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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MYBL2

Z-value: 2.21

Motif logo

Transcription factors associated with MYBL2

Gene Symbol Gene ID Gene Info
ENSG00000101057.11 MYB proto-oncogene like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MYBL2hg19_v2_chr20_+_42295745_422957970.563.7e-19Click!

Activity profile of MYBL2 motif

Sorted Z-values of MYBL2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_14530143 91.68 ENST00000242776.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr14_+_54863739 87.65 ENST00000541304.1
cyclin-dependent kinase inhibitor 3
chr14_+_54863667 83.69 ENST00000335183.6
cyclin-dependent kinase inhibitor 3
chr14_+_54863682 81.32 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
cyclin-dependent kinase inhibitor 3
chr15_-_91537723 65.83 ENST00000394249.3
ENST00000559811.1
ENST00000442656.2
ENST00000557905.1
ENST00000361919.3
protein regulator of cytokinesis 1
chr12_-_57081940 61.64 ENST00000436399.2
prostaglandin E synthase 3 (cytosolic)
chr9_+_91926103 59.10 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr12_+_110906169 49.66 ENST00000377673.5
family with sequence similarity 216, member A
chr19_-_55919087 49.17 ENST00000587845.1
ENST00000589978.1
ENST00000264552.9
ubiquitin-conjugating enzyme E2S
chr17_-_38574169 44.46 ENST00000423485.1
topoisomerase (DNA) II alpha 170kDa
chr11_+_34073757 43.76 ENST00000532820.1
cell cycle associated protein 1
chr1_+_165796753 43.08 ENST00000367879.4
uridine-cytidine kinase 2
chr1_+_45205498 41.26 ENST00000372218.4
kinesin family member 2C
chr20_-_54967187 40.94 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr1_+_45205478 39.61 ENST00000452259.1
ENST00000372224.4
kinesin family member 2C
chr5_+_159848854 39.18 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr17_-_38978847 36.55 ENST00000269576.5
keratin 10
chr19_+_49496705 35.96 ENST00000595090.1
RuvB-like AAA ATPase 2
chr10_+_94352956 35.00 ENST00000260731.3
kinesin family member 11
chr5_+_159848807 34.21 ENST00000352433.5
pituitary tumor-transforming 1
chr3_-_64009658 33.81 ENST00000394431.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr1_+_43824669 32.10 ENST00000372462.1
cell division cycle 20
chr1_+_43824577 31.42 ENST00000310955.6
cell division cycle 20
chr12_-_110906027 30.36 ENST00000537466.2
ENST00000550974.1
ENST00000228827.3
GPN-loop GTPase 3
chr11_+_18433840 29.78 ENST00000541669.1
ENST00000280704.4
lactate dehydrogenase C
chr20_+_55926583 29.55 ENST00000395840.2
ribonucleic acid export 1
chr19_+_49496782 29.31 ENST00000601968.1
ENST00000596837.1
RuvB-like AAA ATPase 2
chr8_-_121457332 28.50 ENST00000518918.1
mitochondrial ribosomal protein L13
chr3_-_64009102 27.95 ENST00000478185.1
ENST00000482510.1
ENST00000497323.1
ENST00000492933.1
ENST00000295901.4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr1_-_197115818 27.44 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr11_+_65769550 27.08 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
barrier to autointegration factor 1
chr19_-_8070474 26.33 ENST00000407627.2
ENST00000593807.1
ELAV like RNA binding protein 1
chr22_-_42342692 26.01 ENST00000404067.1
ENST00000402338.1
centromere protein M
chr7_+_73097890 25.56 ENST00000265758.2
ENST00000423166.2
ENST00000423497.1
Williams Beuren syndrome chromosome region 22
chr20_+_55926274 25.21 ENST00000371242.2
ENST00000527947.1
ribonucleic acid export 1
chr17_-_79481666 25.13 ENST00000575659.1
actin, gamma 1
chr12_+_50144381 24.83 ENST00000552370.1
transmembrane BAX inhibitor motif containing 6
chr11_+_65769946 24.80 ENST00000533166.1
barrier to autointegration factor 1
chr2_+_48010221 24.62 ENST00000234420.5
mutS homolog 6
chr11_-_14541872 24.58 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
proteasome (prosome, macropain) subunit, alpha type, 1
chr18_+_3447572 24.55 ENST00000548489.2
TGFB-induced factor homeobox 1
chr17_+_7155556 24.42 ENST00000570500.1
ENST00000574993.1
ENST00000396628.2
ENST00000573657.1
elongator acetyltransferase complex subunit 5
chr11_-_47664072 24.36 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
mitochondrial carrier 2
chr12_-_57082060 24.33 ENST00000448157.2
ENST00000414274.3
ENST00000262033.6
ENST00000456859.2
prostaglandin E synthase 3 (cytosolic)
chr5_+_170814803 24.23 ENST00000521672.1
ENST00000351986.6
ENST00000393820.2
ENST00000523622.1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr1_+_236558694 23.62 ENST00000359362.5
EDAR-associated death domain
chr4_-_77069573 22.96 ENST00000264883.3
nucleoporin 54kDa
chr17_+_7155819 22.67 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
elongator acetyltransferase complex subunit 5
chr7_+_23146271 22.02 ENST00000545771.1
kelch-like family member 7
chr8_-_67974552 21.80 ENST00000357849.4
COP9 signalosome subunit 5
chr1_-_108735440 21.68 ENST00000370041.4
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr1_+_212208919 21.61 ENST00000366991.4
ENST00000542077.1
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr4_-_77069533 21.50 ENST00000514987.1
ENST00000458189.2
ENST00000514901.1
ENST00000342467.6
nucleoporin 54kDa
chr2_-_128784846 21.39 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
Sin3A-associated protein, 130kDa
chr1_-_156308018 21.14 ENST00000496684.2
ENST00000368259.2
ENST00000368261.3
ENST00000472765.2
ENST00000533194.1
ENST00000478640.2
chaperonin containing TCP1, subunit 3 (gamma)
chr2_-_27632390 21.07 ENST00000350803.4
ENST00000344034.4
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr1_+_91966384 20.87 ENST00000430031.2
ENST00000234626.6
cell division cycle 7
chr12_-_46662772 20.70 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
solute carrier family 38, member 1
chr5_-_68665815 20.67 ENST00000380818.3
ENST00000328663.4
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr8_-_121457608 20.59 ENST00000306185.3
mitochondrial ribosomal protein L13
chr2_+_47630255 19.98 ENST00000406134.1
mutS homolog 2
chr14_-_105487381 19.63 ENST00000392590.3
ENST00000336219.3
cell division cycle associated 4
chr22_+_41258250 19.45 ENST00000544094.1
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr15_+_80364901 19.41 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
zinc finger, AN1-type domain 6
chr16_-_57481278 19.33 ENST00000567751.1
ENST00000568940.1
ENST00000563341.1
ENST00000565961.1
ENST00000569370.1
ENST00000567518.1
ENST00000565786.1
ENST00000394391.4
cytokine induced apoptosis inhibitor 1
chr17_+_76210267 19.33 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
baculoviral IAP repeat containing 5
chr8_-_67976509 19.18 ENST00000518747.1
COP9 signalosome subunit 5
chr17_+_7155343 19.07 ENST00000573513.1
ENST00000354429.2
ENST00000574255.1
ENST00000396627.2
ENST00000356683.2
elongator acetyltransferase complex subunit 5
chr19_-_1095330 19.05 ENST00000586746.1
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr11_-_102323489 18.73 ENST00000361236.3
transmembrane protein 123
chr2_+_47630108 18.57 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
mutS homolog 2
chr11_+_34073872 18.49 ENST00000530820.1
cell cycle associated protein 1
chrX_+_49028265 18.29 ENST00000376322.3
ENST00000376327.5
proteolipid protein 2 (colonic epithelium-enriched)
chr6_-_42981651 18.19 ENST00000244711.3
male-enhanced antigen 1
chr5_-_43557791 17.86 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
poly(A) binding protein interacting protein 1
chr13_+_98628886 17.60 ENST00000490680.1
ENST00000539640.1
ENST00000403772.3
importin 5
chr17_+_30677136 17.58 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
zinc finger protein 207
chr7_+_99006550 17.56 ENST00000222969.5
BUD31 homolog (S. cerevisiae)
chr13_+_53030107 17.44 ENST00000490903.1
ENST00000480747.1
cytoskeleton associated protein 2
chr9_-_113018835 17.26 ENST00000374517.5
thioredoxin
chr17_+_66511540 17.20 ENST00000588188.2
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr11_+_18417813 17.00 ENST00000540430.1
ENST00000379412.5
lactate dehydrogenase A
chr21_-_33984456 16.93 ENST00000431216.1
ENST00000553001.1
ENST00000440966.1
Uncharacterized protein
chromosome 21 open reading frame 59
chr17_+_7210898 16.83 ENST00000572815.1
eukaryotic translation initiation factor 5A
chr1_-_24306835 16.81 ENST00000484146.2
serine/arginine-rich splicing factor 10
chr17_-_40075197 16.75 ENST00000590770.1
ENST00000590151.1
ATP citrate lyase
chr7_+_23145884 16.71 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr1_+_91966656 16.68 ENST00000428239.1
ENST00000426137.1
cell division cycle 7
chr11_-_82997013 16.67 ENST00000529073.1
ENST00000529611.1
coiled-coil domain containing 90B
chr15_-_44116873 16.65 ENST00000267812.3
microfibrillar-associated protein 1
chr11_+_34073269 16.58 ENST00000389645.3
cell cycle associated protein 1
chr7_-_72993033 16.51 ENST00000305632.5
transducin (beta)-like 2
chrX_-_140786896 16.38 ENST00000370515.3
SPANX family, member D
chr11_-_14380664 16.38 ENST00000545643.1
ENST00000256196.4
related RAS viral (r-ras) oncogene homolog 2
chr12_+_53848549 16.38 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
poly(rC) binding protein 2
chr7_-_127983877 16.37 ENST00000415472.2
ENST00000478061.1
ENST00000223073.2
ENST00000459726.1
RNA binding motif protein 28
chr6_+_36562132 16.27 ENST00000373715.6
ENST00000339436.7
serine/arginine-rich splicing factor 3
chr2_-_174828892 16.15 ENST00000418194.2
Sp3 transcription factor
chr6_+_30687978 15.87 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chr1_-_26232522 15.80 ENST00000399728.1
stathmin 1
chr6_+_34725181 15.80 ENST00000244520.5
small nuclear ribonucleoprotein polypeptide C
chr8_+_6565854 15.73 ENST00000285518.6
1-acylglycerol-3-phosphate O-acyltransferase 5
chr21_-_46237883 15.60 ENST00000397893.3
small ubiquitin-like modifier 3
chr11_-_102323740 15.54 ENST00000398136.2
transmembrane protein 123
chr3_+_52740094 15.54 ENST00000602728.1
signal peptidase complex subunit 1 homolog (S. cerevisiae)
chr17_-_17184605 15.50 ENST00000268717.5
COP9 signalosome subunit 3
chr2_-_26101374 15.48 ENST00000435504.4
additional sex combs like 2 (Drosophila)
chr9_+_116037922 15.27 ENST00000374198.4
pre-mRNA processing factor 4
chr12_-_14956396 15.26 ENST00000535328.1
ENST00000261167.2
WW domain binding protein 11
chr21_-_33984888 15.16 ENST00000382549.4
ENST00000540881.1
chromosome 21 open reading frame 59
chr7_-_129592471 15.04 ENST00000473814.2
ENST00000490974.1
ubiquitin-conjugating enzyme E2H
chr21_-_33985127 14.96 ENST00000290155.3
chromosome 21 open reading frame 59
chr21_-_33975547 14.93 ENST00000431599.1
chromosome 21 open reading frame 59
chr17_-_40075219 14.71 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ATP citrate lyase
chr9_-_70488865 14.54 ENST00000377392.5
COBW domain containing 5
chr7_+_99006232 14.53 ENST00000403633.2
BUD31 homolog (S. cerevisiae)
chr4_-_57687847 14.40 ENST00000504762.1
ENST00000248701.4
ENST00000506738.1
serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
chr21_-_33984865 14.25 ENST00000458138.1
chromosome 21 open reading frame 59
chr14_-_75530693 13.92 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
acylphosphatase 1, erythrocyte (common) type
chr2_-_203776864 13.85 ENST00000261015.4
WD repeat domain 12
chr12_-_6961050 13.80 ENST00000538862.2
cell division cycle associated 3
chr8_-_25315905 13.80 ENST00000221200.4
potassium channel tetramerization domain containing 9
chr1_+_43148059 13.79 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr1_+_46049706 13.53 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
nuclear autoantigenic sperm protein (histone-binding)
chr1_-_155990580 13.46 ENST00000531917.1
ENST00000480567.1
ENST00000526212.1
ENST00000529008.1
ENST00000496742.1
ENST00000295702.4
signal sequence receptor, beta (translocon-associated protein beta)
chr22_-_42343117 13.41 ENST00000407253.3
ENST00000215980.5
centromere protein M
chr3_-_165555200 13.36 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
butyrylcholinesterase
chr2_-_55496174 13.29 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
mitochondrial translational initiation factor 2
chr17_+_76210367 13.25 ENST00000592734.1
ENST00000587746.1
baculoviral IAP repeat containing 5
chr2_+_48010312 13.24 ENST00000540021.1
mutS homolog 6
chr18_+_3448455 13.22 ENST00000549780.1
TGFB-induced factor homeobox 1
chr8_-_124054362 13.20 ENST00000405944.3
derlin 1
chr14_-_75536182 13.07 ENST00000555463.1
acylphosphatase 1, erythrocyte (common) type
chr3_-_185655795 13.07 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
transformer 2 beta homolog (Drosophila)
chr21_-_15755446 13.05 ENST00000544452.1
ENST00000285667.3
heat shock protein 70kDa family, member 13
chrX_-_135962876 12.96 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RNA binding motif protein, X-linked
chr17_-_80231300 12.95 ENST00000398519.5
ENST00000580446.1
casein kinase 1, delta
chr11_-_82997420 12.85 ENST00000455220.2
ENST00000529689.1
coiled-coil domain containing 90B
chrX_-_153775426 12.81 ENST00000393562.2
glucose-6-phosphate dehydrogenase
chr19_-_47354082 12.76 ENST00000593442.1
ENST00000263270.6
adaptor-related protein complex 2, sigma 1 subunit
chr10_+_70661014 12.63 ENST00000373585.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr7_+_98476095 12.59 ENST00000359863.4
ENST00000355540.3
transformation/transcription domain-associated protein
chr3_+_138340049 12.55 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr11_-_28129656 12.52 ENST00000263181.6
kinesin family member 18A
chr5_-_43557129 12.39 ENST00000514514.1
ENST00000504075.1
ENST00000306846.3
ENST00000436644.2
poly(A) binding protein interacting protein 1
chr2_-_26101314 12.32 ENST00000336112.4
ENST00000272341.4
additional sex combs like 2 (Drosophila)
chrX_-_129299638 12.32 ENST00000535724.1
ENST00000346424.2
apoptosis-inducing factor, mitochondrion-associated, 1
chr18_+_55888767 12.31 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr8_-_124054484 12.31 ENST00000419562.2
derlin 1
chr1_-_247094628 12.29 ENST00000366508.1
ENST00000326225.3
ENST00000391829.2
AT hook containing transcription factor 1
chr12_-_49075941 12.19 ENST00000553086.1
ENST00000548304.1
KAT8 regulatory NSL complex subunit 2
chr17_-_1588101 11.97 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
pre-mRNA processing factor 8
chr13_+_25670268 11.92 ENST00000281589.3
poly(A) binding protein, cytoplasmic 3
chr19_+_59055814 11.87 ENST00000594806.1
ENST00000253024.5
ENST00000341753.6
tripartite motif containing 28
chr4_+_17812525 11.78 ENST00000251496.2
non-SMC condensin I complex, subunit G
chr2_+_223725652 11.73 ENST00000357430.3
ENST00000392066.3
acyl-CoA synthetase long-chain family member 3
chr15_-_55489097 11.64 ENST00000260443.4
ribosomal L24 domain containing 1
chr4_-_140223670 11.61 ENST00000394228.1
ENST00000539387.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr22_+_32871224 11.53 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
F-box protein 7
chr15_-_89010607 11.46 ENST00000312475.4
mitochondrial ribosomal protein L46
chr19_-_47354023 11.44 ENST00000601649.1
ENST00000599990.1
ENST00000352203.4
adaptor-related protein complex 2, sigma 1 subunit
chr3_+_112709804 11.44 ENST00000383677.3
GTP-binding protein 8 (putative)
chr3_+_52444651 11.42 ENST00000327906.3
PHD finger protein 7
chr6_-_35888824 11.41 ENST00000361690.3
ENST00000512445.1
SRSF protein kinase 1
chr16_+_66586461 11.35 ENST00000264001.4
ENST00000351137.4
ENST00000345436.4
ENST00000362093.4
ENST00000417030.2
ENST00000527729.1
ENST00000532838.1
chemokine-like factor
CKLF-CMTM1 readthrough
chr11_+_34073195 11.34 ENST00000341394.4
cell cycle associated protein 1
chr3_+_150321068 11.30 ENST00000471696.1
ENST00000477889.1
ENST00000485923.1
Selenoprotein T
chr7_-_148581360 11.23 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
enhancer of zeste homolog 2 (Drosophila)
chr10_+_103892787 11.15 ENST00000278070.2
ENST00000413464.2
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr4_+_110736659 11.08 ENST00000394631.3
ENST00000226796.6
GAR1 ribonucleoprotein
chr7_+_24612935 10.91 ENST00000222644.5
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr5_-_176943917 10.87 ENST00000330503.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
chr1_-_110950255 10.85 ENST00000483260.1
ENST00000474861.2
ENST00000602318.1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr16_-_56485257 10.84 ENST00000300291.5
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr13_-_23949671 10.82 ENST00000402364.1
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr6_+_150070857 10.82 ENST00000544496.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr15_+_89010923 10.71 ENST00000353598.6
mitochondrial ribosomal protein S11
chr12_+_6603253 10.65 ENST00000382457.4
ENST00000545962.1
non-SMC condensin I complex, subunit D2
chr17_-_29233769 10.63 ENST00000581216.1
transcription elongation factor, mitochondrial
chr9_-_130637244 10.60 ENST00000373156.1
adenylate kinase 1
chr4_-_140223614 10.60 ENST00000394223.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr1_-_39339777 10.50 ENST00000397572.2
MYC binding protein
chr14_-_21737551 10.45 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr3_+_107241783 10.44 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
bobby sox homolog (Drosophila)
chr5_-_137667459 10.41 ENST00000415130.2
ENST00000356505.3
ENST00000357274.3
ENST00000348983.3
ENST00000323760.6
cell division cycle 25C
chr7_-_42971759 10.34 ENST00000538645.1
ENST00000445517.1
ENST00000223321.4
proteasome (prosome, macropain) subunit, alpha type, 2
chr6_-_43595039 10.06 ENST00000307114.7
GTP binding protein 2
chr12_-_123011536 10.05 ENST00000331738.7
ENST00000354654.2
arginine/serine-rich coiled-coil 2
chr17_+_45608430 10.01 ENST00000322157.4
aminopeptidase puromycin sensitive
chr13_-_19755975 9.99 ENST00000400113.3
tubulin, alpha 3c
chr17_-_62502639 9.91 ENST00000225792.5
ENST00000581697.1
ENST00000584279.1
ENST00000577922.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chrX_+_67718863 9.85 ENST00000374622.2
Yip1 domain family, member 6
chr10_+_5726764 9.83 ENST00000328090.5
ENST00000496681.1
family with sequence similarity 208, member B
chr15_-_101835414 9.66 ENST00000254193.6
small nuclear ribonucleoprotein polypeptide A'
chr14_-_21737610 9.65 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr10_+_75936444 9.61 ENST00000372734.3
ENST00000541550.1
adenosine kinase
chr1_-_46152174 9.54 ENST00000290795.3
ENST00000355105.3
GC-rich promoter binding protein 1-like 1
chr16_+_20817761 9.49 ENST00000568046.1
ENST00000261377.6
Putative RNA exonuclease NEF-sp
chr20_-_45981138 9.45 ENST00000446994.2
zinc finger, MYND-type containing 8
chr10_+_70091847 9.41 ENST00000441000.2
ENST00000354695.5
heterogeneous nuclear ribonucleoprotein H3 (2H9)

Network of associatons between targets according to the STRING database.

First level regulatory network of MYBL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.3 65.3 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
15.8 47.3 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
13.6 40.9 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
11.1 44.5 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
10.8 43.1 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
10.1 30.4 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
8.5 76.4 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
8.1 80.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
6.7 93.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
6.1 49.1 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
5.5 27.4 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
5.5 54.8 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
5.4 32.4 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
5.3 32.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
5.0 29.8 GO:0019249 lactate biosynthetic process(GO:0019249)
4.9 44.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
4.7 37.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
4.6 18.4 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
4.5 13.4 GO:0014016 neuroblast differentiation(GO:0014016)
4.4 8.9 GO:0044211 CTP salvage(GO:0044211)
4.4 8.8 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
4.3 51.9 GO:0015074 DNA integration(GO:0015074)
4.3 12.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
4.0 11.9 GO:1901535 regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) regulation of genetic imprinting(GO:2000653)
3.9 11.7 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
3.9 7.7 GO:0097695 establishment of RNA localization to telomere(GO:0097694) establishment of macromolecular complex localization to telomere(GO:0097695)
3.8 34.1 GO:0030091 protein repair(GO:0030091)
3.7 11.2 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
3.7 63.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
3.5 56.5 GO:0000338 protein deneddylation(GO:0000338)
3.5 65.8 GO:0000022 mitotic spindle elongation(GO:0000022)
3.3 90.2 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
3.3 13.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
3.2 9.6 GO:0044209 AMP salvage(GO:0044209)
3.2 373.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
3.2 15.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
3.0 12.2 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
3.0 14.8 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
2.9 11.6 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
2.9 8.6 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
2.7 21.7 GO:0015866 ADP transport(GO:0015866)
2.7 16.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
2.7 24.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
2.5 27.8 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
2.5 4.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.5 12.3 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
2.5 12.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
2.4 94.6 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
2.1 34.3 GO:0045793 positive regulation of cell size(GO:0045793)
2.1 31.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
2.1 6.3 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
2.1 6.2 GO:0046521 sphingoid catabolic process(GO:0046521)
2.1 20.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
2.0 6.0 GO:0071048 generation of catalytic spliceosome for second transesterification step(GO:0000350) nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
2.0 6.0 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
2.0 13.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.9 13.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.9 7.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
1.9 17.0 GO:0006089 lactate metabolic process(GO:0006089)
1.9 7.5 GO:0021564 vagus nerve development(GO:0021564)
1.9 97.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
1.9 5.6 GO:0019482 purine nucleobase catabolic process(GO:0006145) beta-alanine metabolic process(GO:0019482)
1.9 46.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.8 7.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
1.8 35.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
1.8 7.3 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
1.8 38.3 GO:0046931 pore complex assembly(GO:0046931)
1.8 32.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.8 23.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.8 14.4 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
1.7 27.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
1.7 15.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
1.7 5.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
1.7 8.3 GO:0000710 meiotic mismatch repair(GO:0000710)
1.7 13.3 GO:0032790 ribosome disassembly(GO:0032790)
1.6 3.2 GO:1903423 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
1.6 11.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
1.6 44.1 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.6 9.4 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
1.6 17.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
1.5 4.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.5 21.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.5 22.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
1.5 7.4 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
1.4 24.2 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
1.4 21.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
1.4 2.8 GO:0051684 maintenance of Golgi location(GO:0051684)
1.4 30.2 GO:0048255 mRNA stabilization(GO:0048255)
1.3 4.0 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.3 6.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.3 6.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 7.6 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
1.3 7.6 GO:0001880 Mullerian duct regression(GO:0001880)
1.3 8.8 GO:0089700 protein kinase D signaling(GO:0089700)
1.2 7.5 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
1.2 3.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.2 10.6 GO:0006264 mitochondrial DNA replication(GO:0006264)
1.2 4.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.2 13.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
1.1 5.5 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) negative regulation by host of symbiont molecular function(GO:0052405)
1.1 3.2 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
1.1 6.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
1.1 5.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
1.0 15.7 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
1.0 5.1 GO:0070980 biphenyl catabolic process(GO:0070980)
1.0 13.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.0 3.0 GO:0060437 lung growth(GO:0060437)
1.0 7.9 GO:0019695 choline metabolic process(GO:0019695)
1.0 95.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.9 2.8 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.9 36.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.9 3.7 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.9 3.6 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.9 16.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.9 19.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.9 5.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.9 8.7 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.8 9.8 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.8 18.8 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.8 22.1 GO:0003094 glomerular filtration(GO:0003094)
0.8 5.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.8 8.7 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.8 15.5 GO:0006465 signal peptide processing(GO:0006465)
0.8 5.4 GO:0048511 rhythmic process(GO:0048511)
0.8 6.1 GO:0010624 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.8 6.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.7 6.4 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.7 2.1 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) response to hypobaric hypoxia(GO:1990910)
0.7 2.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.7 25.9 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.7 3.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.7 50.0 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.7 29.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.7 10.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.7 6.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.7 4.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.7 5.3 GO:0015693 magnesium ion transport(GO:0015693)
0.6 2.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.6 12.6 GO:0016578 histone deubiquitination(GO:0016578)
0.6 12.9 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.6 9.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.6 21.6 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.6 21.8 GO:1902475 neutral amino acid transport(GO:0015804) L-alpha-amino acid transmembrane transport(GO:1902475)
0.6 1.1 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.5 8.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 4.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.5 14.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.5 13.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.5 4.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.5 1.9 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.5 26.8 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.5 2.7 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.4 0.9 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.4 2.2 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.4 1.8 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.4 5.2 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.4 1.7 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.4 6.3 GO:0042100 B cell proliferation(GO:0042100)
0.4 2.9 GO:0008218 bioluminescence(GO:0008218)
0.4 1.2 GO:0070233 regulation of T cell apoptotic process(GO:0070232) negative regulation of T cell apoptotic process(GO:0070233) regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.4 4.1 GO:0010265 SCF complex assembly(GO:0010265)
0.4 25.5 GO:0018149 peptide cross-linking(GO:0018149)
0.4 1.9 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.4 6.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.4 12.5 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.4 4.1 GO:0030656 regulation of vitamin metabolic process(GO:0030656)
0.4 2.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 2.6 GO:0048318 axial mesoderm development(GO:0048318)
0.4 3.7 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.4 5.1 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.4 16.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.4 1.4 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.3 4.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.3 6.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 12.2 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.3 1.6 GO:1901906 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 20.2 GO:0001895 retina homeostasis(GO:0001895)
0.3 1.1 GO:0010454 negative regulation of cell fate commitment(GO:0010454) mammary gland bud morphogenesis(GO:0060648) regulation of determination of dorsal identity(GO:2000015)
0.3 10.6 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.3 8.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.3 16.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 15.9 GO:0051225 spindle assembly(GO:0051225)
0.2 10.0 GO:0043171 peptide catabolic process(GO:0043171)
0.2 4.2 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.2 14.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 14.1 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.2 3.5 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 11.5 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 9.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 3.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 9.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 7.8 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.2 5.7 GO:0016071 mRNA metabolic process(GO:0016071)
0.2 5.3 GO:0006298 mismatch repair(GO:0006298)
0.2 0.9 GO:0002002 regulation of angiotensin levels in blood(GO:0002002) angiotensin maturation(GO:0002003) regulation of angiotensin metabolic process(GO:0060177)
0.2 4.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.4 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 1.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 2.2 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 1.9 GO:0045116 protein neddylation(GO:0045116)
0.1 2.8 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.9 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.1 9.7 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 1.3 GO:0017145 stem cell division(GO:0017145)
0.1 2.6 GO:0016486 peptide hormone processing(GO:0016486)
0.1 8.3 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 2.3 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.1 11.0 GO:0006334 nucleosome assembly(GO:0006334)
0.1 4.2 GO:0035987 endodermal cell differentiation(GO:0035987)
0.1 3.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.5 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.1 3.2 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.1 1.8 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 0.7 GO:0007566 embryo implantation(GO:0007566)
0.1 0.6 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 0.6 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 1.4 GO:0001502 cartilage condensation(GO:0001502)
0.1 8.6 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 3.9 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 3.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 1.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 8.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 2.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 7.6 GO:0070585 protein localization to mitochondrion(GO:0070585)
0.0 1.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.6 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 0.5 GO:0051028 mRNA transport(GO:0051028)
0.0 0.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.7 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.1 GO:0035801 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) visceral serous pericardium development(GO:0061032) posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.0 0.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.4 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 2.2 GO:0002576 platelet degranulation(GO:0002576)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
19.1 76.4 GO:0032301 MutSalpha complex(GO:0032301)
14.8 44.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
9.2 73.5 GO:0032133 chromosome passenger complex(GO:0032133)
8.1 32.4 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
7.4 66.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
6.9 69.4 GO:0070938 contractile ring(GO:0070938)
6.5 65.3 GO:0097255 R2TP complex(GO:0097255)
5.9 82.2 GO:0097431 mitotic spindle pole(GO:0097431)
4.1 124.2 GO:0005680 anaphase-promoting complex(GO:0005680)
3.8 15.3 GO:0071001 U4/U6 snRNP(GO:0071001)
3.7 33.3 GO:0000125 PCAF complex(GO:0000125)
3.3 117.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
3.0 27.0 GO:0031616 spindle pole centrosome(GO:0031616)
2.9 34.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.7 21.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.7 10.7 GO:0000799 nuclear condensin complex(GO:0000799)
2.6 71.1 GO:0035371 microtubule plus-end(GO:0035371)
2.4 40.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
2.3 13.9 GO:0070545 PeBoW complex(GO:0070545)
2.3 13.8 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
2.2 15.5 GO:0005787 signal peptidase complex(GO:0005787)
2.2 10.9 GO:0071986 Ragulator complex(GO:0071986)
2.1 12.5 GO:1990023 mitotic spindle midzone(GO:1990023)
2.0 6.0 GO:0071020 post-spliceosomal complex(GO:0071020)
2.0 11.8 GO:0000796 condensin complex(GO:0000796)
1.9 29.2 GO:0005641 nuclear envelope lumen(GO:0005641)
1.9 5.8 GO:1903349 omegasome membrane(GO:1903349)
1.9 61.8 GO:0005838 proteasome regulatory particle(GO:0005838)
1.9 11.5 GO:1990037 Lewy body core(GO:1990037)
1.9 35.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.6 41.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
1.6 4.7 GO:0031213 RSF complex(GO:0031213)
1.6 20.2 GO:0097433 dense body(GO:0097433)
1.6 4.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.5 10.8 GO:0070852 cell body fiber(GO:0070852)
1.5 7.4 GO:0045323 interleukin-1 receptor complex(GO:0045323)
1.5 33.7 GO:0071141 SMAD protein complex(GO:0071141)
1.4 25.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.4 15.8 GO:0000243 commitment complex(GO:0000243)
1.4 70.0 GO:0005876 spindle microtubule(GO:0005876)
1.4 10.8 GO:0042382 paraspeckles(GO:0042382)
1.3 24.2 GO:0036020 endolysosome membrane(GO:0036020)
1.3 75.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.2 8.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
1.2 3.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
1.1 70.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
1.1 5.5 GO:0005726 perichromatin fibrils(GO:0005726)
1.0 5.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
1.0 197.5 GO:0005681 spliceosomal complex(GO:0005681)
1.0 39.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.9 17.2 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.9 41.2 GO:0045171 intercellular bridge(GO:0045171)
0.8 21.4 GO:0070822 Sin3-type complex(GO:0070822)
0.8 12.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 8.9 GO:0045120 pronucleus(GO:0045120)
0.7 2.9 GO:0097413 Lewy body(GO:0097413)
0.7 7.6 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.7 7.5 GO:0005614 interstitial matrix(GO:0005614)
0.7 4.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.7 5.3 GO:0032389 MutLalpha complex(GO:0032389)
0.6 38.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.6 5.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.6 8.7 GO:0008091 spectrin(GO:0008091)
0.6 8.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.6 13.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.6 2.8 GO:0032449 CBM complex(GO:0032449)
0.6 23.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 6.8 GO:0097470 ribbon synapse(GO:0097470)
0.5 3.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 25.5 GO:0001533 cornified envelope(GO:0001533)
0.5 4.2 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.4 7.5 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.4 10.7 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 4.2 GO:0070187 telosome(GO:0070187)
0.4 2.8 GO:0033269 internode region of axon(GO:0033269)
0.4 15.5 GO:0008180 COP9 signalosome(GO:0008180)
0.3 35.9 GO:0000776 kinetochore(GO:0000776)
0.3 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 11.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 8.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 49.9 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.3 1.5 GO:0005899 insulin receptor complex(GO:0005899)
0.3 1.8 GO:1902560 GMP reductase complex(GO:1902560)
0.3 12.3 GO:0005771 multivesicular body(GO:0005771)
0.3 26.9 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.3 6.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 5.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 16.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 8.8 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.3 3.2 GO:0032433 filopodium tip(GO:0032433)
0.3 1.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.3 214.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 12.5 GO:0031672 A band(GO:0031672)
0.2 16.2 GO:0005643 nuclear pore(GO:0005643)
0.2 2.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 0.9 GO:0032009 early phagosome(GO:0032009)
0.2 8.8 GO:0005801 cis-Golgi network(GO:0005801)
0.2 15.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 6.4 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 7.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.2 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.1 68.8 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.1 15.5 GO:0031968 organelle outer membrane(GO:0031968)
0.1 12.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 22.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 13.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 8.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.1 1.0 GO:0005579 membrane attack complex(GO:0005579)
0.1 3.6 GO:0032590 dendrite membrane(GO:0032590)
0.1 3.2 GO:0045095 keratin filament(GO:0045095)
0.1 10.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.2 GO:0005605 basal lamina(GO:0005605)
0.1 4.2 GO:0005811 lipid particle(GO:0005811)
0.1 1.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 2.4 GO:0043034 costamere(GO:0043034)
0.1 4.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.0 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 2.9 GO:0005901 caveola(GO:0005901)
0.0 4.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 2.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 79.4 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 3.2 GO:0031966 mitochondrial membrane(GO:0031966)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 86.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
19.1 76.4 GO:0032143 single thymine insertion binding(GO:0032143)
14.8 44.5 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
10.9 65.3 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
10.6 63.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
10.1 80.9 GO:0019237 centromeric DNA binding(GO:0019237)
8.4 59.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
7.4 51.9 GO:0004849 uridine kinase activity(GO:0004849)
6.6 32.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
6.3 31.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
6.2 43.5 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
6.0 18.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
5.6 16.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
5.4 244.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
5.3 15.8 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
4.5 40.9 GO:0035174 histone serine kinase activity(GO:0035174)
4.5 27.0 GO:0003998 acylphosphatase activity(GO:0003998)
4.3 12.8 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
4.2 21.2 GO:0033265 choline binding(GO:0033265)
4.1 24.8 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
4.1 41.0 GO:0019784 NEDD8-specific protease activity(GO:0019784)
4.0 28.1 GO:0050733 RS domain binding(GO:0050733)
3.9 23.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
3.5 20.9 GO:0035500 MH2 domain binding(GO:0035500)
3.1 12.5 GO:0032038 myosin II heavy chain binding(GO:0032038)
2.7 21.7 GO:0005347 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
2.7 10.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
2.6 36.5 GO:0030280 structural constituent of epidermis(GO:0030280)
2.5 30.6 GO:0031386 protein tag(GO:0031386)
2.5 17.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
2.2 8.8 GO:0038025 glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)
2.2 15.3 GO:0030621 U4 snRNA binding(GO:0030621)
2.0 6.0 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
1.9 7.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
1.9 7.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.8 11.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
1.8 30.2 GO:0008494 translation activator activity(GO:0008494)
1.7 8.7 GO:0010465 nerve growth factor receptor activity(GO:0010465)
1.6 51.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.6 23.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
1.5 20.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.5 12.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
1.5 67.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.5 11.9 GO:0070087 chromo shadow domain binding(GO:0070087)
1.5 43.0 GO:0070410 co-SMAD binding(GO:0070410)
1.5 20.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.4 25.9 GO:0001054 RNA polymerase I activity(GO:0001054)
1.4 40.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.4 4.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
1.4 4.1 GO:0015235 cobalamin transporter activity(GO:0015235)
1.3 10.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.3 104.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.3 24.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
1.3 17.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
1.3 20.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.2 11.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.2 63.8 GO:0019894 kinesin binding(GO:0019894)
1.2 8.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
1.2 34.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.2 16.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.1 5.5 GO:0001849 complement component C1q binding(GO:0001849)
1.1 4.3 GO:0047718 enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
1.1 9.7 GO:0030620 U2 snRNA binding(GO:0030620)
1.1 4.3 GO:0019003 GDP binding(GO:0019003)
1.1 10.6 GO:0004017 adenylate kinase activity(GO:0004017)
1.0 6.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
1.0 20.7 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
1.0 6.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.0 13.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.0 6.8 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.0 9.6 GO:0019206 nucleoside kinase activity(GO:0019206)
0.9 19.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.9 6.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.9 8.7 GO:0042731 PH domain binding(GO:0042731)
0.9 32.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.9 55.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.9 17.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.8 21.7 GO:0070717 poly-purine tract binding(GO:0070717)
0.8 23.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.8 3.2 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.8 13.7 GO:0017091 AU-rich element binding(GO:0017091)
0.8 15.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.7 3.7 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.7 13.8 GO:0097602 cullin family protein binding(GO:0097602)
0.7 10.8 GO:0070628 proteasome binding(GO:0070628)
0.7 12.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.7 15.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.7 3.6 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity(GO:0004306)
0.7 70.4 GO:0043130 ubiquitin binding(GO:0043130)
0.7 2.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.7 28.2 GO:0050699 WW domain binding(GO:0050699)
0.7 11.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.6 21.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 21.5 GO:0001671 ATPase activator activity(GO:0001671)
0.6 5.5 GO:0008144 drug binding(GO:0008144)
0.6 36.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.6 3.4 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.5 18.3 GO:0019956 chemokine binding(GO:0019956)
0.5 4.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.5 5.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.5 3.5 GO:0032405 MutLalpha complex binding(GO:0032405)
0.5 31.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.5 5.5 GO:0034056 estrogen response element binding(GO:0034056)
0.5 7.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.5 22.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 16.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.4 11.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 7.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.4 5.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.4 8.8 GO:0004697 protein kinase C activity(GO:0004697)
0.4 5.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.4 7.4 GO:0043422 protein kinase B binding(GO:0043422)
0.4 52.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 4.4 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.3 1.9 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.3 3.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 7.6 GO:0004527 exonuclease activity(GO:0004527)
0.3 1.6 GO:0052843 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.3 1.8 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.3 15.5 GO:0015485 cholesterol binding(GO:0015485)
0.3 1.7 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.3 7.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.3 6.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 5.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 2.5 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 7.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 48.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 3.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 5.4 GO:0030165 PDZ domain binding(GO:0030165)
0.2 74.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 9.5 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.2 1.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.2 1.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 4.0 GO:0031489 myosin V binding(GO:0031489)
0.2 2.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 49.8 GO:0003924 GTPase activity(GO:0003924)
0.2 6.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 14.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.4 GO:0044548 S100 protein binding(GO:0044548)
0.1 4.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 14.6 GO:0005525 GTP binding(GO:0005525)
0.1 0.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 11.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 3.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 8.8 GO:0004386 helicase activity(GO:0004386)
0.1 4.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.9 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 6.5 GO:0032947 protein complex scaffold(GO:0032947)
0.1 2.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.1 GO:0036122 BMP binding(GO:0036122)
0.1 6.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 2.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 4.2 GO:0070888 E-box binding(GO:0070888)
0.1 5.1 GO:0005496 steroid binding(GO:0005496)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.3 GO:0005080 protein kinase C binding(GO:0005080)
0.1 75.2 GO:0003723 RNA binding(GO:0003723)
0.0 1.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 2.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 216.8 PID AURORA B PATHWAY Aurora B signaling
2.3 140.4 PID PLK1 PATHWAY PLK1 signaling events
2.0 102.3 PID MYC PATHWAY C-MYC pathway
1.2 138.3 PID TELOMERASE PATHWAY Regulation of Telomerase
1.2 41.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.6 36.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 14.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.4 47.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 15.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 7.6 PID ALK2 PATHWAY ALK2 signaling events
0.3 15.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 8.8 PID REELIN PATHWAY Reelin signaling pathway
0.3 47.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 11.8 PID IL2 1PATHWAY IL2-mediated signaling events
0.2 18.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 3.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 9.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 6.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 22.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 3.5 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 9.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.2 17.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 8.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.2 5.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 10.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 4.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 8.5 PID NOTCH PATHWAY Notch signaling pathway
0.2 7.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 2.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 1.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 9.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 6.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 12.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 1.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 51.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
5.0 130.8 REACTOME KINESINS Genes involved in Kinesins
2.7 75.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
2.6 106.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
2.5 204.4 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.7 65.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.7 28.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.5 42.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
1.5 60.4 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
1.4 48.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
1.1 25.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
1.1 24.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
1.0 31.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.9 45.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.9 30.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.9 126.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.8 27.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.7 15.7 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.7 11.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.6 20.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.6 17.0 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.6 49.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 21.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 17.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.5 26.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.5 24.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.5 13.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 6.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 77.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 9.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.4 10.4 REACTOME S PHASE Genes involved in S Phase
0.4 4.2 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.4 8.3 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.4 30.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.4 8.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 7.8 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.3 6.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.3 2.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.2 17.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 2.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 3.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 4.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 7.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 5.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 1.9 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 4.9 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.2 5.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.8 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 3.0 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.1 3.9 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 21.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 1.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 4.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 4.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 5.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 4.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.6 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 6.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.2 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation