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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for LHX2

Z-value: 0.52

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
LHX2
ENSG00000106689.6 LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126777676_126777700,
hg19_v2_chr9_+_126773880_126773895		-0.045.9e-01Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_6309517 12.86 ENST00000382519.4
ENST00000009180.4
CD9
CD9 molecule
chr7_-_5998714 4.98 ENST00000539903.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr6_+_125524785 4.24 ENST00000392482.2
TPD52L1
tumor protein D52-like 1
chr21_-_43735628 4.08 ENST00000291525.10
ENST00000518498.1
TFF3
trefoil factor 3 (intestinal)
chr4_+_70894130 3.57 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr21_-_43735446 3.54 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr14_+_56078695 3.52 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chr10_-_116286656 3.44 ENST00000428430.1
ENST00000369266.3
ENST00000392952.3
ABLIM1
actin binding LIM protein 1
chr1_-_28527152 3.31 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr14_-_69864993 3.22 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chrX_+_19373700 3.18 ENST00000379804.1
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr4_+_70916119 3.10 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr3_-_149095652 3.00 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr17_+_48823975 2.97 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr6_+_30848557 2.94 ENST00000460944.2
ENST00000324771.8
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_153518270 2.91 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr8_-_109260897 2.75 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr16_-_66864806 2.48 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr3_-_131221790 2.32 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
MRPL3
mitochondrial ribosomal protein L3
chr18_+_3247779 2.27 ENST00000578611.1
ENST00000583449.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_-_55237484 2.23 ENST00000394609.2
RTN4
reticulon 4
chr13_+_73632897 2.22 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr4_+_71226468 2.13 ENST00000226460.4
SMR3A
submaxillary gland androgen regulated protein 3A
chr2_+_90139056 2.07 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr4_+_128554081 2.04 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr1_-_147142557 2.03 ENST00000369238.6
ACP6
acid phosphatase 6, lysophosphatidic
chr14_-_106926724 2.00 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr17_+_17082842 2.00 ENST00000579361.1
MPRIP
myosin phosphatase Rho interacting protein
chr19_+_42212526 1.97 ENST00000598976.1
ENST00000435837.2
ENST00000221992.6
ENST00000405816.1
CEA
CEACAM5
Uncharacterized protein
carcinoembryonic antigen-related cell adhesion molecule 5
chr6_+_26199737 1.94 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr2_+_109204909 1.82 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_6554021 1.80 ENST00000266557.3
CD27
CD27 molecule
chr2_-_55496174 1.80 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr7_-_54826869 1.78 ENST00000450622.1
SEC61G
Sec61 gamma subunit
chr7_-_151217166 1.76 ENST00000496004.1
RHEB
Ras homolog enriched in brain
chr1_+_62439037 1.68 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr3_+_108541545 1.68 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr19_+_22235310 1.55 ENST00000600162.1
ZNF257
zinc finger protein 257
chr7_-_54826920 1.48 ENST00000395535.3
ENST00000352861.4
SEC61G
Sec61 gamma subunit
chr1_+_152975488 1.46 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr3_+_108541608 1.40 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr11_+_64001962 1.38 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chrX_-_11284095 1.33 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr13_-_99910673 1.32 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr21_-_27423339 1.31 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr2_-_55276320 1.23 ENST00000357376.3
RTN4
reticulon 4
chrX_+_105937068 1.20 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr2_-_89157161 1.13 ENST00000390237.2
IGKC
immunoglobulin kappa constant
chr1_-_89591749 1.11 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr20_-_31989307 1.07 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr19_+_42212501 1.06 ENST00000398599.4
CEACAM5
carcinoembryonic antigen-related cell adhesion molecule 5
chr2_+_234627424 1.01 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr7_-_99716952 0.97 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrM_+_12331 0.92 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr5_+_180682720 0.89 ENST00000599439.1
AC008443.1
CDNA: FLJ23158 fis, clone LNG09623; Uncharacterized protein
chr13_+_24844819 0.87 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr12_+_16064106 0.87 ENST00000428559.2
DERA
deoxyribose-phosphate aldolase (putative)
chr1_+_145883868 0.86 ENST00000447947.2
GPR89C
G protein-coupled receptor 89C
chr11_-_104827425 0.84 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_-_26199499 0.83 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr12_-_118797475 0.83 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr3_+_38017264 0.83 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr4_+_88532028 0.82 ENST00000282478.7
DSPP
dentin sialophosphoprotein
chr8_-_19459993 0.81 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr21_-_35014027 0.81 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr2_-_231084617 0.80 ENST00000409815.2
SP110
SP110 nuclear body protein
chr2_+_120436733 0.79 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
TMEM177
transmembrane protein 177
chr2_+_103035102 0.77 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr4_+_147096837 0.76 ENST00000296581.5
ENST00000502781.1
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr18_+_29027696 0.76 ENST00000257189.4
DSG3
desmoglein 3
chr7_-_22234381 0.74 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_+_112408768 0.73 ENST00000368656.2
ENST00000604268.1
FAM229B
family with sequence similarity 229, member B
chr7_-_99717463 0.69 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_160709055 0.65 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr3_+_35722487 0.64 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr13_-_99959641 0.60 ENST00000376414.4
GPR183
G protein-coupled receptor 183
chr2_-_10587897 0.60 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr8_+_22424551 0.58 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr10_+_124320156 0.53 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr11_+_120973375 0.53 ENST00000264037.2
TECTA
tectorin alpha
chr1_+_95616933 0.51 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr2_-_99279928 0.50 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_+_56964169 0.48 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr6_-_131291572 0.47 ENST00000529208.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr1_+_160709029 0.47 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr7_+_101460882 0.44 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr15_-_72563585 0.43 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr11_-_104972158 0.43 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr10_+_95326416 0.41 ENST00000371481.4
ENST00000371483.4
ENST00000604414.1
FFAR4
free fatty acid receptor 4
chr10_-_61900762 0.40 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_105416039 0.39 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr5_+_179921344 0.36 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr8_-_82395461 0.33 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr2_+_87135076 0.32 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr10_-_14372870 0.31 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr12_+_9980069 0.31 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_+_34619079 0.31 ENST00000433395.2
AP000295.9
AP000295.9
chrX_+_52513455 0.30 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chr17_-_38859996 0.30 ENST00000264651.2
KRT24
keratin 24
chr8_+_76452097 0.28 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr2_-_175712270 0.28 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr4_-_153332886 0.28 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr20_+_43029911 0.26 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr2_-_231084659 0.25 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr10_-_29923893 0.24 ENST00000355867.4
SVIL
supervillin
chr18_+_34124507 0.24 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3
chr4_-_70626314 0.22 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr11_-_62323702 0.21 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr2_+_68961934 0.20 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr2_+_68961905 0.20 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr7_-_142232071 0.18 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1(gene/pseudogene)
chr9_+_108320392 0.17 ENST00000602661.1
ENST00000223528.2
ENST00000448551.2
ENST00000540160.1
FKTN
fukutin
chr2_-_166930131 0.15 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr20_+_30697298 0.14 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr7_-_103848405 0.13 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
ORC5
origin recognition complex, subunit 5
chr14_-_107211459 0.13 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chrX_-_19988382 0.12 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr1_+_52682052 0.12 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr12_+_64173583 0.10 ENST00000261234.6
TMEM5
transmembrane protein 5
chr6_-_26199471 0.09 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr9_+_116207007 0.09 ENST00000374140.2
RGS3
regulator of G-protein signaling 3
chr16_+_24266874 0.08 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr4_+_69313145 0.05 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_160709076 0.05 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr16_-_23652570 0.04 ENST00000261584.4
PALB2
partner and localizer of BRCA2
chr12_-_10955226 0.04 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr12_-_11548496 0.02 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr6_-_27841289 0.01 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 12.9 GO:0009414 response to water deprivation(GO:0009414)
0.5 2.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 3.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.4 3.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 1.8 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.4 3.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.3 2.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 2.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.3 1.3 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.2 2.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 1.8 GO:0032790 ribosome disassembly(GO:0032790)
0.2 1.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.2 0.8 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 1.8 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.2 1.0 GO:0006789 bilirubin conjugation(GO:0006789)
0.2 6.7 GO:0050832 defense response to fungus(GO:0050832)
0.2 1.4 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.6 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.9 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 2.0 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 1.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 1.3 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.1 1.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 3.0 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 0.4 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 3.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 3.2 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.1 0.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.8 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 1.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.5 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 2.0 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 4.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 3.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.3 GO:0071806 protein transmembrane transport(GO:0071806)
0.0 6.8 GO:0007586 digestion(GO:0007586)
0.0 0.5 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 2.3 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 4.1 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 2.3 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.8 GO:1901661 quinone metabolic process(GO:1901661)
0.0 2.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.8 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 2.5 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 2.9 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 1.7 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.4 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 3.5 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 3.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 1.3 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.2 3.2 GO:0034709 methylosome(GO:0034709)
0.2 3.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 3.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 1.3 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 3.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 2.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 3.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.8 GO:0005688 U6 snRNP(GO:0005688)
0.1 3.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.2 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0008091 spectrin(GO:0008091)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 3.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.0 2.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 6.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 10.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.6 2.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.4 3.0 GO:0034235 GPI anchor binding(GO:0034235)
0.3 3.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3 0.9 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.3 0.8 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.2 1.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 2.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.2 3.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 0.5 GO:0033149 FFAT motif binding(GO:0033149)
0.1 2.9 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 2.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.8 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 3.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.3 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.8 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.3 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 12.9 GO:0005178 integrin binding(GO:0005178)
0.1 3.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0042731 PH domain binding(GO:0042731)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.4 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 1.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 9.2 GO:0045296 cadherin binding(GO:0045296)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 3.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.9 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 7.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 4.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 15.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 3.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 4.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 3.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 1.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA