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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MAX_TFEB
Z-value: 2.06
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Transcription factors associated with MAX_TFEB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFEB | hg19_v2_chr6_-_41701581_41701613 | -0.76 | 7.3e-43 | Click! |
| MAX | hg19_v2_chr14_-_65569186_65569243 | 0.38 | 5.9e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAX_TFEB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 119.6 | 598.1 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 1.4 | 303.7 | GO:0006364 | rRNA processing(GO:0006364) |
| 3.2 | 189.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 3.8 | 188.9 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 6.0 | 185.6 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.6 | 183.7 | GO:0010038 | response to metal ion(GO:0010038) |
| 19.8 | 178.0 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 42.5 | 169.9 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.6 | 140.7 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 2.0 | 139.2 | GO:0031663 | lipopolysaccharide-mediated signaling pathway(GO:0031663) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 99.7 | 598.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 310.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.0 | 289.6 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 28.2 | 197.3 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 1.2 | 161.7 | GO:0005840 | ribosome(GO:0005840) |
| 22.3 | 156.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.2 | 152.5 | GO:0000776 | kinetochore(GO:0000776) |
| 3.7 | 147.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 13.1 | 131.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 8.3 | 123.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.0 | 613.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 4.0 | 305.6 | GO:0005507 | copper ion binding(GO:0005507) |
| 6.5 | 291.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 8.2 | 253.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 1.1 | 245.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 22.2 | 177.7 | GO:0016997 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.2 | 162.5 | GO:0003723 | RNA binding(GO:0003723) |
| 26.8 | 160.9 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 6.3 | 145.6 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 13.1 | 131.4 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.6 | 613.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 3.6 | 500.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.9 | 172.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.6 | 161.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 131.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 2.3 | 111.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 2.1 | 110.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.8 | 103.0 | PID ATR PATHWAY | ATR signaling pathway |
| 1.0 | 92.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 1.2 | 87.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 652.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 2.0 | 320.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 4.9 | 230.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 13.0 | 220.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 2.0 | 200.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 6.4 | 185.6 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 4.1 | 179.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 4.1 | 178.4 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 2.1 | 177.7 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.7 | 163.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |