GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Gene Symbol | Gene ID | Gene Info |
---|---|---|
ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
MYC | hg19_v2_chr8_+_128748466_128748487, hg19_v2_chr8_+_128748308_128748330 | 0.79 | 7.1e-48 | Click! |
MYCN | hg19_v2_chr2_+_16080659_16080686 | -0.63 | 1.8e-25 | Click! |
MXI1 | hg19_v2_chr10_+_111985713_111985774, hg19_v2_chr10_+_111967345_111967442 | -0.34 | 1.9e-07 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.0 | 724.4 | GO:0006364 | rRNA processing(GO:0006364) |
8.1 | 558.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
5.7 | 537.3 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
7.2 | 519.9 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
95.6 | 478.1 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
76.6 | 459.4 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
9.9 | 406.0 | GO:0042407 | cristae formation(GO:0042407) |
49.3 | 394.7 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
43.5 | 391.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
52.4 | 367.0 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3242.0 | GO:0070062 | extracellular exosome(GO:0070062) |
33.4 | 601.3 | GO:0034709 | methylosome(GO:0034709) |
5.3 | 565.5 | GO:0015934 | large ribosomal subunit(GO:0015934) |
3.0 | 529.4 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
80.6 | 483.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
3.3 | 443.7 | GO:0016605 | PML body(GO:0016605) |
48.9 | 391.4 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
7.4 | 377.1 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
8.5 | 374.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
3.2 | 345.9 | GO:0005840 | ribosome(GO:0005840) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.5 | 1107.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
15.8 | 646.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
81.2 | 487.2 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
9.7 | 456.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
5.8 | 447.3 | GO:0005507 | copper ion binding(GO:0005507) |
1.2 | 421.7 | GO:0045296 | cadherin binding(GO:0045296) |
46.8 | 374.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
16.7 | 367.7 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
52.4 | 367.0 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
6.1 | 349.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
11.1 | 1541.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
4.3 | 865.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
21.8 | 544.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
5.6 | 423.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
4.0 | 313.8 | PID E2F PATHWAY | E2F transcription factor network |
2.5 | 225.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
13.2 | 224.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
4.4 | 216.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
4.6 | 187.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
1.8 | 168.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
12.5 | 776.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
45.2 | 767.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
11.2 | 761.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
7.6 | 683.9 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
4.9 | 578.2 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
6.7 | 560.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
5.1 | 495.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
14.3 | 485.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
17.6 | 439.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
11.5 | 403.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |