr19_+_19626531 1.43 ENST00000507754.4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr3_-_15901278 1.38 ENST00000399451.2
ankyrin repeat domain 28
chr19_+_48972459 1.34 ENST00000427476.1
cytohesin 2
chr8_+_28174649 1.31 ENST00000301908.3
prepronociceptin
chr10_+_35415719 1.30 ENST00000474362.1
ENST00000374721.3
cAMP responsive element modulator
chr21_-_46238034 1.24 ENST00000332859.6
small ubiquitin-like modifier 3
chr6_-_33385902 1.23 ENST00000374500.5
cutA divalent cation tolerance homolog (E. coli)
chr17_+_37793378 1.18 ENST00000544210.2
ENST00000581894.1
ENST00000394250.4
ENST00000579479.1
ENST00000577248.1
ENST00000580611.1
StAR-related lipid transfer (START) domain containing 3
chr18_-_34408802 1.15 ENST00000590842.1
tubulin polyglutamylase complex subunit 2
chr17_-_73389737 1.12 ENST00000392563.1
growth factor receptor-bound protein 2
chr12_-_80328700 1.11 ENST00000550107.1
protein phosphatase 1, regulatory subunit 12A
chr17_+_58755184 1.07 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
breast carcinoma amplified sequence 3
chr12_+_7342271 1.05 ENST00000434354.2
ENST00000544456.1
ENST00000545574.1
ENST00000420616.2
peroxisomal biogenesis factor 5
chr14_+_85996507 1.03 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr17_+_37793318 1.01 ENST00000336308.5
StAR-related lipid transfer (START) domain containing 3
chr9_-_37034028 1.00 ENST00000520281.1
ENST00000446742.1
ENST00000522003.1
ENST00000523145.1
ENST00000414447.1
ENST00000377847.2
ENST00000377853.2
ENST00000377852.2
ENST00000523241.1
ENST00000520154.1
ENST00000358127.4
paired box 5
chr19_+_48972265 1.00 ENST00000452733.2
cytohesin 2
chr3_-_15374033 1.00 ENST00000253688.5
ENST00000383791.3
SH3-domain binding protein 5 (BTK-associated)
chr22_+_47158578 0.98 ENST00000355704.3
TBC1 domain family, member 22A
chr1_-_6321035 0.98 ENST00000377893.2
G protein-coupled receptor 153
chr12_+_7342441 0.95 ENST00000412720.2
ENST00000396637.3
peroxisomal biogenesis factor 5
chr14_+_65879437 0.95 ENST00000394585.1
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr1_+_10490127 0.90 ENST00000602787.1
ENST00000602296.1
ENST00000400900.2
apoptosis-inducing, TAF9-like domain 1
APITD1-CORT readthrough
chrX_+_146993534 0.89 ENST00000334557.6
ENST00000439526.2
ENST00000370475.4
fragile X mental retardation 1
chr14_+_102027688 0.89 ENST00000510508.4
ENST00000359323.3
deiodinase, iodothyronine, type III
chr22_+_47158518 0.87 ENST00000337137.4
ENST00000380995.1
ENST00000407381.3
TBC1 domain family, member 22A
chr21_-_46237959 0.81 ENST00000397898.3
ENST00000411651.2
small ubiquitin-like modifier 3
chr1_-_37980344 0.80 ENST00000448519.2
ENST00000373075.2
ENST00000373073.4
ENST00000296214.5
MYST/Esa1-associated factor 6
chr10_-_103603677 0.80 ENST00000358038.3
Kv channel interacting protein 2
chr9_-_98269481 0.76 ENST00000418258.1
ENST00000553011.1
ENST00000551845.1
patched 1
chr12_+_7341759 0.74 ENST00000455147.2
ENST00000540398.1
peroxisomal biogenesis factor 5
chr22_+_44351419 0.71 ENST00000396202.3
SAMM50 sorting and assembly machinery component
chr22_-_36903101 0.70 ENST00000397224.4
FAD-dependent oxidoreductase domain containing 2
chr10_+_35415978 0.69 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
cAMP responsive element modulator
chr10_+_35416223 0.68 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr3_+_185303962 0.68 ENST00000296257.5
SUMO1/sentrin/SMT3 specific peptidase 2
chr10_-_103603568 0.67 ENST00000356640.2
Kv channel interacting protein 2
chr22_-_36903069 0.67 ENST00000216187.6
ENST00000423980.1
FAD-dependent oxidoreductase domain containing 2
chr17_+_46184911 0.65 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
sorting nexin 11
chr2_-_72375167 0.64 ENST00000001146.2
cytochrome P450, family 26, subfamily B, polypeptide 1
chr1_+_2398876 0.63 ENST00000449969.1
phospholipase C, eta 2
chr12_-_76953573 0.62 ENST00000549646.1
ENST00000550628.1
ENST00000553139.1
ENST00000261183.3
ENST00000393250.4
oxysterol binding protein-like 8
chr17_+_38219063 0.62 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
thyroid hormone receptor, alpha
chr8_-_145550571 0.61 ENST00000332324.4
diacylglycerol O-acyltransferase 1
chr3_+_14989186 0.59 ENST00000435454.1
ENST00000323373.6
nuclear receptor subfamily 2, group C, member 2
chr11_-_47400078 0.57 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr2_-_25475120 0.57 ENST00000380746.4
ENST00000402667.1
DNA (cytosine-5-)-methyltransferase 3 alpha
chrX_-_71525742 0.54 ENST00000450875.1
ENST00000417400.1
ENST00000431381.1
ENST00000445983.1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
chr17_-_47755436 0.52 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr7_-_91509986 0.52 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
mitochondrial transcription termination factor
chr14_-_104313824 0.52 ENST00000553739.1
ENST00000202556.9
protein phosphatase 1, regulatory subunit 13B
chr10_+_91061712 0.52 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr18_-_51750948 0.52 ENST00000583046.1
ENST00000398398.2
methyl-CpG binding domain protein 2
chr9_-_98269699 0.51 ENST00000429896.2
patched 1
chr22_+_20104947 0.51 ENST00000402752.1
RAN binding protein 1
chr17_-_47755338 0.48 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
speckle-type POZ protein
chrX_+_146993449 0.46 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
fragile X mental retardation 1
chr12_+_120105558 0.45 ENST00000229328.5
ENST00000541640.1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr6_-_31125850 0.44 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
coiled-coil alpha-helical rod protein 1
chr9_+_116263639 0.43 ENST00000343817.5
regulator of G-protein signaling 3
chr7_+_94536898 0.40 ENST00000433360.1
ENST00000340694.4
ENST00000424654.1
protein phosphatase 1, regulatory subunit 9A
chr17_+_45608614 0.40 ENST00000544660.1
aminopeptidase puromycin sensitive
chr17_+_27369918 0.38 ENST00000323372.4
pipecolic acid oxidase
chr1_-_39325431 0.30 ENST00000373001.3
Ras-related GTP binding C
chr9_+_116263778 0.30 ENST00000394646.3
regulator of G-protein signaling 3
chr16_+_67360712 0.29 ENST00000569499.2
ENST00000329956.6
ENST00000561948.1
leucine rich repeat containing 36
chr11_-_47399942 0.29 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_+_42128812 0.27 ENST00000520810.1
ENST00000416505.2
ENST00000519735.1
ENST00000520835.1
ENST00000379708.3
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr11_-_66445219 0.27 ENST00000525754.1
ENST00000531969.1
ENST00000524637.1
ENST00000531036.2
ENST00000310046.4
RNA binding motif protein 4B
chr16_+_23569021 0.26 ENST00000567212.1
ENST00000567264.1
ubiquitin family domain containing 1
chr10_+_76585303 0.25 ENST00000372725.1
K(lysine) acetyltransferase 6B
chr20_+_32077880 0.24 ENST00000342704.6
ENST00000375279.2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr4_+_619347 0.24 ENST00000255622.6
phosphodiesterase 6B, cGMP-specific, rod, beta
chr15_-_65426174 0.21 ENST00000204549.4
programmed cell death 7
chr1_+_210001309 0.18 ENST00000491415.2
digestive organ expansion factor homolog (zebrafish)
chr3_+_185304059 0.17 ENST00000427465.2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_+_10490779 0.17 ENST00000477755.1
apoptosis-inducing, TAF9-like domain 1
chr12_-_52715179 0.15 ENST00000293670.3
keratin 83
chr19_+_10196981 0.14 ENST00000591813.1
chromosome 19 open reading frame 66
chr4_+_619386 0.11 ENST00000496514.1
phosphodiesterase 6B, cGMP-specific, rod, beta
chr6_+_32938665 0.09 ENST00000374831.4
ENST00000395289.2
bromodomain containing 2
chr1_+_168148273 0.07 ENST00000367830.3
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr19_+_14142535 0.07 ENST00000263379.2
interleukin 27 receptor, alpha
chr5_+_154238096 0.06 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CCR4-NOT transcription complex, subunit 8
chr13_-_52027134 0.04 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
integrator complex subunit 6
chr1_-_205326161 0.03 ENST00000367156.3
ENST00000606887.1
ENST00000607173.1
kelch domain containing 8A
chr18_+_46065483 0.03 ENST00000382998.4
CBP80/20-dependent translation initiation factor
chr1_+_10490441 0.02 ENST00000470413.2
ENST00000309048.3
APITD1-CORT readthrough
apoptosis-inducing, TAF9-like domain 1
chr14_+_31343747 0.02 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
cochlin
chr5_+_154238149 0.01 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CCR4-NOT transcription complex, subunit 8
chrX_+_69674943 0.00 ENST00000542398.1
discs, large homolog 3 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of INSM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 31.7 GO:0030382 sperm mitochondrion organization(GO:0030382)
5.3 15.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.3 9.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
2.0 5.9 GO:1903028 positive regulation of opsonization(GO:1903028)
1.8 10.8 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
1.4 20.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.2 3.6 GO:0036071 N-glycan fucosylation(GO:0036071)
1.1 10.2 GO:0003190 atrioventricular valve formation(GO:0003190)
1.1 5.5 GO:1901090 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
1.0 3.0 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
1.0 18.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.9 2.7 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.7 10.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.6 9.0 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.6 4.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.5 2.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.4 3.6 GO:1903751 negative regulation of establishment of protein localization to mitochondrion(GO:1903748) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.4 4.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.4 2.2 GO:0000189 MAPK import into nucleus(GO:0000189)
0.4 4.4 GO:0070459 prolactin secretion(GO:0070459)
0.3 1.3 GO:0021997 response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.3 5.7 GO:0005513 detection of calcium ion(GO:0005513)
0.3 1.7 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.3 1.4 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 6.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 2.2 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.2 17.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 0.6 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809)
0.2 2.3 GO:0033227 dsRNA transport(GO:0033227)
0.2 0.6 GO:0008050 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.2 0.8 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 4.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 1.4 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.2 1.0 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.2 5.8 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.2 2.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2 1.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.9 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 0.4 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.5 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 3.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.6 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.1 0.5 GO:0071105 response to interleukin-11(GO:0071105)
0.1 0.6 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.1 1.0 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.1 0.7 GO:0090151 protein import into mitochondrial outer membrane(GO:0045040) establishment of protein localization to mitochondrial membrane(GO:0090151)
0.1 1.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 2.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 2.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 2.0 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 5.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.0 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 2.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.5 GO:0035878 nail development(GO:0035878)
0.0 1.6 GO:0001510 RNA methylation(GO:0001510)
0.0 1.9 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.9 GO:0046323 glucose import(GO:0046323)
0.0 4.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 3.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 1.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 1.4 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 1.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 31.7 GO:0097227 sperm annulus(GO:0097227)
0.7 2.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 10.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.5 11.5 GO:0044295 axonal growth cone(GO:0044295)
0.5 2.7 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.5 1.4 GO:0019034 viral replication complex(GO:0019034)
0.4 5.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.4 2.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 2.7 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 15.8 GO:0015030 Cajal body(GO:0015030)
0.2 0.4 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 11.0 GO:0043198 dendritic shaft(GO:0043198)
0.2 19.1 GO:0042734 presynaptic membrane(GO:0042734)
0.2 1.0 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 1.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 16.4 GO:0005882 intermediate filament(GO:0005882)
0.1 2.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 3.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 17.1 GO:0043204 perikaryon(GO:0043204)
0.1 2.2 GO:0031143 pseudopodium(GO:0031143)
0.1 4.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 5.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 5.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.3 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 4.4 GO:0030175 filopodium(GO:0030175)
0.0 3.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.3 GO:0030426 growth cone(GO:0030426)
0.0 12.1 GO:0005874 microtubule(GO:0005874)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.9 GO:0016605 PML body(GO:0016605)
0.0 1.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 3.5 GO:0030027 lamellipodium(GO:0030027)
0.0 4.2 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.0 GO:0043679 axon terminus(GO:0043679)
0.0 5.1 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:0008859 exoribonuclease II activity(GO:0008859)
4.1 20.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
2.6 10.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.2 3.6 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
1.1 5.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
1.0 4.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.9 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.9 4.4 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.9 9.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.7 2.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 2.3 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4 1.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 3.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.4 GO:0034046 poly(G) binding(GO:0034046)
0.3 1.3 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 0.8 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 0.6 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.2 10.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 3.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 5.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 2.0 GO:0031386 protein tag(GO:0031386)
0.2 4.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 2.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.9 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 1.0 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 15.5 GO:0008013 beta-catenin binding(GO:0008013)
0.1 2.7 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.1 1.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 32.0 GO:0000287 magnesium ion binding(GO:0000287)
0.1 5.9 GO:0043531 ADP binding(GO:0043531)
0.1 3.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 3.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 2.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 3.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.2 GO:0004707 MAP kinase activity(GO:0004707)
0.1 4.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 2.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 11.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 0.5 GO:0003696 satellite DNA binding(GO:0003696)
0.0 4.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0050693 LBD domain binding(GO:0050693)
0.0 1.6 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.6 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 4.0 GO:0008017 microtubule binding(GO:0008017)
0.0 5.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.4 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID BCR 5PATHWAY BCR signaling pathway
0.0 3.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 22.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 17.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 8.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 5.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 16.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 4.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 4.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.6 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 9.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 4.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type