ISMARA results: IRX5

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRX5

Z-value: 0.67

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Transcription factors associated with IRX5

Gene Symbol	Gene ID	Gene Info
IRX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000176842.10	iroquois homeobox 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRX5	hg19_v2_chr16_+_54964740_54964789	-0.14	3.4e-02	Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_73563735 Show fit	13.73	ENST00000532192.1	RBM25 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding motif protein 25
chr14_+_56127989 Show fit	11.98	ENST00000555573.1	KTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	kinectin 1 (kinesin receptor)
chr1_-_197115818 Show fit	10.89	ENST00000367409.4 ENST00000294732.7	ASPM Ensembl NCBI GeneCards UniProt NextProt Show fit	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr4_-_104119528 Show fit	9.32	ENST00000380026.3 ENST00000503705.1 ENST00000265148.3	CENPE Ensembl NCBI GeneCards UniProt NextProt Show fit	centromere protein E, 312kDa
chrX_+_49294472 Show fit	8.93	ENST00000361446.5	GAGE12B Ensembl NCBI GeneCards UniProt NextProt Show fit	G antigen 12B
chrX_-_52258669 Show fit	7.88	ENST00000441417.1	XAGE1A Ensembl NCBI GeneCards UniProt NextProt Show fit	X antigen family, member 1A
chrX_+_52513455 Show fit	7.38	ENST00000446098.1	XAGE1C Ensembl NCBI GeneCards UniProt NextProt Show fit	X antigen family, member 1C
chr14_+_35747825 Show fit	7.03	ENST00000540871.1	PSMA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, alpha type, 6
chr1_+_220267429 Show fit	6.70	ENST00000366922.1 ENST00000302637.5	IARS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	isoleucyl-tRNA synthetase 2, mitochondrial
chr3_+_180586536 Show fit	6.22	ENST00000465551.1	FXR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fragile X mental retardation, autosomal homolog 1

Showing 1 to 10 of 168 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	12.0	GO:0007018	microtubule-based movement(GO:0007018)
1.8	10.9	GO:0051661	maintenance of centrosome location(GO:0051661)
1.5	10.5	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3	9.7	GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
1.6	9.3	GO:0007079	mitotic chromosome movement towards spindle pole(GO:0007079)
0.1	8.5	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.3	7.3	GO:1903894	regulation of IRE1-mediated unfolded protein response(GO:1903894)
0.3	6.8	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
2.2	6.7	GO:0006428	isoleucyl-tRNA aminoacylation(GO:0006428)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	15.0	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	12.9	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	11.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
1.6	10.9	GO:0036449	microtubule minus-end(GO:0036449)
1.5	10.5	GO:0044326	dendritic spine neck(GO:0044326)
0.1	9.1	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	8.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.6	7.0	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	7.0	GO:0005814	centriole(GO:0005814)
0.0	6.9	GO:0005681	spliceosomal complex(GO:0005681)

Showing 1 to 10 of 55 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	19.0	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175)
0.1	15.6	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
3.8	15.0	GO:0043515	kinetochore binding(GO:0043515)
0.2	12.0	GO:0019894	kinesin binding(GO:0019894)
0.3	10.6	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	10.0	GO:0005516	calmodulin binding(GO:0005516)
0.2	7.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.2	6.7	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.3	6.5	GO:0000339	RNA cap binding(GO:0000339)
0.6	6.2	GO:0002151	G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)

Showing 1 to 10 of 69 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.7	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	5.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	4.7	PID PLK1 PATHWAY	PLK1 signaling events
0.1	4.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	4.3	PID RHOA PATHWAY	RhoA signaling pathway
0.0	4.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	3.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	3.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.7	PID CDC42 PATHWAY	CDC42 signaling events
0.1	2.3	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.0	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3	6.7	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.1	6.5	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2	6.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	5.1	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.2	5.0	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.2	4.9	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	4.8	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.2	4.4	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.2	3.8	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins

Showing 1 to 10 of 38 entries

Results for IRX5

Z-value: 0.67

Motif logo

Transcription factors associated with IRX5

Activity-expression correlation:

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: