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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRX2

Z-value: 0.65

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
IRX2
ENSG00000170561.8 iroquois homeobox 2

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_88896819 20.59 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr5_+_36608422 17.72 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_10292308 16.16 ENST00000377081.1
KIF1B
kinesin family member 1B
chr4_+_158141843 14.47 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_158142750 14.27 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_158141899 13.19 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr12_-_16758059 9.96 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758304 9.62 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_153332886 8.59 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr15_-_45670924 8.08 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr8_-_82359662 7.59 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr4_+_114214125 6.41 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr5_-_138210977 6.08 ENST00000274711.6
ENST00000521094.2
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr18_-_53070913 5.10 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr14_+_29236269 5.09 ENST00000313071.4
FOXG1
forkhead box G1
chr5_+_156696362 5.04 ENST00000377576.3
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_-_166060552 5.03 ENST00000283254.7
ENST00000453007.1
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr19_-_51466681 4.96 ENST00000456750.2
KLK6
kallikrein-related peptidase 6
chr3_-_127441406 4.40 ENST00000487473.1
ENST00000484451.1
MGLL
monoglyceride lipase
chr13_-_24007815 4.39 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr1_+_110527308 4.14 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr2_-_166060571 4.12 ENST00000360093.3
SCN3A
sodium channel, voltage-gated, type III, alpha subunit
chr18_-_33702078 3.96 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr13_+_35516390 3.48 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA
neurobeachin
chr12_+_112856690 3.16 ENST00000392597.1
ENST00000351677.2
PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr11_-_33795893 3.11 ENST00000526785.1
ENST00000534136.1
ENST00000265651.3
ENST00000530401.1
ENST00000448981.2
FBXO3
F-box protein 3
chr2_+_196313239 2.90 ENST00000413290.1
AC064834.1
AC064834.1
chr1_+_67673297 2.76 ENST00000425614.1
ENST00000395227.1
IL23R
interleukin 23 receptor
chr7_-_150020578 2.61 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr8_+_26240414 2.45 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_+_16083154 2.44 ENST00000375771.1
FBLIM1
filamin binding LIM protein 1
chr7_-_14880892 2.13 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr1_+_215747118 2.11 ENST00000448333.1
KCTD3
potassium channel tetramerization domain containing 3
chrX_-_118739835 1.99 ENST00000542113.1
ENST00000304449.5
NKRF
NFKB repressing factor
chr1_-_173793458 1.98 ENST00000356198.2
CENPL
centromere protein L
chr17_+_34842473 1.93 ENST00000490126.2
ENST00000225410.4
ZNHIT3
zinc finger, HIT-type containing 3
chr4_+_119606523 1.92 ENST00000388822.5
ENST00000506780.1
ENST00000508801.1
METTL14
methyltransferase like 14
chr5_-_94417339 1.88 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chrX_+_19373700 1.82 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr17_+_34842512 1.78 ENST00000588253.1
ENST00000592616.1
ENST00000590858.1
ENST00000588357.1
ZNHIT3
zinc finger, HIT-type containing 3
chr3_-_15140629 1.76 ENST00000507357.1
ENST00000449050.1
ENST00000253699.3
ENST00000435849.3
ENST00000476527.2
ZFYVE20
zinc finger, FYVE domain containing 20
chr10_+_102672712 1.70 ENST00000370271.3
ENST00000370269.3
ENST00000609386.1
FAM178A
family with sequence similarity 178, member A
chr7_+_99686577 1.68 ENST00000303904.3
ENST00000419210.1
ENST00000418625.1
COPS6
COP9 signalosome subunit 6
chr1_-_8939265 1.60 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr14_-_75536182 1.58 ENST00000555463.1
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr14_+_23790655 1.47 ENST00000397276.2
PABPN1
poly(A) binding protein, nuclear 1
chr1_+_206516200 1.44 ENST00000295713.5
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr19_-_38720294 1.40 ENST00000412732.1
ENST00000456296.1
DPF1
D4, zinc and double PHD fingers family 1
chr6_+_13272904 1.40 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr9_+_35792151 1.34 ENST00000342694.2
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr16_+_58426296 1.34 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3
GINS complex subunit 3 (Psf3 homolog)
chr6_+_24775153 1.33 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr2_+_234637754 1.27 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr16_-_20367584 1.27 ENST00000570689.1
UMOD
uromodulin
chr5_-_150138061 1.26 ENST00000521533.1
ENST00000424236.1
DCTN4
dynactin 4 (p62)
chr12_-_112856623 1.24 ENST00000551291.2
RPL6
ribosomal protein L6
chr14_-_65289812 1.18 ENST00000389720.3
ENST00000389721.5
ENST00000389722.3
SPTB
spectrin, beta, erythrocytic
chr2_+_46844290 1.16 ENST00000238892.3
CRIPT
cysteine-rich PDZ-binding protein
chr2_+_171034646 1.15 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr9_-_13175823 1.14 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr4_-_120243545 1.12 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr10_+_11047259 1.11 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr19_-_38720354 1.11 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr11_-_59383617 1.06 ENST00000263847.1
OSBP
oxysterol binding protein
chr1_-_190446759 1.03 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr3_-_194072019 1.02 ENST00000429275.1
ENST00000323830.3
CPN2
carboxypeptidase N, polypeptide 2
chr2_-_46844159 0.99 ENST00000474980.1
ENST00000306465.4
PIGF
phosphatidylinositol glycan anchor biosynthesis, class F
chr16_+_69373323 0.92 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr3_-_58419537 0.87 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr4_+_69681710 0.81 ENST00000265403.7
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B10
chr17_-_26127525 0.80 ENST00000313735.6
NOS2
nitric oxide synthase 2, inducible
chrX_-_138790348 0.80 ENST00000414978.1
ENST00000519895.1
MCF2
MCF.2 cell line derived transforming sequence
chr9_+_79792410 0.76 ENST00000357409.5
VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr2_-_46844242 0.74 ENST00000281382.6
PIGF
phosphatidylinositol glycan anchor biosynthesis, class F
chr12_+_66218212 0.67 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
HMGA2
high mobility group AT-hook 2
chr8_-_124428569 0.65 ENST00000521903.1
ATAD2
ATPase family, AAA domain containing 2
chr2_+_27851863 0.60 ENST00000264718.3
ENST00000610189.1
GPN1
GPN-loop GTPase 1
chr1_+_152691998 0.59 ENST00000368775.2
C1orf68
chromosome 1 open reading frame 68
chrX_-_100129320 0.58 ENST00000372966.3
NOX1
NADPH oxidase 1
chr19_-_29704448 0.55 ENST00000304863.4
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr18_+_32455201 0.54 ENST00000590831.2
DTNA
dystrobrevin, alpha
chr1_-_207095212 0.53 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chrX_-_100129128 0.51 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr5_-_142814241 0.49 ENST00000504572.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr15_+_44580955 0.48 ENST00000345795.2
ENST00000360824.3
CASC4
cancer susceptibility candidate 4
chr1_+_113009163 0.47 ENST00000256640.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr10_+_96522361 0.46 ENST00000371321.3
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr6_+_27925019 0.46 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr12_+_66218598 0.41 ENST00000541363.1
HMGA2
high mobility group AT-hook 2
chr1_+_113010056 0.41 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr2_-_98280383 0.40 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr15_+_57998923 0.40 ENST00000380557.4
POLR2M
polymerase (RNA) II (DNA directed) polypeptide M
chr6_-_53013620 0.40 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr6_-_136847610 0.37 ENST00000454590.1
ENST00000432797.2
MAP7
microtubule-associated protein 7
chr16_-_5083917 0.32 ENST00000312251.3
ENST00000381955.3
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chrX_+_30261847 0.32 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr6_-_136847099 0.24 ENST00000438100.2
MAP7
microtubule-associated protein 7
chr2_-_109605663 0.18 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr5_+_167913450 0.17 ENST00000231572.3
ENST00000538719.1
RARS
arginyl-tRNA synthetase
chr2_+_168675182 0.15 ENST00000305861.1
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_148676974 0.13 ENST00000524178.1
HSFX2
heat shock transcription factor family, X linked 2
chrX_+_148855726 0.13 ENST00000370416.4
HSFX1
heat shock transcription factor family, X linked 1
chr4_-_80247162 0.11 ENST00000286794.4
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr3_+_46616017 0.11 ENST00000542931.1
TDGF1
teratocarcinoma-derived growth factor 1
chr3_-_114343768 0.10 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr13_+_28519343 0.08 ENST00000381026.3
ATP5EP2
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2
chr10_+_1095416 0.08 ENST00000358220.1
WDR37
WD repeat domain 37
chr4_-_168155417 0.08 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr11_+_98891797 0.07 ENST00000527185.1
ENST00000528682.1
ENST00000524871.1
CNTN5
contactin 5
chr20_+_43835638 0.07 ENST00000372781.3
ENST00000244069.6
SEMG1
semenogelin I
chrX_+_135618258 0.06 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr16_+_82068830 0.04 ENST00000199936.4
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr16_-_4401258 0.01 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.6 GO:0035938 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
5.4 16.2 GO:1904647 response to rotenone(GO:1904647)
3.3 19.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.5 17.7 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.1 6.4 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.7 8.6 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.1 3.2 GO:0043400 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462)
0.9 41.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 8.1 GO:0006600 creatine metabolic process(GO:0006600)
0.7 2.8 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.6 5.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.6 4.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.6 4.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 6.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.5 1.5 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.4 2.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.4 4.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 1.9 GO:0080009 mRNA methylation(GO:0080009)
0.4 1.1 GO:0035978 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.3 1.3 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 2.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.3 1.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.3 4.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 1.6 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.3 1.3 GO:0070980 biphenyl catabolic process(GO:0070980)
0.3 1.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.2 4.7 GO:0016540 protein autoprocessing(GO:0016540)
0.2 1.3 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.2 0.6 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.2 1.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 9.2 GO:0019228 neuronal action potential(GO:0019228)
0.2 2.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 1.3 GO:0007097 nuclear migration(GO:0007097)
0.1 0.9 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.1 1.4 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.1 0.4 GO:0051685 maintenance of ER location(GO:0051685)
0.1 0.4 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 1.7 GO:0000338 protein deneddylation(GO:0000338)
0.1 1.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.8 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.1 0.5 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.1 0.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 2.0 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 2.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 2.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.3 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 1.1 GO:0016032 viral process(GO:0016032)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.1 GO:0050953 visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953)
0.0 0.9 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.1 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 1.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 1.1 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 1.2 GO:0051693 actin filament capping(GO:0051693)
0.0 1.0 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 4.0 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0098843 postsynaptic endocytic zone(GO:0098843)
1.2 8.6 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7 2.8 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.6 1.9 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.6 4.4 GO:0070852 cell body fiber(GO:0070852)
0.5 9.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 16.2 GO:1904115 axon cytoplasm(GO:1904115)
0.3 2.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.3 1.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.4 GO:0044327 dendritic spine head(GO:0044327)
0.1 6.4 GO:0031430 M band(GO:0031430) costamere(GO:0043034)
0.1 1.7 GO:0005869 dynactin complex(GO:0005869)
0.1 1.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.5 GO:0071565 nBAF complex(GO:0071565)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 8.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 20.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.1 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 1.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.6 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.8 GO:0031045 dense core granule(GO:0031045)
0.0 20.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 6.2 GO:0043209 myelin sheath(GO:0043209)
0.0 6.1 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 2.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 6.3 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 3.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 3.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 41.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.5 17.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 8.6 GO:0050816 phosphothreonine binding(GO:0050816)
1.0 1.0 GO:0008235 metallocarboxypeptidase activity(GO:0004181) metalloexopeptidase activity(GO:0008235)
0.7 2.8 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.7 4.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.7 2.7 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.6 1.9 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.4 6.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.7 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.4 5.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 9.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 1.1 GO:0035501 MH1 domain binding(GO:0035501)
0.3 4.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 8.1 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 16.2 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.3 1.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.6 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 3.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 1.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 15.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 4.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 1.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.2 8.7 GO:0005504 fatty acid binding(GO:0005504)
0.2 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.1 6.4 GO:0030507 spectrin binding(GO:0030507)
0.1 2.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.4 GO:0031005 filamin binding(GO:0031005)
0.1 2.2 GO:0070628 proteasome binding(GO:0070628)
0.1 0.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 2.5 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0034618 arginine binding(GO:0034618)
0.1 3.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.6 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.3 GO:0019864 IgG binding(GO:0019864)
0.1 2.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 1.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.5 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.3 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.1 GO:0003774 motor activity(GO:0003774)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 45.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.5 21.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.2 8.6 PID MYC PATHWAY C-MYC pathway
0.1 5.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 5.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 5.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 5.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 41.9 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 17.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 8.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 4.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 2.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 20.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 6.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 2.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 8.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production