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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRF3

Z-value: 0.87

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168861_501688730.393.8e-09Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32821924 20.03 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_127413677 13.73 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr2_+_127413481 13.61 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr2_+_127413704 13.28 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr14_+_24605361 11.80 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_-_10022735 11.78 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr19_-_17516449 11.61 ENST00000252593.6
BST2
bone marrow stromal cell antigen 2
chr2_-_231084820 11.21 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr14_+_24605389 11.11 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_231084617 10.21 ENST00000409815.2
SP110
SP110 nuclear body protein
chr6_-_32821599 10.01 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_615570 9.97 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr6_+_26440700 9.88 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr21_+_42792442 9.79 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_615942 9.69 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr19_+_10196781 9.62 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr11_-_57335280 9.17 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr19_+_18284477 9.12 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr1_+_948803 8.83 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr2_-_231084659 8.80 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr16_-_67970990 8.53 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr15_-_62352570 8.52 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr8_-_67525473 8.31 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr1_+_79115503 7.67 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr4_-_74847800 7.59 ENST00000296029.3
PF4
platelet factor 4
chr7_-_138794081 6.99 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr3_-_172241250 6.43 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr6_+_26365443 6.35 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr7_-_92747269 6.08 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr12_+_113416191 5.90 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr22_+_31892261 5.78 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr5_-_95158644 5.72 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr19_+_49977466 5.67 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr6_+_26402465 5.60 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr12_+_6561190 5.54 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr3_+_63898275 5.19 ENST00000538065.1
ATXN7
ataxin 7
chr4_-_169239921 4.91 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_-_138794394 4.64 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr10_+_91087651 4.54 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_201981527 4.48 ENST00000441224.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr9_-_95087838 4.33 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
NOL8
nucleolar protein 8
chr22_-_36556821 4.30 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr15_+_45003675 4.21 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr9_-_95087604 4.16 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
NOL8
nucleolar protein 8
chr19_+_49977818 4.13 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr15_-_55611306 4.00 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr17_+_36861735 3.94 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_+_31892373 3.94 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr14_+_73525144 3.93 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr3_+_63897605 3.90 ENST00000487717.1
ATXN7
ataxin 7
chr4_-_87855851 3.84 ENST00000473559.1
C4orf36
chromosome 4 open reading frame 36
chr5_-_96143602 3.84 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr17_+_25958174 3.78 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr14_+_73525229 3.70 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr19_+_10196981 3.60 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr2_+_201980827 3.50 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
CFLAR
CASP8 and FADD-like apoptosis regulator
chr5_-_77656175 3.49 ENST00000513755.1
ENST00000421004.3
CTD-2037K23.2
CTD-2037K23.2
chr22_+_36649056 3.37 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
APOL1
apolipoprotein L, 1
chr11_-_4414880 3.27 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr9_-_32526184 3.23 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_-_24615805 3.15 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr5_-_95158375 3.07 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr6_+_26402517 3.01 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr4_+_87928140 2.83 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr4_+_118955500 2.79 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr2_-_157198860 2.77 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr4_+_87856129 2.63 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr17_+_6659153 2.61 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr5_-_135701164 2.60 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr6_-_41039567 2.55 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr2_-_163175133 2.50 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr4_-_156875003 2.47 ENST00000433477.3
CTSO
cathepsin O
chr12_-_99288536 2.41 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr12_+_133614119 2.39 ENST00000327668.7
ZNF84
zinc finger protein 84
chr1_+_145292806 2.33 ENST00000448873.2
NBPF10
neuroblastoma breakpoint family, member 10
chr17_-_63052929 2.32 ENST00000439174.2
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chrX_-_109561294 2.31 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr11_+_5646213 2.30 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr6_-_32806506 2.29 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr10_-_14996017 2.28 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
DCLRE1C
DNA cross-link repair 1C
chr9_-_140082983 2.23 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr1_-_25747283 2.22 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
RHCE
Rh blood group, CcEe antigens
chr22_+_39436862 2.19 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr17_-_40264692 2.14 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr7_-_32931387 2.03 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr9_-_32526299 1.87 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_-_28223166 1.83 ENST00000304658.5
XPO6
exportin 6
chr12_+_133613878 1.76 ENST00000392319.2
ENST00000543758.1
ZNF84
zinc finger protein 84
chr12_+_133613937 1.71 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
ZNF84
zinc finger protein 84
chr3_+_42190714 1.70 ENST00000449246.1
TRAK1
trafficking protein, kinesin binding 1
chr2_+_201981119 1.63 ENST00000395148.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr10_-_14996070 1.61 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DCLRE1C
DNA cross-link repair 1C
chr3_-_53079281 1.57 ENST00000394750.1
SFMBT1
Scm-like with four mbt domains 1
chr20_+_388935 1.53 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_+_50887585 1.48 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr14_-_91976794 1.46 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr15_+_55611128 1.37 ENST00000164305.5
ENST00000539642.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr14_+_73525265 1.36 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr2_-_73869508 1.31 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chrX_-_48937531 1.29 ENST00000473974.1
ENST00000475880.1
ENST00000396681.4
ENST00000553851.1
ENST00000471338.1
ENST00000476728.1
ENST00000376368.2
ENST00000485908.1
ENST00000376372.3
ENST00000376358.3
WDR45
AF196779.12
WD repeat domain 45
WD repeat domain phosphoinositide-interacting protein 4
chr2_+_99771418 1.23 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr12_-_8218997 1.23 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr4_+_89378261 1.12 ENST00000264350.3
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr6_+_3068606 1.08 ENST00000259808.4
RIPK1
receptor (TNFRSF)-interacting serine-threonine kinase 1
chr20_+_388679 1.02 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_159046617 1.02 ENST00000368130.4
AIM2
absent in melanoma 2
chr16_-_11350036 0.99 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr3_-_160283348 0.99 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr8_+_145438870 0.93 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr17_+_79373540 0.92 ENST00000307745.7
RP11-1055B8.7
BAH and coiled-coil domain-containing protein 1
chr1_+_221054584 0.92 ENST00000549319.1
HLX
H2.0-like homeobox
chr16_+_58283814 0.91 ENST00000443128.2
ENST00000219299.4
CCDC113
coiled-coil domain containing 113
chr14_-_24615523 0.91 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_+_100495864 0.86 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr6_-_90529418 0.85 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr6_+_31540056 0.81 ENST00000418386.2
LTA
lymphotoxin alpha
chr20_+_61436146 0.76 ENST00000290291.6
OGFR
opioid growth factor receptor
chr5_-_96143796 0.74 ENST00000296754.3
ERAP1
endoplasmic reticulum aminopeptidase 1
chr16_-_29875057 0.73 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr19_-_47735918 0.72 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr17_-_61517572 0.70 ENST00000582997.1
CYB561
cytochrome b561
chr1_-_89664595 0.69 ENST00000355754.6
GBP4
guanylate binding protein 4
chr22_+_36044411 0.69 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr9_-_100954910 0.68 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr2_+_113672770 0.66 ENST00000311328.2
IL37
interleukin 37
chr1_+_25598989 0.65 ENST00000454452.2
RHD
Rh blood group, D antigen
chr1_+_25598872 0.59 ENST00000328664.4
RHD
Rh blood group, D antigen
chr15_-_88799948 0.57 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr16_-_29874462 0.56 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr19_+_50432400 0.46 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
ATF5
activating transcription factor 5
chr12_-_48963829 0.45 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr9_+_140083099 0.45 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr11_+_124735282 0.44 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr6_-_30181133 0.41 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr2_+_69240302 0.40 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr2_+_69240415 0.40 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr11_+_66008698 0.39 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr6_-_30181156 0.31 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr8_+_22446763 0.28 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr1_-_154580616 0.23 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr3_+_187086120 0.22 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr1_+_76190357 0.22 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr14_-_20881579 0.20 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
TEP1
telomerase-associated protein 1
chr7_+_134832808 0.18 ENST00000275767.3
TMEM140
transmembrane protein 140
chr12_-_322821 0.16 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chrX_+_119384607 0.16 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr1_+_25599018 0.12 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr6_-_27840099 0.10 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chrX_+_154610428 0.02 ENST00000354514.4
H2AFB2
H2A histone family, member B2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.7 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
3.9 11.6 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
3.3 9.8 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
2.8 8.5 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
2.7 10.9 GO:0046967 cytosol to ER transport(GO:0046967)
2.4 19.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
2.1 4.2 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.9 7.6 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.8 7.0 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.5 7.6 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.3 3.8 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
1.1 8.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.9 2.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.9 9.8 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.9 8.8 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.8 5.9 GO:0018377 protein myristoylation(GO:0018377)
0.8 5.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.8 9.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.8 3.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.8 2.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.8 4.6 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.7 40.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.7 4.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.6 15.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.6 5.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.6 55.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.5 1.6 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.5 8.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.4 2.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.4 1.1 GO:0032242 regulation of nucleoside transport(GO:0032242)
0.3 6.4 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3 2.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 0.8 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 2.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 0.8 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 2.5 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.3 2.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 1.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 2.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 0.6 GO:0052026 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2 1.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.2 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 1.0 GO:0070269 pyroptosis(GO:0070269)
0.1 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 2.2 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 5.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 2.6 GO:0006828 manganese ion transport(GO:0006828)
0.1 1.2 GO:0009249 protein lipoylation(GO:0009249)
0.1 9.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 3.6 GO:0015695 organic cation transport(GO:0015695)
0.1 7.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.2 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.1 0.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 7.9 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 1.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 2.6 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 1.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 2.7 GO:0019835 cytolysis(GO:0019835)
0.1 0.7 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 1.0 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.3 GO:0070206 protein trimerization(GO:0070206)
0.0 1.0 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 1.8 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.6 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 1.3 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 3.2 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 27.0 GO:0008537 proteasome activator complex(GO:0008537)
3.6 28.6 GO:1990111 spermatoproteasome complex(GO:1990111)
2.5 7.6 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.8 10.9 GO:0042825 TAP complex(GO:0042825)
0.8 4.2 GO:0031905 early endosome lumen(GO:0031905)
0.7 2.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.5 9.9 GO:0097342 ripoptosome(GO:0097342)
0.4 2.2 GO:0071797 LUBAC complex(GO:0071797)
0.4 9.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.4 1.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 40.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 3.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 1.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 11.6 GO:0005771 multivesicular body(GO:0005771)
0.1 1.0 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 5.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 9.7 GO:0005814 centriole(GO:0005814)
0.1 9.1 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 7.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 8.9 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0031527 lamellipodium membrane(GO:0031258) filopodium membrane(GO:0031527)
0.0 1.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 9.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.4 GO:0031968 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 1.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0015030 Cajal body(GO:0015030)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.0 9.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.9 GO:0043235 receptor complex(GO:0043235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 27.0 GO:0061133 endopeptidase activator activity(GO:0061133)
1.7 10.3 GO:0042296 ISG15 transferase activity(GO:0042296)
1.7 10.0 GO:0046979 TAP2 binding(GO:0046979)
1.5 7.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.3 3.8 GO:0048030 disaccharide binding(GO:0048030)
1.1 4.6 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
1.0 28.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 8.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.7 8.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.7 8.8 GO:0031386 protein tag(GO:0031386)
0.5 3.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.5 2.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 11.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 2.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 0.9 GO:0046977 TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.3 1.0 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.3 1.4 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.3 9.9 GO:0005123 death receptor binding(GO:0005123)
0.3 1.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.3 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 5.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 22.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 2.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 7.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 9.1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.2 0.7 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.2 4.0 GO:0031489 myosin V binding(GO:0031489)
0.1 1.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 2.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 9.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.1 3.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 13.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 1.2 GO:0004875 complement receptor activity(GO:0004875)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 6.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 32.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 11.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 5.2 GO:0005319 lipid transporter activity(GO:0005319)
0.0 9.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 9.8 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.0 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 5.2 GO:0019902 phosphatase binding(GO:0019902)
0.0 2.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 1.5 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 25.7 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 4.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 7.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 2.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 19.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 10.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 15.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 0.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 5.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 8.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 19.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.8 7.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.8 55.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.6 16.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 11.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.5 7.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 19.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 8.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 2.2 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 4.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 2.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 4.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 10.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.2 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 1.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 2.3 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 2.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 1.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling