Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ISX
Z-value: 1.10
Motif logo
Transcription factors associated with ISX
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ISX
|
ENSG00000175329.8 | intestine specific homeobox |
Activity profile of ISX motif
Sorted Z-values of ISX motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_159848807 | 46.26 |
ENST00000352433.5
|
PTTG1
|
pituitary tumor-transforming 1 |
| chr6_+_34204642 | 34.15 |
ENST00000347617.6
ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3 |
HMGA1
|
high mobility group AT-hook 1 |
| chr12_+_104680659 | 32.34 |
ENST00000526691.1
ENST00000531691.1 ENST00000388854.3 ENST00000354940.6 ENST00000526390.1 ENST00000531689.1 |
TXNRD1
|
thioredoxin reductase 1 |
| chr1_-_197115818 | 32.20 |
ENST00000367409.4
ENST00000294732.7 |
ASPM
|
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
| chr5_+_177631523 | 24.57 |
ENST00000506339.1
ENST00000355836.5 ENST00000514633.1 ENST00000515193.1 ENST00000506259.1 ENST00000504898.1 |
HNRNPAB
|
heterogeneous nuclear ribonucleoprotein A/B |
| chr20_+_44441271 | 23.89 |
ENST00000335046.3
ENST00000243893.6 |
UBE2C
|
ubiquitin-conjugating enzyme E2C |
| chr5_+_177631497 | 23.37 |
ENST00000358344.3
|
HNRNPAB
|
heterogeneous nuclear ribonucleoprotein A/B |
| chr5_+_159848854 | 22.68 |
ENST00000517480.1
ENST00000520452.1 ENST00000393964.1 |
PTTG1
|
pituitary tumor-transforming 1 |
| chr19_-_14945933 | 22.02 |
ENST00000322301.3
|
OR7A5
|
olfactory receptor, family 7, subfamily A, member 5 |
| chr4_-_174255536 | 21.04 |
ENST00000446922.2
|
HMGB2
|
high mobility group box 2 |
| chr22_+_24309089 | 20.30 |
ENST00000215770.5
|
DDTL
|
D-dopachrome tautomerase-like |
| chr20_+_44441304 | 19.11 |
ENST00000352551.5
|
UBE2C
|
ubiquitin-conjugating enzyme E2C |
| chr20_+_44441215 | 18.53 |
ENST00000356455.4
ENST00000405520.1 |
UBE2C
|
ubiquitin-conjugating enzyme E2C |
| chr10_+_124914285 | 18.17 |
ENST00000407911.2
|
BUB3
|
BUB3 mitotic checkpoint protein |
| chr2_+_172778952 | 17.59 |
ENST00000392584.1
ENST00000264108.4 |
HAT1
|
histone acetyltransferase 1 |
| chr16_-_31105870 | 16.51 |
ENST00000394971.3
|
VKORC1
|
vitamin K epoxide reductase complex, subunit 1 |
| chr9_+_131452239 | 16.27 |
ENST00000372688.4
ENST00000372686.5 |
SET
|
SET nuclear oncogene |
| chr1_+_220267429 | 16.14 |
ENST00000366922.1
ENST00000302637.5 |
IARS2
|
isoleucyl-tRNA synthetase 2, mitochondrial |
| chr3_-_149095652 | 15.92 |
ENST00000305366.3
|
TM4SF1
|
transmembrane 4 L six family member 1 |
| chr22_-_24316648 | 15.64 |
ENST00000403754.3
ENST00000430101.2 ENST00000398344.4 |
DDT
|
D-dopachrome tautomerase |
| chr5_-_98262240 | 13.73 |
ENST00000284049.3
|
CHD1
|
chromodomain helicase DNA binding protein 1 |
| chr6_+_30687978 | 13.62 |
ENST00000327892.8
ENST00000435534.1 |
TUBB
|
tubulin, beta class I |
| chr16_+_3070313 | 13.17 |
ENST00000326577.4
|
TNFRSF12A
|
tumor necrosis factor receptor superfamily, member 12A |
| chr19_-_10227503 | 13.10 |
ENST00000593054.1
|
EIF3G
|
eukaryotic translation initiation factor 3, subunit G |
| chr5_-_177580777 | 12.65 |
ENST00000314397.4
|
NHP2
|
NHP2 ribonucleoprotein |
| chr1_+_62902308 | 12.57 |
ENST00000339950.4
|
USP1
|
ubiquitin specific peptidase 1 |
| chrX_+_77154935 | 12.02 |
ENST00000481445.1
|
COX7B
|
cytochrome c oxidase subunit VIIb |
| chr11_-_111741994 | 11.82 |
ENST00000398006.2
|
ALG9
|
ALG9, alpha-1,2-mannosyltransferase |
| chr1_-_150669500 | 11.74 |
ENST00000271732.3
|
GOLPH3L
|
golgi phosphoprotein 3-like |
| chr2_+_217524323 | 11.53 |
ENST00000456764.1
|
IGFBP2
|
insulin-like growth factor binding protein 2, 36kDa |
| chr1_+_155278539 | 11.46 |
ENST00000447866.1
|
FDPS
|
farnesyl diphosphate synthase |
| chr6_+_36562132 | 11.27 |
ENST00000373715.6
ENST00000339436.7 |
SRSF3
|
serine/arginine-rich splicing factor 3 |
| chr1_+_155278625 | 10.81 |
ENST00000368356.4
ENST00000356657.6 |
FDPS
|
farnesyl diphosphate synthase |
| chr17_-_18266660 | 10.60 |
ENST00000582653.1
ENST00000352886.6 |
SHMT1
|
serine hydroxymethyltransferase 1 (soluble) |
| chr16_-_31106048 | 10.40 |
ENST00000300851.6
|
VKORC1
|
vitamin K epoxide reductase complex, subunit 1 |
| chr16_+_3070356 | 10.28 |
ENST00000341627.5
ENST00000575124.1 ENST00000575836.1 |
TNFRSF12A
|
tumor necrosis factor receptor superfamily, member 12A |
| chr7_-_86849883 | 10.24 |
ENST00000433078.1
|
TMEM243
|
transmembrane protein 243, mitochondrial |
| chr16_-_31106211 | 10.14 |
ENST00000532364.1
ENST00000529564.1 ENST00000319788.7 ENST00000354895.4 ENST00000394975.2 |
RP11-196G11.1
VKORC1
|
Uncharacterized protein vitamin K epoxide reductase complex, subunit 1 |
| chr17_-_18266797 | 9.95 |
ENST00000316694.3
ENST00000539052.1 |
SHMT1
|
serine hydroxymethyltransferase 1 (soluble) |
| chr10_+_124913930 | 9.95 |
ENST00000368858.5
|
BUB3
|
BUB3 mitotic checkpoint protein |
| chr16_-_58585513 | 9.89 |
ENST00000245138.4
ENST00000567285.1 |
CNOT1
|
CCR4-NOT transcription complex, subunit 1 |
| chr17_-_18266765 | 9.26 |
ENST00000354098.3
|
SHMT1
|
serine hydroxymethyltransferase 1 (soluble) |
| chr5_-_177580855 | 9.03 |
ENST00000514354.1
ENST00000511078.1 |
NHP2
|
NHP2 ribonucleoprotein |
| chr1_-_209824643 | 8.39 |
ENST00000391911.1
ENST00000415782.1 |
LAMB3
|
laminin, beta 3 |
| chr20_-_43133491 | 8.12 |
ENST00000411544.1
|
SERINC3
|
serine incorporator 3 |
| chr6_-_111927062 | 8.12 |
ENST00000359831.4
|
TRAF3IP2
|
TRAF3 interacting protein 2 |
| chr11_+_63953587 | 7.77 |
ENST00000305218.4
ENST00000538945.1 |
STIP1
|
stress-induced-phosphoprotein 1 |
| chr1_+_23345930 | 7.71 |
ENST00000356634.3
|
KDM1A
|
lysine (K)-specific demethylase 1A |
| chr5_-_177580933 | 7.40 |
ENST00000274606.3
|
NHP2
|
NHP2 ribonucleoprotein |
| chr17_-_30228678 | 7.11 |
ENST00000261708.4
|
UTP6
|
UTP6, small subunit (SSU) processome component, homolog (yeast) |
| chr1_+_23345943 | 7.07 |
ENST00000400181.4
ENST00000542151.1 |
KDM1A
|
lysine (K)-specific demethylase 1A |
| chr1_-_68698197 | 6.70 |
ENST00000370973.2
ENST00000370971.1 |
WLS
|
wntless Wnt ligand secretion mediator |
| chr15_+_80351910 | 6.56 |
ENST00000261749.6
ENST00000561060.1 |
ZFAND6
|
zinc finger, AN1-type domain 6 |
| chr1_-_43833628 | 6.52 |
ENST00000413844.2
ENST00000372458.3 |
ELOVL1
|
ELOVL fatty acid elongase 1 |
| chr8_+_110551925 | 6.40 |
ENST00000395785.2
|
EBAG9
|
estrogen receptor binding site associated, antigen, 9 |
| chr4_-_66536057 | 6.19 |
ENST00000273854.3
|
EPHA5
|
EPH receptor A5 |
| chr2_+_242089833 | 6.09 |
ENST00000404405.3
ENST00000439916.1 ENST00000406106.3 ENST00000401987.1 |
PPP1R7
|
protein phosphatase 1, regulatory subunit 7 |
| chr17_+_45286387 | 6.03 |
ENST00000572316.1
ENST00000354968.1 ENST00000576874.1 ENST00000536623.2 |
MYL4
|
myosin, light chain 4, alkali; atrial, embryonic |
| chr10_+_124913793 | 5.97 |
ENST00000368865.4
ENST00000538238.1 ENST00000368859.2 |
BUB3
|
BUB3 mitotic checkpoint protein |
| chr4_+_108911036 | 5.89 |
ENST00000505878.1
|
HADH
|
hydroxyacyl-CoA dehydrogenase |
| chr17_+_45286706 | 5.77 |
ENST00000393450.1
ENST00000572303.1 |
MYL4
|
myosin, light chain 4, alkali; atrial, embryonic |
| chr3_-_151034734 | 5.75 |
ENST00000260843.4
|
GPR87
|
G protein-coupled receptor 87 |
| chr11_+_95523621 | 5.75 |
ENST00000325542.5
ENST00000325486.5 ENST00000544522.1 ENST00000541365.1 |
CEP57
|
centrosomal protein 57kDa |
| chr10_-_1095050 | 5.74 |
ENST00000381344.3
|
IDI1
|
isopentenyl-diphosphate delta isomerase 1 |
| chr11_+_57480046 | 5.65 |
ENST00000378312.4
ENST00000278422.4 |
TMX2
|
thioredoxin-related transmembrane protein 2 |
| chr5_-_82969405 | 5.35 |
ENST00000510978.1
|
HAPLN1
|
hyaluronan and proteoglycan link protein 1 |
| chr4_+_110736659 | 5.32 |
ENST00000394631.3
ENST00000226796.6 |
GAR1
|
GAR1 ribonucleoprotein |
| chr5_+_176811431 | 5.25 |
ENST00000512593.1
ENST00000324417.5 |
SLC34A1
|
solute carrier family 34 (type II sodium/phosphate contransporter), member 1 |
| chr8_+_110552046 | 5.23 |
ENST00000529931.1
|
EBAG9
|
estrogen receptor binding site associated, antigen, 9 |
| chr3_+_133292574 | 5.12 |
ENST00000264993.3
|
CDV3
|
CDV3 homolog (mouse) |
| chr3_+_148709128 | 5.09 |
ENST00000345003.4
ENST00000296048.6 ENST00000483267.1 |
GYG1
|
glycogenin 1 |
| chr4_-_66536196 | 5.06 |
ENST00000511294.1
|
EPHA5
|
EPH receptor A5 |
| chr10_-_48416849 | 5.06 |
ENST00000249598.1
|
GDF2
|
growth differentiation factor 2 |
| chr2_+_204571375 | 4.85 |
ENST00000374478.4
|
CD28
|
CD28 molecule |
| chr22_-_29137771 | 4.85 |
ENST00000439200.1
ENST00000405598.1 ENST00000398017.2 ENST00000425190.2 ENST00000348295.3 ENST00000382578.1 ENST00000382565.1 ENST00000382566.1 ENST00000382580.2 ENST00000328354.6 |
CHEK2
|
checkpoint kinase 2 |
| chr17_-_77005801 | 4.84 |
ENST00000392446.5
|
CANT1
|
calcium activated nucleotidase 1 |
| chr7_+_150929550 | 4.82 |
ENST00000482173.1
ENST00000495645.1 ENST00000035307.2 |
CHPF2
|
chondroitin polymerizing factor 2 |
| chr12_-_10955226 | 4.71 |
ENST00000240687.2
|
TAS2R7
|
taste receptor, type 2, member 7 |
| chr16_+_12059091 | 4.51 |
ENST00000562385.1
|
TNFRSF17
|
tumor necrosis factor receptor superfamily, member 17 |
| chr15_+_64680003 | 4.48 |
ENST00000261884.3
|
TRIP4
|
thyroid hormone receptor interactor 4 |
| chr17_-_48785216 | 4.46 |
ENST00000285243.6
|
ANKRD40
|
ankyrin repeat domain 40 |
| chr8_+_9953214 | 4.43 |
ENST00000382490.5
|
MSRA
|
methionine sulfoxide reductase A |
| chr6_-_33385854 | 4.36 |
ENST00000488478.1
|
CUTA
|
cutA divalent cation tolerance homolog (E. coli) |
| chr10_-_114206649 | 4.33 |
ENST00000369404.3
ENST00000369405.3 |
ZDHHC6
|
zinc finger, DHHC-type containing 6 |
| chr11_-_62414070 | 4.32 |
ENST00000540933.1
ENST00000346178.4 ENST00000356638.3 ENST00000534779.1 ENST00000525994.1 |
GANAB
|
glucosidase, alpha; neutral AB |
| chr8_+_9953061 | 4.24 |
ENST00000522907.1
ENST00000528246.1 |
MSRA
|
methionine sulfoxide reductase A |
| chr10_+_91461337 | 4.20 |
ENST00000260753.4
ENST00000416354.1 ENST00000394289.2 ENST00000371728.3 |
KIF20B
|
kinesin family member 20B |
| chr9_+_34646624 | 4.17 |
ENST00000450095.2
ENST00000556278.1 |
GALT
GALT
|
galactose-1-phosphate uridylyltransferase Uncharacterized protein |
| chr7_+_115862858 | 4.09 |
ENST00000393481.2
|
TES
|
testis derived transcript (3 LIM domains) |
| chr17_-_7307358 | 4.07 |
ENST00000576017.1
ENST00000302422.3 ENST00000535512.1 |
TMEM256
TMEM256-PLSCR3
|
transmembrane protein 256 TMEM256-PLSCR3 readthrough (NMD candidate) |
| chrX_-_24690771 | 4.04 |
ENST00000379145.1
|
PCYT1B
|
phosphate cytidylyltransferase 1, choline, beta |
| chr11_+_75526212 | 3.96 |
ENST00000356136.3
|
UVRAG
|
UV radiation resistance associated |
| chr15_+_58430567 | 3.92 |
ENST00000536493.1
|
AQP9
|
aquaporin 9 |
| chrX_+_108779004 | 3.81 |
ENST00000218004.1
|
NXT2
|
nuclear transport factor 2-like export factor 2 |
| chr17_-_27418537 | 3.75 |
ENST00000408971.2
|
TIAF1
|
TGFB1-induced anti-apoptotic factor 1 |
| chr15_+_58430368 | 3.73 |
ENST00000558772.1
ENST00000219919.4 |
AQP9
|
aquaporin 9 |
| chr16_+_12059050 | 3.72 |
ENST00000396495.3
|
TNFRSF17
|
tumor necrosis factor receptor superfamily, member 17 |
| chr14_-_51027838 | 3.61 |
ENST00000555216.1
|
MAP4K5
|
mitogen-activated protein kinase kinase kinase kinase 5 |
| chr17_-_74733404 | 3.58 |
ENST00000508921.3
ENST00000583836.1 ENST00000358156.6 ENST00000392485.2 ENST00000359995.5 |
SRSF2
|
serine/arginine-rich splicing factor 2 |
| chr17_+_46970134 | 3.57 |
ENST00000503641.1
ENST00000514808.1 |
ATP5G1
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
| chr12_+_15125954 | 3.50 |
ENST00000266395.2
|
PDE6H
|
phosphodiesterase 6H, cGMP-specific, cone, gamma |
| chr14_-_20801427 | 3.38 |
ENST00000557665.1
ENST00000358932.4 ENST00000353689.4 |
CCNB1IP1
|
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
| chr17_+_46970178 | 3.34 |
ENST00000393366.2
ENST00000506855.1 |
ATP5G1
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
| chr11_+_77532233 | 3.30 |
ENST00000525409.1
|
AAMDC
|
adipogenesis associated, Mth938 domain containing |
| chr4_-_70080449 | 3.00 |
ENST00000446444.1
|
UGT2B11
|
UDP glucuronosyltransferase 2 family, polypeptide B11 |
| chr17_+_46970127 | 2.95 |
ENST00000355938.5
|
ATP5G1
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
| chr6_-_33385655 | 2.95 |
ENST00000440279.3
ENST00000607266.1 |
CUTA
|
cutA divalent cation tolerance homolog (E. coli) |
| chr12_-_57039739 | 2.90 |
ENST00000552959.1
ENST00000551020.1 ENST00000553007.2 ENST00000552919.1 ENST00000552104.1 ENST00000262030.3 |
ATP5B
|
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
| chr7_+_130020932 | 2.79 |
ENST00000484324.1
|
CPA1
|
carboxypeptidase A1 (pancreatic) |
| chr6_-_111927449 | 2.77 |
ENST00000368761.5
ENST00000392556.4 ENST00000340026.6 |
TRAF3IP2
|
TRAF3 interacting protein 2 |
| chr12_-_10978957 | 2.75 |
ENST00000240619.2
|
TAS2R10
|
taste receptor, type 2, member 10 |
| chr19_+_1275917 | 2.64 |
ENST00000469144.1
|
C19orf24
|
chromosome 19 open reading frame 24 |
| chr3_-_15563229 | 2.58 |
ENST00000383786.5
ENST00000383787.2 ENST00000383785.2 ENST00000383788.5 ENST00000603808.1 |
COLQ
|
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase |
| chr17_+_79650962 | 2.57 |
ENST00000329138.4
|
HGS
|
hepatocyte growth factor-regulated tyrosine kinase substrate |
| chr6_+_29795595 | 2.56 |
ENST00000360323.6
ENST00000376818.3 ENST00000376815.3 |
HLA-G
|
major histocompatibility complex, class I, G |
| chr2_+_87135076 | 2.52 |
ENST00000409776.2
|
RGPD1
|
RANBP2-like and GRIP domain containing 1 |
| chr6_-_30080863 | 2.37 |
ENST00000540829.1
|
TRIM31
|
tripartite motif containing 31 |
| chr9_+_34646651 | 2.35 |
ENST00000378842.3
|
GALT
|
galactose-1-phosphate uridylyltransferase |
| chr22_-_24303340 | 2.33 |
ENST00000404172.3
ENST00000290765.4 |
GSTT2B
|
glutathione S-transferase theta 2B (gene/pseudogene) |
| chr17_+_78965624 | 2.28 |
ENST00000325167.5
|
CHMP6
|
charged multivesicular body protein 6 |
| chr6_-_33385823 | 2.20 |
ENST00000494751.1
ENST00000374496.3 |
CUTA
|
cutA divalent cation tolerance homolog (E. coli) |
| chr16_+_1359511 | 2.11 |
ENST00000397514.3
ENST00000397515.2 ENST00000567383.1 ENST00000403747.2 ENST00000566587.1 |
UBE2I
|
ubiquitin-conjugating enzyme E2I |
| chr1_+_28261492 | 2.09 |
ENST00000373894.3
|
SMPDL3B
|
sphingomyelin phosphodiesterase, acid-like 3B |
| chr7_+_120628731 | 2.06 |
ENST00000310396.5
|
CPED1
|
cadherin-like and PC-esterase domain containing 1 |
| chr4_-_186733363 | 2.03 |
ENST00000393523.2
ENST00000393528.3 ENST00000449407.2 |
SORBS2
|
sorbin and SH3 domain containing 2 |
| chr22_+_24322322 | 1.94 |
ENST00000215780.5
ENST00000402588.3 |
GSTT2
|
glutathione S-transferase theta 2 |
| chr6_-_33385870 | 1.90 |
ENST00000488034.1
|
CUTA
|
cutA divalent cation tolerance homolog (E. coli) |
| chr21_+_35014783 | 1.86 |
ENST00000381291.4
ENST00000381285.4 ENST00000399367.3 ENST00000399352.1 ENST00000399355.2 ENST00000399349.1 |
ITSN1
|
intersectin 1 (SH3 domain protein) |
| chr2_-_79315112 | 1.80 |
ENST00000305089.3
|
REG1B
|
regenerating islet-derived 1 beta |
| chr2_-_89247338 | 1.79 |
ENST00000496168.1
|
IGKV1-5
|
immunoglobulin kappa variable 1-5 |
| chr13_+_73632897 | 1.77 |
ENST00000377687.4
|
KLF5
|
Kruppel-like factor 5 (intestinal) |
| chr3_+_113775576 | 1.72 |
ENST00000485050.1
ENST00000281273.4 |
QTRTD1
|
queuine tRNA-ribosyltransferase domain containing 1 |
| chr3_+_37284668 | 1.62 |
ENST00000361924.2
ENST00000444882.1 ENST00000356847.4 ENST00000450863.2 ENST00000429018.1 |
GOLGA4
|
golgin A4 |
| chr17_-_45266542 | 1.58 |
ENST00000531206.1
ENST00000527547.1 ENST00000446365.2 ENST00000575483.1 ENST00000066544.3 |
CDC27
|
cell division cycle 27 |
| chr10_+_1095416 | 1.46 |
ENST00000358220.1
|
WDR37
|
WD repeat domain 37 |
| chr19_-_46285736 | 1.42 |
ENST00000291270.4
ENST00000447742.2 ENST00000354227.5 |
DMPK
|
dystrophia myotonica-protein kinase |
| chr9_+_136501478 | 1.41 |
ENST00000393056.2
ENST00000263611.2 |
DBH
|
dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| chr14_-_94789663 | 1.35 |
ENST00000557225.1
ENST00000341584.3 |
SERPINA6
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
| chr1_+_28261621 | 1.25 |
ENST00000549094.1
|
SMPDL3B
|
sphingomyelin phosphodiesterase, acid-like 3B |
| chr1_-_68698222 | 1.23 |
ENST00000370976.3
ENST00000354777.2 ENST00000262348.4 ENST00000540432.1 |
WLS
|
wntless Wnt ligand secretion mediator |
| chr5_+_174151536 | 1.19 |
ENST00000239243.6
ENST00000507785.1 |
MSX2
|
msh homeobox 2 |
| chr11_-_102709441 | 1.08 |
ENST00000434103.1
|
MMP3
|
matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| chr19_+_13001840 | 1.06 |
ENST00000222214.5
ENST00000589039.1 ENST00000591470.1 ENST00000457854.1 ENST00000422947.2 ENST00000588905.1 ENST00000587072.1 |
GCDH
|
glutaryl-CoA dehydrogenase |
| chr12_-_51422017 | 1.03 |
ENST00000394904.3
|
SLC11A2
|
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
| chrX_+_19362011 | 1.01 |
ENST00000379806.5
ENST00000545074.1 ENST00000540249.1 ENST00000423505.1 ENST00000417819.1 ENST00000422285.2 ENST00000355808.5 ENST00000379805.3 |
PDHA1
|
pyruvate dehydrogenase (lipoamide) alpha 1 |
| chr12_+_3000037 | 0.90 |
ENST00000544943.1
ENST00000448120.2 |
TULP3
|
tubby like protein 3 |
| chr6_-_33385902 | 0.80 |
ENST00000374500.5
|
CUTA
|
cutA divalent cation tolerance homolog (E. coli) |
| chr14_-_73925225 | 0.78 |
ENST00000356296.4
ENST00000355058.3 ENST00000359560.3 ENST00000557597.1 ENST00000554394.1 ENST00000555238.1 ENST00000535282.1 ENST00000555987.1 ENST00000555394.1 ENST00000554546.1 |
NUMB
|
numb homolog (Drosophila) |
| chr7_-_100493482 | 0.75 |
ENST00000411582.1
ENST00000419336.2 ENST00000241069.5 ENST00000302913.4 |
ACHE
|
acetylcholinesterase (Yt blood group) |
| chr19_-_6424783 | 0.75 |
ENST00000398148.3
|
KHSRP
|
KH-type splicing regulatory protein |
| chr17_-_2966901 | 0.68 |
ENST00000575751.1
|
OR1D5
|
olfactory receptor, family 1, subfamily D, member 5 |
| chr2_-_183387064 | 0.57 |
ENST00000536095.1
ENST00000331935.6 ENST00000358139.2 ENST00000456212.1 |
PDE1A
|
phosphodiesterase 1A, calmodulin-dependent |
| chr1_-_190446759 | 0.57 |
ENST00000367462.3
|
BRINP3
|
bone morphogenetic protein/retinoic acid inducible neural-specific 3 |
| chr11_+_77532155 | 0.56 |
ENST00000532481.1
ENST00000526415.1 ENST00000393427.2 ENST00000527134.1 ENST00000304716.8 |
AAMDC
|
adipogenesis associated, Mth938 domain containing |
| chr2_-_183387283 | 0.50 |
ENST00000435564.1
|
PDE1A
|
phosphodiesterase 1A, calmodulin-dependent |
| chr1_-_23670813 | 0.40 |
ENST00000374612.1
|
HNRNPR
|
heterogeneous nuclear ribonucleoprotein R |
| chr19_-_46285646 | 0.35 |
ENST00000458663.2
|
DMPK
|
dystrophia myotonica-protein kinase |
| chr1_+_151735431 | 0.33 |
ENST00000321531.5
ENST00000315067.8 |
OAZ3
|
ornithine decarboxylase antizyme 3 |
| chr11_-_13517565 | 0.30 |
ENST00000282091.1
ENST00000529816.1 |
PTH
|
parathyroid hormone |
| chr11_-_77532050 | 0.29 |
ENST00000308488.6
|
RSF1
|
remodeling and spacing factor 1 |
| chr2_+_86947296 | 0.27 |
ENST00000283632.4
|
RMND5A
|
required for meiotic nuclear division 5 homolog A (S. cerevisiae) |
| chr1_-_23670817 | 0.26 |
ENST00000478691.1
|
HNRNPR
|
heterogeneous nuclear ribonucleoprotein R |
| chr11_-_63381823 | 0.24 |
ENST00000323646.5
|
PLA2G16
|
phospholipase A2, group XVI |
| chr6_-_30080876 | 0.17 |
ENST00000376734.3
|
TRIM31
|
tripartite motif containing 31 |
| chr8_+_50824233 | 0.12 |
ENST00000522124.1
|
SNTG1
|
syntrophin, gamma 1 |
| chr6_-_135271260 | 0.08 |
ENST00000265605.2
|
ALDH8A1
|
aldehyde dehydrogenase 8 family, member A1 |
| chrX_+_44703249 | 0.07 |
ENST00000339042.4
|
DUSP21
|
dual specificity phosphatase 21 |
| chr6_-_135271219 | 0.06 |
ENST00000367847.2
ENST00000367845.2 |
ALDH8A1
|
aldehyde dehydrogenase 8 family, member A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ISX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.9 | 29.8 | GO:1904481 | response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482) |
| 8.5 | 34.2 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 7.7 | 61.5 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) positive regulation of exit from mitosis(GO:0031536) |
| 5.8 | 29.1 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 5.4 | 16.1 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 4.9 | 14.8 | GO:0046098 | guanine metabolic process(GO:0046098) |
| 4.5 | 22.3 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 4.0 | 32.2 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 3.7 | 37.0 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 3.6 | 32.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 2.9 | 23.5 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 2.7 | 5.3 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 2.6 | 7.9 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 2.2 | 17.6 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 2.2 | 6.5 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499) |
| 2.1 | 21.0 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 2.0 | 96.5 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 1.7 | 5.2 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 1.6 | 13.1 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 1.6 | 4.8 | GO:1903925 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 1.5 | 7.7 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 1.4 | 5.7 | GO:0009240 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490) |
| 1.4 | 9.9 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 1.2 | 8.1 | GO:0009597 | detection of virus(GO:0009597) |
| 1.1 | 6.5 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 1.1 | 4.2 | GO:1903438 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 1.0 | 12.6 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 1.0 | 8.7 | GO:0030091 | protein repair(GO:0030091) |
| 0.8 | 13.7 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.7 | 11.8 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.7 | 3.3 | GO:0001507 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) |
| 0.7 | 4.0 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098) |
| 0.7 | 16.3 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.6 | 12.0 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.5 | 11.3 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.5 | 10.9 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.5 | 22.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 15.6 | GO:0042438 | melanin biosynthetic process(GO:0042438) |
| 0.4 | 2.6 | GO:0002767 | immune response-inhibiting signal transduction(GO:0002765) immune response-inhibiting cell surface receptor signaling pathway(GO:0002767) |
| 0.4 | 12.8 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.4 | 1.2 | GO:0051795 | catagen(GO:0042637) regulation of catagen(GO:0051794) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) activation of meiosis(GO:0090427) |
| 0.4 | 5.1 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.4 | 3.4 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.3 | 11.5 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.3 | 4.0 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.3 | 4.9 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.3 | 11.8 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.3 | 0.3 | GO:1900158 | negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.3 | 8.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 5.7 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.3 | 5.7 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.3 | 3.3 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.3 | 7.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.3 | 4.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 6.6 | GO:0006625 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.3 | 0.8 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.3 | 47.9 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.3 | 4.9 | GO:1903541 | regulation of exosomal secretion(GO:1903541) |
| 0.2 | 2.2 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.2 | 1.0 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.2 | 1.4 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
| 0.2 | 1.8 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.2 | 0.4 | GO:0060434 | bronchus morphogenesis(GO:0060434) |
| 0.2 | 3.6 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.2 | 7.1 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.2 | 12.9 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.2 | 3.8 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.2 | 3.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 5.9 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.1 | 4.1 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.1 | 9.7 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.1 | 1.8 | GO:0051823 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of synapse structural plasticity(GO:0051823) |
| 0.1 | 1.4 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
| 0.1 | 5.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 8.2 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.1 | 1.6 | GO:0010965 | regulation of mitotic sister chromatid separation(GO:0010965) |
| 0.1 | 1.0 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.1 | 1.1 | GO:0006554 | lysine catabolic process(GO:0006554) |
| 0.1 | 11.3 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
| 0.1 | 4.8 | GO:0035306 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.1 | 1.1 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.1 | 2.5 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.1 | 3.5 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.1 | 4.5 | GO:0045661 | regulation of myoblast differentiation(GO:0045661) |
| 0.1 | 2.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.8 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) regulation of miRNA metabolic process(GO:2000628) |
| 0.1 | 3.9 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.1 | 2.3 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.1 | 3.0 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 0.3 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 1.5 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.0 | 0.7 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 2.1 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.0 | 0.6 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 2.0 | GO:0010038 | response to metal ion(GO:0010038) |
| 0.0 | 0.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 1.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 1.7 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.3 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.0 | 1.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 3.8 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling(GO:0007249) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.4 | 34.1 | GO:0033597 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 5.7 | 34.4 | GO:0090661 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 4.6 | 32.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 3.1 | 34.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 2.1 | 63.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.4 | 7.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 1.0 | 8.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 1.0 | 9.9 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.9 | 13.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.9 | 2.6 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 0.7 | 3.6 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.7 | 12.0 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.5 | 9.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.5 | 13.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.4 | 4.2 | GO:1990023 | contractile ring(GO:0070938) mitotic spindle midzone(GO:1990023) |
| 0.4 | 2.9 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.3 | 14.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.3 | 7.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 1.5 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.2 | 2.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 36.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 1.0 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.2 | 5.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.2 | 2.3 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.2 | 11.8 | GO:0031672 | A band(GO:0031672) |
| 0.2 | 29.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 0.3 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 1.4 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.1 | 13.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.3 | GO:0034657 | GID complex(GO:0034657) |
| 0.1 | 10.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 21.0 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.1 | 1.0 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 3.3 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 4.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 23.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 1.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 6.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 4.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 7.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 4.8 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 23.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.0 | GO:1902554 | serine/threonine protein kinase complex(GO:1902554) |
| 0.0 | 15.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 45.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 5.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.8 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 5.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 93.4 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 6.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 9.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 2.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 2.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 0.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.4 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 4.5 | GO:0009986 | cell surface(GO:0009986) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.8 | 32.3 | GO:0098626 | methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626) |
| 9.3 | 37.0 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 6.0 | 29.8 | GO:0070905 | serine binding(GO:0070905) |
| 5.7 | 34.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 5.4 | 16.1 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 5.3 | 21.0 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 4.9 | 14.8 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 4.5 | 22.3 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 3.9 | 11.8 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 3.9 | 15.6 | GO:0033981 | D-dopachrome decarboxylase activity(GO:0033981) |
| 3.0 | 11.8 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 2.0 | 34.2 | GO:0003906 | AT DNA binding(GO:0003680) DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 1.9 | 7.7 | GO:0015254 | glycerol channel activity(GO:0015254) urea channel activity(GO:0015265) |
| 1.7 | 8.7 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 1.6 | 4.8 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 1.6 | 4.8 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 1.3 | 61.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.3 | 5.1 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 1.1 | 11.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 1.1 | 6.5 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.1 | 2.1 | GO:0061650 | ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 1.0 | 11.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.8 | 4.0 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.8 | 11.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.8 | 68.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.7 | 7.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.7 | 7.5 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.7 | 8.1 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.7 | 9.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.7 | 15.1 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.7 | 5.2 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.6 | 13.6 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.6 | 6.5 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.5 | 5.7 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.5 | 4.1 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.5 | 2.9 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.5 | 22.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 11.6 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.4 | 9.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.4 | 12.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 16.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.3 | 5.9 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.3 | 7.1 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.3 | 40.6 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.3 | 13.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.3 | 4.3 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.3 | 5.7 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 1.0 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.2 | 1.4 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.2 | 2.2 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.2 | 1.0 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.2 | 5.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 3.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 0.8 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.2 | 13.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 7.8 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.2 | 5.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 11.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 3.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 4.2 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 4.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 7.9 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 4.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 3.6 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 20.3 | GO:0016829 | lyase activity(GO:0016829) |
| 0.1 | 26.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 6.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 4.9 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.1 | 2.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 4.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 5.1 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 2.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 2.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 0.3 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 1.1 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 0.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 12.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 4.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 4.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.6 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 1.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 64.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 8.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 26.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 11.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 2.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.2 | 11.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 26.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 4.8 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 3.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 6.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 5.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 4.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 5.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 11.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 2.6 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 34.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 3.4 | 97.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 2.5 | 37.0 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 1.1 | 21.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 1.0 | 12.6 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 1.0 | 32.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.9 | 68.9 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 0.9 | 28.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.8 | 29.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.7 | 16.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.6 | 4.8 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.6 | 12.8 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.5 | 7.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.5 | 11.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 22.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.4 | 29.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 5.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.3 | 6.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.3 | 12.1 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.3 | 2.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 4.3 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.2 | 4.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.2 | 19.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 4.9 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.2 | 5.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 4.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 13.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 11.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 12.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 14.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 8.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 1.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 8.5 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 1.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 5.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 1.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.8 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.7 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 0.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 4.6 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |