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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MSX2

Z-value: 0.55

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Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
MSX2
ENSG00000120149.7 msh homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg19_v2_chr5_+_174151536_174151610-0.161.9e-02Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_34204642 12.66 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_-_197115818 11.84 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr5_+_162864575 11.57 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1
cyclin G1
chr20_-_54967187 9.53 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr9_+_80912059 9.25 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr12_+_28410128 8.23 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr17_-_38574169 7.81 ENST00000423485.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr5_+_95997918 7.71 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
CAST
calpastatin
chr11_-_102323740 7.63 ENST00000398136.2
TMEM123
transmembrane protein 123
chr2_+_187371440 7.27 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_+_17298297 6.63 ENST00000529010.1
NUCB2
nucleobindin 2
chr9_-_95056010 6.32 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr11_+_17298255 6.11 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
NUCB2
nucleobindin 2
chr6_+_30687978 6.00 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr5_-_31532160 5.77 ENST00000511367.2
ENST00000513349.1
DROSHA
drosha, ribonuclease type III
chr6_-_111927062 5.70 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr5_+_95998070 5.69 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chrX_+_77154935 5.38 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr5_+_31532373 5.26 ENST00000325366.9
ENST00000355907.3
ENST00000507818.2
C5orf22
chromosome 5 open reading frame 22
chr14_-_23504337 4.81 ENST00000361611.6
PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr12_+_53662073 4.76 ENST00000553219.1
ENST00000257934.4
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr12_-_9102549 4.70 ENST00000000412.3
M6PR
mannose-6-phosphate receptor (cation dependent)
chr15_-_37393406 4.59 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr1_-_151965048 4.52 ENST00000368809.1
S100A10
S100 calcium binding protein A10
chr11_+_108535752 4.50 ENST00000322536.3
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr14_-_23504432 4.38 ENST00000425762.2
PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr6_-_31830655 4.29 ENST00000375631.4
NEU1
sialidase 1 (lysosomal sialidase)
chr12_-_120315074 4.11 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr7_+_130794846 4.04 ENST00000421797.2
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr11_-_71823266 3.97 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr20_+_56964253 3.93 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr3_-_141747950 3.81 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_160183492 3.77 ENST00000541436.1
ACAT2
acetyl-CoA acetyltransferase 2
chr19_+_17378159 3.64 ENST00000598188.1
ENST00000359435.4
ENST00000599474.1
ENST00000599057.1
ENST00000601043.1
ENST00000447614.2
BABAM1
BRISC and BRCA1 A complex member 1
chr11_-_71823796 3.58 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr19_+_17378278 3.56 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
BABAM1
BRISC and BRCA1 A complex member 1
chr17_-_48785216 3.34 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr1_-_151431647 3.28 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr15_+_80351910 3.26 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr11_-_71823715 3.08 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr1_-_94050668 2.96 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chr1_-_68698197 2.83 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr12_+_53662110 2.80 ENST00000552462.1
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
chr6_-_111927449 2.44 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr12_-_57039739 2.43 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chrX_+_70752917 2.10 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr22_-_30960876 1.99 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr16_+_69345243 1.99 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_-_11685345 1.86 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr7_-_99716952 1.70 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_21377383 1.61 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr17_-_80250663 1.56 ENST00000581489.1
RP13-516M14.4
RP13-516M14.4
chr12_-_10955226 1.51 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr12_+_54718904 1.32 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
COPZ1
coatomer protein complex, subunit zeta 1
chr3_+_186353756 1.27 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr19_-_19249255 1.18 ENST00000587583.2
ENST00000450333.2
ENST00000587096.1
ENST00000162044.9
ENST00000592369.1
ENST00000587915.1
TMEM161A
transmembrane protein 161A
chr7_+_91570165 1.06 ENST00000356239.3
ENST00000359028.2
ENST00000358100.2
AKAP9
A kinase (PRKA) anchor protein 9
chr7_-_99717463 1.04 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_151431909 1.00 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr3_-_151034734 0.88 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr6_+_25652501 0.83 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr20_+_56964169 0.73 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr8_+_1993173 0.71 ENST00000523438.1
MYOM2
myomesin 2
chr5_-_132200477 0.66 ENST00000296875.2
GDF9
growth differentiation factor 9
chr1_-_68698222 0.55 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr2_-_55647057 0.53 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr2_-_55646957 0.52 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr5_-_148758839 0.50 ENST00000261796.3
IL17B
interleukin 17B
chr20_+_49126881 0.43 ENST00000371621.3
ENST00000541713.1
PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr7_-_56174161 0.42 ENST00000395422.3
CHCHD2
coiled-coil-helix-coiled-coil-helix domain containing 2
chr7_+_134331550 0.41 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
BPGM
2,3-bisphosphoglycerate mutase
chr9_+_34646624 0.37 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr1_-_190446759 0.31 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr7_-_25268104 0.24 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr14_-_51027838 0.21 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chrX_+_70752945 0.17 ENST00000373701.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr17_-_10372875 0.12 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr4_-_46996424 0.09 ENST00000264318.3
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr3_-_164796269 0.09 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr1_+_175036966 0.09 ENST00000239462.4
TNN
tenascin N
chr3_-_48672859 0.06 ENST00000395550.2
ENST00000455886.2
ENST00000431739.1
ENST00000426599.1
ENST00000383733.3
ENST00000420764.2
ENST00000337000.8
SLC26A6
solute carrier family 26 (anion exchanger), member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
3.2 12.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
2.4 11.8 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
2.1 6.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.8 9.2 GO:0042816 vitamin B6 metabolic process(GO:0042816)
1.1 3.4 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.1 15.4 GO:0051307 meiotic chromosome separation(GO:0051307)
1.0 13.4 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.8 2.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.7 8.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.7 2.0 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.6 5.8 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.6 5.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.6 10.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.5 3.9 GO:0006689 ganglioside catabolic process(GO:0006689)
0.5 7.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.5 4.7 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.4 8.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.3 4.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 2.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.3 7.2 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.3 1.0 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 5.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 4.5 GO:0001765 membrane raft assembly(GO:0001765)
0.2 2.0 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.7 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.2 1.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 3.3 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 3.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 11.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 3.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 6.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 9.2 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 0.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 4.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 4.6 GO:0008542 visual learning(GO:0008542)
0.1 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 3.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.3 GO:1901998 toxin transport(GO:1901998)
0.0 2.7 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 1.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 4.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.2 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:2001023 regulation of response to drug(GO:2001023)
0.0 0.1 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.4 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
2.4 21.4 GO:0072687 meiotic spindle(GO:0072687)
1.2 12.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.9 7.2 GO:0070552 BRISC complex(GO:0070552)
0.6 9.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.4 6.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 10.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 2.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.3 5.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 6.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 4.7 GO:0030904 retromer complex(GO:0030904)
0.2 2.0 GO:0000815 ESCRT III complex(GO:0000815)
0.1 5.8 GO:1902555 endoribonuclease complex(GO:1902555)
0.1 2.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 1.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 3.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 12.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 4.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 4.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 4.1 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 7.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 2.3 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 7.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 4.0 GO:0001726 ruffle(GO:0001726)
0.0 1.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.8 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.2 13.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
2.1 6.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
1.6 4.7 GO:0033149 FFAT motif binding(GO:0033149)
1.2 5.8 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
1.1 4.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.1 9.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.9 3.8 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.9 12.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.8 2.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 2.4 GO:0043532 angiostatin binding(GO:0043532)
0.3 3.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 9.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 6.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 2.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 4.7 GO:0005537 mannose binding(GO:0005537)
0.2 5.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.3 GO:0008483 transaminase activity(GO:0008483)
0.1 2.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 3.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.6 GO:0000339 RNA cap binding(GO:0000339)
0.1 7.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 4.1 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.0 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 12.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.7 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 3.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 3.3 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.0 0.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 8.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 9.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.5 PID AURORA A PATHWAY Aurora A signaling
0.2 12.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 6.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 11.6 PID P53 REGULATION PATHWAY p53 pathway
0.1 7.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 4.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 3.8 PID E2F PATHWAY E2F transcription factor network
0.0 5.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 6.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3 9.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 5.8 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.2 18.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 6.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 4.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 5.9 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 4.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 7.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 5.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes