ISMARA results: MNT_HEY1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MNT_HEY1_HEY2

Z-value: 1.65

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Transcription factors associated with MNT_HEY1_HEY2

Gene Symbol	Gene ID	Gene Info
MNT Ensembl NCBI GeneCards UniProt NextProt	ENSG00000070444.10	MAX network transcriptional repressor
HEY1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000164683.12	hes related family bHLH transcription factor with YRPW motif 1
HEY2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135547.4	hes related family bHLH transcription factor with YRPW motif 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HEY2	hg19_v2_chr6_+_126070726_126070768	0.65	4.6e-28	Click!
HEY1	hg19_v2_chr8_-_80680078_80680101	0.29	1.1e-05	Click!
MNT	hg19_v2_chr17_-_2304365_2304412	-0.26	9.9e-05	Click!

Activity profile of MNT_HEY1_HEY2 motif

Sorted Z-values of MNT_HEY1_HEY2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_154193009 Show fit	91.05	ENST00000368518.1 ENST00000368519.1 ENST00000368521.5	C1orf43 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 43
chr1_+_11866270 Show fit	82.57	ENST00000376497.3 ENST00000376487.3 ENST00000376496.3	CLCN6 Ensembl NCBI GeneCards UniProt NextProt Show fit	chloride channel, voltage-sensitive 6
chr1_-_11866034 Show fit	73.15	ENST00000376590.3	MTHFR Ensembl NCBI GeneCards UniProt NextProt Show fit	methylenetetrahydrofolate reductase (NAD(P)H)
chrX_-_13956497 Show fit	63.91	ENST00000398361.3	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr1_+_11866207 Show fit	61.48	ENST00000312413.6 ENST00000346436.6	CLCN6 Ensembl NCBI GeneCards UniProt NextProt Show fit	chloride channel, voltage-sensitive 6
chr22_+_40390930 Show fit	61.00	ENST00000333407.6	FAM83F Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 83, member F
chr1_-_11865982 Show fit	59.46	ENST00000418034.1	MTHFR Ensembl NCBI GeneCards UniProt NextProt Show fit	methylenetetrahydrofolate reductase (NAD(P)H)
chr2_-_38604398 Show fit	59.32	ENST00000443098.1 ENST00000449130.1 ENST00000378954.4 ENST00000539122.1 ENST00000419554.2 ENST00000451483.1 ENST00000406122.1	ATL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	atlastin GTPase 2
chr4_+_76439665 Show fit	58.46	ENST00000508105.1 ENST00000311638.3 ENST00000380837.3 ENST00000507556.1 ENST00000504190.1 ENST00000507885.1 ENST00000502620.1 ENST00000514480.1	THAP6 Ensembl NCBI GeneCards UniProt NextProt Show fit	THAP domain containing 6
chr16_+_66914264 Show fit	56.41	ENST00000311765.2 ENST00000568869.1 ENST00000561704.1 ENST00000568398.1 ENST00000566776.1	PDP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	pyruvate dehyrogenase phosphatase catalytic subunit 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MNT_HEY1_HEY2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.3	144.4	GO:0006884	cell volume homeostasis(GO:0006884)
13.9	138.5	GO:0051610	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
26.5	132.6	GO:0033274	response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
15.5	124.2	GO:0034587	piRNA metabolic process(GO:0034587)
5.6	101.3	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
4.5	75.9	GO:0090129	positive regulation of synapse maturation(GO:0090129)
17.5	69.9	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.7	68.0	GO:0007286	spermatid development(GO:0007286)
0.9	67.7	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1	65.7	GO:0043547	positive regulation of GTPase activity(GO:0043547)

Showing 1 to 10 of 560 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	129.7	GO:0045202	synapse(GO:0045202)
3.1	101.0	GO:0000795	synaptonemal complex(GO:0000795)
1.7	90.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
6.3	75.7	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
8.5	67.8	GO:0005672	transcription factor TFIIA complex(GO:0005672)
8.3	66.7	GO:0033391	chromatoid body(GO:0033391)
0.0	65.6	GO:0016021	integral component of membrane(GO:0016021)
3.9	51.2	GO:0030897	HOPS complex(GO:0030897)
0.5	50.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.4	45.7	GO:0005814	centriole(GO:0005814)

Showing 1 to 10 of 217 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.6	167.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.3	141.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
26.5	132.6	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4	100.7	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
8.8	96.9	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.8	79.0	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.2	71.3	GO:0005096	GTPase activator activity(GO:0005096)
11.5	68.8	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
1.6	64.5	GO:0017025	TBP-class protein binding(GO:0017025)
15.9	63.4	GO:0042030	ATPase inhibitor activity(GO:0042030)

Showing 1 to 10 of 358 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	61.9	PID AURORA A PATHWAY	Aurora A signaling
1.6	56.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.1	50.3	PID REELIN PATHWAY	Reelin signaling pathway
1.3	44.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3	34.8	PID P73PATHWAY	p73 transcription factor network
0.4	33.4	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
1.2	30.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.6	25.6	PID RAS PATHWAY	Regulation of Ras family activation
0.6	25.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.0	24.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 10 of 80 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	105.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
6.0	101.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
2.0	76.1	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
1.1	74.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.8	74.2	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.6	73.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
1.3	66.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
1.0	51.0	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.6	46.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.5	44.9	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events

Showing 1 to 10 of 119 entries

Results for MNT_HEY1_HEY2

Z-value: 1.65

Motif logo

Transcription factors associated with MNT_HEY1_HEY2

Activity-expression correlation:

Activity profile of MNT_HEY1_HEY2 motif

Sorted Z-values of MNT_HEY1_HEY2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MNT_HEY1_HEY2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: