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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 3.28

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.6 interferon regulatory factor 2
ENSG00000170581.9 signal transducer and activator of transcription 2
ENSG00000140968.6 interferon regulatory factor 8
ENSG00000125347.9 interferon regulatory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF1hg19_v2_chr5_-_131826457_1318265140.773.1e-44Click!
IRF2hg19_v2_chr4_-_185395672_1853957340.721.2e-36Click!
IRF8hg19_v2_chr16_+_85942594_859426350.561.6e-19Click!
STAT2hg19_v2_chr12_-_56753858_567539300.028.1e-01Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 199.84 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr1_+_948803 165.30 ENST00000379389.4
ISG15 ubiquitin-like modifier
chr16_-_67970990 147.63 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_615942 126.93 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr6_-_33282163 109.81 ENST00000434618.2
ENST00000456592.2
TAP binding protein (tapasin)
chr21_+_42733870 106.90 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
myxovirus (influenza virus) resistance 2 (mouse)
chr6_+_32811885 105.61 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32811771 104.75 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr19_-_17516449 98.27 ENST00000252593.6
bone marrow stromal cell antigen 2
chr1_+_158979792 95.71 ENST00000359709.3
ENST00000430894.2
interferon, gamma-inducible protein 16
chr1_+_158979680 92.83 ENST00000368131.4
ENST00000340979.6
interferon, gamma-inducible protein 16
chr1_+_158979686 92.43 ENST00000368132.3
ENST00000295809.7
interferon, gamma-inducible protein 16
chr11_-_615570 89.81 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_+_1077393 89.17 ENST00000590577.1
histocompatibility (minor) HA-1
chr1_+_174843548 87.50 ENST00000478442.1
ENST00000465412.1
RAB GTPase activating protein 1-like
chr2_-_231084820 87.29 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr7_+_74188309 85.50 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr6_-_32821599 82.69 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr21_+_42792442 77.84 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr10_-_91174215 76.32 ENST00000371837.1
lipase A, lysosomal acid, cholesterol esterase
chr1_+_79086088 74.45 ENST00000370751.5
ENST00000342282.3
interferon-induced protein 44-like
chr1_+_79115503 68.63 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr14_+_58711539 67.56 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr11_+_5710919 65.61 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr6_+_26365443 65.00 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chr6_+_6588902 61.35 ENST00000230568.4
lymphocyte antigen 86
chr6_+_26440700 59.85 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr2_+_201981527 59.52 ENST00000441224.1
CASP8 and FADD-like apoptosis regulator
chr2_-_231084659 59.29 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr12_+_25205446 58.58 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr2_-_231084617 58.00 ENST00000409815.2
SP110 nuclear body protein
chr16_-_88851618 56.96 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr12_-_49319265 56.70 ENST00000552878.1
ENST00000453172.2
FK506 binding protein 11, 19 kDa
chr12_-_49318715 55.78 ENST00000444214.2
FK506 binding protein 11, 19 kDa
chr3_-_49851313 55.60 ENST00000333486.3
ubiquitin-like modifier activating enzyme 7
chr13_+_50070077 55.38 ENST00000378319.3
ENST00000426879.1
PHD finger protein 11
chr15_+_45003675 54.91 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
beta-2-microglobulin
chr4_+_147096837 54.82 ENST00000296581.5
ENST00000502781.1
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr14_+_24605361 54.82 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_+_113416191 54.61 ENST00000342315.4
ENST00000392583.2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr14_+_24605389 54.55 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_-_100841930 53.66 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
tryptophanyl-tRNA synthetase
chr11_-_57335280 53.58 ENST00000287156.4
ubiquitin-conjugating enzyme E2L 6
chr13_+_50070491 53.48 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHD finger protein 11
chr2_-_152146385 52.52 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr14_-_100841670 51.94 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
tryptophanyl-tRNA synthetase
chr15_+_89182178 51.77 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr1_-_154580616 49.69 ENST00000368474.4
adenosine deaminase, RNA-specific
chr11_-_104905840 49.21 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
caspase 1, apoptosis-related cysteine peptidase
chr6_-_31324943 49.20 ENST00000412585.2
ENST00000434333.1
major histocompatibility complex, class I, B
chr12_+_113344755 48.62 ENST00000550883.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr2_-_191878874 48.34 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
signal transducer and activator of transcription 1, 91kDa
chr20_+_388935 48.27 ENST00000382181.2
ENST00000400247.3
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_104972158 47.92 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr19_+_18284477 47.48 ENST00000407280.3
interferon, gamma-inducible protein 30
chr15_+_89181974 46.67 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr4_-_185395672 46.43 ENST00000393593.3
interferon regulatory factor 2
chr8_+_144640477 46.15 ENST00000262580.4
gasdermin D
chr1_+_12227035 46.04 ENST00000376259.3
ENST00000536782.1
tumor necrosis factor receptor superfamily, member 1B
chr16_-_31214051 45.49 ENST00000350605.4
PYD and CARD domain containing
chr1_-_151319710 43.22 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
regulatory factor X, 5 (influences HLA class II expression)
chr3_-_49142178 43.20 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
glutaminyl-tRNA synthetase
chrX_+_123095546 42.53 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
stromal antigen 2
chr3_-_49142504 41.70 ENST00000306125.6
ENST00000420147.2
glutaminyl-tRNA synthetase
chr11_+_63304273 40.67 ENST00000439013.2
ENST00000255688.3
retinoic acid receptor responder (tazarotene induced) 3
chr19_+_10196781 38.71 ENST00000253110.11
chromosome 19 open reading frame 66
chr5_-_95158375 38.59 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
glutaredoxin (thioltransferase)
chr17_+_46908350 38.00 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
calcium binding and coiled-coil domain 2
chrX_+_37639264 37.66 ENST00000378588.4
cytochrome b-245, beta polypeptide
chr1_+_179050512 34.86 ENST00000367627.3
torsin family 3, member A
chr20_+_388679 34.67 ENST00000356286.5
ENST00000475269.1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_158801095 34.59 ENST00000368141.4
myeloid cell nuclear differentiation antigen
chr21_+_42798094 34.58 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr1_-_89531041 34.47 ENST00000370473.4
guanylate binding protein 1, interferon-inducible
chr2_-_191878681 34.37 ENST00000409465.1
signal transducer and activator of transcription 1, 91kDa
chr16_+_12058961 34.10 ENST00000053243.1
tumor necrosis factor receptor superfamily, member 17
chr2_+_231280908 33.74 ENST00000427101.2
ENST00000432979.1
SP100 nuclear antigen
chr2_+_120687335 33.70 ENST00000544261.1
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr18_+_3262954 32.51 ENST00000584539.1
myosin, light chain 12B, regulatory
chr4_+_37892682 31.49 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr5_-_95158644 31.48 ENST00000237858.6
glutaredoxin (thioltransferase)
chr17_+_25958174 31.12 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr16_+_12059050 30.85 ENST00000396495.3
tumor necrosis factor receptor superfamily, member 17
chr15_+_89182156 30.09 ENST00000379224.5
interferon stimulated exonuclease gene 20kDa
chr12_+_25205666 29.97 ENST00000547044.1
lymphoid-restricted membrane protein
chr6_-_41909191 29.60 ENST00000512426.1
ENST00000372987.4
cyclin D3
chr12_-_10022735 28.50 ENST00000228438.2
C-type lectin domain family 2, member B
chr20_-_5100591 28.47 ENST00000379143.5
proliferating cell nuclear antigen
chr15_+_78832747 28.41 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr2_+_201981119 28.27 ENST00000395148.2
CASP8 and FADD-like apoptosis regulator
chr12_+_6561190 28.10 ENST00000544021.1
ENST00000266556.7
TAP binding protein-like
chr16_+_12059091 27.90 ENST00000562385.1
tumor necrosis factor receptor superfamily, member 17
chr6_-_159239257 27.88 ENST00000337147.7
ENST00000392177.4
ezrin
chr12_+_94542459 27.80 ENST00000258526.4
plexin C1
chr5_+_49962495 27.73 ENST00000515175.1
poly (ADP-ribose) polymerase family, member 8
chr5_+_96212185 27.52 ENST00000379904.4
endoplasmic reticulum aminopeptidase 2
chr3_+_63898275 26.98 ENST00000538065.1
ataxin 7
chr3_-_146262488 26.32 ENST00000487389.1
phospholipid scramblase 1
chr12_+_25205568 26.11 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr12_+_113344811 26.10 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr5_+_96211643 26.01 ENST00000437043.3
ENST00000510373.1
endoplasmic reticulum aminopeptidase 2
chr9_-_100881466 25.97 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
tripartite motif containing 14
chr5_-_142783694 25.74 ENST00000394466.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr14_+_35452104 25.73 ENST00000216774.6
ENST00000546080.1
signal recognition particle 54kDa
chr11_-_4414880 25.57 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr10_+_91087651 25.53 ENST00000371818.4
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_111746966 25.32 ENST00000369752.5
DENN/MADD domain containing 2D
chr2_+_201994569 25.27 ENST00000457277.1
CASP8 and FADD-like apoptosis regulator
chr14_-_24615805 25.18 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_-_67169253 25.12 ENST00000527663.1
ENST00000312989.7
protein phosphatase 1, catalytic subunit, alpha isozyme
chr6_+_37400974 24.53 ENST00000455891.1
ENST00000373451.4
cap methyltransferase 1
chr3_-_172241250 24.39 ENST00000420541.2
ENST00000241261.2
tumor necrosis factor (ligand) superfamily, member 10
chr3_-_30936153 24.11 ENST00000454381.3
ENST00000282538.5
glutamate decarboxylase-like 1
chr14_+_24630465 23.98 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr3_-_146262365 23.86 ENST00000448787.2
phospholipid scramblase 1
chr14_+_35452169 23.75 ENST00000555557.1
signal recognition particle 54kDa
chr16_+_29831715 23.67 ENST00000563915.1
ENST00000357402.5
major vault protein
chr11_-_60719213 23.57 ENST00000227880.3
solute carrier family 15 (oligopeptide transporter), member 3
chr6_+_25963020 23.31 ENST00000357085.3
tripartite motif containing 38
chr18_+_48405463 23.16 ENST00000382927.3
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr11_+_1874200 22.96 ENST00000311604.3
lymphocyte-specific protein 1
chr12_-_53594227 22.83 ENST00000550743.2
integrin, beta 7
chr3_-_121379739 22.76 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr14_+_73563735 22.76 ENST00000532192.1
RNA binding motif protein 25
chr16_-_75681522 22.75 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
lysyl-tRNA synthetase
chr16_+_29831757 22.71 ENST00000452209.2
ENST00000395353.1
ENST00000566066.1
ENST00000563558.1
major vault protein
chrX_+_37639302 22.61 ENST00000545017.1
ENST00000536160.1
cytochrome b-245, beta polypeptide
chr17_+_6659153 22.57 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XIAP associated factor 1
chr7_-_138794081 22.47 ENST00000464606.1
zinc finger CCCH-type, antiviral 1
chr2_+_201994208 22.23 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr15_-_80263506 21.81 ENST00000335661.6
BCL2-related protein A1
chr12_-_31479045 21.74 ENST00000539409.1
ENST00000395766.1
family with sequence similarity 60, member A
chr5_-_149792295 21.60 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr12_+_113344582 21.60 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr18_+_48405419 21.49 ENST00000321341.5
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr1_-_25291475 21.43 ENST00000338888.3
ENST00000399916.1
runt-related transcription factor 3
chr3_-_146262428 21.30 ENST00000486631.1
phospholipid scramblase 1
chr6_-_32920794 21.18 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr2_+_201994042 21.15 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr22_+_39436862 21.08 ENST00000381565.2
ENST00000452957.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr3_+_151986709 21.08 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr1_-_27998689 21.00 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
interferon, alpha-inducible protein 6
chr4_-_103748271 20.85 ENST00000343106.5
ubiquitin-conjugating enzyme E2D 3
chr2_+_202122703 20.82 ENST00000447616.1
ENST00000358485.4
caspase 8, apoptosis-related cysteine peptidase
chr6_+_29691198 20.77 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr5_-_96143602 20.55 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
endoplasmic reticulum aminopeptidase 1
chr1_+_165864800 20.47 ENST00000469256.2
uridine-cytidine kinase 2
chr10_+_91152303 20.46 ENST00000371804.3
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_86669118 20.30 ENST00000427678.1
ENST00000542128.1
lysine (K)-specific demethylase 3A
chr6_+_26402465 20.29 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr6_+_29691056 20.16 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
major histocompatibility complex, class I, F
chr17_-_40264692 20.14 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_231191875 20.11 ENST00000444636.1
ENST00000415673.2
ENST00000243810.6
ENST00000396563.4
SP140 nuclear body protein-like
chr19_+_49838653 19.98 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr11_-_14358620 19.92 ENST00000531421.1
related RAS viral (r-ras) oncogene homolog 2
chr11_+_5646213 19.83 ENST00000429814.2
tripartite motif containing 34
chr5_+_118690466 19.51 ENST00000503646.1
tumor necrosis factor, alpha-induced protein 8
chr14_-_35099315 19.50 ENST00000396526.3
ENST00000396534.3
ENST00000355110.5
ENST00000557265.1
sorting nexin 6
chr2_+_85811525 19.36 ENST00000306384.4
vesicle-associated membrane protein 5
chr2_+_86668464 19.31 ENST00000409064.1
lysine (K)-specific demethylase 3A
chr3_+_152017181 19.04 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
muscleblind-like splicing regulator 1
chr14_+_91580777 18.79 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
chromosome 14 open reading frame 159
chr4_-_83765613 18.75 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr17_+_18380051 18.38 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr1_+_165864821 18.36 ENST00000470820.1
uridine-cytidine kinase 2
chr6_-_170862322 18.32 ENST00000262193.6
proteasome (prosome, macropain) subunit, beta type, 1
chr14_+_91581011 18.30 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
chromosome 14 open reading frame 159
chr13_+_53216565 18.21 ENST00000357495.2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr17_-_5342380 18.01 ENST00000225698.4
complement component 1, q subcomponent binding protein
chr6_-_26056695 17.79 ENST00000343677.2
histone cluster 1, H1c
chr3_-_146262352 17.36 ENST00000462666.1
phospholipid scramblase 1
chr3_-_146262637 17.35 ENST00000472349.1
ENST00000342435.4
phospholipid scramblase 1
chr6_-_31239846 17.25 ENST00000415537.1
ENST00000376228.5
ENST00000383329.3
major histocompatibility complex, class I, C
chr4_-_103747011 17.19 ENST00000350435.7
ubiquitin-conjugating enzyme E2D 3
chr11_-_73687997 17.19 ENST00000545212.1
uncoupling protein 2 (mitochondrial, proton carrier)
chr4_-_103746683 16.88 ENST00000504211.1
ENST00000508476.1
ubiquitin-conjugating enzyme E2D 3
chr11_+_60223225 16.76 ENST00000524807.1
ENST00000345732.4
membrane-spanning 4-domains, subfamily A, member 1
chr14_+_91580732 16.75 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
chromosome 14 open reading frame 159
chr1_+_64058939 16.73 ENST00000371084.3
phosphoglucomutase 1
chr1_-_153919128 16.68 ENST00000361217.4
DENN/MADD domain containing 4B
chr11_-_65381643 16.61 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
mitogen-activated protein kinase kinase kinase 11
chr3_-_167452262 16.53 ENST00000487947.2
programmed cell death 10
chr1_-_19426149 16.45 ENST00000429347.2
ubiquitin protein ligase E3 component n-recognin 4
chr12_+_75874460 16.36 ENST00000266659.3
GLI pathogenesis-related 1
chr11_+_313503 16.35 ENST00000528780.1
ENST00000328221.5
interferon induced transmembrane protein 1
chr11_+_60223312 16.14 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
membrane-spanning 4-domains, subfamily A, member 1
chr1_+_158149737 16.00 ENST00000368171.3
CD1d molecule
chr22_-_36556821 15.91 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
apolipoprotein L, 3
chr3_-_146262293 15.71 ENST00000448205.1
phospholipid scramblase 1
chr2_-_225434538 15.71 ENST00000409096.1
cullin 3
chr17_+_41158742 15.65 ENST00000415816.2
ENST00000438323.2
interferon-induced protein 35
chr11_-_67169265 15.24 ENST00000358239.4
ENST00000376745.4
protein phosphatase 1, catalytic subunit, alpha isozyme
chrX_+_80457442 15.18 ENST00000373212.5
SH3 domain binding glutamic acid-rich protein like
chr3_+_38179969 15.11 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
myeloid differentiation primary response 88
chr5_+_133861790 15.03 ENST00000395003.1
jade family PHD finger 2
chr16_+_50776021 14.98 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chrX_-_20236970 14.97 ENST00000379548.4
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chrX_+_70503037 14.97 ENST00000535149.1
non-POU domain containing, octamer-binding
chr10_+_51572408 14.95 ENST00000374082.1
nuclear receptor coactivator 4
chr9_-_32526184 14.92 ENST00000545044.1
ENST00000379868.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
44.8 223.8 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
42.8 128.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
34.3 274.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
32.8 98.3 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
28.3 84.9 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
28.1 28.1 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
25.4 101.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
21.6 280.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
21.1 105.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
20.7 82.7 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
19.9 219.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
19.0 57.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
17.5 52.5 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
16.6 49.7 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
16.5 49.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
15.4 46.2 GO:0035915 pore formation in membrane of other organism(GO:0035915)
15.2 121.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
15.2 152.2 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
15.2 45.5 GO:0002585 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
13.8 69.0 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
13.2 39.6 GO:0007290 spermatid nucleus elongation(GO:0007290)
12.1 60.3 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
11.8 11.8 GO:0034165 regulation of toll-like receptor 9 signaling pathway(GO:0034163) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
11.6 46.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
11.5 46.1 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
11.5 103.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
11.2 67.1 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
11.1 89.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
10.4 1007.3 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
10.1 40.4 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
9.7 38.8 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
9.5 47.3 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
9.0 27.0 GO:0039516 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
8.8 70.3 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
7.8 54.6 GO:0018377 protein myristoylation(GO:0018377)
7.8 31.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
7.6 22.8 GO:0002276 basophil activation involved in immune response(GO:0002276)
7.3 22.0 GO:1990108 protein linear deubiquitination(GO:1990108)
7.1 28.5 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
6.9 27.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
6.8 20.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
6.7 6.7 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
6.6 39.7 GO:1901098 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
6.6 32.9 GO:0072642 positive regulation of interferon-beta secretion(GO:0035549) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
6.4 44.6 GO:1902031 regulation of NADP metabolic process(GO:1902031)
5.9 293.4 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
5.7 22.8 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
5.3 21.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
4.9 24.5 GO:0080009 mRNA methylation(GO:0080009)
4.9 24.5 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
4.6 36.5 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
4.5 49.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
4.4 35.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
4.4 35.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
4.3 17.4 GO:1903121 regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
4.3 13.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
4.1 12.3 GO:0045062 extrathymic T cell selection(GO:0045062)
4.0 16.0 GO:0019883 antigen processing and presentation of endogenous antigen(GO:0019883)
4.0 23.8 GO:0070383 DNA cytosine deamination(GO:0070383)
3.9 15.7 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.9 19.5 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
3.9 70.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
3.8 46.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
3.8 15.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
3.7 43.9 GO:0035455 response to interferon-alpha(GO:0035455)
3.6 10.9 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
3.6 10.9 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
3.6 82.8 GO:0072643 interferon-gamma secretion(GO:0072643)
3.6 14.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
3.3 23.3 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
3.3 23.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
3.2 12.8 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
3.1 12.4 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
2.9 8.8 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
2.9 11.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.9 8.7 GO:1903028 positive regulation of opsonization(GO:1903028)
2.9 20.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
2.8 2.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
2.8 25.1 GO:0016584 nucleosome positioning(GO:0016584)
2.8 16.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
2.7 8.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
2.7 10.8 GO:0090527 actin filament reorganization(GO:0090527)
2.6 15.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
2.6 7.9 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
2.6 10.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
2.6 46.4 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
2.5 7.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
2.5 7.4 GO:0032621 central nervous system myelin formation(GO:0032289) interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661) toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
2.5 17.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.5 12.3 GO:0006741 NADP biosynthetic process(GO:0006741)
2.4 116.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
2.4 16.6 GO:0007256 activation of JNKK activity(GO:0007256)
2.4 9.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
2.3 106.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
2.2 29.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
2.2 10.9 GO:0033625 positive regulation of integrin activation(GO:0033625)
2.2 8.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.2 6.5 GO:0007518 myoblast fate determination(GO:0007518)
2.1 10.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.1 4.1 GO:0042256 mature ribosome assembly(GO:0042256)
2.0 13.9 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.0 4.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
1.9 5.8 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.9 7.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
1.9 15.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
1.9 5.8 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.9 3.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.9 5.6 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
1.8 3.6 GO:0006059 hexitol metabolic process(GO:0006059)
1.8 5.4 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.8 34.2 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
1.8 5.4 GO:0071283 cellular response to iron(III) ion(GO:0071283)
1.8 32.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
1.8 3.6 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
1.8 10.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
1.7 6.9 GO:0016554 cytidine to uridine editing(GO:0016554)
1.7 39.1 GO:0016578 histone deubiquitination(GO:0016578)
1.7 76.3 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
1.7 5.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.7 9.9 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152) positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.7 5.0 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) negative regulation of mitotic cell cycle DNA replication(GO:1903464) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.6 95.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
1.6 8.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.6 19.6 GO:0010623 programmed cell death involved in cell development(GO:0010623)
1.6 14.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.6 19.4 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
1.6 9.4 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.6 14.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.5 7.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
1.5 63.1 GO:0006536 glutamate metabolic process(GO:0006536)
1.5 5.9 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.5 7.3 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
1.5 2.9 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.5 2.9 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
1.5 2.9 GO:0072300 positive regulation of metanephric glomerulus development(GO:0072300)
1.4 5.8 GO:0005986 sucrose biosynthetic process(GO:0005986)
1.4 53.4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
1.4 114.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.4 18.5 GO:0019388 galactose catabolic process(GO:0019388)
1.4 15.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.4 6.8 GO:0070836 caveola assembly(GO:0070836)
1.4 13.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.3 4.0 GO:0002384 hepatic immune response(GO:0002384)
1.3 4.0 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
1.3 6.7 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
1.3 140.8 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
1.3 3.8 GO:0021569 rhombomere 3 development(GO:0021569)
1.2 13.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
1.2 26.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
1.2 100.3 GO:0006906 vesicle fusion(GO:0006906)
1.2 4.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
1.2 3.6 GO:0071492 cellular response to UV-A(GO:0071492)
1.2 4.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
1.2 6.9 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
1.1 21.8 GO:0008053 mitochondrial fusion(GO:0008053)
1.1 6.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.1 3.3 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391) positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.0 1.0 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
1.0 3.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
1.0 5.1 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
1.0 1.0 GO:0048087 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of developmental pigmentation(GO:0048087) positive regulation of pigment cell differentiation(GO:0050942) positive regulation of neuroepithelial cell differentiation(GO:1902913)
1.0 2.9 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
1.0 4.8 GO:0097338 response to clozapine(GO:0097338)
1.0 7.6 GO:0090344 negative regulation of cell aging(GO:0090344)
0.9 18.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.9 0.9 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.9 8.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.9 10.6 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.9 3.5 GO:0043335 protein unfolding(GO:0043335)
0.9 10.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 4.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.9 11.1 GO:0016180 snRNA processing(GO:0016180)
0.9 5.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.8 7.5 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.8 5.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.8 4.9 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.8 14.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.8 4.0 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.8 5.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.8 28.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.8 11.9 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.8 6.2 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.8 12.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.8 7.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.8 7.6 GO:0015886 heme transport(GO:0015886)
0.8 3.8 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.8 6.0 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.8 3.0 GO:0043248 proteasome assembly(GO:0043248)
0.7 14.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.7 5.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.7 2.2 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.7 2.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.7 37.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.7 15.1 GO:0006828 manganese ion transport(GO:0006828)
0.7 7.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.7 3.6 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.7 15.0 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.7 2.8 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.7 3.4 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.7 11.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.7 5.4 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.6 5.2 GO:0045779 negative regulation of bone resorption(GO:0045779)
0.6 3.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.6 16.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.6 3.0 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.6 1.7 GO:0070842 aggresome assembly(GO:0070842)
0.6 1.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.6 14.9 GO:0003094 glomerular filtration(GO:0003094)
0.6 10.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 11.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.6 27.7 GO:0006298 mismatch repair(GO:0006298)
0.6 29.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.6 3.3 GO:1990441 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990441)
0.6 3.9 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.6 4.4 GO:0015867 ADP transport(GO:0015866) ATP transport(GO:0015867) adenine nucleotide transport(GO:0051503)
0.5 4.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.5 10.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.5 7.3 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.5 9.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.5 0.5 GO:1990791 dorsal root ganglion development(GO:1990791)
0.5 2.0 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.5 10.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 6.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 6.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.5 10.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.5 1.9 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.5 30.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.4 1.3 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.4 4.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 4.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 6.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.4 12.0 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.4 2.4 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.4 1.2 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.4 1.2 GO:0070541 response to platinum ion(GO:0070541)
0.4 1.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 2.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 2.6 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.4 4.1 GO:0033227 dsRNA transport(GO:0033227)
0.4 3.3 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.4 1.8 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 10.1 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.3 35.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.3 13.0 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.3 2.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 9.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.3 1.0 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 6.1 GO:0032418 lysosome localization(GO:0032418)
0.3 5.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.3 0.6 GO:1904252 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.3 1.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 3.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.3 5.7 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 45.1 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 1.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.3 2.6 GO:0001783 B cell apoptotic process(GO:0001783)
0.3 0.6 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.3 1.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.3 3.7 GO:0043583 ear development(GO:0043583) inner ear development(GO:0048839)
0.3 5.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.3 0.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 6.1 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.3 1.9 GO:0006105 succinate metabolic process(GO:0006105)
0.3 6.6 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.4 GO:0036258 multivesicular body organization(GO:0036257) multivesicular body assembly(GO:0036258)
0.3 6.3 GO:0014904 myotube cell development(GO:0014904)
0.3 0.8 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3 1.0 GO:0090309 regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 2.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.3 4.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 8.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 1.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 13.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 3.5 GO:0051639 actin filament network formation(GO:0051639)
0.2 6.3 GO:0006491 N-glycan processing(GO:0006491)
0.2 10.5 GO:0051972 regulation of telomerase activity(GO:0051972)
0.2 7.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 6.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.2 15.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.2 11.2 GO:0045576 mast cell activation(GO:0045576)
0.2 3.0 GO:0003014 renal system process(GO:0003014)
0.2 29.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 6.5 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.2 8.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 5.5 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.2 2.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 5.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 2.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 12.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 5.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 3.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 4.9 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.2 3.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 8.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 0.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 0.5 GO:0001897 cytolysis by symbiont of host cells(GO:0001897) hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.1 3.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 9.9 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.3 GO:0071698 olfactory placode formation(GO:0030910) ureteric bud formation(GO:0060676) cranial ganglion development(GO:0061550) trigeminal ganglion development(GO:0061551) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) mesonephric tubule formation(GO:0072172) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 7.1 GO:0006968 cellular defense response(GO:0006968)
0.1 1.6 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.6 GO:0006574 valine catabolic process(GO:0006574)
0.1 11.5 GO:0008652 cellular amino acid biosynthetic process(GO:0008652)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 1.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.1 8.3 GO:0006413 translational initiation(GO:0006413)
0.1 0.7 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.1 5.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 53.9 GO:0016032 viral process(GO:0016032)
0.1 1.6 GO:0008356 asymmetric cell division(GO:0008356)
0.1 0.7 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 3.1 GO:0006342 chromatin silencing(GO:0006342)
0.1 1.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 2.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 1.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 2.2 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 0.5 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 1.1 GO:0033151 V(D)J recombination(GO:0033151)
0.1 2.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 1.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 4.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.2 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 0.5 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 9.7 GO:0008360 regulation of cell shape(GO:0008360)
0.1 4.1 GO:0030641 regulation of cellular pH(GO:0030641)
0.1 2.7 GO:0048477 oogenesis(GO:0048477)
0.1 3.2 GO:0006400 tRNA modification(GO:0006400)
0.1 3.6 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.7 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.7 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 2.0 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 3.2 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 3.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.2 GO:0043473 pigmentation(GO:0043473)
0.0 0.5 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.2 GO:0015992 proton transport(GO:0015992)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 2.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
69.7 557.8 GO:1990111 spermatoproteasome complex(GO:1990111)
30.6 183.7 GO:0042825 TAP complex(GO:0042825)
24.4 146.4 GO:0008537 proteasome activator complex(GO:0008537)
23.8 142.6 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
17.8 89.1 GO:0071797 LUBAC complex(GO:0071797)
11.8 129.6 GO:0042612 MHC class I protein complex(GO:0042612)
11.5 34.5 GO:0044393 microspike(GO:0044393)
10.7 85.5 GO:0032010 phagolysosome(GO:0032010)
9.9 49.7 GO:0044530 supraspliceosomal complex(GO:0044530)
9.7 116.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
9.6 173.1 GO:0097342 ripoptosome(GO:0097342)
9.5 28.5 GO:0070557 PCNA-p21 complex(GO:0070557)
7.0 21.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
6.7 53.9 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
6.2 130.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
6.2 49.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
5.7 22.8 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
5.7 34.0 GO:0030905 retromer, tubulation complex(GO:0030905)
5.6 39.0 GO:0030870 Mre11 complex(GO:0030870)
5.0 54.8 GO:0005688 U6 snRNP(GO:0005688)
5.0 14.9 GO:0071751 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
4.6 59.8 GO:0043020 NADPH oxidase complex(GO:0043020)
4.3 34.1 GO:0043196 varicosity(GO:0043196)
4.0 40.5 GO:0042587 glycogen granule(GO:0042587)
4.0 32.1 GO:0070552 BRISC complex(GO:0070552)
3.7 11.2 GO:0036398 TCR signalosome(GO:0036398)
3.2 29.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
3.1 21.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
3.0 14.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.9 202.5 GO:0015030 Cajal body(GO:0015030)
2.9 14.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
2.8 205.2 GO:0035577 azurophil granule membrane(GO:0035577)
2.8 8.4 GO:1990622 CHOP-ATF3 complex(GO:1990622)
2.6 7.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.5 7.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
2.5 27.0 GO:0035631 CD40 receptor complex(GO:0035631)
2.4 7.3 GO:0031213 RSF complex(GO:0031213)
2.4 28.9 GO:0044754 autolysosome(GO:0044754)
2.4 7.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.2 4.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
2.0 8.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.9 15.0 GO:0042382 paraspeckles(GO:0042382)
1.8 60.5 GO:0031258 lamellipodium membrane(GO:0031258)
1.8 3.6 GO:0097454 Schwann cell microvillus(GO:0097454)
1.8 8.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.7 15.7 GO:0005827 polar microtubule(GO:0005827)
1.7 11.6 GO:0072487 MSL complex(GO:0072487)
1.5 10.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.4 13.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
1.3 162.6 GO:0005643 nuclear pore(GO:0005643)
1.3 12.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
1.3 5.0 GO:0070985 TFIIK complex(GO:0070985)
1.2 11.1 GO:0032039 integrator complex(GO:0032039)
1.2 3.5 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
1.1 10.3 GO:0072546 ER membrane protein complex(GO:0072546)
1.1 7.9 GO:0070765 gamma-secretase complex(GO:0070765)
1.1 30.2 GO:0070822 Sin3-type complex(GO:0070822)
1.1 7.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.1 38.0 GO:0000421 autophagosome membrane(GO:0000421)
1.1 21.2 GO:0042611 MHC protein complex(GO:0042611)
1.0 8.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.0 4.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.0 5.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.9 4.7 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.9 26.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.9 59.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.8 7.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.8 18.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.8 8.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.8 9.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.8 338.1 GO:0016607 nuclear speck(GO:0016607)
0.7 8.9