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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MXI1_MYC_MYCN

Z-value: 4.34

Motif logo

Transcription factors associated with MXI1_MYC_MYCN

Gene Symbol Gene ID Gene Info
ENSG00000119950.16 MAX interactor 1, dimerization protein
ENSG00000136997.10 MYC proto-oncogene, bHLH transcription factor
ENSG00000134323.10 MYCN proto-oncogene, bHLH transcription factor

Activity-expression correlation:

Activity profile of MXI1_MYC_MYCN motif

Sorted Z-values of MXI1_MYC_MYCN motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_58146128 239.34 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
cyclin-dependent kinase 4
chr12_-_58146048 238.77 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
cyclin-dependent kinase 4
chr11_-_64014379 213.77 ENST00000309318.3
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_-_10588630 198.46 ENST00000234111.4
ornithine decarboxylase 1
chr19_+_50180409 184.63 ENST00000391851.4
protein arginine methyltransferase 1
chr19_+_50180507 181.90 ENST00000454376.2
ENST00000524771.1
protein arginine methyltransferase 1
chr2_+_216176540 164.98 ENST00000236959.9
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_+_49230897 164.65 ENST00000393196.3
ENST00000336097.3
ENST00000480143.1
ENST00000511355.1
ENST00000013034.3
ENST00000393198.3
ENST00000608447.1
ENST00000393193.2
ENST00000376392.6
ENST00000555572.1
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 2
chr4_+_57302297 162.90 ENST00000399688.3
ENST00000512576.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chrX_+_23685653 161.40 ENST00000379331.3
peroxiredoxin 4
chr4_+_57301896 155.70 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr8_+_55047763 152.16 ENST00000260102.4
ENST00000519831.1
mitochondrial ribosomal protein L15
chr14_+_20923350 148.53 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr2_+_216176761 147.07 ENST00000540518.1
ENST00000435675.1
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr22_+_20105259 129.06 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr6_-_43197189 129.01 ENST00000509253.1
ENST00000393987.2
ENST00000230431.6
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr1_+_43148625 127.79 ENST00000436427.1
Y box binding protein 1
chr1_-_11120057 127.51 ENST00000376957.2
spermidine synthase
chr2_+_113403434 122.79 ENST00000272542.3
solute carrier family 20 (phosphate transporter), member 1
chr8_+_98656336 118.06 ENST00000336273.3
metadherin
chrX_+_23685563 113.84 ENST00000379341.4
peroxiredoxin 4
chr9_+_131452239 110.94 ENST00000372688.4
ENST00000372686.5
SET nuclear oncogene
chr13_+_27998681 105.80 ENST00000381140.4
general transcription factor IIIA
chr3_+_52719936 103.82 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr19_+_50180317 103.33 ENST00000534465.1
protein arginine methyltransferase 1
chr7_+_150759634 98.63 ENST00000392826.2
ENST00000461735.1
solute carrier family 4 (anion exchanger), member 2
chr1_-_26233423 95.59 ENST00000357865.2
stathmin 1
chr19_-_2427863 94.82 ENST00000215570.3
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr1_+_165797024 94.60 ENST00000372212.4
uridine-cytidine kinase 2
chr12_+_57624085 94.56 ENST00000553474.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_-_10530784 93.43 ENST00000593124.1
cell division cycle 37
chr1_-_26232951 93.41 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr17_-_47492164 92.44 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
prohibitin
chr17_+_49337881 91.69 ENST00000225298.7
UTP18 small subunit (SSU) processome component homolog (yeast)
chr12_-_49318715 90.49 ENST00000444214.2
FK506 binding protein 11, 19 kDa
chr11_-_64013663 89.81 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr6_-_33385854 88.93 ENST00000488478.1
cutA divalent cation tolerance homolog (E. coli)
chr2_+_198365122 86.23 ENST00000604458.1
HSPE1-MOB4 readthrough
chr2_+_198365095 86.14 ENST00000409468.1
heat shock 10kDa protein 1
chr12_+_57624119 84.23 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_-_17706618 84.20 ENST00000262077.2
ENST00000537253.1
nucleoporin 153kDa
chr4_-_99850243 82.49 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
eukaryotic translation initiation factor 4E
chr19_-_42806723 82.42 ENST00000262890.3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr11_-_122931881 81.55 ENST00000526110.1
ENST00000227378.3
heat shock 70kDa protein 8
chr10_+_81107271 80.76 ENST00000448165.1
peptidylprolyl isomerase F
chr20_+_44441304 80.52 ENST00000352551.5
ubiquitin-conjugating enzyme E2C
chr2_-_10587897 80.22 ENST00000405333.1
ENST00000443218.1
ornithine decarboxylase 1
chr17_+_49243792 78.78 ENST00000393183.3
ENST00000393190.1
NME1-NME2 readthrough
chr17_+_49243639 77.64 ENST00000512737.1
ENST00000503064.1
NME1-NME2 readthrough
chr1_-_8938736 76.89 ENST00000234590.4
enolase 1, (alpha)
chr12_+_57623869 76.86 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_58893832 76.58 ENST00000556007.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr8_+_97274119 75.75 ENST00000455950.2
phosphatidylserine synthase 1
chr18_+_12947981 74.89 ENST00000262124.11
SEH1-like (S. cerevisiae)
chr1_-_8939265 74.88 ENST00000489867.1
enolase 1, (alpha)
chr16_-_87903079 74.81 ENST00000261622.4
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr11_+_114310164 74.77 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
RNA exonuclease 2
chr20_+_44441215 74.70 ENST00000356455.4
ENST00000405520.1
ubiquitin-conjugating enzyme E2C
chr21_-_46237883 74.23 ENST00000397893.3
small ubiquitin-like modifier 3
chr14_-_58894223 73.89 ENST00000555593.1
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr19_-_2427536 73.04 ENST00000591871.1
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr11_+_114310237 72.86 ENST00000539119.1
RNA exonuclease 2
chr6_-_33385655 72.75 ENST00000440279.3
ENST00000607266.1
cutA divalent cation tolerance homolog (E. coli)
chr22_+_20105012 72.63 ENST00000331821.3
ENST00000411892.1
RAN binding protein 1
chr1_-_155232221 72.50 ENST00000355379.3
secretory carrier membrane protein 3
chr6_-_32811771 72.26 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr11_+_114310102 72.07 ENST00000265881.5
RNA exonuclease 2
chr16_-_81129845 70.73 ENST00000569885.1
ENST00000566566.1
glycine cleavage system protein H (aminomethyl carrier)
chr1_-_43638168 70.46 ENST00000431635.2
EBNA1 binding protein 2
chr1_+_19578033 70.32 ENST00000330263.4
mRNA turnover 4 homolog (S. cerevisiae)
chr10_-_71993176 69.69 ENST00000373232.3
pyrophosphatase (inorganic) 1
chr6_-_8102714 68.96 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
eukaryotic translation elongation factor 1 epsilon 1
chr1_+_165796753 68.41 ENST00000367879.4
uridine-cytidine kinase 2
chr12_+_131356582 67.77 ENST00000448750.3
ENST00000541630.1
ENST00000392369.2
ENST00000254675.3
ENST00000535090.1
ENST00000392367.3
RAN, member RAS oncogene family
chr8_+_98656693 67.65 ENST00000519934.1
metadherin
chr12_+_57623477 67.64 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr10_-_120840309 66.42 ENST00000369144.3
eukaryotic translation initiation factor 3, subunit A
chr6_-_8102279 66.00 ENST00000488226.2
eukaryotic translation elongation factor 1 epsilon 1
chr7_+_100464760 65.27 ENST00000200457.4
thyroid hormone receptor interactor 6
chr13_+_114238997 65.11 ENST00000538138.1
ENST00000375370.5
transcription factor Dp-1
chr8_+_22224760 65.00 ENST00000359741.5
ENST00000520644.1
ENST00000240095.6
solute carrier family 39 (zinc transporter), member 14
chr2_+_27440229 64.76 ENST00000264705.4
ENST00000403525.1
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr1_-_155232047 63.77 ENST00000302631.3
secretory carrier membrane protein 3
chr1_+_111991474 62.74 ENST00000369722.3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr6_-_33385823 62.49 ENST00000494751.1
ENST00000374496.3
cutA divalent cation tolerance homolog (E. coli)
chr12_+_64798095 61.56 ENST00000332707.5
exportin, tRNA
chr17_+_76164639 61.43 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
synaptogyrin 2
chr17_+_42148225 61.40 ENST00000591696.1
glucose 6 phosphatase, catalytic, 3
chr19_-_5719860 61.26 ENST00000590729.1
lon peptidase 1, mitochondrial
chr12_+_66217911 60.65 ENST00000403681.2
high mobility group AT-hook 2
chr17_+_36908984 60.40 ENST00000225426.4
ENST00000579088.1
proteasome (prosome, macropain) subunit, beta type, 3
chr6_-_33385870 59.84 ENST00000488034.1
cutA divalent cation tolerance homolog (E. coli)
chr17_+_42148097 59.76 ENST00000269097.4
glucose 6 phosphatase, catalytic, 3
chr11_+_844067 59.72 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
tetraspanin 4
chr19_-_5720123 59.18 ENST00000587365.1
ENST00000585374.1
ENST00000593119.1
lon peptidase 1, mitochondrial
chr2_+_131100710 58.65 ENST00000452955.1
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr19_-_42806842 58.36 ENST00000596265.1
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr9_+_112542591 58.10 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr9_-_113018835 57.93 ENST00000374517.5
thioredoxin
chr1_-_43637915 57.85 ENST00000236051.2
EBNA1 binding protein 2
chr17_+_65713925 57.13 ENST00000253247.4
nucleolar protein 11
chr12_+_108079664 57.12 ENST00000541166.1
PWP1 homolog (S. cerevisiae)
chr1_-_159894319 56.91 ENST00000320307.4
transgelin 2
chr13_-_31038370 56.77 ENST00000399489.1
ENST00000339872.4
high mobility group box 1
chr6_+_24775153 56.57 ENST00000356509.3
ENST00000230056.3
geminin, DNA replication inhibitor
chr1_+_111992064 56.21 ENST00000483994.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr7_-_132766800 55.99 ENST00000542753.1
ENST00000448878.1
coiled-coil-helix-coiled-coil-helix domain containing 3
chr19_+_47634039 55.75 ENST00000597808.1
ENST00000413379.3
ENST00000600706.1
ENST00000540850.1
ENST00000598840.1
ENST00000600753.1
ENST00000270225.7
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr7_-_132766818 55.73 ENST00000262570.5
coiled-coil-helix-coiled-coil-helix domain containing 3
chr14_-_105487381 55.55 ENST00000392590.3
ENST00000336219.3
cell division cycle associated 4
chr16_-_81129951 55.17 ENST00000315467.3
glycine cleavage system protein H (aminomethyl carrier)
chr16_-_30441293 55.05 ENST00000565758.1
ENST00000567983.1
ENST00000319285.4
dCTP pyrophosphatase 1
chr2_+_131100423 55.02 ENST00000409935.1
ENST00000409649.1
ENST00000428740.1
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr9_+_91926103 54.84 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr12_+_104359576 54.23 ENST00000392872.3
ENST00000436021.2
thymine-DNA glycosylase
chr1_+_38478378 54.12 ENST00000373014.4
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr3_-_183967296 54.05 ENST00000455059.1
ENST00000445626.2
ALG3, alpha-1,3- mannosyltransferase
chrX_-_47518498 53.96 ENST00000335890.2
ubiquitously-expressed, prefoldin-like chaperone
chr13_+_76123883 53.95 ENST00000377595.3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr8_-_102217796 53.89 ENST00000519744.1
ENST00000311212.4
ENST00000521272.1
ENST00000519882.1
zinc finger protein 706
chr17_+_76165213 53.67 ENST00000590201.1
synaptogyrin 2
chr19_+_34855874 53.42 ENST00000588991.2
glucose-6-phosphate isomerase
chr6_+_32811885 53.29 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_41768401 52.78 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr20_+_31407692 52.48 ENST00000375571.5
microtubule-associated protein, RP/EB family, member 1
chr11_+_60609537 51.67 ENST00000227520.5
coiled-coil domain containing 86
chr1_-_115259337 51.65 ENST00000369535.4
neuroblastoma RAS viral (v-ras) oncogene homolog
chr19_-_40336969 51.24 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
fibrillarin
chr8_-_97273807 51.07 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
MTERF domain containing 1
chr17_+_7476136 50.82 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
eukaryotic translation initiation factor 4A1
chr11_+_34127142 50.79 ENST00000257829.3
ENST00000531159.2
N-acetyltransferase 10 (GCN5-related)
chr8_-_117768023 50.71 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chrX_+_48433326 50.70 ENST00000376755.1
RNA binding motif (RNP1, RRM) protein 3
chr17_-_40075219 50.48 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ATP citrate lyase
chr11_-_118972575 50.39 ENST00000432443.2
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr3_+_127317066 50.35 ENST00000265056.7
minichromosome maintenance complex component 2
chr2_+_88991162 50.23 ENST00000283646.4
ribose 5-phosphate isomerase A
chr17_-_47492236 50.17 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
prohibitin
chr11_+_9406169 50.12 ENST00000379719.3
ENST00000527431.1
importin 7
chr16_-_88851618 50.03 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr19_-_41903161 49.81 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
exosome component 5
chr17_-_48474828 49.13 ENST00000576448.1
ENST00000225972.7
leucine rich repeat containing 59
chrX_-_47518527 49.11 ENST00000333119.3
ubiquitously-expressed, prefoldin-like chaperone
chr8_+_98788003 48.84 ENST00000521545.2
lysosomal protein transmembrane 4 beta
chr9_-_113018746 48.71 ENST00000374515.5
thioredoxin
chr7_-_23510086 48.50 ENST00000258729.3
insulin-like growth factor 2 mRNA binding protein 3
chrX_-_16887963 48.18 ENST00000380084.4
retinoblastoma binding protein 7
chr11_+_844406 47.95 ENST00000397404.1
tetraspanin 4
chr20_+_35202909 47.89 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr12_+_96252706 47.63 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
small nuclear ribonucleoprotein polypeptide F
chr10_+_70715884 47.38 ENST00000354185.4
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr10_-_97416400 47.38 ENST00000371224.2
ENST00000371221.3
aldehyde dehydrogenase 18 family, member A1
chr1_+_32479430 47.15 ENST00000327300.7
ENST00000492989.1
KH domain containing, RNA binding, signal transduction associated 1
chr6_-_53213780 47.01 ENST00000304434.6
ENST00000370918.4
ELOVL fatty acid elongase 5
chr6_+_30689401 46.87 ENST00000396389.1
ENST00000396384.1
tubulin, beta class I
chr6_-_33385902 46.82 ENST00000374500.5
cutA divalent cation tolerance homolog (E. coli)
chr16_-_88878305 46.67 ENST00000569616.1
ENST00000563655.1
ENST00000567713.1
ENST00000426324.2
ENST00000378364.3
adenine phosphoribosyltransferase
chr5_+_172386419 46.61 ENST00000265100.2
ENST00000519239.1
ribosomal protein L26-like 1
chr21_-_46238034 46.27 ENST00000332859.6
small ubiquitin-like modifier 3
chr11_+_18416133 46.20 ENST00000227157.4
ENST00000478970.2
ENST00000495052.1
lactate dehydrogenase A
chr17_-_46688334 46.06 ENST00000239165.7
homeobox B7
chr15_+_52311398 46.01 ENST00000261845.5
mitogen-activated protein kinase 6
chr3_-_63849571 45.89 ENST00000295899.5
THO complex 7 homolog (Drosophila)
chr4_-_2935674 45.85 ENST00000514800.1
major facilitator superfamily domain containing 10
chr7_+_16685756 45.84 ENST00000415365.1
ENST00000258761.3
ENST00000433922.2
ENST00000452975.2
ENST00000405202.1
basic leucine zipper and W2 domains 2
chr6_+_44191290 45.67 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_-_40041925 45.34 ENST00000372862.3
poly(A) binding protein, cytoplasmic 4 (inducible form)
chr8_-_103668114 45.26 ENST00000285407.6
Kruppel-like factor 10
chr20_+_23331373 45.07 ENST00000254998.2
NTF2-like export factor 1
chr1_-_78148324 45.05 ENST00000370801.3
ENST00000433749.1
zinc finger, ZZ-type containing 3
chr19_+_5681153 44.78 ENST00000579559.1
ENST00000577222.1
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr1_+_155178481 44.76 ENST00000368376.3
metaxin 1
chr17_+_40985407 44.74 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr5_-_133340326 44.61 ENST00000425992.1
ENST00000395044.3
ENST00000395047.2
voltage-dependent anion channel 1
chr12_-_56709786 44.59 ENST00000547423.1
ENST00000548360.1
ENST00000551475.1
Uncharacterized protein
canopy FGF signaling regulator 2
chr3_-_131221790 44.21 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
mitochondrial ribosomal protein L3
chr17_-_61850894 43.87 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
coiled-coil domain containing 47
chr2_+_187350883 43.80 ENST00000337859.6
zinc finger CCCH-type containing 15
chr21_-_38445470 43.67 ENST00000399098.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr17_-_7590745 43.61 ENST00000514944.1
ENST00000503591.1
ENST00000455263.2
ENST00000420246.2
ENST00000445888.2
ENST00000509690.1
ENST00000604348.1
ENST00000269305.4
tumor protein p53
chr6_-_153304148 43.61 ENST00000229758.3
F-box protein 5
chr6_+_30689350 43.54 ENST00000330914.3
tubulin, beta class I
chr1_-_86174065 43.54 ENST00000370574.3
ENST00000431532.2
zinc finger, HIT-type containing 6
chr6_+_44191507 43.47 ENST00000371724.1
ENST00000371713.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr3_+_133293278 43.36 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3 homolog (mouse)
chr6_-_7911042 43.27 ENST00000379757.4
thioredoxin domain containing 5 (endoplasmic reticulum)
chr9_-_2844058 43.26 ENST00000397885.2
KIAA0020
chr10_-_16859361 43.19 ENST00000377921.3
Ras suppressor protein 1
chr10_+_75910960 43.15 ENST00000539909.1
ENST00000286621.2
adenosine kinase
chr2_-_175113088 42.96 ENST00000409546.1
ENST00000428402.2
Obg-like ATPase 1
chr14_-_54908043 42.93 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
cornichon family AMPA receptor auxiliary protein 1
chr9_-_95087838 42.74 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
nucleolar protein 8
chr9_-_95087604 42.70 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
nucleolar protein 8
chrX_-_153285251 42.63 ENST00000444230.1
ENST00000393682.1
ENST00000393687.2
ENST00000429936.2
ENST00000369974.2
interleukin-1 receptor-associated kinase 1
chr3_-_49066811 42.62 ENST00000442157.1
ENST00000326739.4
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr12_+_109535923 42.40 ENST00000336865.2
uracil-DNA glycosylase
chr1_-_6259613 42.25 ENST00000465387.1
ribosomal protein L22
chr20_-_49547910 42.22 ENST00000396032.3
activity-dependent neuroprotector homeobox
chr11_-_47664072 42.12 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
mitochondrial carrier 2
chr11_-_57298187 42.10 ENST00000525158.1
ENST00000257245.4
ENST00000525587.1
translocase of inner mitochondrial membrane 10 homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of MXI1_MYC_MYCN

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
95.6 478.1 GO:1904636 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
78.0 312.0 GO:0046452 dihydrofolate metabolic process(GO:0046452)
76.6 459.4 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
69.7 278.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
58.9 294.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
52.4 367.0 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
51.1 153.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
50.5 252.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
49.5 148.5 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
49.3 394.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
43.5 391.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
40.8 163.0 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
37.6 112.7 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
37.6 112.7 GO:0044209 AMP salvage(GO:0044209)
31.0 155.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
30.7 122.8 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
30.3 90.9 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
27.5 55.0 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
26.9 80.6 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
26.4 26.4 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
25.4 76.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
25.4 50.8 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
25.4 126.8 GO:0031126 snoRNA 3'-end processing(GO:0031126)
25.0 74.9 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
24.4 122.0 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
24.2 72.7 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
23.8 142.6 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
23.2 69.7 GO:0071344 diphosphate metabolic process(GO:0071344)
23.0 184.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
22.3 66.8 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
22.1 66.4 GO:0002188 formation of cytoplasmic translation initiation complex(GO:0001732) translation reinitiation(GO:0002188)
22.0 109.8 GO:0015862 uridine transport(GO:0015862)
21.8 43.5 GO:0048254 snoRNA localization(GO:0048254)
20.9 104.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
20.0 59.9 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
19.8 138.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
19.7 137.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
19.5 136.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
19.3 192.6 GO:0018202 peptidyl-histidine modification(GO:0018202)
19.3 57.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
19.2 95.8 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
18.7 187.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
18.6 74.3 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
18.4 147.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
17.3 121.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
17.3 69.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
17.0 34.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
16.4 49.3 GO:0046098 guanine metabolic process(GO:0046098)
16.2 48.7 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
15.8 47.3 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
15.7 125.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
15.5 62.1 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
15.3 30.5 GO:0006597 spermine biosynthetic process(GO:0006597)
15.2 45.6 GO:0006014 D-ribose metabolic process(GO:0006014)
15.1 60.5 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
15.0 74.8 GO:0061198 fungiform papilla formation(GO:0061198)
14.9 59.7 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
14.6 73.1 GO:0019640 glucuronate catabolic process(GO:0006064) glucuronate catabolic process to xylulose 5-phosphate(GO:0019640) xylulose 5-phosphate metabolic process(GO:0051167) xylulose 5-phosphate biosynthetic process(GO:1901159)
14.5 57.9 GO:1902903 regulation of fibril organization(GO:1902903)
14.3 14.3 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
14.3 99.9 GO:0008295 spermidine biosynthetic process(GO:0008295)
14.2 28.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
14.2 56.8 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
14.2 269.5 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
14.1 84.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
14.1 56.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
13.9 41.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
13.7 41.1 GO:0035978 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
13.6 40.8 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
13.6 40.8 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
13.4 120.7 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
13.4 80.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
13.3 26.6 GO:0044416 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
13.1 26.3 GO:0016074 snoRNA metabolic process(GO:0016074)
13.1 65.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
12.9 38.6 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
12.8 12.8 GO:1901856 negative regulation of cellular respiration(GO:1901856)
12.3 196.8 GO:0002192 IRES-dependent translational initiation(GO:0002192)
12.3 36.8 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
12.3 122.8 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
12.3 36.8 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
12.2 48.8 GO:0006218 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
12.1 48.4 GO:1902570 protein localization to nucleolus(GO:1902570)
11.9 107.5 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
11.9 83.1 GO:0002190 cap-independent translational initiation(GO:0002190)
11.8 47.2 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
11.7 70.4 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
11.7 23.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
11.6 69.6 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
11.3 34.0 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
11.3 33.9 GO:1901873 regulation of post-translational protein modification(GO:1901873)
11.0 21.9 GO:0042256 mature ribosome assembly(GO:0042256)
10.9 21.9 GO:0006344 maintenance of chromatin silencing(GO:0006344)
10.8 140.7 GO:0006089 lactate metabolic process(GO:0006089)
10.7 107.1 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
10.6 265.5 GO:0006999 nuclear pore organization(GO:0006999)
10.5 41.9 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
10.3 31.0 GO:0046294 formaldehyde catabolic process(GO:0046294)
10.2 30.6 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
10.2 61.0 GO:0022614 membrane to membrane docking(GO:0022614)
10.2 60.9 GO:0006177 GMP biosynthetic process(GO:0006177)
9.9 39.8 GO:0043335 protein unfolding(GO:0043335)
9.9 9.9 GO:1901536 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
9.9 19.8 GO:0019322 pentose-phosphate shunt, oxidative branch(GO:0009051) pentose biosynthetic process(GO:0019322)
9.9 406.0 GO:0042407 cristae formation(GO:0042407)
9.9 39.5 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
9.9 148.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
9.9 49.3 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
9.8 19.7 GO:0002572 pro-T cell differentiation(GO:0002572)
9.8 49.1 GO:0019348 dolichol metabolic process(GO:0019348)
9.7 19.4 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
9.7 48.3 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
9.6 57.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
9.5 28.6 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
9.5 9.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
9.5 75.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
9.5 66.2 GO:0042113 B cell activation(GO:0042113)
9.4 18.8 GO:0016321 female meiosis chromosome segregation(GO:0016321)
9.4 122.2 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
9.4 28.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
9.4 28.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
9.3 27.9 GO:0048627 myoblast development(GO:0048627)
9.1 18.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
9.1 9.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
9.0 17.9 GO:0044211 CTP salvage(GO:0044211)
8.9 26.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
8.9 142.0 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
8.8 35.4 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
8.7 26.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
8.6 86.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
8.5 59.7 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
8.4 41.9 GO:0006740 NADPH regeneration(GO:0006740)
8.4 41.8 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
8.4 58.5 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
8.2 98.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
8.1 81.3 GO:0045008 depyrimidination(GO:0045008)
8.1 558.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
8.1 8.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
8.0 23.9 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
7.9 71.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
7.9 55.4 GO:0033484 nitric oxide homeostasis(GO:0033484)
7.8 47.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
7.7 30.7 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
7.6 45.4 GO:0001887 selenium compound metabolic process(GO:0001887)
7.5 59.7 GO:0045019 negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406)
7.5 29.8 GO:0007144 female meiosis I(GO:0007144)
7.5 149.1 GO:0006337 nucleosome disassembly(GO:0006337)
7.4 22.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
7.3 51.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
7.3 87.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
7.2 29.0 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
7.2 519.9 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
7.2 28.7 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
7.1 21.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
7.1 42.5 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
6.9 20.8 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
6.9 20.8 GO:0006738 nicotinamide riboside catabolic process(GO:0006738) inosine metabolic process(GO:0046102) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
6.9 20.7 GO:0010628 positive regulation of gene expression(GO:0010628)
6.7 67.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
6.7 100.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
6.7 20.0 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
6.6 111.7 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
6.6 32.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
6.5 19.6 GO:1902822 lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822)
6.5 45.7 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
6.5 13.0 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
6.5 32.3 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
6.5 45.2 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
6.4 38.7 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
6.4 25.7 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
6.4 12.8 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
6.4 44.9 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
6.4 280.9 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
6.4 25.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
6.2 18.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
6.1 30.7 GO:0090204 protein localization to nuclear pore(GO:0090204)
6.1 18.4 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
6.1 90.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
6.1 78.7 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
6.0 259.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
6.0 18.0 GO:0040012 regulation of locomotion(GO:0040012)
6.0 42.0 GO:0002191 cap-dependent translational initiation(GO:0002191)
6.0 12.0 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
6.0 17.9 GO:0006550 isoleucine catabolic process(GO:0006550)
5.9 17.8 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
5.9 29.6 GO:0007008 outer mitochondrial membrane organization(GO:0007008)
5.8 17.5 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
5.8 115.8 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
5.8 17.4 GO:0032759 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
5.7 17.1 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
5.7 17.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
5.7 11.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
5.7 537.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
5.6 89.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
5.6 16.8 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
5.5 16.5 GO:0014736 negative regulation of muscle atrophy(GO:0014736) response to injury involved in regulation of muscle adaptation(GO:0014876)
5.5 21.8 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
5.4 21.8 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
5.4 21.8 GO:0021564 vagus nerve development(GO:0021564)
5.4 10.7 GO:0015920 lipopolysaccharide transport(GO:0015920)
5.3 10.6 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
5.2 187.7 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
5.2 20.8 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
5.2 15.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
5.2 20.6 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
5.2 20.6 GO:0009956 radial pattern formation(GO:0009956)
5.1 162.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
5.1 15.2 GO:0040013 negative regulation of locomotion(GO:0040013)
5.0 164.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
4.9 84.1 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
4.9 14.6 GO:0010643 cell communication by chemical coupling(GO:0010643)
4.9 14.6 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
4.8 9.7 GO:0007386 compartment pattern specification(GO:0007386)
4.8 19.2 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
4.8 28.7 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
4.8 19.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
4.8 14.3 GO:0006679 glucosylceramide biosynthetic process(GO:0006679)
4.8 42.8 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
4.7 61.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
4.7 23.3 GO:0072553 terminal button organization(GO:0072553)
4.7 18.6 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
4.6 18.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
4.6 18.6 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
4.6 45.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
4.6 13.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
4.5 13.4 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
4.5 13.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
4.4 93.4 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
4.4 26.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
4.4 26.5 GO:0006021 inositol biosynthetic process(GO:0006021)
4.4 13.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
4.4 13.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
4.3 30.2 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
4.3 64.4 GO:0000338 protein deneddylation(GO:0000338)
4.3 12.8 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
4.3 21.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.2 12.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
4.2 314.5 GO:0045454 cell redox homeostasis(GO:0045454)
4.2 25.4 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
4.2 33.7 GO:0070141 response to UV-A(GO:0070141)
4.2 29.2 GO:0022417 protein maturation by protein folding(GO:0022417)
4.2 12.5 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
4.2 49.8 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
4.1 41.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
4.1 12.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
4.1 37.2 GO:0006552 leucine catabolic process(GO:0006552)
4.1 20.5 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
4.1 16.4 GO:0002545 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
4.1 32.7 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
4.1 36.5 GO:0006983 ER overload response(GO:0006983)
4.0 724.4 GO:0006364 rRNA processing(GO:0006364)
4.0 20.1 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
4.0 12.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
3.9 11.8 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
3.9 23.5 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
3.9 15.6 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
3.9 34.7 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
3.8 19.1 GO:0002084 protein depalmitoylation(GO:0002084)
3.8 41.5 GO:0032310 prostaglandin secretion(GO:0032310)
3.7 11.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
3.7 15.0 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
3.7 11.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
3.7 3.7 GO:0014806 smooth muscle hyperplasia(GO:0014806)
3.7 11.1 GO:0031507 heterochromatin assembly(GO:0031507)
3.7 11.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
3.7 14.7 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
3.7 88.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
3.6 14.5 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
3.6 25.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
3.6 243.1 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
3.6 46.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
3.5 7.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
3.5 93.7 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
3.4 75.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
3.4 136.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
3.4 10.2 GO:1901355 response to rapamycin(GO:1901355)
3.4 13.6 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
3.4 13.5 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
3.4 10.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
3.3 43.0 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
3.3 13.2 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
3.3 79.0 GO:0007035 vacuolar acidification(GO:0007035)
3.3 19.7 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
3.3 6.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
3.2 13.0 GO:0051013 microtubule severing(GO:0051013)
3.2 34.7 GO:0038092 nodal signaling pathway(GO:0038092)
3.1 18.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
3.1 6.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
3.1 6.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
3.1 12.3 GO:0045218 zonula adherens maintenance(GO:0045218)
3.0 3.0 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
3.0 9.0 GO:0007021 tubulin complex assembly(GO:0007021)
3.0 12.0 GO:0048478 replication fork protection(GO:0048478)
3.0 3.0 GO:1903421 regulation of synaptic vesicle recycling(GO:1903421)
3.0 3.0 GO:0072054 renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054)
3.0 29.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
2.9 32.3 GO:0006265 DNA topological change(GO:0006265)
2.9 11.7 GO:1900125 regulation of hyaluronan biosynthetic process(GO:1900125)
2.9 20.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
2.9 17.5 GO:0008298 intracellular mRNA localization(GO:0008298)
2.9 5.8 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
2.9 8.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
2.9 37.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
2.9 2.9 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
2.9 25.8 GO:0051382 kinetochore assembly(GO:0051382)
2.8 5.7 GO:0098502 DNA dephosphorylation(GO:0098502)
2.8 8.4 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
2.8 11.2 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
2.8 11.2 GO:0015911 plasma membrane long-chain fatty acid transport(GO:0015911)
2.8 8.4 GO:0032771 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
2.8 8.3 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
2.7 32.6 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
2.6 23.7 GO:0015074 DNA integration(GO:0015074)
2.6 28.7 GO:0009414 response to water deprivation(GO:0009414)
2.6 51.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
2.6 10.3 GO:0072683 T cell extravasation(GO:0072683)
2.6 10.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
2.6 2.6 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
2.6 150.7 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
2.5 188.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
2.5 38.1 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
2.5 22.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
2.5 10.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
2.5 32.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
2.5 7.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
2.5 47.5 GO:0051290 protein heterotetramerization(GO:0051290)
2.5 12.5 GO:0042695 thelarche(GO:0042695) development of secondary female sexual characteristics(GO:0046543) mammary gland branching involved in thelarche(GO:0060744)
2.5 10.0 GO:0035879 plasma membrane lactate transport(GO:0035879)
2.5 14.8 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
2.4 26.9 GO:0006570 tyrosine metabolic process(GO:0006570)
2.4 9.7 GO:0006551 leucine metabolic process(GO:0006551)
2.4 7.2 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
2.4 7.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
2.4 31.0 GO:0070327 thyroid hormone transport(GO:0070327)
2.4 16.6 GO:1900223 positive regulation of beta-amyloid clearance(GO:1900223)
2.4 82.9 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
2.4 28.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
2.4 58.9 GO:0032508 DNA duplex unwinding(GO:0032508)
2.4 21.2 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
2.3 7.0 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
2.3 91.3 GO:0006270 DNA replication initiation(GO:0006270)
2.3 4.7 GO:0071462 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) cellular response to water stimulus(GO:0071462)
2.3 7.0 GO:0061010 gall bladder development(GO:0061010)
2.3 14.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
2.3 18.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
2.3 9.3 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
2.3 4.6 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
2.3 13.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
2.3 16.0 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
2.3 18.1 GO:0015939 pantothenate metabolic process(GO:0015939)
2.3 78.9 GO:1901998 toxin transport(GO:1901998)
2.2 71.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
2.2 9.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
2.2 6.7 GO:0042727 flavin-containing compound biosynthetic process(GO:0042727)
2.2 10.9 GO:0031053 primary miRNA processing(GO:0031053)
2.1 21.5 GO:0045116 protein neddylation(GO:0045116)
2.1 4.3 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
2.1 17.2 GO:1904753 positive regulation of heart rate by epinephrine(GO:0003065) negative regulation of vascular associated smooth muscle cell migration(GO:1904753)
2.1 21.5 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
2.1 14.8 GO:0070836 caveola assembly(GO:0070836)
2.1 12.6 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
2.1 20.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
2.1 16.6 GO:0060155 platelet dense granule organization(GO:0060155)
2.1 6.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
2.1 4.1 GO:0034982 mitochondrial protein processing(GO:0034982)
2.1 33.0 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
2.0 16.4 GO:1900625 monocyte aggregation(GO:0070487) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
2.0 8.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
2.0 4.0 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
2.0 3.9 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
2.0 11.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
1.9 15.6 GO:0071763 nuclear membrane organization(GO:0071763)
1.9 15.5 GO:0044351 macropinocytosis(GO:0044351)
1.9 3.9 GO:1902410 mitotic cytokinetic process(GO:1902410)
1.9 3.9 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.9 19.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.9 15.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.9 9.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
1.9 19.2 GO:0021769 orbitofrontal cortex development(GO:0021769)
1.9 37.8 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
1.9 17.0 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
1.9 3.8 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.9 11.2 GO:0048143 astrocyte activation(GO:0048143)
1.9 7.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
1.9 3.7 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
1.9 5.6 GO:0048368 lateral mesoderm development(GO:0048368)
1.9 1.9 GO:1902908 regulation of melanosome transport(GO:1902908)
1.9 18.5 GO:0001895 retina homeostasis(GO:0001895)
1.8 5.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
1.8 9.2 GO:0006041 glucosamine metabolic process(GO:0006041)
1.8 23.9 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.8 12.9 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.8 5.5 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.8 38.5 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
1.8 20.0 GO:0051451 myoblast migration(GO:0051451)
1.8 16.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
1.8 9.0 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541) Peyer's patch morphogenesis(GO:0061146)
1.8 8.9 GO:0006529 asparagine biosynthetic process(GO:0006529)
1.8 10.6 GO:0032328 alanine transport(GO:0032328)
1.8 3.5 GO:0042761 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
1.7 15.7 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
1.7 13.9 GO:0006689 ganglioside catabolic process(GO:0006689)
1.7 3.5 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
1.7 5.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
1.7 12.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
1.7 6.8 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
1.7 1.7 GO:1990791 dorsal root ganglion development(GO:1990791)
1.7 5.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
1.7 8.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.6 4.9 GO:0051684 maintenance of Golgi location(GO:0051684)
1.6 23.0 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
1.6 22.9 GO:0007076 mitotic chromosome condensation(GO:0007076)
1.6 9.6 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.6 17.6 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
1.6 12.8 GO:0043457 regulation of cellular respiration(GO:0043457)
1.6 46.0 GO:0032008 positive regulation of TOR signaling(GO:0032008)
1.6 3.2 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
1.6 3.2 GO:0071888 macrophage apoptotic process(GO:0071888)
1.6 23.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
1.6 7.9 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
1.6 1.6 GO:0040031 snRNA modification(GO:0040031)
1.6 18.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
1.5 9.3 GO:0010659 cardiac muscle cell apoptotic process(GO:0010659)
1.5 4.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
1.5 4.6 GO:2000489 regulation of hepatic stellate cell activation(GO:2000489) positive regulation of hepatic stellate cell activation(GO:2000491)
1.5 44.2 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.5 18.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
1.5 12.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.5 12.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.5 13.5 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
1.5 4.4 GO:0006711 estrogen catabolic process(GO:0006711)
1.5 4.4 GO:0008063 Toll signaling pathway(GO:0008063)
1.5 38.2 GO:0006491 N-glycan processing(GO:0006491)
1.5 42.2 GO:0031581 hemidesmosome assembly(GO:0031581)
1.5 4.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.4 4.3 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
1.4 14.4 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
1.4 27.3 GO:0030488 tRNA methylation(GO:0030488)
1.4 15.8 GO:0006105 succinate metabolic process(GO:0006105)
1.4 1.4 GO:0051182 coenzyme transport(GO:0051182)
1.4 5.6 GO:0046952 ketone body catabolic process(GO:0046952)
1.4 132.9 GO:0001909 leukocyte mediated cytotoxicity(GO:0001909)
1.4 14.9 GO:0061462 protein localization to lysosome(GO:0061462)
1.3 30.8 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
1.3 5.3 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
1.3 8.0 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
1.3 4.0 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
1.3 18.4 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
1.3 34.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.3 3.9 GO:0035989 tendon development(GO:0035989)
1.3 3.8 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
1.3 3.8 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
1.3 7.5 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
1.2 20.0 GO:0090383 phagosome acidification(GO:0090383)
1.2 8.5 GO:0060872 semicircular canal development(GO:0060872)
1.2 13.2 GO:0030575 nuclear body organization(GO:0030575)
1.2 8.4 GO:0000012 single strand break repair(GO:0000012)
1.2 2.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
1.2 15.5 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
1.2 24.6 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
1.2 3.5 GO:0036010 protein localization to endosome(GO:0036010)
1.2 8.1 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
1.2 20.8 GO:0008228 opsonization(GO:0008228)
1.2 5.8 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
1.2 1.2 GO:0007405 neuroblast proliferation(GO:0007405)
1.1 6.8 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
1.1 6.7 GO:0030421 defecation(GO:0030421)
1.1 33.6 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
1.1 2.2 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
1.1 21.0 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
1.1 8.8 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
1.1 5.4 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
1.1 18.3 GO:0002021 response to dietary excess(GO:0002021)
1.1 48.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.1 94.8 GO:0006626 protein targeting to mitochondrion(GO:0006626)
1.1 10.6 GO:0046835 carbohydrate phosphorylation(GO:0046835)
1.1 12.7 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
1.1 16.9 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
1.1 55.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
1.0 7.3 GO:0034501 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
1.0 6.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
1.0 12.3 GO:0051014 actin filament severing(GO:0051014)
1.0 4.1 GO:0098838 methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
1.0 63.8 GO:0043488 regulation of mRNA stability(GO:0043488)
1.0 1.0 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
1.0 5.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
1.0 6.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
1.0 4.0 GO:0033619 membrane protein ectodomain proteolysis(GO:0006509) membrane protein proteolysis(GO:0033619)
1.0 58.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
1.0 7.9 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
1.0 7.9 GO:0090161 Golgi ribbon formation(GO:0090161)
1.0 10.8 GO:0035456 response to interferon-beta(GO:0035456)
1.0 7.8 GO:0006020 inositol metabolic process(GO:0006020)
1.0 6.8 GO:0045048 protein insertion into ER membrane(GO:0045048)
1.0 17.4 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
1.0 2.9 GO:2000641 regulation of early endosome to late endosome transport(GO:2000641)
1.0 2.9 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.9 6.6 GO:0030656 regulation of vitamin metabolic process(GO:0030656)
0.9 16.0 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.9 0.9 GO:0032423 regulation of mismatch repair(GO:0032423) positive regulation of mismatch repair(GO:0032425)
0.9 3.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 3.7 GO:0035425 autocrine signaling(GO:0035425)
0.9 3.7 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.9 73.9 GO:0006901 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.9 27.7 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.9 1.8 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.9 8.9 GO:0001778 plasma membrane repair(GO:0001778)
0.9 6.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.9 10.6 GO:0021670 lateral ventricle development(GO:0021670)
0.9 3.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.9 1.7 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.9 4.3 GO:0031947 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.9 28.1 GO:0031648 protein destabilization(GO:0031648)
0.8 9.2 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.8 17.4 GO:0051923 sulfation(GO:0051923)
0.8 5.0 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.8 0.8 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.8 4.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.8 8.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.8 52.4 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.8 8.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.8 7.1 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.8 33.8 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.8 2.3 GO:0046203 spermidine catabolic process(GO:0046203)
0.8 3.8 GO:0031054 pre-miRNA processing(GO:0031054)
0.8 19.7 GO:0050832 defense response to fungus(GO:0050832)
0.8 3.0 GO:0001541 ovarian follicle development(GO:0001541)
0.8 4.5 GO:0031935 regulation of chromatin silencing(GO:0031935)
0.7 1.5 GO:0006566 threonine metabolic process(GO:0006566)
0.7 1.5 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.7 2.9 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.7 66.3 GO:0002576 platelet degranulation(GO:0002576)
0.7 13.0 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.7 2.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.7 6.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.7 2.8 GO:0048102 autophagic cell death(GO:0048102)
0.7 4.3 GO:0006450 regulation of translational fidelity(GO:0006450)
0.7 9.2 GO:0097186 amelogenesis(GO:0097186)
0.7 19.1 GO:0033198 response to ATP(GO:0033198)
0.7 3.5 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.7 1.4 GO:0033341 regulation of collagen binding(GO:0033341)
0.7 2.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.7 4.1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.7 6.1 GO:0060056 mammary gland involution(GO:0060056)
0.7 2.0 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.7 5.3 GO:0045176 apical protein localization(GO:0045176)
0.7 1.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.7 4.6 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.7 2.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.7 7.9 GO:0006505 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.7 14.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.6 37.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.6 3.2 GO:0055070 copper ion homeostasis(GO:0055070)
0.6 1.9 GO:0006574 valine catabolic process(GO:0006574)
0.6 0.6 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.6 3.8 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.6 2.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.6 4.3 GO:1990090 response to nerve growth factor(GO:1990089) cellular response to nerve growth factor stimulus(GO:1990090)
0.6 23.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.6 19.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.6 4.3 GO:0008218 bioluminescence(GO:0008218)
0.6 8.5 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.6 3.0 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.6 9.9 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.6 21.4 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.6 6.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.6 10.8 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.6 6.2 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.6 3.4 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.6 1.7 GO:0031133 regulation of axon diameter(GO:0031133)
0.5 2.2 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.5 9.8 GO:0048246 macrophage chemotaxis(GO:0048246)
0.5 6.4 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.5 0.5 GO:0006408 snRNA export from nucleus(GO:0006408)
0.5 1.1 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.5 1.6 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.5 8.3 GO:0032400 melanosome localization(GO:0032400)
0.5 2.1 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.5 1.0 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.5 9.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.5 3.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.5 7.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.5 6.9 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.5 5.9 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.5 3.4 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.5 4.4 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.5 9.7 GO:0070585 protein localization to mitochondrion(GO:0070585)
0.5 10.1 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.5 22.6 GO:0007569 cell aging(GO:0007569)
0.5 10.3 GO:0006413 translational initiation(GO:0006413)
0.5 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.5 21.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.5 3.7 GO:0030316 osteoclast differentiation(GO:0030316)
0.5 1.8 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.5 6.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.5 25.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.5 1.8 GO:0002115 store-operated calcium entry(GO:0002115)
0.4 3.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.4 1.3 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.4 8.4 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.4 4.4 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.4 2.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.4 6.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.4 22.6 GO:0030641 regulation of cellular pH(GO:0030641)
0.4 2.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.4 4.4 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4 5.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.4 3.4 GO:0030099 myeloid cell differentiation(GO:0030099)
0.4 1.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.4 10.8 GO:0035329 hippo signaling(GO:0035329)
0.4 9.5 GO:0008209 androgen metabolic process(GO:0008209)
0.3 3.1 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.3 7.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.3 2.7 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.3 0.3 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.3 3.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 0.7 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.3 1.6 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.3 1.6 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.3 2.5 GO:0016180 snRNA processing(GO:0016180)
0.3 3.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.3 4.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.3 1.3 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.3 0.6 GO:0016246 RNA interference(GO:0016246)
0.3 1.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.3 4.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.3 45.4 GO:0006457 protein folding(GO:0006457)
0.3 2.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.3 2.7 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.3 1.5 GO:0001881 receptor recycling(GO:0001881)
0.3 5.0 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.3 3.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 1.5 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.3 12.8 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.3 3.1 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.3 4.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 10.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 1.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.3 8.6 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.3 5.9 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.3 0.8 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.3 3.8 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.3 7.1 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 5.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 3.6 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.2 1.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.2 6.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 0.9 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 6.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 1.4 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.2 2.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.2 1.8 GO:0006751 glutathione catabolic process(GO:0006751) leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 6.5 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.2 5.6 GO:2001022 positive regulation of response to DNA damage stimulus(GO:2001022)
0.2 5.5 GO:0014823 response to activity(GO:0014823)
0.2 1.4 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.2 2.0 GO:0036344 platelet morphogenesis(GO:0036344)
0.2 2.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 2.8 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.2 2.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 0.8 GO:0030728 ovulation(GO:0030728)
0.2 2.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 1.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.2 4.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 1.4 GO:0006568 tryptophan metabolic process(GO:0006568)
0.2 0.4 GO:0015709 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2 2.8 GO:0017145 stem cell division(GO:0017145)
0.2 3.3 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.2 1.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 10.4 GO:0006334 nucleosome assembly(GO:0006334)
0.2 1.4 GO:0070995 NADPH oxidation(GO:0070995)
0.2 2.2 GO:0042481 regulation of odontogenesis(GO:0042481)
0.2 1.2 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.2 1.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 2.6 GO:0042438 melanin biosynthetic process(GO:0042438)
0.2 3.3 GO:0006308 DNA catabolic process(GO:0006308)
0.2 3.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 2.2 GO:0006706 steroid catabolic process(GO:0006706)
0.2 1.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 4.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 1.5 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 5.5 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 2.7 GO:0019915 lipid storage(GO:0019915)
0.1 2.1 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 1.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.4 GO:0010193 response to ozone(GO:0010193)
0.1 1.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.7 GO:0009650 UV protection(GO:0009650)
0.1 3.1 GO:0032801 receptor catabolic process(GO:0032801)
0.1 1.5 GO:0045471 response to ethanol(GO:0045471)
0.1 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 1.0 GO:0007498 mesoderm development(GO:0007498)
0.1 0.4 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 24.4 GO:0010038 response to metal ion(GO:0010038)
0.1 0.8 GO:0048311 mitochondrion distribution(GO:0048311)
0.1 0.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.6 GO:0072319 vesicle uncoating(GO:0072319)
0.1 0.4 GO:0046831 regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831)
0.1 1.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.5 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 0.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.1 5.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 1.1 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 0.8 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 0.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 10.1 GO:0016042 lipid catabolic process(GO:0016042)
0.1 0.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.1 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.5 GO:0097070 ductus arteriosus closure(GO:0097070)
0.1 0.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.3 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.5 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.1 GO:0014063 regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.0 0.2 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.0 0.4 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703) regulation of interleukin-1 alpha secretion(GO:0050705)
0.0 1.1 GO:0043473 pigmentation(GO:0043473)
0.0 0.1 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.2 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.2 GO:0006720 isoprenoid metabolic process(GO:0006720) terpenoid metabolic process(GO:0006721)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.1 GO:0014856 skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842) skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.0 0.2 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.4 GO:0050881 multicellular organismal movement(GO:0050879) musculoskeletal movement(GO:0050881)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
80.6 483.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
48.9 391.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
40.7 122.0 GO:0005960 glycine cleavage complex(GO:0005960)
40.4 323.3 GO:0070552 BRISC complex(GO:0070552)
33.4 601.3 GO:0034709 methylosome(GO:0034709)
30.2 181.4 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
28.3 84.8 GO:0034455 t-UTP complex(GO:0034455)
26.7 133.7 GO:0045323 interleukin-1 receptor complex(GO:0045323)
26.6 186.2 GO:0046581 intercellular canaliculus(GO:0046581)
26.5 132.6 GO:0034457 Mpp10 complex(GO:0034457)
25.3 151.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
24.0 167.9 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
23.6 118.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
23.1 69.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
20.8 166.8 GO:1990111 spermatoproteasome complex(GO:1990111)
19.7 137.8 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
19.6 78.3 GO:0070985 TFIIK complex(GO:0070985)
19.3 173.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
18.7 130.9 GO:0031415 NatA complex(GO:0031415)
17.9 125.4 GO:0061617 MICOS complex(GO:0061617)
16.4 49.1 GO:0097447 dendritic tree(GO:0097447)
16.1 64.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
14.8 103.6 GO:0061700 GATOR2 complex(GO:0061700)
14.5 72.7 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
13.9 55.7 GO:0031510 SUMO activating enzyme complex(GO:0031510)
13.8 248.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
13.5 81.1 GO:0070545 PeBoW complex(GO:0070545)
12.5 124.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
11.8 47.3 GO:0005606 laminin-1 complex(GO:0005606)
11.8 11.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
11.7 93.4 GO:0070761 pre-snoRNP complex(GO:0070761)
11.3 11.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
11.1 77.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
10.8 32.5 GO:0001740 Barr body(GO:0001740)
10.8 32.3 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
10.5 20.9 GO:0030689 Noc complex(GO:0030689)
10.4 229.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
10.3 102.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
10.3 215.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
10.1 253.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
10.0 120.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
9.9 49.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
9.7 38.7 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
9.3 65.3 GO:0016272 prefoldin complex(GO:0016272)
9.2 27.7 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
9.2 36.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
9.1 45.3 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
8.8 52.7 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
8.7 52.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
8.5 17.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
8.5 110.9 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
8.5 374.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
8.5 17.0 GO:0005675 holo TFIIH complex(GO:0005675)
8.5 101.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
8.4 336.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
8.4 25.2 GO:0044393 microspike(GO:0044393)
8.4 41.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
8.3 41.7 GO:0071986 Ragulator complex(GO:0071986)
8.1 97.2 GO:0031595 nuclear proteasome complex(GO:0031595)
8.0 80.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
8.0 207.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
7.9 142.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
7.8 133.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
7.8 62.8 GO:0042382 paraspeckles(GO:0042382)
7.7 85.2 GO:0005688 U6 snRNP(GO:0005688)
7.5 67.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
7.5 119.6 GO:0031088 platelet dense granule membrane(GO:0031088)
7.5 44.7 GO:0008537 proteasome activator complex(GO:0008537)
7.4 22.3 GO:0031372 UBC13-MMS2 complex(GO:0031372)
7.4 81.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
7.4 377.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
7.3 117.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
7.2 78.8 GO:0005641 nuclear envelope lumen(GO:0005641)
7.1 21.4 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
7.1 214.0 GO:0005680 anaphase-promoting complex(GO:0005680)
6.9 20.8 GO:0005826 actomyosin contractile ring(GO:0005826)
6.6 6.6 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
6.6 45.9 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
6.5 58.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
6.2 73.9 GO:0090543 Flemming body(GO:0090543)
5.9 47.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
5.8 17.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
5.7 57.3 GO:0030686 90S preribosome(GO:0030686)
5.7 28.6 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
5.7 56.8 GO:0000439 core TFIIH complex(GO:0000439)
5.4 76.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
5.3 565.5 GO:0015934 large ribosomal subunit(GO:0015934)
5.3 21.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
5.1 20.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
5.0 60.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
5.0 30.0 GO:0030905 retromer, tubulation complex(GO:0030905)
5.0 79.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
4.9 53.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
4.7 51.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
4.6 105.4 GO:0032156 septin cytoskeleton(GO:0032156)
4.5 36.2 GO:0097255 R2TP complex(GO:0097255)
4.5 44.7 GO:0044232 organelle membrane contact site(GO:0044232)
4.4 13.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
4.4 21.9 GO:0033503 HULC complex(GO:0033503)
4.4 39.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
4.4 13.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
4.3 108.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
4.3 65.0 GO:0005686 U2 snRNP(GO:0005686)
4.3 47.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
4.3 114.9 GO:0000930 gamma-tubulin complex(GO:0000930)
4.2 38.2 GO:0005642 annulate lamellae(GO:0005642)
4.2 42.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
4.1 16.6 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
4.1 24.6 GO:0035861 site of double-strand break(GO:0035861)
4.0 16.0 GO:0005726 perichromatin fibrils(GO:0005726)
4.0 12.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
3.9 3.9 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
3.8 26.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
3.7 11.1 GO:0030906 retromer, cargo-selective complex(GO:0030906) tubular endosome(GO:0097422)
3.6 286.8 GO:0031970 organelle envelope lumen(GO:0031970)
3.6 14.2 GO:0001940 male pronucleus(GO:0001940)
3.5 130.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.5 10.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
3.5 13.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
3.4 30.8 GO:0070765 gamma-secretase complex(GO:0070765)
3.4 30.6 GO:0097413 Lewy body(GO:0097413)
3.4 27.0 GO:0031931 TORC1 complex(GO:0031931)
3.4 26.8 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
3.3 13.4 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
3.3 26.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
3.3 33.4 GO:0031080 nuclear pore outer ring(GO:0031080)
3.3 443.7 GO:0016605 PML body(GO:0016605)
3.3 43.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
3.3 46.4 GO:0005685 U1 snRNP(GO:0005685)
3.3 46.3 GO:0000178 exosome (RNase complex)(GO:0000178)
3.3 13.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
3.2 29.1 GO:0044194 cytolytic granule(GO:0044194)
3.2 74.2 GO:0005640 nuclear outer membrane(GO:0005640)
3.2 345.9 GO:0005840 ribosome(GO:0005840)
3.1 74.7 GO:0071564 npBAF complex(GO:0071564)
3.1 161.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
3.0 24.3 GO:0005814 centriole(GO:0005814)
3.0 9.0 GO:0070195 growth hormone receptor complex(GO:0070195)
3.0 15.0 GO:0000408 EKC/KEOPS complex(GO:0000408)
3.0 529.4 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
2.9 191.6 GO:0005643 nuclear pore(GO:0005643)
2.8 31.2 GO:0008385 IkappaB kinase complex(GO:0008385)
2.8 53.5 GO:0071437 invadopodium(GO:0071437)
2.8 8.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
2.8 16.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
2.7 10.7 GO:0009368 endopeptidase Clp complex(GO:0009368)
2.7 96.6 GO:0031258 lamellipodium membrane(GO:0031258)
2.7 39.9 GO:0043020 NADPH oxidase complex(GO:0043020)
2.6 13.2 GO:0044530 supraspliceosomal complex(GO:0044530)
2.6 13.0 GO:0097149 centralspindlin complex(GO:0097149)
2.5 5.1 GO:0032389 MutLalpha complex(GO:0032389)
2.5 12.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
2.5 9.8 GO:1990425 ryanodine receptor complex(GO:1990425)
2.4 48.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
2.4 14.6 GO:0031597 cytosolic proteasome complex(GO:0031597)
2.4 23.7 GO:0030126 COPI vesicle coat(GO:0030126)
2.3 18.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.3 11.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
2.2 22.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
2.2 11.2 GO:0000938 GARP complex(GO:0000938)
2.2 4.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
2.2 11.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
2.2 8.7 GO:0071001 U4/U6 snRNP(GO:0071001)
2.1 23.2 GO:0042555 MCM complex(GO:0042555)
2.1 6.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.0 38.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
2.0 4.0 GO:0097454 Schwann cell microvillus(GO:0097454)
2.0 17.6 GO:0072546 ER membrane protein complex(GO:0072546)
1.9 7.8 GO:0055087 Ski complex(GO:0055087)
1.9 16.9 GO:0005677 chromatin silencing complex(GO:0005677)
1.9 1.9 GO:0061689 tricellular tight junction(GO:0061689)
1.8 5.5 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.8 27.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.8 18.1 GO:1990909 Wnt signalosome(GO:1990909)
1.8 3.6 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
1.8 32.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
1.8 14.3 GO:0016580 Sin3 complex(GO:0016580)
1.7 132.2 GO:0035578 azurophil granule lumen(GO:0035578)
1.6 6.6 GO:0042405 nuclear inclusion body(GO:0042405)
1.6 18.0 GO:0043601 nuclear replisome(GO:0043601)
1.6 178.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
1.6 110.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
1.6 57.6 GO:0008180 COP9 signalosome(GO:0008180)
1.6 17.6 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
1.5 95.0 GO:0005903 brush border(GO:0005903)
1.5 29.1 GO:1902555 endoribonuclease complex(GO:1902555)
1.5 19.6 GO:0030137 COPI-coated vesicle(GO:0030137)
1.5 12.0 GO:0031298 replication fork protection complex(GO:0031298)
1.5 25.2 GO:0032059 bleb(GO:0032059)
1.5 17.6 GO:0030008 TRAPP complex(GO:0030008)
1.5 80.6 GO:0005637 nuclear inner membrane(GO:0005637)
1.4 5.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.4 5.6 GO:0098576 lumenal side of membrane(GO:0098576)
1.4 33.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.4 111.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
1.4 63.8 GO:0043034 costamere(GO:0043034)
1.3 4.0 GO:0042575 DNA polymerase complex(GO:0042575)
1.3 31.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.3 14.6 GO:0097443 sorting endosome(GO:0097443)
1.3 85.7 GO:0005811 lipid particle(GO:0005811)
1.3 14.4 GO:0005614 interstitial matrix(GO:0005614)
1.3 43.8 GO:0031941 filamentous actin(GO:0031941)
1.2 16.0 GO:0031209 SCAR complex(GO:0031209)
1.2 9.8 GO:0016011 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
1.2 28.2 GO:0097228 sperm principal piece(GO:0097228)
1.2 8.2 GO:0070852 cell body fiber(GO:0070852)
1.2 12.8 GO:0030904 retromer complex(GO:0030904)
1.2 4.6 GO:0035838 growing cell tip(GO:0035838)
1.2 12.7 GO:0001673 male germ cell nucleus(GO:0001673)
1.1 59.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
1.1 5.7 GO:0030056 hemidesmosome(GO:0030056)
1.1 5.7 GO:0001739 sex chromatin(GO:0001739)
1.1 5.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
1.1 63.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
1.1 4.3 GO:0016589 NURF complex(GO:0016589)
1.1 3242.0 GO:0070062 extracellular exosome(GO:0070062)
1.1 31.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.1 9.6 GO:0097470 ribbon synapse(GO:0097470)
1.0 11.3 GO:0030673 axolemma(GO:0030673)
1.0 20.5 GO:0005771 multivesicular body(GO:0005771)
1.0 4.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.0 2.9 GO:1902554 serine/threonine protein kinase complex(GO:1902554)
1.0 3.8 GO:0070531 BRCA1-A complex(GO:0070531)
0.9 10.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.9 11.9 GO:0030125 clathrin vesicle coat(GO:0030125)
0.9 155.7 GO:0016324 apical plasma membrane(GO:0016324)
0.9 4.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.8 40.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 4.0 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.8 15.9 GO:0005657 replication fork(GO:0005657)
0.7 2.2 GO:0043291 RAVE complex(GO:0043291)
0.7 5.8 GO:0031143 pseudopodium(GO:0031143)
0.7 2.1 GO:0005879 axonemal microtubule(GO:0005879)
0.7 2.7 GO:0005846 nuclear cap binding complex(GO:0005846)
0.7 67.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.7 155.5 GO:0005635 nuclear envelope(GO:0005635)
0.7 3.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.7 2.6 GO:0005899 insulin receptor complex(GO:0005899)
0.6 0.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.6 32.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 5.5 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.6 52.8 GO:0005681 spliceosomal complex(GO:0005681)
0.6 4.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.6 6.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.6 33.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.6 5.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.5 1.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.5 37.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.5 14.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.5 3.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 13.4 GO:0042641 actomyosin(GO:0042641)
0.5 6.7 GO:0030057 desmosome(GO:0030057)
0.4 1.8 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.4 1.6 GO:0031264 death-inducing signaling complex(GO:0031264)
0.4 6.4 GO:0002102 podosome(GO:0002102)
0.4 1.2 GO:0031417 NatC complex(GO:0031417)
0.4 36.5 GO:0030027 lamellipodium(GO:0030027)
0.4 2.5 GO:0032039 integrator complex(GO:0032039)
0.4 4.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.3 6.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 5.5 GO:0000812 Swr1 complex(GO:0000812)
0.3 1.4 GO:1990031 pinceau fiber(GO:1990031)
0.3 9.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 4.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 2.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.3 9.6 GO:0045171 intercellular bridge(GO:0045171)
0.3 1.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 2.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 1.1 GO:0032449 CBM complex(GO:0032449)
0.2 0.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 3.1 GO:0045095 keratin filament(GO:0045095)
0.2 10.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 1.2 GO:0035580 specific granule lumen(GO:0035580)
0.2 4.5 GO:0045177 apical part of cell(GO:0045177)
0.2 9.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 2.3 GO:0001533 cornified envelope(GO:0001533)
0.2 1.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 2.8 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0000502 proteasome complex(GO:0000502)
0.1 5.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.9 GO:0035869 ciliary transition zone(GO:0035869)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.1 0.6 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 2.0 GO:0016363 nuclear matrix(GO:0016363)
0.1 44.5 GO:0005730 nucleolus(GO:0005730)
0.1 0.3 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.4 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.1 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.1 GO:0031672 A band(GO:0031672)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
81.2 487.2 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
56.3 337.7 GO:0019238 cyclohydrolase activity(GO:0019238)
52.4 367.0 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
51.1 153.3 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
49.5 148.5 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
46.8 374.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
45.1 135.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
42.5 127.5 GO:0004766 spermidine synthase activity(GO:0004766)
40.9 122.8 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
40.2 201.0 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
37.6 112.7 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
36.5 146.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
31.5 125.9 GO:0004047 aminomethyltransferase activity(GO:0004047)
30.7 122.8 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
30.3 121.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
30.2 181.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
28.7 86.2 GO:0017130 poly(C) RNA binding(GO:0017130)
25.9 181.0 GO:0004849 uridine kinase activity(GO:0004849)
25.3 151.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
25.0 74.9 GO:0004730 pseudouridylate synthase activity(GO:0004730)
24.9 99.6 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
23.1 69.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
23.0 69.0 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
21.6 64.8 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
21.3 106.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
20.2 80.9 GO:0004132 dCMP deaminase activity(GO:0004132)
19.8 79.4 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
19.4 19.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
19.3 57.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
19.3 57.8 GO:0008859 exoribonuclease II activity(GO:0008859)
19.1 57.3 GO:0031177 phosphopantetheine binding(GO:0031177)
18.6 74.3 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
18.2 218.4 GO:0031386 protein tag(GO:0031386)
17.9 250.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
17.4 69.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
16.9 118.2 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
16.9 67.4 GO:0002060 purine nucleobase binding(GO:0002060)
16.8 50.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
16.7 367.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
15.8 646.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
15.6 78.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
15.5 46.5 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
15.2 60.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
14.4 101.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
13.7 41.1 GO:0035501 MH1 domain binding(GO:0035501)
13.6 40.8 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
13.2 39.5 GO:0005047 signal recognition particle binding(GO:0005047)
12.9 38.6 GO:0003883 CTP synthase activity(GO:0003883)
12.8 51.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
12.8 76.6 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
12.7 126.6 GO:0008097 5S rRNA binding(GO:0008097)
12.6 100.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
12.5 124.7 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
12.4 24.8 GO:0016936 galactoside binding(GO:0016936)
12.3 36.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
12.2 48.8 GO:0004850 uridine phosphorylase activity(GO:0004850)
12.1 36.3 GO:0004797 thymidine kinase activity(GO:0004797)
11.8 47.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
11.6 104.7 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
11.6 347.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
11.3 34.0 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
11.3 56.6 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
11.1 77.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
11.0 55.0 GO:0032552 deoxyribonucleotide binding(GO:0032552)
10.6 42.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
10.4 41.4 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
10.3 277.7 GO:0051059 NF-kappaB binding(GO:0051059)
10.1 71.0 GO:0030620 U2 snRNA binding(GO:0030620)
9.9 9.9 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
9.9 39.5 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
9.8 206.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
9.7 58.3 GO:0019776 Atg8 ligase activity(GO:0019776)
9.7 456.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
9.7 48.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
9.6 77.1 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
9.6 57.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
9.5 19.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
9.5 47.4 GO:0097322 7SK snRNA binding(GO:0097322)
9.5 56.8 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
9.4 28.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
9.3 27.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
9.1 73.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
9.1 136.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
9.1 45.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
9.0 224.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
8.9 80.1 GO:0070883 pre-miRNA binding(GO:0070883)
8.8 97.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
8.6 60.5 GO:0019206 nucleoside kinase activity(GO:0019206)
8.6 25.8 GO:0030984 kininogen binding(GO:0030984)
8.5 76.5 GO:0015288 porin activity(GO:0015288)
8.5 25.4 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
8.3 148.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
8.2 221.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
8.1 64.6 GO:1990446 U1 snRNP binding(GO:1990446)
8.1 24.2 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
7.9 103.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
7.9 39.6 GO:0030348 syntaxin-3 binding(GO:0030348)
7.9 142.6 GO:0001054 RNA polymerase I activity(GO:0001054)
7.9 39.3 GO:1990460 leptin receptor binding(GO:1990460)
7.8 31.1 GO:0051920 peroxiredoxin activity(GO:0051920)
7.7 263.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
7.7 99.8 GO:0030957 Tat protein binding(GO:0030957)
7.7 23.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
7.6 106.2 GO:0016018 cyclosporin A binding(GO:0016018)
7.3 210.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
7.2 333.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
7.2 36.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
7.2 21.7 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
7.2 14.4 GO:0045294 alpha-catenin binding(GO:0045294)
7.2 122.4 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
7.2 21.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
7.1 134.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
7.0 21.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
6.9 165.7 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
6.9 27.6 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
6.9 68.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
6.8 41.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
6.7 33.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
6.5 45.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
6.5 156.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
6.5 77.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
6.4 6.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
6.4 44.7 GO:0061133 endopeptidase activator activity(GO:0061133)
6.3 63.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
6.2 49.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
6.2 31.0 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
6.2 111.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
6.2 18.6 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
6.2 61.6 GO:0042731 PH domain binding(GO:0042731)
6.1 349.7 GO:0003743 translation initiation factor activity(GO:0003743)
6.1 61.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
6.1 18.2 GO:0033149 FFAT motif binding(GO:0033149)
6.1 42.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
5.8 447.3 GO:0005507 copper ion binding(GO:0005507)
5.8 17.4 GO:0035500 MH2 domain binding(GO:0035500)
5.8 28.9 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
5.6 22.6 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
5.6 16.8 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
5.5 22.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
5.5 16.6 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
5.5 1107.6 GO:0003735 structural constituent of ribosome(GO:0003735)
5.4 5.4 GO:0019788 NEDD8 transferase activity(GO:0019788)
5.4 32.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
5.3 216.5 GO:0008536 Ran GTPase binding(GO:0008536)
5.2 10.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
5.2 15.5 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
5.1 72.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
5.1 20.5 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
5.0 15.0 GO:0015235 cobalamin transporter activity(GO:0015235)
5.0 15.0 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
5.0 34.7 GO:0019212 phosphatase inhibitor activity(GO:0019212)
4.9 14.8 GO:0004170 dUTP diphosphatase activity(GO:0004170)
4.9 14.8 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
4.8 178.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
4.8 53.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
4.8 81.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
4.7 32.6 GO:1990226 histone methyltransferase binding(GO:1990226)
4.6 18.6 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
4.6 41.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
4.5 22.5 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
4.5 53.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
4.5 26.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
4.5 13.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
4.4 13.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
4.4 13.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
4.3 100.0 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
4.3 13.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
4.3 218.8 GO:0016831 carboxy-lyase activity(GO:0016831)
4.3 128.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
4.3 47.0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
4.3 17.1 GO:0000339 RNA cap binding(GO:0000339)
4.3 21.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
4.2 104.9 GO:0003746 translation elongation factor activity(GO:0003746)
4.2 16.7 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
4.1 12.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
4.0 12.1 GO:0034511 U3 snoRNA binding(GO:0034511)
4.0 60.5 GO:0070061 fructose binding(GO:0070061)
4.0 56.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
4.0 12.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
4.0 16.0 GO:0004461 lactose synthase activity(GO:0004461)
4.0 79.1 GO:0032794 GTPase activating protein binding(GO:0032794)
3.9 23.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
3.9 11.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
3.9 15.5 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
3.8 26.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
3.8 26.8 GO:0004046 aminoacylase activity(GO:0004046)
3.8 328.3 GO:0051087 chaperone binding(GO:0051087)
3.7 11.2 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
3.7 44.7 GO:0019534 toxin transporter activity(GO:0019534)
3.6 21.8 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
3.6 82.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
3.5 10.6 GO:0001069 regulatory region RNA binding(GO:0001069)
3.5 14.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
3.5 10.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
3.5 60.0 GO:0003688 DNA replication origin binding(GO:0003688)
3.5 10.6 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
3.5 34.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
3.5 13.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
3.4 10.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
3.4 20.5 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
3.4 27.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
3.4 13.5 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
3.4 13.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
3.3 40.1 GO:0035613 RNA stem-loop binding(GO:0035613)
3.2 9.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
3.2 15.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
3.1 28.2 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
3.1 12.4 GO:0051373 FATZ binding(GO:0051373)
3.1 9.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
3.0 27.4 GO:0035877 death effector domain binding(GO:0035877)
3.0 89.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
2.9 11.7 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
2.9 26.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
2.9 80.3 GO:0000049 tRNA binding(GO:0000049)
2.9 40.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
2.9 34.3 GO:0030515 snoRNA binding(GO:0030515)
2.8 42.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
2.8 44.6 GO:0097602 cullin family protein binding(GO:0097602)
2.8 2.8 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
2.8 13.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
2.8 27.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
2.8 11.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
2.8 13.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
2.8 24.9 GO:1901612 cardiolipin binding(GO:1901612)
2.8 22.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
2.8 13.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.8 5.5 GO:0070699 type II activin receptor binding(GO:0070699)
2.7 18.7 GO:1990459 transferrin receptor binding(GO:1990459)
2.6 21.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
2.6 15.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
2.6 62.8 GO:0005123 death receptor binding(GO:0005123)
2.6 112.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.5 122.1 GO:0004364 glutathione transferase activity(GO:0004364)
2.5 30.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
2.5 7.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
2.5 10.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
2.5 39.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
2.5 41.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
2.4 2.4 GO:0032407 MutSalpha complex binding(GO:0032407)
2.4 34.2 GO:0003993 acid phosphatase activity(GO:0003993)
2.4 78.1 GO:0004385 guanylate kinase activity(GO:0004385)
2.4 9.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
2.4 14.4 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
2.4 19.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
2.4 16.5 GO:0017070 U6 snRNA binding(GO:0017070)
2.3 9.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.3 52.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
2.3 4.6 GO:0000403 Y-form DNA binding(GO:0000403)
2.3 228.8 GO:0003697 single-stranded DNA binding(GO:0003697)
2.3 18.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
2.3 36.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
2.2 4.5 GO:0004530 deoxyribonuclease I activity(GO:0004530)
2.2 35.5 GO:0005537 mannose binding(GO:0005537)
2.2 30.5 GO:0048156 tau protein binding(GO:0048156)
2.2 188.5 GO:0032947 protein complex scaffold(GO:0032947)
2.2 13.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
2.1 4.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.1 12.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
2.1 74.4 GO:0004407 histone deacetylase activity(GO:0004407)
2.1 12.6 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
2.1 68.8 GO:0042605 peptide antigen binding(GO:0042605)
2.1 10.3 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
2.1 158.7 GO:0003725 double-stranded RNA binding(GO:0003725)
2.1 22.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.0 76.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
2.0 6.0 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.9 5.8 GO:0031896 alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762) V2 vasopressin receptor binding(GO:0031896)
1.9 13.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
1.9 47.5 GO:0051010 microtubule plus-end binding(GO:0051010)
1.9 58.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
1.9 39.7 GO:0042609 CD4 receptor binding(GO:0042609)
1.9 5.6 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
1.9 11.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.8 14.6 GO:0070087 chromo shadow domain binding(GO:0070087)
1.8 7.3 GO:0043515 kinetochore binding(GO:0043515)
1.8 10.9 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
1.8 12.7 GO:0050733 RS domain binding(GO:0050733)
1.8 3.6 GO:0070851 growth factor receptor binding(GO:0070851)
1.8 14.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
1.8 29.8 GO:0031491 nucleosome binding(GO:0031491)
1.7 29.7 GO:0031593 polyubiquitin binding(GO:0031593)
1.7 12.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.7 10.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.6 3.3 GO:0031369 translation initiation factor binding(GO:0031369)
1.6 24.3 GO:0019213 deacetylase activity(GO:0019213)
1.6 30.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
1.6 32.1 GO:0004707 MAP kinase activity(GO:0004707)
1.6 6.4 GO:0004074 biliverdin reductase activity(GO:0004074)
1.6 4.7 GO:0048763 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
1.5 18.4 GO:0017049 GTP-Rho binding(GO:0017049)
1.5 4.6 GO:0035198 miRNA binding(GO:0035198)
1.5 57.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
1.5 7.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
1.5 4.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
1.5 6.0 GO:0004594 pantothenate kinase activity(GO:0004594)
1.5 1.5 GO:0016453 C-acetyltransferase activity(GO:0016453)
1.5 7.3 GO:0070644 vitamin D response element binding(GO:0070644)
1.4 40.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.4 24.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
1.4 8.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.4 1.4 GO:0051185 coenzyme transporter activity(GO:0051185)
1.4 19.6 GO:0016004 phospholipase activator activity(GO:0016004)
1.4 12.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.4 25.2 GO:0070064 proline-rich region binding(GO:0070064)
1.4 7.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
1.4 11.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.4 9.6 GO:0043426 MRF binding(GO:0043426)
1.4 83.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
1.4 8.1 GO:0047685 amine sulfotransferase activity(GO:0047685)
1.4 6.8 GO:0045134 uridine-diphosphatase activity(GO:0045134)
1.3 18.4 GO:0046527 glucosyltransferase activity(GO:0046527)
1.3 3.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
1.3 9.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.3 3.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
1.3 2.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.3 7.6 GO:0000400 four-way junction DNA binding(GO:0000400)
1.3 8.8 GO:0050786 RAGE receptor binding(GO:0050786)
1.3 3.8 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
1.3 78.1 GO:0051082 unfolded protein binding(GO:0051082)
1.2 97.1 GO:0008565 protein transporter activity(GO:0008565)
1.2 421.7 GO:0045296 cadherin binding(GO:0045296)
1.2 3.7 GO:0034452 dynactin binding(GO:0034452)
1.2 3.7 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
1.2 15.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.2 2.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
1.2 4.6 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
1.1 14.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.1 41.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
1.1 12.0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity(GO:0008757)
1.1 20.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.1 5.4 GO:0035497 cAMP response element binding(GO:0035497)
1.0 4.1 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
1.0 10.2 GO:0003680 AT DNA binding(GO:0003680)
1.0 12.2 GO:0043274 phospholipase binding(GO:0043274)
1.0 16.0 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
1.0 10.0 GO:0048406 nerve growth factor binding(GO:0048406)
1.0 6.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
1.0 151.2 GO:0005178 integrin binding(GO:0005178)
0.9 56.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.9 3.7 GO:0046790 virion binding(GO:0046790)
0.9 11.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.9 7.1 GO:0045545 syndecan binding(GO:0045545)
0.9 3.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.9 29.3 GO:0001972 retinoic acid binding(GO:0001972)
0.9 13.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.8 5.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.8 4.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.8 44.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.8 7.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.8 3.9 GO:0031708 endothelin B receptor binding(GO:0031708)
0.8 31.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.8 20.7 GO:0019956 chemokine binding(GO:0019956)
0.8 19.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.8 6.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.8 4.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.8 6.0 GO:0070403 NAD+ binding(GO:0070403)
0.7 6.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.7 4.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.7 4.3 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.7 2.8 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.7 2.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.7 8.3 GO:0008143 poly(A) binding(GO:0008143)
0.7 8.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 2.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.7 4.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.7 2.7 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.7 10.4 GO:0001968 fibronectin binding(GO:0001968)
0.6 21.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.6 4.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.6 7.4 GO:0031402 sodium ion binding(GO:0031402)
0.6 5.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.6 9.5 GO:0008301 DNA binding, bending(GO:0008301)
0.6 3.0 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.6 11.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.6 4.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.6 16.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.6 0.6 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.6 12.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.5 33.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5 2.7 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 2.7 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.5 13.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.5 9.0 GO:0017166 vinculin binding(GO:0017166)
0.5 4.6 GO:0043022 ribosome binding(GO:0043022)
0.5 6.0 GO:0070628 proteasome binding(GO:0070628)
0.5 8.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 8.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 1.5 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.5 2.9 GO:0098821 BMP receptor activity(GO:0098821)
0.5 34.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 2.8 GO:0017069 snRNA binding(GO:0017069)
0.5 7.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.5 7.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.5 14.1 GO:0005504 fatty acid binding(GO:0005504)
0.4 4.9 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.4 1.3 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.4 2.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.4 15.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.4 23.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.4 1.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 14.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 5.7 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.4 6.5 GO:0005112 Notch binding(GO:0005112)
0.4 4.8 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 12.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 3.1 GO:0042379 chemokine receptor binding(GO:0042379)
0.3 5.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 0.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 15.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 1.6 GO:0097016 L27 domain binding(GO:0097016)
0.3 13.2 GO:0050699 WW domain binding(GO:0050699)
0.3 1.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.3 8.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 1.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 0.9 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.3 0.9 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.3 1.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 7.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.3 3.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.9 GO:0051400 BH domain binding(GO:0051400)
0.2 1.7 GO:0000182 rDNA binding(GO:0000182)
0.2 2.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.2 2.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 0.8 GO:0005113 patched binding(GO:0005113)
0.2 4.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 1.8 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 11.9 GO:0019003 GDP binding(GO:0019003)
0.2 170.1 GO:0003723 RNA binding(GO:0003723)
0.2 4.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 0.4 GO:0015141 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.2 0.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 23.4 GO:0005125 cytokine activity(GO:0005125)
0.2 13.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.2 1.3 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 14.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 4.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 10.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.7 GO:0050436 microfibril binding(GO:0050436)
0.1 2.0 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 1.0 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.7 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.6 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 5.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.6 GO:0016829 lyase activity(GO:0016829)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.7 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.3 GO:0015295 solute:proton symporter activity(GO:0015295)
0.0 0.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
21.8 544.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
13.2 224.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
11.1 1541.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
6.8 27.2 PID IFNG PATHWAY IFN-gamma pathway
6.0 66.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
5.6 423.3 PID ILK PATHWAY Integrin-linked kinase signaling
5.5 82.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
4.6 187.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
4.4 216.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
4.3 865.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
4.0 313.8 PID E2F PATHWAY E2F transcription factor network
3.9 108.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
3.6 14.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
3.6 35.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
3.4 86.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
3.0 95.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
2.9 55.5 ST STAT3 PATHWAY STAT3 Pathway
2.9 121.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
2.6 33.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
2.5 225.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
2.3 82.0 PID BARD1 PATHWAY BARD1 signaling events
2.1 109.7 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
2.1 39.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
2.0 87.1 PID PLK1 PATHWAY PLK1 signaling events
2.0 104.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
1.9 3.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
1.9 94.8 PID CDC42 PATHWAY CDC42 signaling events
1.9 15.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.8 59.0 PID INSULIN PATHWAY Insulin Pathway
1.8 168.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
1.8 17.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
1.7 79.6 PID ATR PATHWAY ATR signaling pathway
1.7 5.0 PID EPO PATHWAY EPO signaling pathway
1.6 109.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
1.6 91.5 PID IL4 2PATHWAY IL4-mediated signaling events
1.6 83.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
1.6 75.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
1.6 39.4 PID RAC1 PATHWAY RAC1 signaling pathway
1.5 32.2 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
1.4 21.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.4 30.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.4 113.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
1.4 23.8 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
1.4 73.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.3 56.0 PID TELOMERASE PATHWAY Regulation of Telomerase
1.3 11.7 PID FAS PATHWAY FAS (CD95) signaling pathway
1.3 20.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
1.3 9.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
1.2 26.4 PID RHOA PATHWAY RhoA signaling pathway
1.2 13.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
1.2 34.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.1 20.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
1.1 7.8 PID REELIN PATHWAY Reelin signaling pathway
1.1 11.2 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
1.1 17.3 ST GAQ PATHWAY G alpha q Pathway
1.1 11.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
1.0 44.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.9 42.7 PID AP1 PATHWAY AP-1 transcription factor network
0.9 17.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.9 9.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.9 54.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.9 3.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.8 23.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.8 2.3 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.7 16.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.7 3.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.7 38.8 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.7 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.7 31.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.7 17.0 PID FOXO PATHWAY FoxO family signaling
0.6 10.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.5 5.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.5 16.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.5 5.9 PID CD40 PATHWAY CD40/CD40L signaling
0.5 8.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.5 27.1 PID CMYB PATHWAY C-MYB transcription factor network
0.4 14.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 10.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.4 5.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.4 5.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.4 5.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.4 7.9 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.4 9.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.4 3.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 23.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.3 6.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.3 12.4 PID NOTCH PATHWAY Notch signaling pathway
0.3 4.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 1.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.3 2.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 3.8 PID ATM PATHWAY ATM pathway
0.2 3.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 7.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 1.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 0.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
45.2 767.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
17.6 439.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
14.3 485.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
13.5 243.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
12.5 776.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
12.0 72.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
11.7 188.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
11.5 403.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
11.2 761.1 REACTOME G1 PHASE Genes involved in G1 Phase
11.1 66.8 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
10.7 85.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
9.4 365.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
9.4 28.1 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
9.1 81.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
8.5 382.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
8.1 292.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
8.0 223.5 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
7.6 683.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
6.9 194.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
6.9 82.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
6.8 102.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
6.7 560.1 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
6.5 182.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
6.4 153.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
6.3 145.3 REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX Genes involved in Assembly of the pre-replicative complex
6.1 103.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
5.7 131.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
5.7 67.8 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
5.1 81.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
5.1 495.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
4.9 156.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
4.9 578.2 REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
4.8 111.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
4.8 28.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
4.5 170.2 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
4.3 39.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
4.3 43.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
4.2 54.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
4.2 21.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
4.0 76.4 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
4.0 79.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
3.9 123.5 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
3.8 207.4 REACTOME TRANSLATION Genes involved in Translation
3.8 148.0 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
3.7 98.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
3.6 61.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
3.6 60.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
3.5 56.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
3.3 85.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
3.2 169.7 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
3.2 80.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
3.1 144.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
3.1 102.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
3.1 49.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
3.0 57.4 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
3.0 75.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
3.0 44.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
3.0 65.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
2.8 84.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
2.8 22.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
2.7 106.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
2.6 15.7 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
2.5 76.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
2.4 139.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.3 39.9 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
2.3 158.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.2 38.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
2.1 15.0 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
2.1 16.8 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
2.1 34.9 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
2.0 14.0 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
1.9 42.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.9 52.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.8 16.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
1.8 42.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
1.8 30.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
1.8 255.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7 104.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
1.7 42.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.7 23.4 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
1.7 50.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
1.6 36.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.6 16.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
1.6 15.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.6 18.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
1.6 53.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.6 10.9 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.5 52.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.5 11.9 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
1.5 62.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
1.4 138.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
1.4 54.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
1.4 30.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
1.4 9.7 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
1.4 22.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
1.3 138.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.3 9.0 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
1.2 66.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
1.2 4.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
1.1 23.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
1.1 25.0 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.1 42.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
1.0 27.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
1.0 4.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.0 10.6 REACTOME PROTEIN FOLDING Genes involved in Protein folding
1.0 13.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.9 3.8 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.9 14.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.9 16.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.9 16.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.9 56.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.9 7.0 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.8 5.9 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.8 5.0 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.8 16.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.8 20.8 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.8 6.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.7 78.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.7 87.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 7.9 REACTOME OPSINS Genes involved in Opsins
0.7 71.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.7 15.8 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.6 41.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 10.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.5 18.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.5 5.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.5 1.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 2.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.5 14.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.5 9.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.5 29.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.4 3.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4 29.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.4 3.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.4 22.5 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.4 7.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.4 23.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 4.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 3.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 24.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.3 23.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 1.3 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.2 2.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 0.9 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.2 5.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 3.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 3.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 13.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.0 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 1.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 2.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism