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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for JUN
Z-value: 1.00
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Transcription factors associated with JUN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUN | hg19_v2_chr1_-_59249732_59249785 | 0.05 | 4.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of JUN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 66.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.6 | 25.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.7 | 24.1 | GO:0050427 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.0 | 19.0 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 4.7 | 18.9 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 1.1 | 18.6 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.2 | 18.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 5.9 | 17.6 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.3 | 16.8 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.4 | 16.1 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 55.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 41.7 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.1 | 38.6 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 1.4 | 25.0 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 21.8 | GO:0030424 | axon(GO:0030424) |
| 0.2 | 20.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 19.8 | GO:0043204 | perikaryon(GO:0043204) |
| 1.3 | 18.9 | GO:0005916 | fascia adherens(GO:0005916) |
| 1.3 | 18.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.4 | 17.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 63.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.5 | 42.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.2 | 38.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 32.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.0 | 24.1 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.4 | 22.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 1.3 | 20.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 3.3 | 19.9 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.2 | 19.8 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.7 | 19.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.4 | 25.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.5 | 22.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.5 | 22.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 19.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 17.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.6 | 16.8 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 12.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 11.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 11.6 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.0 | 25.7 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.9 | 24.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.1 | 19.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 1.0 | 19.0 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 1.0 | 18.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 18.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.5 | 14.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.6 | 12.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.8 | 10.9 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |